Motif ID: SMAD1..7,9.p2

Z-value: 1.282


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD2chr18_-_437114520.683.6e-03Click!
SMAD5chr5_+_1354964210.552.7e-02Click!
SMAD3chr15_+_651452480.524.0e-02Click!
SMAD7chr18_-_447310780.514.3e-02Click!
SMAD4chr18_+_468104810.458.0e-02Click!
SMAD1chr4_+_1466221540.332.2e-01Click!
SMAD6chr15_+_64787983-0.263.2e-01Click!
SMAD9chr13_-_363923700.029.4e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_11171213 1.478 NM_001098212
HRH1
histamine receptor H1
chr15_-_81744469 1.396 NM_001717
BNC1
basonuclin 1
chr11_-_65860450 1.322 NM_004292
RIN1
Ras and Rab interactor 1
chr5_-_151046638 1.292 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr5_-_151046680 1.217 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr1_-_6368324 1.082 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr9_-_109291130 1.039 KLF4
Kruppel-like factor 4 (gut)
chr1_+_15145001 1.027 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr8_+_22493928 0.979 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr2_+_102169864 0.890 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chrX_+_102749489 0.874 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr10_+_22765996 0.868 LOC100289455
hypothetical LOC100289455
chr9_-_109291575 0.815 KLF4
Kruppel-like factor 4 (gut)
chr14_+_51850754 0.811 NM_000956
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr13_-_32822759 0.798 STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_310925 0.739 IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr6_-_30151526 0.732 NM_170769
NM_025236
RNF39

ring finger protein 39

chr19_+_40299058 0.728 FXYD3
FXYD domain containing ion transport regulator 3
chr11_+_66580884 0.707 RHOD
ras homolog gene family, member D
chr3_+_114414064 0.680 NM_033254
BOC
Boc homolog (mouse)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
6.35 2.33e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
3.23 2.70e-02 GO:0021675 nerve development
2.20 2.27e-02 GO:0035023 regulation of Rho protein signal transduction
1.82 2.72e-04 GO:0007411 axon guidance
1.79 2.05e-05 GO:0007409 axonogenesis
1.77 1.91e-05 GO:0048812 neuron projection morphogenesis
1.77 3.20e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.72 3.17e-05 GO:0031175 neuron projection development
1.70 4.06e-05 GO:0032990 cell part morphogenesis
1.70 4.91e-05 GO:0048858 cell projection morphogenesis
1.64 3.52e-04 GO:0006935 chemotaxis
1.64 3.52e-04 GO:0042330 taxis
1.64 8.29e-04 GO:0000904 cell morphogenesis involved in differentiation
1.62 1.90e-04 GO:0048666 neuron development
1.61 6.89e-05 GO:0030030 cell projection organization
1.56 1.70e-03 GO:0000902 cell morphogenesis
1.54 1.86e-03 GO:0032989 cellular component morphogenesis
1.53 1.01e-03 GO:0030182 neuron differentiation
1.52 3.67e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.47 4.56e-04 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
2.35 8.84e-04 GO:0005925 focal adhesion
2.30 9.76e-04 GO:0005924 cell-substrate adherens junction
2.29 1.67e-06 GO:0070161 anchoring junction
2.29 9.02e-06 GO:0005912 adherens junction
2.22 2.45e-03 GO:0030055 cell-substrate junction
1.26 2.20e-02 GO:0005856 cytoskeleton
1.15 8.81e-03 GO:0071944 cell periphery
1.15 1.08e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.59 5.00e-02 GO:0003779 actin binding
1.57 4.30e-04 GO:0008092 cytoskeletal protein binding
1.50 2.81e-02 GO:0030695 GTPase regulator activity