Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 7.405


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RFX3chr9_-_35159730.758.1e-04Click!
RFX2chr19_-_60614910.674.2e-03Click!
RFXANKchr19_+_19164649-0.601.5e-02Click!
RFX1chr19_-_139780960.572.2e-02Click!
RFX4chr12_+_105519049-0.341.9e-01Click!
RFXAPchr13_+_362913060.263.4e-01Click!
RFX5chr1_-_149586298-0.117.0e-01Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_42701460 14.155 CCDC30
coiled-coil domain containing 30
chr14_+_105012106 12.799 NM_001312
CRIP2
cysteine-rich protein 2
chr2_-_187422141 12.412 NM_182521
ZSWIM2
zinc finger, SWIM-type containing 2
chr22_+_21817512 12.193 NM_004914
RAB36
RAB36, member RAS oncogene family
chr15_+_68971835 11.033 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr15_-_68971665 10.726 NM_020147
THAP10
THAP domain containing 10
chr19_+_59062962 9.466 MYADM
myeloid-associated differentiation marker
chr7_-_139987044 9.419 DENND2A
DENN/MADD domain containing 2A
chr5_-_14064846 9.357 DNAH5
dynein, axonemal, heavy chain 5
chr19_+_59062937 9.294 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr11_-_65860450 9.206 NM_004292
RIN1
Ras and Rab interactor 1
chr4_+_87734489 8.860 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr2_+_27046952 8.856 NM_012326
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr9_-_109291575 8.356 KLF4
Kruppel-like factor 4 (gut)
chr19_+_59062982 8.330 MYADM
myeloid-associated differentiation marker
chr11_+_102485293 8.151 NM_001080463
NM_001377
DYNC2H1

dynein, cytoplasmic 2, heavy chain 1

chr9_-_109291866 7.994 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr2_+_74502364 7.832 NM_032118
WDR54
WD repeat domain 54
chr18_+_30544193 7.804 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr17_-_61618276 7.683 NM_145036
CCDC46
coiled-coil domain containing 46
chr19_-_63776547 7.405 MZF1
myeloid zinc finger 1
chr11_+_7997366 7.399 TUB
tubby homolog (mouse)
chr19_-_63776442 7.368 MZF1
myeloid zinc finger 1
chr4_-_156517423 7.274 MAP9
microtubule-associated protein 9
chr11_+_101423378 7.038 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr6_-_152744022 6.973 SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_+_123501186 6.930 DAB2IP
DAB2 interacting protein
chr6_-_152744143 6.895 SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_+_6998275 6.740 NM_176822
NLRP14
NLR family, pyrin domain containing 14
chr1_-_33669190 6.678 PHC2
polyhomeotic homolog 2 (Drosophila)
chr3_-_114643008 6.629 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr11_-_6998041 6.590 NM_013249
ZNF214
zinc finger protein 214
chr19_-_63301402 6.418 ZSCAN18
zinc finger and SCAN domain containing 18
chr17_+_75625025 6.409 NM_017950
CCDC40
coiled-coil domain containing 40
chr4_-_156517394 6.398 MAP9
microtubule-associated protein 9
chr20_-_49612745 6.376 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr11_+_131285747 6.364 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr14_-_88087575 6.314 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr19_-_63301418 6.228 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr12_-_88270375 6.178 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr6_+_109276280 6.153 NM_032131
ARMC2
armadillo repeat containing 2
chr3_-_59010777 6.055 C3orf67
chromosome 3 open reading frame 67
chr19_-_63301386 6.029 ZSCAN18
zinc finger and SCAN domain containing 18
chr4_-_156517544 6.026 NM_001039580
MAP9
microtubule-associated protein 9
chr14_+_99329198 5.991 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr13_-_43259032 5.936 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr12_-_88270369 5.830 DUSP6
dual specificity phosphatase 6
chr14_-_101841222 5.741 NM_014226
RAGE
renal tumor antigen
chr21_-_35181278 5.735 RUNX1
runt-related transcription factor 1
chr3_-_59010797 5.733 C3orf67
chromosome 3 open reading frame 67
chr4_+_128773529 5.710 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr15_+_96304911 5.657 NM_183376
ARRDC4
arrestin domain containing 4
chr21_-_35181094 5.641


chr5_+_92944680 5.569 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr12_-_88270128 5.526 DUSP6
dual specificity phosphatase 6
chr20_-_49612574 5.495 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr19_-_63776740 5.456 NM_003422
NM_198055
MZF1

myeloid zinc finger 1

chr11_+_133444175 5.216 JAM3
junctional adhesion molecule 3
chr8_-_49810270 5.207 NM_001142857
NM_024593
EFCAB1

EF-hand calcium binding domain 1

chr15_+_96304942 5.156 ARRDC4
arrestin domain containing 4
chr19_-_63643400 5.153 NM_003433
ZNF132
zinc finger protein 132
chr3_+_159771646 5.041 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr2_+_228444570 5.002 NM_178821
WDR69
WD repeat domain 69
chr11_+_133444029 5.000 NM_032801
JAM3
junctional adhesion molecule 3
chrX_-_99778340 4.993 NM_003270
TSPAN6
tetraspanin 6
chr7_+_48041632 4.961 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr3_-_41978464 4.956 NM_017886
ULK4
unc-51-like kinase 4 (C. elegans)
chr3_-_59010740 4.953 NM_198463
C3orf67
chromosome 3 open reading frame 67
chr2_+_48521411 4.918 NM_001135629
NM_001193475
NM_152994
KLRAQ1


KLRAQ motif containing 1


chr22_+_29393914 4.897


chr3_-_139315011 4.889 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr18_+_76006795 4.870 LOC100130522
hypothetical LOC100130522
chr6_-_46728188 4.840 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr4_-_177353707 4.816 NM_144644
SPATA4
spermatogenesis associated 4
chr8_-_485330 4.809 NM_175075
C8orf42
chromosome 8 open reading frame 42
chr16_-_66007650 4.790 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr7_-_13997389 4.729 NM_001163149
ETV1
ets variant 1
chr22_-_29393591 4.685 DUSP18
dual specificity phosphatase 18
chr21_-_42789369 4.681 NM_080860
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr12_-_123568781 4.642


chr13_-_95092283 4.641 DZIP1
DAZ interacting protein 1
chr1_-_36688556 4.597 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr16_-_56393871 4.575 KIFC3
kinesin family member C3
chr11_-_114880275 4.566 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr8_+_94836247 4.554 NM_001142301
NM_153704
TMEM67

transmembrane protein 67

chr11_-_62230078 4.528 NM_032667
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr8_+_13468722 4.519 NM_001007090
C8orf48
chromosome 8 open reading frame 48
chr1_+_167603817 4.509 NM_003666
BLZF1
basic leucine zipper nuclear factor 1
chr1_+_201862845 4.494 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr2_-_175578156 4.476 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr9_+_115396020 4.454 NM_144489
RGS3
regulator of G-protein signaling 3
chr8_+_120497732 4.416 NM_002514
NOV
nephroblastoma overexpressed gene
chr6_+_46728590 4.381 NM_004277
SLC25A27
solute carrier family 25, member 27
chr1_-_167603623 4.381 NM_013330
NM_197972
NME7

non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)

chr22_-_29393786 4.344 NM_152511
DUSP18
dual specificity phosphatase 18
chr1_+_215871288 4.288 NM_138796
SPATA17
spermatogenesis associated 17
chr3_-_109423858 4.279 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr22_-_43272567 4.278 NM_032287
LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr21_-_45532176 4.272 NM_015227
NM_133635
POFUT2

protein O-fucosyltransferase 2

chr5_+_34875025 4.235 NM_144725
TTC23L
tetratricopeptide repeat domain 23-like
chr14_+_23908141 4.212 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr5_-_142045770 4.193 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr16_+_56219802 4.183 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr19_+_63237211 4.182 NM_182572
ZSCAN1
zinc finger and SCAN domain containing 1
chr1_+_167604056 4.171 BLZF1
basic leucine zipper nuclear factor 1
chr1_-_215870935 4.165 NM_018040
GPATCH2
G patch domain containing 2
chr13_+_23451919 4.146 SPATA13
spermatogenesis associated 13
chr10_-_74788508 4.146 NM_145170
TTC18
tetratricopeptide repeat domain 18
chr1_+_153445113 4.097 NM_002455
NM_198883
MTX1

metaxin 1

chr12_-_52939636 4.046 NM_001127321
CBX5
chromobox homolog 5
chr16_-_56393881 4.017 NM_001130100
NM_005550
KIFC3

kinesin family member C3

chr11_-_56846246 3.913 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr6_+_117044334 3.910 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chr1_-_86634511 3.899 NM_001007022
NM_001184765
NM_001184766
NM_020729
ODF2L



outer dense fiber of sperm tails 2-like



chr20_+_43425501 3.850 SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr20_+_43425153 3.804 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 read-through transcript
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr15_+_65334169 3.779 NM_001031715
NM_022784
IQCH

IQ motif containing H

chr3_+_185538998 3.759 FAM131A
family with sequence similarity 131, member A
chr6_-_161614962 3.731 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr5_-_179712920 3.726 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr1_+_201862552 3.693 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr15_-_65334022 3.672 NM_024666
AAGAB
alpha- and gamma-adaptin binding protein
chr21_+_45532377 3.665 LOC642852
hypothetical LOC642852
chr17_-_39211706 3.655 NM_004090
DUSP3
dual specificity phosphatase 3
chr22_-_29082880 3.649 NM_001005409
NM_005877
SF3A1

splicing factor 3a, subunit 1, 120kDa

chr10_-_17283623 3.638 TRDMT1
tRNA aspartic acid methyltransferase 1
chr3_-_47299259 3.628 NM_001134878
NM_022342
NM_182902
KIF9


kinesin family member 9


chr9_+_134275431 3.580 NM_207417
C9orf171
chromosome 9 open reading frame 171
chr3_+_48482213 3.560 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr9_+_134744105 3.551 NM_018956
C9orf9
chromosome 9 open reading frame 9
chr12_+_51979721 3.509 NM_021640
C12orf10
chromosome 12 open reading frame 10
chr12_+_83954229 3.459 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr22_-_37382252 3.446 LOC646851
hypothetical LOC646851
chr3_+_47299333 3.431 NM_025010
KLHL18
kelch-like 18 (Drosophila)
chr4_+_20311121 3.427 NM_001130727
NM_145048
PACRGL

PARK2 co-regulated-like

chr10_+_63092724 3.421 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr12_-_52939584 3.416 NM_001127322
CBX5
chromobox homolog 5
chr9_-_134743984 3.405 NM_152572
AK8
adenylate kinase 8
chr17_-_23686566 3.402 NM_174887
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chr19_+_55221023 3.394 NM_001006656
NM_015428
ZNF473

zinc finger protein 473

chr12_+_46863632 3.370 NM_001013635
C12orf68
chromosome 12 open reading frame 68
chr12_-_83954185 3.356 NM_001100917
TSPAN19
tetraspanin 19
chr2_+_38956606 3.349 NM_001145450
MORN2
MORN repeat containing 2
chr13_-_30634031 3.345 NM_006644
HSPH1
heat shock 105kDa/110kDa protein 1
chr17_+_23686674 3.343 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr3_-_50357994 3.332 NM_015896
ZMYND10
zinc finger, MYND-type containing 10
chrX_-_71268475 3.327 NM_001024455
RGAG4
retrotransposon gag domain containing 4
chr8_-_101187346 3.313 RGS22
regulator of G-protein signaling 22
chr16_-_69822058 3.300 NM_032821
NM_017558
HYDIN

hydrocephalus inducing homolog (mouse)

chr8_-_133756943 3.296 NM_012472
LRRC6
leucine rich repeat containing 6
chr22_+_37382574 3.294 NM_001002880
NM_015373
CBY1

chibby homolog 1 (Drosophila)

chr1_+_201862548 3.290 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr10_-_25344871 3.288 NM_145010
ENKUR
enkurin, TRPC channel interacting protein
chr18_-_46046771 3.284 NM_145020
CCDC11
coiled-coil domain containing 11
chr17_+_52026058 3.265 NM_005450
NOG
noggin
chr22_+_37382617 3.262 CBY1
chibby homolog 1 (Drosophila)
chr8_+_38363150 3.221 NM_144652
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr6_+_52392907 3.219 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chr22_-_29082746 3.213 SF3A1
splicing factor 3a, subunit 1, 120kDa
chr7_-_13997574 3.194 NM_001163148
ETV1
ets variant 1
chr17_+_7199178 3.182 NM_198154
TMEM95
transmembrane protein 95
chrX_+_53095230 3.176 NM_018969
GPR173
G protein-coupled receptor 173
chr15_+_73803351 3.167 NM_175881
ODF3L1
outer dense fiber of sperm tails 3-like 1
chr1_+_37795101 3.159 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr12_+_8958397 3.158 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr2_-_38956496 3.152 NM_198963
DHX57
DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
chr1_-_48710378 3.136 NM_019073
SPATA6
spermatogenesis associated 6
chr22_-_37382525 3.135 NM_001013647
LOC646851
hypothetical LOC646851
chr12_-_62348506 3.128 NM_173812
DPY19L2
dpy-19-like 2 (C. elegans)
chr8_-_94781836 3.118 LOC642924
hypothetical LOC642924
chrX_+_103243762 3.117 NM_001143978
ZCCHC18
zinc finger, CCHC domain containing 18
chr5_-_142046175 3.115 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr2_-_110319828 3.106 NPHP1
nephronophthisis 1 (juvenile)
chr11_+_93394025 3.096 NM_001098672
HEPHL1
hephaestin-like 1
chr10_-_116382089 3.095 ABLIM1
actin binding LIM protein 1
chr17_-_959007 3.024 NM_001092
ABR
active BCR-related gene
chr1_-_24612742 2.998 NM_001199013
NM_001199014
NM_178122
C1orf201


chromosome 1 open reading frame 201


chr2_+_55600220 2.971 NM_080667
CCDC104
coiled-coil domain containing 104
chr5_+_72148173 2.969 NM_002270
TNPO1
transportin 1
chr13_+_35904408 2.935 NM_001111045
NM_003914
CCNA1

cyclin A1

chr14_+_59628381 2.930 NM_022495
C14orf135
chromosome 14 open reading frame 135
chr3_-_151171576 2.915 PFN2
profilin 2
chr3_-_132228273 2.907 NM_014065
ASTE1
asteroid homolog 1 (Drosophila)
chr1_-_48710263 2.904 SPATA6
spermatogenesis associated 6
chr16_-_69822097 2.899 NM_001198542
NM_001198543
HYDIN

hydrocephalus inducing homolog (mouse)

chr3_+_132228383 2.887 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr14_+_73486381 2.880 NM_182480
COQ6
coenzyme Q6 homolog, monooxygenase (S. cerevisiae)
chr2_-_110319866 2.873 NM_000272
NM_001128178
NM_001128179
NM_207181
NPHP1



nephronophthisis 1 (juvenile)



chr17_-_76003407 2.861 LOC100294362
hypothetical LOC100294362
chr5_-_133730663 2.850 NM_001113575
NM_016508
CDKL3

cyclin-dependent kinase-like 3

chr17_-_6675731 2.837 NM_053285
TEKT1
tektin 1
chr13_-_35818396 2.824 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr12_+_104248769 2.809 C12orf75
chromosome 12 open reading frame 75
chr19_+_55221106 2.804 ZNF473
zinc finger protein 473
chr19_+_55221088 2.758 ZNF473
zinc finger protein 473
chr4_+_114433551 2.750 ANK2
ankyrin 2, neuronal
chr15_-_41572660 2.723 TP53BP1
tumor protein p53 binding protein 1
chr1_-_167663278 2.691 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr8_+_94781910 2.676 NM_145269
FAM92A1
family with sequence similarity 92, member A1
chr13_-_35818491 2.673 SPG20
spastic paraplegia 20 (Troyer syndrome)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.44 7.92e-08 GO:0030031 cell projection assembly
8.36 4.74e-07 GO:0042384 cilium assembly
6.32 9.86e-06 GO:0060271 cilium morphogenesis
4.91 1.59e-04 GO:0010927 cellular component assembly involved in morphogenesis
2.78 1.75e-04 GO:0007017 microtubule-based process
3.62 1.75e-03 GO:0007018 microtubule-based movement
13.44 1.69e-02 GO:0035082 axoneme assembly

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.89 7.20e-14 GO:0005929 cilium
6.74 4.95e-10 GO:0044441 cilium part
2.43 6.29e-10 GO:0015630 microtubule cytoskeleton
7.05 6.52e-10 GO:0005930 axoneme
8.31 1.41e-09 GO:0035085 cilium axoneme
7.82 1.79e-08 GO:0005932 microtubule basal body
1.75 4.11e-07 GO:0005856 cytoskeleton
2.95 4.81e-07 GO:0005874 microtubule
1.21 6.74e-06 GO:0005737 cytoplasm
2.56 2.73e-05 GO:0005815 microtubule organizing center
2.30 1.69e-04 GO:0044463 cell projection part
1.73 3.31e-04 GO:0044430 cytoskeletal part
1.41 7.37e-04 GO:0043228 non-membrane-bounded organelle
1.41 7.37e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.76 1.93e-03 GO:0042995 cell projection
11.94 7.82e-03 GO:0005952 cAMP-dependent protein kinase complex
1.11 8.72e-03 GO:0044424 intracellular part
2.43 1.33e-02 GO:0005813 centrosome
4.57 1.66e-02 GO:0019861 flagellum
1.10 1.95e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.12 2.30e-03 GO:0003777 microtubule motor activity
1.42 2.36e-02 GO:0017076 purine nucleotide binding
1.46 3.22e-02 GO:0030554 adenyl nucleotide binding
2.77 3.57e-02 GO:0003774 motor activity
1.46 4.16e-02 GO:0032559 adenyl ribonucleotide binding
1.40 4.42e-02 GO:0032553 ribonucleotide binding
1.40 4.42e-02 GO:0032555 purine ribonucleotide binding