Motif ID: REST.p3

Z-value: 0.993


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57469122-0.214.4e-01Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_99599984 1.646 NM_001010917
GOLGA7B
golgin A7 family, member B
chr20_+_30019465 1.272 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr11_-_72170533 1.266 STARD10
StAR-related lipid transfer (START) domain containing 10
chr8_-_145530639 1.243 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr12_+_46133 1.200 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr3_-_48675321 1.064 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr19_+_45728270 1.021 SPTBN4
spectrin, beta, non-erythrocytic 4
chr19_+_45728207 1.014 NM_025213
SPTBN4
spectrin, beta, non-erythrocytic 4
chr1_-_207892420 0.980 NM_000228
LAMB3
laminin, beta 3
chr10_+_60607232 0.937 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr9_+_116131889 0.780 NM_000608
ORM2
orosomucoid 2
chr11_-_125278296 0.712 NM_031307
PUS3
pseudouridylate synthase 3
chr7_+_145444385 0.704 NM_014141
CNTNAP2
contactin associated protein-like 2
chrX_-_48943582 0.682 NM_003179
SYP
synaptophysin
chr12_-_3472245 0.612 LOC100129223
hypothetical LOC100129223
chr20_-_61755145 0.585 NM_015894
STMN3
stathmin-like 3
chr11_-_65871592 0.572 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr14_-_73962557 0.555 NM_001105579
TMEM90A
transmembrane protein 90A
chr19_-_60383280 0.554 NM_003180
SYT5
synaptotagmin V
chr6_+_43711532 0.544 NM_014628
MAD2L1BP
MAD2L1 binding protein
chr6_+_43711566 0.530 MAD2L1BP
MAD2L1 binding protein
chr10_+_26545241 0.520 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr5_-_151284515 0.484 NM_000171
NM_001146040
GLRA1

glycine receptor, alpha 1

chr20_-_60228665 0.482 NM_007232
HRH3
histamine receptor H3
chr7_-_100595552 0.472 NM_003378
VGF
VGF nerve growth factor inducible
chr12_+_117903682 0.462 NM_194286
SRRM4
serine/arginine repetitive matrix 4
chr19_-_50619015 0.461 NM_001166049
NM_001983
ERCC1

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

chr6_+_25760352 0.450 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr14_-_93829347 0.436 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr15_-_81175542 0.416 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr16_+_4948318 0.406 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr5_-_175969697 0.401 NM_052899
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr11_+_64565118 0.394 SAC3D1
SAC3 domain containing 1
chr19_-_50618982 0.393 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr1_-_102235377 0.380 NM_058170
OLFM3
olfactomedin 3
chr3_+_195336625 0.378 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr17_-_24357014 0.366 NM_001098635
NM_178860
SEZ6

seizure related 6 homolog (mouse)

chr12_-_97812633 0.359 ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_-_175986952 0.357 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr15_+_92575767 0.357 MCTP2
multiple C2 domains, transmembrane 2
chrX_-_152794478 0.341 L1CAM
L1 cell adhesion molecule
chr19_-_50618921 0.335 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chrX_-_47364173 0.322 NM_006950
NM_133499
SYN1

synapsin I

chr2_-_51112743 0.314 NRXN1
neurexin 1
chr3_-_133236447 0.311 NM_130808
CPNE4
copine IV
chr1_-_102234959 0.306 OLFM3
olfactomedin 3
chr3_+_122109716 0.303 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr6_+_158877640 0.290 TMEM181
transmembrane protein 181
chr1_+_208178198 0.284 SYT14
synaptotagmin XIV
chr12_-_29828958 0.284 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr1_-_149955870 0.275 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr3_+_195336631 0.265 HES1
hairy and enhancer of split 1, (Drosophila)
chr19_-_45416043 0.259 TTC9B
tetratricopeptide repeat domain 9B
chr17_+_70178850 0.252 NM_175738
RAB37
RAB37, member RAS oncogene family
chr20_+_44091219 0.248 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr5_+_175231210 0.244 CPLX2
complexin 2
chr10_+_69990050 0.243 NM_030625
TET1
tet oncogene 1
chr8_-_145723209 0.242 NM_001024678
LRRC24
leucine rich repeat containing 24
chr10_-_50640327 0.241 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr5_+_175231170 0.240


chr6_+_44346457 0.236 NM_001137560
TMEM151B
transmembrane protein 151B
chr6_+_158877455 0.234 NM_020823
TMEM181
transmembrane protein 181
chr17_+_70178911 0.231 RAB37
RAB37, member RAS oncogene family
chr19_-_45416112 0.226 NM_152479
TTC9B
tetratricopeptide repeat domain 9B
chr20_+_5839973 0.225 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr8_-_91164100 0.224 NM_004929
CALB1
calbindin 1, 28kDa
chr19_-_50618599 0.220 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr17_-_3283884 0.215 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr20_+_44091265 0.213 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_+_38867273 0.212 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr15_-_29950188 0.212 OTUD7A
OTU domain containing 7A
chr5_+_175231098 0.211 NM_001008220
CPLX2
complexin 2
chr19_-_50618659 0.205 NM_202001
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr5_-_135729062 0.195 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chrX_-_47364039 0.178


chr15_-_29950070 0.174 OTUD7A
OTU domain containing 7A
chr1_+_33124658 0.173 NM_002143
HPCA
hippocalcin
chr16_+_24174975 0.169 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr18_-_5187240 0.161 NM_001145194
LOC642597
hypothetical protein LOC642597
chr17_-_7095622 0.160 NM_001143775
CTDNEP1
CTD nuclear envelope phosphatase 1
chr14_+_92459197 0.159 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr19_-_44427446 0.155 NM_172139
IL28B
interleukin 28B (interferon, lambda 3)
chr17_+_39741306 0.155 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr2_+_131230252 0.154 NM_001105194
NM_001105195
FAM123C

family with sequence similarity 123C

chr9_-_138236775 0.154 NM_178138
LHX3
LIM homeobox 3
chr8_-_94046891 0.140 NM_001191036
C8orf83
chromosome 8 open reading frame 83
chr14_+_92459244 0.140 CHGA
chromogranin A (parathyroid secretory protein 1)
chr1_+_170017452 0.139 METTL13
methyltransferase like 13
chr4_+_158361185 0.137 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr12_+_112280753 0.136 NM_001159727
NM_173542
PLBD2

phospholipase B domain containing 2

chr1_-_33108876 0.132 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr1_+_208178160 0.130 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr14_+_20226762 0.129 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chrX_-_152794592 0.125 NM_000425
NM_001143963
NM_024003
L1CAM


L1 cell adhesion molecule


chr1_+_1836125 0.121 NM_138705
CALML6
calmodulin-like 6
chr5_+_175231144 0.113 CPLX2
complexin 2
chr9_-_103397023 0.109 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr16_+_66244314 0.109 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr1_+_210672817 0.108 NM_013349
NENF
neuron derived neurotrophic factor
chr6_+_138767007 0.106 NM_014320
HEBP2
heme binding protein 2
chr10_+_26545599 0.104 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr10_+_73225533 0.103 NM_001171933
NM_001171934
CDH23

cadherin-related 23

chr6_+_138767151 0.103 HEBP2
heme binding protein 2
chr11_+_62136788 0.102 NM_000327
ROM1
retinal outer segment membrane protein 1
chr12_+_112280757 0.102 PLBD2
phospholipase B domain containing 2
chr6_-_32121784 0.099 NM_032470
TNXB
tenascin XB
chr1_+_152806924 0.099 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr6_+_35881048 0.096 NM_182548
LHFPL5
lipoma HMGIC fusion partner-like 5
chr16_+_2959342 0.091 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr17_-_3248453 0.088 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr22_+_18388656 0.086 C22orf25
chromosome 22 open reading frame 25
chr1_+_170017430 0.083 METTL13
methyltransferase like 13
chr22_+_18388633 0.079 C22orf25
chromosome 22 open reading frame 25
chr8_-_94047440 0.075 NM_001191035
NM_001171795
NM_001171796
NM_001171797
NM_001171798
NM_001171799
C8orf83





chromosome 8 open reading frame 83





chr16_+_2959362 0.075 PAQR4
progestin and adipoQ receptor family member IV
chr1_-_173979292 0.074 NM_003285
TNR
tenascin R (restrictin, janusin)
chr6_+_43257903 0.073 CUL9
cullin 9
chr1_+_170017383 0.072 NM_001007239
NM_014955
NM_015935
METTL13


methyltransferase like 13


chr2_-_219791638 0.070 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr16_+_24175173 0.070 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr7_+_8439762 0.070 NXPH1
neurexophilin 1
chr19_-_50429306 0.068 NM_138568
EXOC3L2
exocyst complex component 3-like 2
chr2_-_219791902 0.067 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr2_+_207215386 0.064 NM_001102659
LOC200726
hCG1657980
chr11_-_122357545 0.064 NM_001098169
BSX
brain-specific homeobox
chr22_+_18388602 0.063 NM_152906
C22orf25
chromosome 22 open reading frame 25
chr7_+_154943466 0.051 NM_001427
EN2
engrailed homeobox 2
chr7_+_8440109 0.040 NM_152745
NXPH1
neurexophilin 1
chr9_+_139153409 0.039 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr6_+_43257883 0.038 NM_015089
CUL9
cullin 9
chr8_+_11703368 0.037 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr3_+_9720509 0.037 NM_153635
CPNE9
copine family member IX
chr1_-_239749634 0.036 FH
fumarate hydratase
chrX_+_152891184 0.035 NM_003492
TMEM187
transmembrane protein 187
chr17_+_77925441 0.034 NM_018949
UTS2R
urotensin 2 receptor
chr16_+_2450081 0.033 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr12_+_111713931 0.032 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr10_+_28862514 0.032 WAC
WW domain containing adaptor with coiled-coil
chr17_-_37022465 0.031 NM_005557
KRT16
keratin 16
chr5_-_70621688 0.030 SMA4
glucuronidase, beta pseudogene
chr9_-_130078017 0.030 NM_004486
GOLGA2
golgin A2
chr18_-_53404783 0.030 NM_000140
NM_001012515
FECH

ferrochelatase

chr8_+_80685859 0.027 STMN2
stathmin-like 2
chr6_+_154402135 0.024 NM_000914
NM_001008503
NM_001008504
NM_001008505
NM_001145282
NM_001145283
NM_001145285
NM_001145286
NM_001145284
OPRM1








opioid receptor, mu 1








chr8_-_57521065 0.023 NM_006211
PENK
proenkephalin
chr17_-_62793097 0.021 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr17_-_62793129 0.019 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr17_+_27838041 0.016 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr19_-_11500912 0.016 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr20_+_56861430 0.016 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr2_-_51113040 0.015 NM_001135659
NM_004801
NRXN1

neurexin 1

chr1_-_239749683 0.015 NM_000143
FH
fumarate hydratase
chr3_-_188870799 0.013 NM_001048
SST
somatostatin
chr21_-_34749908 0.012 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr15_+_73074882 0.012 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr3_-_25680723 0.011 NM_001068
TOP2B
topoisomerase (DNA) II beta 180kDa
chr15_-_24570010 0.010 NM_021912
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr17_-_77474597 0.010 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr5_-_69917721 0.008 SMA4
glucuronidase, beta pseudogene
chr1_-_20707103 0.000 MUL1
mitochondrial E3 ubiquitin protein ligase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.06 1.25e-06 GO:0019226 transmission of nerve impulse
6.06 1.25e-06 GO:0035637 multicellular organismal signaling
6.41 1.76e-06 GO:0007268 synaptic transmission
3.09 2.66e-04 GO:0050877 neurological system process
3.94 6.26e-04 GO:0007267 cell-cell signaling
6.04 1.03e-03 GO:0007610 behavior
2.68 1.19e-03 GO:0003008 system process
3.32 1.80e-03 GO:0007154 cell communication
4.44 1.88e-02 GO:0006873 cellular ion homeostasis
4.29 2.58e-02 GO:0055082 cellular chemical homeostasis
4.10 3.87e-02 GO:0050801 ion homeostasis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.18 2.75e-06 GO:0045202 synapse
7.22 4.29e-06 GO:0044456 synapse part
21.22 5.24e-05 GO:0030672 synaptic vesicle membrane
6.77 1.01e-04 GO:0030659 cytoplasmic vesicle membrane
5.40 1.23e-04 GO:0043005 neuron projection
6.54 1.42e-04 GO:0012506 vesicle membrane
13.11 1.53e-04 GO:0030665 clathrin coated vesicle membrane
12.96 1.66e-04 GO:0008021 synaptic vesicle
4.20 3.83e-04 GO:0030054 cell junction
5.62 6.18e-04 GO:0044433 cytoplasmic vesicle part
3.72 8.28e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
3.65 1.05e-03 GO:0031988 membrane-bounded vesicle
7.96 1.11e-03 GO:0030136 clathrin-coated vesicle
9.69 1.17e-03 GO:0030662 coated vesicle membrane
3.50 1.77e-03 GO:0031410 cytoplasmic vesicle
7.45 1.80e-03 GO:0043025 neuronal cell body
7.24 2.22e-03 GO:0044297 cell body
3.39 2.65e-03 GO:0031982 vesicle
6.50 4.82e-03 GO:0030135 coated vesicle
7.53 6.02e-03 GO:0045211 postsynaptic membrane
28.09 2.28e-02 GO:0032589 neuron projection membrane
79.57 3.45e-02 GO:0032590 dendrite membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
13.27 7.65e-04 GO:0005230 extracellular ligand-gated ion channel activity
16.94 1.42e-03 GO:0005231 excitatory extracellular ligand-gated ion channel activity
36.73 8.51e-03 GO:0016594 glycine binding
7.65 1.76e-02 GO:0015276 ligand-gated ion channel activity
7.65 1.76e-02 GO:0022834 ligand-gated channel activity
79.57 3.01e-02 GO:0016933 extracellular-glycine-gated ion channel activity
79.57 3.01e-02 GO:0016934 extracellular-glycine-gated chloride channel activity