Motif ID: SRY.p2

Z-value: 1.519


Transcription factors associated with SRY.p2:

Gene SymbolEntrez IDGene Name
SRY 6736 sex determining region Y



Activity profile for motif SRY.p2.

activity profile for motif SRY.p2


Sorted Z-values histogram for motif SRY.p2

Sorted Z-values for motif SRY.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_105511615 4.566 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr3_+_152970904 3.571 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr11_-_16380967 2.237 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr2_+_201756048 1.843 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr17_-_53847937 1.805 RNF43
ring finger protein 43
chr3_+_39484073 1.778 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr11_+_22652957 1.774 GAS2
growth arrest-specific 2
chr11_+_22652894 1.722 NM_005256
GAS2
growth arrest-specific 2
chr1_-_108032645 1.622 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_+_190990142 1.609 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr3_+_173043832 1.541 NM_001164436
TMEM212
transmembrane protein 212
chr7_+_106293112 1.496 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr1_-_47468029 1.468 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr20_+_31613800 1.452 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr4_-_186969041 1.381 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr2_+_228386800 1.350 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr18_+_3584056 1.349 FLJ35776
hypothetical LOC649446
chr1_+_61319976 1.345 NM_001145512
NFIA
nuclear factor I/A
chrX_+_107569671 1.334 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr20_+_10363949 1.294 NM_001009608
C20orf94
chromosome 20 open reading frame 94
chr17_-_59817575 1.268 PECAM1
platelet/endothelial cell adhesion molecule
chr18_+_53863865 1.266 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_-_59817456 1.262 PECAM1
platelet/endothelial cell adhesion molecule
chr2_+_201755865 1.221 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr13_-_47885248 1.216 LPAR6
lysophosphatidic acid receptor 6
chr13_-_47885653 1.175 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr3_-_150422474 1.157 NM_000096
CP
ceruloplasmin (ferroxidase)
chr9_+_126460511 1.154


chr15_-_32398220 1.149 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr7_+_106292932 1.143 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr10_-_105835525 1.109 COL17A1
collagen, type XVII, alpha 1
chr14_-_64479198 1.106 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr17_-_59817722 1.104 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr4_-_139382672 1.098 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr9_-_129752687 1.097 NM_203305
FAM102A
family with sequence similarity 102, member A
chr6_-_49712483 1.093 NM_000324
RHAG
Rh-associated glycoprotein
chr17_-_59817654 1.074 PECAM1
platelet/endothelial cell adhesion molecule
chr14_-_37134050 1.060 FOXA1
forkhead box A1
chr10_+_63331018 1.056 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr7_+_116238309 1.037 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr8_-_110724594 1.009 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr6_-_116488458 1.005 NM_002031
FRK
fyn-related kinase
chr13_-_47885018 0.984 LPAR6
lysophosphatidic acid receptor 6
chr4_-_186969202 0.976 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr17_-_59818033 0.973 PECAM1
platelet/endothelial cell adhesion molecule
chr10_-_105835609 0.957 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr2_+_138438277 0.926 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr17_-_46479127 0.924 SPAG9
sperm associated antigen 9
chr12_-_120276394 0.922 NM_001137559
ANAPC5
anaphase promoting complex subunit 5
chr12_+_14429499 0.916 ATF7IP
activating transcription factor 7 interacting protein
chr4_+_74491272 0.915 ALB
albumin
chr3_-_121884091 0.909 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr1_+_153366928 0.899 NM_004428
NM_182685
EFNA1

ephrin-A1

chr7_+_45894480 0.860 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr11_+_57285809 0.857 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr17_+_34114924 0.852 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr17_+_69939130 0.849 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr3_-_121883647 0.847 HGD
homogentisate 1,2-dioxygenase
chr13_-_40491405 0.842 ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_-_26202626 0.836 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr12_+_56114724 0.834 NM_005538
INHBC
inhibin, beta C
chr13_-_40491491 0.830 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_+_82117978 0.825


chr2_-_192420168 0.820 NM_004657
SDPR
serum deprivation response
chr6_-_28663045 0.818 NM_052923
SCAND3
SCAN domain containing 3
chr7_+_106292975 0.807 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr3_-_71376919 0.803 FOXP1
forkhead box P1
chrX_-_107569256 0.799 NM_001847
COL4A6
collagen, type IV, alpha 6
chr13_-_40454360 0.765 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_-_56615544 0.748 NM_001723
NM_015548
DST

dystonin

chr17_+_75366524 0.742 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr20_+_34635362 0.740 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr2_+_127892489 0.737 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr2_+_101680594 0.735 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr7_+_113853790 0.732 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr2_+_143351536 0.730 NM_001032998
NM_003937
KYNU

kynureninase

chr17_+_72795567 0.727 NM_001113492
SEPT9
septin 9
chr4_+_74493918 0.726 ALB
albumin
chr2_+_127892459 0.723 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr5_+_140454382 0.723 NM_018936
PCDHB2
protocadherin beta 2
chr14_-_22825148 0.720 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr17_-_53849888 0.707 RNF43
ring finger protein 43
chr4_+_140806536 0.706 MGST2
microsomal glutathione S-transferase 2
chr2_+_169631777 0.701 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_+_20005704 0.697 NAV2
neuron navigator 2
chrX_+_84385693 0.686 ZNF711
zinc finger protein 711
chr20_+_23293020 0.685 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr8_-_17797127 0.684 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr9_+_674193 0.673


chr10_-_31328426 0.673 NM_001143769
ZNF438
zinc finger protein 438
chr5_+_34723420 0.668 NM_001145523
RAI14
retinoic acid induced 14
chr13_-_74799898 0.668 TBC1D4
TBC1 domain family, member 4
chr14_-_22722658 0.665 SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr6_+_29902734 0.656 NM_002127
HLA-G
major histocompatibility complex, class I, G
chr14_-_22722680 0.653 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr21_+_42492867 0.642 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr10_+_70650064 0.641 NM_025130
HKDC1
hexokinase domain containing 1
chr14_-_22825072 0.639 HOMEZ
homeobox and leucine zipper encoding
chr4_+_140806371 0.638 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr8_+_22266256 0.631 PIWIL2
piwi-like 2 (Drosophila)
chr15_+_64661560 0.630


chr18_+_27425727 0.627 NM_000371
TTR
transthyretin
chr10_-_123347493 0.623 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr18_+_71051713 0.615 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr12_+_50633430 0.613 NM_020327
ACVR1B
activin A receptor, type IB
chr10_-_123346148 0.612 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr22_+_38770610 0.611 NM_001024843
TNRC6B
trinucleotide repeat containing 6B
chr7_-_16471817 0.611 NM_015464
SOSTDC1
sclerostin domain containing 1
chr1_+_144149794 0.608 NM_006472
TXNIP
thioredoxin interacting protein
chr21_+_39681558 0.606 NM_001146218
WRB
tryptophan rich basic protein
chr16_-_45562840 0.604 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr12_+_77963563 0.594 NM_001135806
SYT1
synaptotagmin I
chr7_+_106897737 0.588 NM_005295
GPR22
G protein-coupled receptor 22
chr6_-_130072971 0.588 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr22_+_18091065 0.586 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr12_-_101115677 0.585 NM_002674
PMCH
pro-melanin-concentrating hormone
chr5_-_98290117 0.583 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr2_+_183290912 0.579 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr6_+_31791063 0.579 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr6_-_31789824 0.575


chr4_+_90252990 0.572 NM_145715
TIGD2
tigger transposable element derived 2
chr14_+_34583863 0.569 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr13_-_33148899 0.566 STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_174475528 0.565


chr10_-_21854616 0.565 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr15_+_47249700 0.561 NM_002044
GALK2
galactokinase 2
chr1_+_66230977 0.561 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_+_556968 0.561


chr1_+_153366559 0.560 EFNA1
ephrin-A1
chr2_-_160181206 0.555 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr4_-_101658094 0.555 NM_001159694
NM_016242
EMCN

endomucin

chr2_+_120233676 0.549 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr6_-_138862271 0.545 NM_001144060
NHSL1
NHS-like 1
chr1_-_218329773 0.542 NM_006085
BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr10_-_5436781 0.541 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr10_-_116276560 0.541 ABLIM1
actin binding LIM protein 1
chr11_+_129496792 0.539 APLP2
amyloid beta (A4) precursor-like protein 2
chr12_-_28016182 0.538 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_-_148495642 0.538 NM_181742
ORC4
origin recognition complex, subunit 4
chr12_+_68028407 0.537 LYZ
lysozyme
chr11_-_18214891 0.533 NM_006512
SAA4
serum amyloid A4, constitutive
chrX_-_19598912 0.532 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr4_+_109763119 0.530 RPL34
ribosomal protein L34
chr5_+_147754467 0.529 FBXO38
F-box protein 38
chr13_+_48582389 0.529 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr6_-_52776558 0.524 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr9_+_27099138 0.520 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr7_-_92693716 0.517 NM_001039372
HEPACAM2
HEPACAM family member 2
chr6_-_138862273 0.517


chr10_-_116276651 0.517 NM_006720
ABLIM1
actin binding LIM protein 1
chr20_-_45418818 0.516 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr10_-_73953699 0.516 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr1_-_218329684 0.515 BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr2_-_45691887 0.513 NM_018079
SRBD1
S1 RNA binding domain 1
chr1_+_1351370 0.512 NM_001146685
TMEM88B
transmembrane protein 88B
chr6_-_47385313 0.511 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chrX_+_152565849 0.511 DUSP9
dual specificity phosphatase 9
chr12_+_68028397 0.510 NM_000239
LYZ
lysozyme
chr3_+_195336631 0.509 HES1
hairy and enhancer of split 1, (Drosophila)
chr1_-_180624380 0.505 GLUL
glutamate-ammonia ligase
chr10_+_111957292 0.503 NM_130439
MXI1
MAX interactor 1
chr11_-_106833715 0.503 NM_152434
CWF19L2
CWF19-like 2, cell cycle control (S. pombe)
chr16_+_21152516 0.499 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr2_+_108604111 0.494 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr11_+_22644732 0.494 NM_001143830
GAS2
growth arrest-specific 2
chr17_+_34115383 0.493 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr15_+_41672543 0.492 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr12_-_51173238 0.491 NM_005554
KRT6A
keratin 6A
chr1_+_61320213 0.491 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr2_+_158666627 0.489 NM_173355
UPP2
uridine phosphorylase 2
chr16_+_4842077 0.489 NM_016936
UBN1
ubinuclein 1
chr12_-_9159707 0.480 A2M
alpha-2-macroglobulin
chr8_-_82769761 0.477 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr10_-_52315390 0.469 A1CF
APOBEC1 complementation factor
chr9_-_103237851 0.469 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr12_-_9159742 0.468 A2M
alpha-2-macroglobulin
chr5_+_145297490 0.463 SH3RF2
SH3 domain containing ring finger 2
chr11_-_125278296 0.462 NM_031307
PUS3
pseudouridylate synthase 3
chr16_+_52027020 0.461 RBL2
retinoblastoma-like 2 (p130)
chr7_+_113842284 0.461 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr18_+_45342398 0.461 NM_006033
LIPG
lipase, endothelial
chr13_-_40454188 0.458 ELF1
E74-like factor 1 (ets domain transcription factor)
chr20_-_1396336 0.458 NM_016143
NM_018839
NM_182483
NSFL1C


NSFL1 (p97) cofactor (p47)


chr10_-_13430195 0.457 NM_001195602
NM_001195604
NM_012247
SEPHS1


selenophosphate synthetase 1


chr2_-_65447370 0.456 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr7_-_30032649 0.454 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr2_+_181553783 0.454 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr12_-_101835183 0.453 PAH
phenylalanine hydroxylase
chr11_+_66764064 0.452 KDM2A
lysine (K)-specific demethylase 2A
chr6_+_64414389 0.451 NM_015153
PHF3
PHD finger protein 3
chr19_+_53450743 0.451


chr4_+_74488947 0.449 ALB
albumin
chr17_-_38978772 0.449 NM_001986
ETV4
ets variant 4
chr16_-_45339605 0.447 NM_182493
MYLK3
myosin light chain kinase 3
chr3_-_71715431 0.447 NM_001012505
NM_032682
FOXP1

forkhead box P1

chr11_+_20000938 0.445 NAV2
neuron navigator 2
chr14_-_37133927 0.445 FOXA1
forkhead box A1
chr7_-_100077072 0.444 NM_003227
TFR2
transferrin receptor 2
chr2_+_181554048 0.442 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chrX_+_84385649 0.441 NM_021998
ZNF711
zinc finger protein 711

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.55 2.88e-02 GO:0006325 chromatin organization
4.93 3.08e-02 GO:0048745 smooth muscle tissue development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 1.07e-03 GO:0005634 nucleus
1.27 1.21e-03 GO:0031981 nuclear lumen
1.23 1.82e-03 GO:0043233 organelle lumen
1.23 2.04e-03 GO:0031974 membrane-enclosed lumen
1.23 5.61e-03 GO:0044428 nuclear part
1.21 1.57e-02 GO:0070013 intracellular organelle lumen
1.28 2.60e-02 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.36 4.09e-02 GO:0003723 RNA binding