Motif ID: CRX.p2

Z-value: 2.085


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CRXchr19_+_530169100.292.7e-01Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_56567839 3.224 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr1_+_559618 2.929


chr1_+_559129 2.720


chr10_-_76538859 2.554 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr3_+_50281582 2.353 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr20_-_48165886 2.340 NM_022442
NM_021988
NM_199144
UBE2V1


ubiquitin-conjugating enzyme E2 variant 1


chr15_+_21361546 2.299 NM_005664
MKRN3
makorin ring finger protein 3
chr2_+_37282516 2.179 LOC100505876
hypothetical LOC100505876
chr9_-_99740243 2.042 NM_197978
HEMGN
hemogen
chr11_+_61473931 2.034 NM_001139443
NM_004183
BEST1

bestrophin 1

chr5_-_134290789 2.025


chr6_-_49712483 2.013 NM_000324
RHAG
Rh-associated glycoprotein
chr1_-_156923111 1.882 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr11_+_61279436 1.843 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr18_+_53865455 1.835 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_-_118405288 1.825 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr2_-_200033445 1.808 SATB2
SATB homeobox 2
chr6_+_163904564 1.785 QKI
quaking homolog, KH domain RNA binding (mouse)
chr12_+_56114724 1.782 NM_005538
INHBC
inhibin, beta C
chrX_-_24600661 1.773 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr3_+_186529376 1.722 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr17_+_35718948 1.658 NM_000964
RARA
retinoic acid receptor, alpha
chr6_-_149847809 1.611 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr15_+_57691272 1.539 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr7_+_111850367 1.535 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr19_-_56585603 1.526 NM_001193623
LOC147646
hypothetical protein LOC147646
chr19_-_12858956 1.500 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr4_-_186969041 1.474 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr6_+_132000134 1.467 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr3_+_50281309 1.419 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr12_+_130004404 1.408 NM_198827
GPR133
G protein-coupled receptor 133
chr17_+_50333021 1.361 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr1_+_61319976 1.359 NM_001145512
NFIA
nuclear factor I/A
chr21_+_39745649 1.352 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr11_-_5110383 1.350 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr20_+_42417752 1.328 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr3_+_82117978 1.310


chr20_+_41621079 1.296 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chrX_-_70248022 1.290 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr6_-_31812251 1.287 CLIC1
chloride intracellular channel 1
chr20_+_41621119 1.277 SGK2
serum/glucocorticoid regulated kinase 2
chr11_-_116168316 1.274 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr5_-_74568458 1.269 NM_001164443
ANKRD31
ankyrin repeat domain 31
chr3_+_63928459 1.236 NM_001128149
ATXN7
ataxin 7
chr6_+_105511615 1.220 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr1_+_202033273 1.219 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr9_+_4829763 1.206 RCL1
RNA terminal phosphate cyclase-like 1
chr7_-_99115454 1.201 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr6_-_31812260 1.196 CLIC1
chloride intracellular channel 1
chr1_-_100003936 1.187 NM_001013660
FRRS1
ferric-chelate reductase 1
chr7_+_142692165 1.172 NM_153345
TMEM139
transmembrane protein 139
chr15_-_50270856 1.166 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr8_+_77928372 1.161 ZFHX4
zinc finger homeobox 4
chr6_-_31812214 1.145 CLIC1
chloride intracellular channel 1
chr14_-_22516271 1.140 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr12_+_108038774 1.128 ACACB
acetyl-CoA carboxylase beta
chr9_+_132990760 1.121 NM_005085
NUP214
nucleoporin 214kDa
chr2_-_88208650 1.112 NM_001443
FABP1
fatty acid binding protein 1, liver
chr1_-_26266571 1.107 NM_032588
TRIM63
tripartite motif containing 63
chr7_+_128367961 1.101 NM_001098627
IRF5
interferon regulatory factor 5
chr6_-_31812266 1.072 CLIC1
chloride intracellular channel 1
chr6_-_31812283 1.064 CLIC1
chloride intracellular channel 1
chr2_+_201806410 1.054 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr2_+_211050653 1.054 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr17_+_1586034 1.051 WDR81
WD repeat domain 81
chr6_+_147568795 1.046 STXBP5
syntaxin binding protein 5 (tomosyn)
chr11_-_46569489 1.042 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr21_-_38415273 1.042 NM_005867
DSCR4
Down syndrome critical region gene 4
chr4_-_186969202 1.006 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr6_-_31812297 1.000 NM_001288
CLIC1
chloride intracellular channel 1
chr20_-_43972061 0.993 PLTP
phospholipid transfer protein
chr1_+_144149794 0.992 NM_006472
TXNIP
thioredoxin interacting protein
chr6_-_144427340 0.987 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr16_-_68317945 0.986 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr3_-_52712639 0.978 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr4_-_88531245 0.975 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr10_+_4995685 0.975 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr10_-_82039158 0.974 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_-_109651140 0.960 NM_001010985
MYBPHL
myosin binding protein H-like
chr6_+_28425666 0.959 NM_024493
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr2_-_75650355 0.943 NM_032181
FAM176A
family with sequence similarity 176, member A
chr3_-_19950675 0.939 NM_144715
EFHB
EF-hand domain family, member B
chr4_+_110968594 0.938 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr5_+_140454382 0.937 NM_018936
PCDHB2
protocadherin beta 2
chr14_-_23847000 0.935 CIDEB
cell death-inducing DFFA-like effector b
chr4_+_17125885 0.931 NM_001079827
CLRN2
clarin 2
chr16_+_56286212 0.930 NM_032269
CCDC135
coiled-coil domain containing 135
chr2_+_3605611 0.927 RPS7
ribosomal protein S7
chr20_-_16501911 0.921 NM_024704
KIF16B
kinesin family member 16B
chr8_+_26206648 0.908 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr12_-_69434330 0.907 PTPRR
protein tyrosine phosphatase, receptor type, R
chr17_-_44847214 0.896 PHB
prohibitin
chr17_-_44847215 0.886 NM_002634
PHB
prohibitin
chr16_-_68317855 0.885 NQO1
NAD(P)H dehydrogenase, quinone 1
chr14_-_23846993 0.882 CIDEB
cell death-inducing DFFA-like effector b
chr11_-_117589283 0.875 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr19_+_43616167 0.870 NM_000540
NM_001042723
RYR1

ryanodine receptor 1 (skeletal)

chr19_+_17377502 0.863 LOC100507535
hypothetical LOC100507535
chr19_-_17377383 0.855 NM_004335
BST2
bone marrow stromal cell antigen 2
chr10_+_70745615 0.854 NM_033496
HK1
hexokinase 1
chr16_-_68317868 0.838 NQO1
NAD(P)H dehydrogenase, quinone 1
chr3_-_195553297 0.828 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr13_-_45654296 0.823 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_24597717 0.822 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr1_-_153537362 0.820 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr16_+_29597829 0.813 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr18_+_27210737 0.813 NM_001134453
NM_177986
DSG4

desmoglein 4

chr13_-_45654292 0.811 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr16_+_29597965 0.810 QPRT
quinolinate phosphoribosyltransferase
chrX_-_129347101 0.803 NM_178471
GPR119
G protein-coupled receptor 119
chr17_+_38306339 0.802 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr1_+_205329206 0.794 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr1_-_167822248 0.793 F5
coagulation factor V (proaccelerin, labile factor)
chr2_+_62787534 0.793 NM_001142614
EHBP1
EH domain binding protein 1
chrX_-_135783496 0.785


chr2_+_157822355 0.776 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr19_-_5789740 0.776 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr12_+_54000611 0.774 NM_001005182
OR6C1
olfactory receptor, family 6, subfamily C, member 1
chr2_-_111152075 0.771 NM_004336
BUB1
budding uninhibited by benzimidazoles 1 homolog (yeast)
chr4_+_95595419 0.770 PDLIM5
PDZ and LIM domain 5
chr14_-_23847024 0.769 CIDEB
cell death-inducing DFFA-like effector b
chr8_-_38324809 0.767 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr18_-_13905534 0.765 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr2_+_108360798 0.759 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr1_+_152560179 0.753 NM_080429
AQP10
aquaporin 10
chr14_+_87560646 0.750 LOC283587
hypothetical protein LOC283587
chr6_-_149847718 0.748 ZC3H12D
zinc finger CCCH-type containing 12D
chr6_-_25940247 0.745 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr22_+_23329113 0.743 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr15_+_89248423 0.740 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr12_-_52975823 0.736 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr14_-_23846904 0.732 CIDEB
cell death-inducing DFFA-like effector b
chr1_-_93030538 0.730 NM_005665
EVI5
ecotropic viral integration site 5
chrX_-_11194015 0.730 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr12_-_112058403 0.728 NM_001193520
NM_004658
RASAL1

RAS protein activator like 1 (GAP1 like)

chr2_+_113601608 0.726 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr1_-_167822334 0.712 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chrX_+_69426603 0.703 NM_012310
KIF4A
kinesin family member 4A
chr19_+_60283571 0.698 NM_017729
EPS8L1
EPS8-like 1
chr1_+_144152864 0.696 TXNIP
thioredoxin interacting protein
chr17_+_52689372 0.692 NM_170721
MSI2
musashi homolog 2 (Drosophila)
chr18_+_31488530 0.691 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr21_+_44729875 0.688


chr9_+_38382696 0.686 ALDH1B1
aldehyde dehydrogenase 1 family, member B1
chr17_-_37599953 0.686 NM_001142622
NM_001142623
NM_032484
GHDC


GH3 domain containing


chr8_-_17797127 0.684 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr5_-_169657192 0.683 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_+_139008667 0.682 CXXC5
CXXC finger protein 5
chr12_-_53153613 0.681 GTSF1
gametocyte specific factor 1
chr1_+_179164195 0.671


chr6_-_127705244 0.671 NM_001139510
ECHDC1
enoyl CoA hydratase domain containing 1
chr9_+_38382700 0.670 NM_000692
ALDH1B1
aldehyde dehydrogenase 1 family, member B1
chr1_+_182287388 0.665 NM_001127394
NM_052965
TSEN15

tRNA splicing endonuclease 15 homolog (S. cerevisiae)

chr12_-_9804682 0.665 NM_001781
CD69
CD69 molecule
chr6_+_43651855 0.644 NM_006502
POLH
polymerase (DNA directed), eta
chr5_-_169657360 0.643 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_+_10693964 0.642 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr6_-_2696152 0.639 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chrX_-_48655978 0.635 PIM2
pim-2 oncogene
chr1_-_239865724 0.635 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr17_-_36346240 0.633 KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_34262862 0.633 RPL23
ribosomal protein L23
chr16_-_65108605 0.631 TK2
thymidine kinase 2, mitochondrial
chr2_-_55090759 0.630 NM_007008
RTN4
reticulon 4
chr13_-_45654327 0.629 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_113601616 0.627 IL1RN
interleukin 1 receptor antagonist
chr10_-_5035967 0.625 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr17_-_31231421 0.622 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr2_+_228386800 0.616 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr2_-_73781974 0.610 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chr11_-_59707074 0.609 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr9_-_74757735 0.608 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr4_-_155753249 0.606 FGG
fibrinogen gamma chain
chr7_+_116447499 0.603 ST7
suppression of tumorigenicity 7
chr10_+_74540215 0.595 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr5_-_39255335 0.595 NM_001465
NM_199335
FYB

FYN binding protein

chr10_-_101831579 0.593 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr5_+_43645018 0.591 NNT
nicotinamide nucleotide transhydrogenase
chr6_+_31661934 0.590 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr6_-_11887265 0.590 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr3_-_17757402 0.588 NM_014744
TBC1D5
TBC1 domain family, member 5
chr1_-_246045653 0.577 NM_001001966
OR14A16
olfactory receptor, family 14, subfamily A, member 16
chr22_+_21370394 0.575 IGL@
immunoglobulin lambda locus
chr4_+_187424336 0.574 F11
coagulation factor XI
chr7_-_33047042 0.573 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr14_+_22911857 0.572 NM_172314
NM_022789
IL25

interleukin 25

chr20_+_42417502 0.571 HNF4A
hepatocyte nuclear factor 4, alpha
chr22_+_21359175 0.570 IGLV3-25
immunoglobulin lambda variable 3-25
chr2_+_3683660 0.568 NM_018436
ALLC
allantoicase
chr19_+_47272173 0.567 ZNF574
zinc finger protein 574
chr1_-_159604287 0.565 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr19_-_56018815 0.565 NM_002257
KLK1
kallikrein 1
chr7_-_142369519 0.562 KEL
Kell blood group, metallo-endopeptidase
chr6_-_66473790 0.562 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr16_-_28322441 0.558 EIF3C
eukaryotic translation initiation factor 3, subunit C
chr6_-_32265489 0.554 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr9_-_103237851 0.553 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr1_+_159462456 0.550 NM_032174
TOMM40L
translocase of outer mitochondrial membrane 40 homolog (yeast)-like
chr2_-_73723001 0.548 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr4_+_74491272 0.546 ALB
albumin

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
11.51 3.74e-02 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity