Motif ID: HLF.p2

Z-value: 2.304


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HLFchr17_+_506981690.731.3e-03Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113601608 6.895 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr2_+_113601616 4.306 IL1RN
interleukin 1 receptor antagonist
chr9_+_116125123 4.167 NM_000607
ORM1
orosomucoid 1
chr9_+_116131889 3.840 NM_000608
ORM2
orosomucoid 2
chr2_-_113310796 3.577 NM_000576
IL1B
interleukin 1, beta
chr3_-_49701085 3.319 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr9_-_129752687 3.208 NM_203305
FAM102A
family with sequence similarity 102, member A
chr16_+_70654625 3.115 NM_020995
HPR
haptoglobin-related protein
chr10_-_52315436 3.049 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr16_+_55963899 2.966 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr3_-_121883647 2.922 HGD
homogentisate 1,2-dioxygenase
chr12_-_28016182 2.913 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr16_+_70646008 2.891 NM_001126102
NM_005143
HP

haptoglobin

chr17_-_38978772 2.840 NM_001986
ETV4
ets variant 4
chr10_-_95350949 2.753 NM_006744
RBP4
retinol binding protein 4, plasma
chr1_-_228916486 2.567 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_-_30151526 2.564 NM_170769
NM_025236
RNF39

ring finger protein 39

chr4_-_87989291 2.551 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr8_+_124264054 2.519 FAM83A
family with sequence similarity 83, member A
chr17_-_31352643 2.460 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr8_-_145187553 2.447 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr1_-_62557655 2.388 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr1_+_149221122 2.352 NM_003568
ANXA9
annexin A9
chr8_+_124263932 2.245 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr17_-_31352720 2.225 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr9_+_676640 2.183


chr1_-_228916470 2.182 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr11_+_93394025 2.020 NM_001098672
HEPHL1
hephaestin-like 1
chr19_+_40465249 1.990 NM_021175
HAMP
hepcidin antimicrobial peptide
chr3_+_187813538 1.905 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr3_-_12561962 1.903 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr2_+_65517316 1.806 FLJ16124
FLJ16124 protein
chr17_-_36346240 1.773 KRT23
keratin 23 (histone deacetylase inducible)
chr4_+_187424336 1.770 F11
coagulation factor XI
chr13_-_45577144 1.769 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr1_-_228916559 1.743 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_-_17426416 1.703 PEMT
phosphatidylethanolamine N-methyltransferase
chr20_+_61842880 1.663 SLC2A4RG
SLC2A4 regulator
chr6_+_32003180 1.652 NM_000063
NM_001145903
C2

complement component 2

chr5_+_73145098 1.628 RGNEF
190 kDa guanine nucleotide exchange factor
chr10_-_82039158 1.571 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr17_-_38530935 1.547 NM_007297
NM_007299
NM_007294
NM_007300
BRCA1



breast cancer 1, early onset



chr3_+_120984246 1.544 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr2_-_73723001 1.538 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr1_+_205328834 1.502 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr3_+_187813553 1.491 AHSG
alpha-2-HS-glycoprotein
chr9_-_98421894 1.479 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr3_+_187917791 1.471 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr20_+_41621079 1.464 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr6_+_32003380 1.460 C2
complement component 2
chr11_-_116168316 1.453 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr1_-_62557559 1.451 KANK4
KN motif and ankyrin repeat domains 4
chr1_-_177106702 1.447 NM_004673
ANGPTL1
angiopoietin-like 1
chr6_-_24491498 1.430 NM_001195610
DCDC2
doublecortin domain containing 2
chr19_-_6410735 1.390 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr14_+_23633101 1.372 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr17_-_17426469 1.362 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr12_-_51132129 1.357 NM_005555
KRT6B
keratin 6B
chr17_-_75427644 1.356 NM_003655
CBX4
chromobox homolog 4
chr2_-_31491102 1.351 NM_000379
XDH
xanthine dehydrogenase
chr19_+_50663089 1.350 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr2_-_32344192 1.343 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr11_-_76862197 1.288 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr20_+_47328575 1.271 NCRNA00275
non-protein coding RNA 275
chr5_-_138746840 1.250 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr11_-_66431910 1.237 NM_022172
PC
pyruvate carboxylase
chr22_+_23309717 1.236 NM_013430
GGT1
gamma-glutamyltransferase 1
chr6_-_2785682 1.217 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr2_-_31491057 1.207 XDH
xanthine dehydrogenase
chr3_-_58175437 1.200 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr19_+_53951155 1.198 NM_019113
FGF21
fibroblast growth factor 21
chr22_+_49272078 1.197 NM_017584
MIOX
myo-inositol oxygenase
chr1_+_239762179 1.176 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr20_+_41621119 1.170 SGK2
serum/glucocorticoid regulated kinase 2
chr17_-_31353196 1.165 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr2_+_219453487 1.148 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr18_+_54039779 1.136 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr20_+_31613800 1.134 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr19_-_411995 1.129 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr19_-_4491078 1.124 LRG1
leucine-rich alpha-2-glycoprotein 1
chr9_+_102987137 1.122 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr19_-_56147971 1.116 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr19_-_52308848 1.114 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr20_+_47328585 1.111 NCRNA00275
non-protein coding RNA 275
chr11_-_102081654 1.078 NM_022122
MMP27
matrix metallopeptidase 27
chr14_+_59785723 1.045 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr12_+_56424930 1.035 NM_005981
TSPAN31
tetraspanin 31
chr14_+_59785703 1.025 NM_021003
NM_177951
PPM1A

protein phosphatase, Mg2+/Mn2+ dependent, 1A

chr17_-_53849888 1.025 RNF43
ring finger protein 43
chr5_-_138746917 1.024 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr5_+_150612805 1.017 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr3_+_42107711 1.016 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr9_+_36159384 1.007 NM_005893
CCIN
calicin
chr2_-_98646367 0.999 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chrX_+_9391314 0.994 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr17_-_53849929 0.985 NM_017763
RNF43
ring finger protein 43
chr18_+_59705918 0.974 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr16_-_4528739 0.960 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr17_+_11442472 0.931 NM_001372
DNAH9
dynein, axonemal, heavy chain 9
chr13_+_96726415 0.930 MBNL2
muscleblind-like 2 (Drosophila)
chr14_+_102458745 0.915 NM_030943
AMN
amnionless homolog (mouse)
chr20_+_23419765 0.910 NM_005492
CST8
cystatin 8 (cystatin-related epididymal specific)
chr18_+_59405513 0.902 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr22_+_33792125 0.901 NM_001008494
ISX
intestine-specific homeobox
chr10_+_85994788 0.898 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr20_+_54533191 0.897 NM_001012971
C20orf106
C20orf107
chromosome 20 open reading frame 106
chromosome 20 open reading frame 107
chr12_-_121767272 0.896 NM_006018
GPR109B
G protein-coupled receptor 109B
chr18_+_54039730 0.895 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_+_108360798 0.875 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr14_+_31868229 0.860 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr2_+_3683660 0.860 NM_018436
ALLC
allantoicase
chr16_-_66614599 0.859 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr17_-_71352017 0.850 UNC13D
unc-13 homolog D (C. elegans)
chr17_+_38531134 0.845 NBR2
neighbor of BRCA1 gene 2 (non-protein coding)
chr10_+_70650064 0.845 NM_025130
HKDC1
hexokinase domain containing 1
chr18_-_41932255 0.836 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr16_-_54424517 0.823 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr9_-_68552337 0.820 NM_001085457
CBWD5
CBWD3
CBWD1
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 1
COBW domain containing 6
chr14_-_22354457 0.819 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr12_-_121753795 0.818 NM_177551
GPR109A
G protein-coupled receptor 109A
chr9_+_674193 0.816


chr3_+_123526700 0.812 NM_005213
CSTA
cystatin A (stefin A)
chr17_-_36792161 0.809 NM_021013
KRT34
keratin 34
chr19_-_4491024 0.803 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr2_+_113119985 0.790 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr3_+_187813405 0.789 AHSG
alpha-2-HS-glycoprotein
chrX_-_13744933 0.788 GPM6B
glycoprotein M6B
chr18_-_41932249 0.781 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr17_-_38530830 0.772 BRCA1
breast cancer 1, early onset
chr17_+_632262 0.771 NM_018146
RNMTL1
RNA methyltransferase like 1
chr3_-_150422474 0.765 NM_000096
CP
ceruloplasmin (ferroxidase)
chr4_+_39084867 0.765 NM_175737
KLB
klotho beta
chr11_-_102219450 0.763 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr12_-_1791146 0.751 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr11_+_76516957 0.746 NM_000260
NM_001127179
NM_001127180
MYO7A


myosin VIIA


chr18_-_41932231 0.740 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr8_-_6722848 0.738 NM_005218
DEFB1
defensin, beta 1
chr21_-_42060266 0.732 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr16_-_54424473 0.726 CES1
carboxylesterase 1
chr7_+_55987046 0.719 NM_015969
MRPS17
mitochondrial ribosomal protein S17
chr18_-_41932228 0.719 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr12_-_115803614 0.714 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr3_-_172227152 0.714 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr5_-_42847716 0.713 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_+_63928459 0.709 NM_001128149
ATXN7
ataxin 7
chr11_+_62893836 0.709 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr6_-_32206029 0.706 NM_022110
FKBPL
FK506 binding protein like
chr2_+_68548173 0.701 NM_173545
APLF
aprataxin and PNKP like factor
chr2_-_191580567 0.697 STAT1
signal transducer and activator of transcription 1, 91kDa
chr16_-_66614621 0.696 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr16_+_66614645 0.677 NM_017803
DUS2L
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
chr14_+_59785739 0.670 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr6_+_131936057 0.662 NM_000045
ARG1
arginase, liver
chr9_-_69729965 0.658 CBWD5
COBW domain containing 5
chr18_-_41932271 0.646 NM_004046
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr17_+_38575939 0.642 NM_031862
NM_031858
NBR1

neighbor of BRCA1 gene 1

chr18_-_41932185 0.641 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr14_-_19871267 0.635 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr9_-_69729958 0.632 CBWD6
COBW domain containing 6
chr2_+_201464884 0.631 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr20_-_43177137 0.620 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr9_+_70046658 0.615 NM_201453
CBWD5
CBWD3
CBWD1
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 1
COBW domain containing 6
chr14_-_22354389 0.614 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr9_-_106705867 0.613 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr10_+_74323344 0.613 NM_152635
OIT3
oncoprotein induced transcript 3
chr14_-_49399317 0.612 RN7SL2
RNA, 7SL, cytoplasmic 2
chr16_+_30391550 0.602 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr17_-_36528113 0.597 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr12_-_47031287 0.592 NM_001172682
ZNF641
zinc finger protein 641
chr20_+_58064360 0.592 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr1_+_110456584 0.592 NM_203412
UBL4B
ubiquitin-like 4B
chr17_+_59205289 0.588 NM_007372
NM_203499
DDX42

DEAD (Asp-Glu-Ala-Asp) box polypeptide 42

chr3_+_138132006 0.579 NM_001190796
NCK1
NCK adaptor protein 1
chr14_-_23802184 0.577 NM_000359
TGM1
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
chr14_-_21074875 0.577 NM_005407
SALL2
sal-like 2 (Drosophila)
chr10_+_89257569 0.576 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr1_-_228916958 0.574 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr16_+_30391460 0.572 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr10_-_46593923 0.571 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr2_-_43676603 0.570 NM_001083953
NM_022065
THADA

thyroid adenoma associated

chr6_+_17501589 0.570 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr2_+_69995807 0.568 MXD1
MAX dimerization protein 1
chr2_+_161980865 0.565 NM_006593
TBR1
T-box, brain, 1
chr15_-_81412354 0.563 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr2_-_114230455 0.561 SLC35F5
solute carrier family 35, member F5
chr1_+_115373937 0.559 NM_000549
TSHB
thyroid stimulating hormone, beta
chr6_+_144654565 0.555 NM_007124
UTRN
utrophin
chr2_-_114230666 0.554 NM_025181
SLC35F5
solute carrier family 35, member F5
chr1_-_202449659 0.554 NM_198447
GOLT1A
golgi transport 1A
chr14_-_69333624 0.553 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr20_+_16676997 0.553 NM_020157
OTOR
otoraplin
chrX_+_41191630 0.552 NM_022567
NYX
nyctalopin
chr14_-_94053933 0.550 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr2_+_228386800 0.545 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr8_-_10550026 0.544 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr21_-_29286982 0.538 NM_015565
LTN1
listerin E3 ubiquitin protein ligase 1
chr3_-_172227223 0.538 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr10_+_114123765 0.536 ACSL5
acyl-CoA synthetase long-chain family member 5
chr9_-_94095787 0.535 NM_013417
IARS
isoleucyl-tRNA synthetase
chr4_-_23500706 0.531 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.01 4.55e-05 GO:0005615 extracellular space
1.81 2.63e-04 GO:0044421 extracellular region part
1.45 7.35e-03 GO:0005576 extracellular region
7.24 8.99e-03 GO:0034364 high-density lipoprotein particle
5.67 1.69e-02 GO:0032994 protein-lipid complex
5.67 1.69e-02 GO:0034358 plasma lipoprotein particle

Nothing significant found in function category.