Motif ID: PRRX1,2.p2

Z-value: 2.596


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRRX2chr9_+_131467837-0.391.4e-01Click!
PRRX1chr1_+_168899936-0.243.6e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_107807415 5.822 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr3_-_143230124 5.701 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr10_-_32707549 3.878 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr10_+_94584449 3.765 NM_001013848
EXOC6
exocyst complex component 6
chr5_-_169340321 3.411 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr7_-_92615593 3.386 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr10_-_95231933 3.370 NM_013451
NM_133337
MYOF

myoferlin

chr5_+_36642424 3.260 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_-_104696678 3.226 NM_182691
SRPK2
SRSF protein kinase 2
chr11_+_5667494 3.201 NM_006074
TRIM22
tripartite motif containing 22
chr5_+_36642213 3.182 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr5_-_88215034 3.130 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr12_+_52697160 3.116 HOXC5
HOXC6
homeobox C5
homeobox C6
chr16_+_7322751 3.078 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr1_+_242283129 2.869 NM_006352
ZNF238
zinc finger protein 238
chr4_-_90197140 2.841 NM_014883
FAM13A
family with sequence similarity 13, member A
chr7_-_13992351 2.799 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr4_+_86918870 2.724 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr5_+_162862808 2.719 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr13_-_40454188 2.688 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_98428244 2.670 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr7_-_26202626 2.651 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr22_-_34566367 2.649 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr11_+_5667392 2.639 TRIM22
tripartite motif containing 22
chr4_-_74307637 2.610 ANKRD17
ankyrin repeat domain 17
chr7_-_27171648 2.594 HOXA9
homeobox A9
chr8_-_122722674 2.569 NM_005328
HAS2
hyaluronan synthase 2
chr8_-_72431274 2.567 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr1_+_194887630 2.526 NM_000186
NM_001014975
CFH

complement factor H

chr18_+_19826734 2.518 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr2_-_144994038 2.517 ZEB2
zinc finger E-box binding homeobox 2
chr4_-_152366970 2.504 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr10_+_69539255 2.489 NM_032578
MYPN
myopalladin
chr7_-_27171600 2.481 HOXA9
homeobox A9
chr4_+_86918882 2.453 ARHGAP24
Rho GTPase activating protein 24
chr22_-_34566210 2.449 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr5_-_134290789 2.441


chr7_-_27171673 2.435 NM_152739
HOXA9
homeobox A9
chr3_-_115960807 2.433 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr12_+_52696908 2.394 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr12_-_48902692 2.386 NM_001113547
LIMA1
LIM domain and actin binding 1
chr5_-_94442941 2.376 MCTP1
multiple C2 domains, transmembrane 1
chr1_-_197173159 2.371 LOC100131234
familial acute myelogenous leukemia related factor
chr3_-_115585178 2.360 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr12_+_14429499 2.345 ATF7IP
activating transcription factor 7 interacting protein
chr3_+_138132006 2.309 NM_001190796
NCK1
NCK adaptor protein 1
chr22_-_34566276 2.304 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_152517204 2.262 NM_023915
GPR87
G protein-coupled receptor 87
chr2_-_162808123 2.255 NM_004460
FAP
fibroblast activation protein, alpha
chr6_-_139654807 2.238 NM_153235
TXLNB
taxilin beta
chr4_-_152368492 2.217 SH3D19
SH3 domain containing 19
chr7_+_102340579 2.211 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr17_-_44037332 2.204 NM_018952
HOXB6
homeobox B6
chr17_-_43977273 2.155 NM_002145
HOXB2
homeobox B2
chr1_-_171441234 2.128 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr12_-_15005761 2.123 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr13_-_40491405 2.110 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_74799898 2.108 TBC1D4
TBC1 domain family, member 4
chr9_+_124072947 2.101 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr21_+_29439768 2.082 C21orf7
chromosome 21 open reading frame 7
chr13_-_40491491 2.074 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_-_52939584 2.052 NM_001127322
CBX5
chromobox homolog 5
chr3_-_71262426 2.023 FOXP1
forkhead box P1
chr1_+_149299530 2.010 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr12_-_52939636 1.990 NM_001127321
CBX5
chromobox homolog 5
chr2_-_144991556 1.984 ZEB2
zinc finger E-box binding homeobox 2
chr4_+_146820805 1.951 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr3_-_71262405 1.938 FOXP1
forkhead box P1
chr1_-_93030538 1.932 NM_005665
EVI5
ecotropic viral integration site 5
chr8_-_108579270 1.927 NM_001146
ANGPT1
angiopoietin 1
chr11_+_113672378 1.925 NNMT
nicotinamide N-methyltransferase
chr5_+_174084137 1.905 NM_002449
MSX2
msh homeobox 2
chr8_-_17599438 1.894 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr10_+_49279647 1.888 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr2_-_55090759 1.883 NM_007008
RTN4
reticulon 4
chr7_-_13995811 1.871 ETV1
ets variant 1
chr4_-_38710376 1.825 NM_024943
TMEM156
transmembrane protein 156
chr6_-_117853710 1.797 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr7_-_41709191 1.794 NM_002192
INHBA
inhibin, beta A
chr12_-_15706340 1.791 EPS8
epidermal growth factor receptor pathway substrate 8
chrX_-_19727775 1.759 SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_149299504 1.745 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_+_29297806 1.741 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chrX_+_114734074 1.719 NM_001136025
NM_001172335
PLS3

plastin 3

chr2_+_36777406 1.705 VIT
vitrin
chr5_-_124108672 1.703 NM_020747
ZNF608
zinc finger protein 608
chr9_+_18464138 1.685 ADAMTSL1
ADAMTS-like 1
chr4_-_153493133 1.661 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr7_+_111908143 1.661 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr4_+_86968069 1.657 ARHGAP24
Rho GTPase activating protein 24
chr4_+_169789327 1.624 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr4_+_160408447 1.621 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr1_-_89261021 1.618 NM_018284
GBP3
guanylate binding protein 3
chr12_-_9804682 1.616 NM_001781
CD69
CD69 molecule
chr3_+_46423682 1.610 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chrX_-_19727828 1.610 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr10_-_64698831 1.606 NM_004241
JMJD1C
jumonji domain containing 1C
chr5_+_147775652 1.597 FBXO38
F-box protein 38
chr6_+_121798443 1.593 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr5_-_88155360 1.592 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_-_160764819 1.586 NM_000888
ITGB6
integrin, beta 6
chr2_+_108604111 1.574 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr3_-_15814678 1.571 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr3_+_35696119 1.553 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr5_+_40877053 1.548 NM_032587
CARD6
caspase recruitment domain family, member 6
chr21_-_35174742 1.546 RUNX1
runt-related transcription factor 1
chr7_+_18501876 1.545 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr4_+_106851415 1.545 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr9_+_74956614 1.543 ANXA1
annexin A1
chr1_+_84540921 1.540 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr9_+_126460511 1.521


chr8_-_49996353 1.514 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr3_+_153468518 1.513 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr3_+_161040439 1.505 SCHIP1
schwannomin interacting protein 1
chr2_-_188021117 1.488 NM_005795
CALCRL
calcitonin receptor-like
chr8_+_67201684 1.488 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr2_+_108571209 1.487 LIMS1
LIM and senescent cell antigen-like domains 1
chr1_+_149299490 1.480 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_-_7724762 1.477 NM_002947
RPA3
replication protein A3, 14kDa
chr5_-_94443300 1.448 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr3_+_69895310 1.445 NM_001184967
MITF
microphthalmia-associated transcription factor
chr10_+_86174665 1.440 FAM190B
family with sequence similarity 190, member B
chrX_+_102471769 1.438 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr17_+_46176105 1.430 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr3_+_190147633 1.425 TPRG1
tumor protein p63 regulated 1
chr2_-_175170674 1.398 WIPF1
WAS/WASL interacting protein family, member 1
chr13_+_22653059 1.393 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr8_-_116749382 1.391 TRPS1
trichorhinophalangeal syndrome I
chr7_+_113853790 1.386 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr7_-_13996166 1.383 NM_001163147
NM_004956
ETV1

ets variant 1

chr9_+_74956494 1.379 NM_000700
ANXA1
annexin A1
chr3_+_35697432 1.357 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_-_30032649 1.354 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr6_+_134800533 1.353 LOC154092
hypothetical LOC154092
chr21_-_14840506 1.335 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr4_+_3341521 1.334 NM_198227
RGS12
regulator of G-protein signaling 12
chr8_-_102029997 1.331 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_-_114215768 1.326 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr7_+_18515488 1.315 HDAC9
histone deacetylase 9
chr7_-_112545840 1.311 LOC401397
hypothetical LOC401397
chr4_+_74825138 1.309 NM_000584
IL8
interleukin 8
chr14_+_69307914 1.309 SRSF5
serine/arginine-rich splicing factor 5
chr2_+_33514896 1.307 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr7_+_18515440 1.294 HDAC9
histone deacetylase 9
chr8_+_77756077 1.293 ZFHX4
zinc finger homeobox 4
chr8_+_77756061 1.293 NM_024721
ZFHX4
zinc finger homeobox 4
chr11_+_33306652 1.289 HIPK3
homeodomain interacting protein kinase 3
chr12_-_9913199 1.269 CLEC2B
C-type lectin domain family 2, member B
chr5_-_75954807 1.267 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr4_-_91979113 1.266 NM_183049
TMSL3
thymosin-like 3
chr13_+_100902942 1.259 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chrX_-_138552517 1.252 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr3_+_157877146 1.250 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr2_-_190635566 1.249 NM_005259
MSTN
myostatin
chr12_-_16650687 1.248 LMO3
LIM domain only 3 (rhombotin-like 2)
chr18_-_51406359 1.225 TCF4
transcription factor 4
chr4_+_75393053 1.222 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr17_-_46479127 1.220 SPAG9
sperm associated antigen 9
chr1_-_68470585 1.217 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr3_+_161040343 1.212 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr12_-_41269679 1.206 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr22_-_34564611 1.205 RPL41P5
ribosomal protein L41 pseudogene 5
chr8_-_116750277 1.204 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr11_-_58099884 1.198 NM_004811
LPXN
leupaxin
chr6_+_136214495 1.184 NM_018945
PDE7B
phosphodiesterase 7B
chr3_-_11585264 1.183 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr5_-_98290117 1.182 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr7_+_115650240 1.182 NM_152829
TES
testis derived transcript (3 LIM domains)
chr2_+_178893216 1.180 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr3_+_35658852 1.180 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr22_+_24468168 1.177 MYO18B
myosin XVIIIB
chr11_+_86710076 1.175 TMEM135
transmembrane protein 135
chr10_-_29963906 1.174 NM_021738
SVIL
supervillin
chr5_+_86712376 1.171


chr8_+_42671718 1.157 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr12_-_16650697 1.150 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr22_+_24468110 1.147 NM_032608
MYO18B
myosin XVIIIB
chr6_-_85530617 1.147 NM_001080508
TBX18
T-box 18
chr5_+_125786975 1.142 GRAMD3
GRAM domain containing 3
chr12_+_18305740 1.139 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr1_+_86662356 1.138 NM_006536
CLCA2
chloride channel accessory 2
chr21_-_35343331 1.130 RUNX1
runt-related transcription factor 1
chr2_+_237143118 1.122 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr2_-_198248828 1.121 NM_144629
RFTN2
raftlin family member 2
chr3_-_11598829 1.118 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr2_+_108571336 1.115 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_+_559618 1.113


chr5_-_88235624 1.101 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr21_+_45396903 1.099 ADARB1
adenosine deaminase, RNA-specific, B1
chr15_-_68781662 1.099 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr10_-_129581037 1.096


chr14_+_51025604 1.092 NM_001042481
FRMD6
FERM domain containing 6
chr1_+_149299307 1.091 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_+_119506446 1.091 TLR4
toll-like receptor 4
chr9_+_119506428 1.089 TLR4
toll-like receptor 4
chr12_-_101036407 1.085 NM_024057
NUP37
nucleoporin 37kDa
chr3_-_116272911 1.083 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_78243181 1.080 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr11_-_85103438 1.070 NM_032379
SYTL2
synaptotagmin-like 2
chrX_-_64112993 1.066 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.33 1.23e-02 GO:0050793 regulation of developmental process
1.35 3.77e-02 GO:2000026 regulation of multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 2.83e-02 GO:0005886 plasma membrane

Nothing significant found in function category.