Motif ID: TP53.p2

Z-value: 1.118


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TP53chr17_-_7531456-0.204.6e-01Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_62151216 1.725 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr1_-_10455100 1.358 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr11_-_47356642 1.290 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47356650 1.287 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47356672 1.263 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr8_-_23138517 1.229 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr17_+_73721924 1.206 BIRC5
baculoviral IAP repeat containing 5
chr11_+_279113 1.175 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr1_-_10455190 1.105 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr11_-_47356562 1.100 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47356479 0.973 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr9_+_129962292 0.939 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr19_-_6542012 0.899 CD70
CD70 molecule
chr4_-_40211324 0.895 RBM47
RNA binding motif protein 47
chr1_-_52936573 0.877 C1orf163
chromosome 1 open reading frame 163
chr1_-_52936611 0.875 NM_023077
C1orf163
chromosome 1 open reading frame 163
chr8_-_145671947 0.870 FOXH1
forkhead box H1
chr19_-_47438583 0.842 GSK3A
glycogen synthase kinase 3 alpha
chr22_-_16637221 0.841 BID
BH3 interacting domain death agonist
chr18_-_26876622 0.838 NM_001941
NM_024423
DSC3

desmocollin 3

chr1_-_52936602 0.830 C1orf163
chromosome 1 open reading frame 163
chr17_+_73721871 0.805 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr2_-_74610325 0.802 AUP1
ancient ubiquitous protein 1
chr2_+_74610395 0.791 HTRA2
HtrA serine peptidase 2
chr5_-_176763991 0.786 F12
coagulation factor XII (Hageman factor)
chr22_-_16637194 0.780 BID
BH3 interacting domain death agonist
chr11_+_63758550 0.775 NM_003377
VEGFB
vascular endothelial growth factor B
chr2_-_74610332 0.750 AUP1
ancient ubiquitous protein 1
chr2_-_74610331 0.741 AUP1
ancient ubiquitous protein 1
chr2_-_74610346 0.737 AUP1
ancient ubiquitous protein 1
chr1_+_25471470 0.733 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr19_-_47438518 0.733 GSK3A
glycogen synthase kinase 3 alpha
chr1_+_42920946 0.731 YBX1
Y box binding protein 1
chr16_+_387176 0.723 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr2_-_74610323 0.722 AUP1
ancient ubiquitous protein 1
chr19_-_47438563 0.700 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr11_+_817584 0.695 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr12_-_14612057 0.690 NM_024829
PLBD1
phospholipase B domain containing 1
chr19_-_6542082 0.689 CD70
CD70 molecule
chr2_-_74610481 0.685 NM_181575
AUP1
ancient ubiquitous protein 1
chr3_-_13032130 0.680


chr17_+_69939130 0.678 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr19_-_47438548 0.676 GSK3A
glycogen synthase kinase 3 alpha
chr6_+_24511123 0.654 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr2_+_171998988 0.648 NM_001164821
NM_025000
DCAF17

DDB1 and CUL4 associated factor 17

chr2_-_171998681 0.630 METTL8
methyltransferase like 8
chr2_+_74610494 0.630 HTRA2
HtrA serine peptidase 2
chr19_+_17766907 0.628 NM_014256
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr2_+_74610751 0.625 HTRA2
HtrA serine peptidase 2
chr1_-_25619863 0.621 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr1_+_43084846 0.621 NM_015911
ZNF691
zinc finger protein 691
chr22_-_16637160 0.620 BID
BH3 interacting domain death agonist
chr19_+_13090101 0.609 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr13_-_99422163 0.602 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr16_-_10943656 0.601 DEXI
Dexi homolog (mouse)
chr19_+_61344501 0.597 ZNF444
zinc finger protein 444
chr4_+_6726699 0.593 LOC93622
hypothetical LOC93622
chr19_-_47438384 0.586 GSK3A
glycogen synthase kinase 3 alpha
chr21_-_42172476 0.585 NM_001040424
NM_022115
PRDM15

PR domain containing 15

chr2_+_74610333 0.584 HTRA2
HtrA serine peptidase 2
chr22_+_18085990 0.580 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr7_+_92699588 0.560 NM_017667
NM_024553
CCDC132

coiled-coil domain containing 132

chr3_-_184363126 0.551 LAMP3
lysosomal-associated membrane protein 3
chr12_-_112257283 0.549 NM_024959
SLC24A6
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
chr2_+_74610624 0.546 HTRA2
HtrA serine peptidase 2
chr19_+_17766935 0.538 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr2_+_112372651 0.537 NM_006343
MERTK
c-mer proto-oncogene tyrosine kinase
chr22_-_37569962 0.532 NM_014293
NPTXR
neuronal pentraxin receptor
chr20_-_47238082 0.522 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr11_-_107969554 0.515 NM_015065
EXPH5
exophilin 5
chr12_-_14611820 0.515 PLBD1
phospholipase B domain containing 1
chr4_-_9727598 0.513 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr2_-_74610263 0.507 AUP1
ancient ubiquitous protein 1
chr9_-_125732005 0.507 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr2_+_171999042 0.503 DCAF17
DDB1 and CUL4 associated factor 17
chr1_-_45578193 0.499 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
MUTYH





mutY homolog (E. coli)





chr12_-_52980914 0.493 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr4_+_6726555 0.491 LOC93622
hypothetical LOC93622
chr2_+_11213053 0.490 PQLC3
PQ loop repeat containing 3
chr12_+_54832470 0.486 NM_002475
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr10_-_118755077 0.484 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr1_-_114249158 0.478 NM_006594
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr16_-_10943716 0.476 NM_014015
DEXI
Dexi homolog (mouse)
chr19_+_15644885 0.473 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr9_-_137992967 0.470 NM_016172
UBAC1
UBA domain containing 1
chr22_-_16637238 0.469 NM_001196
NM_197967
BID

BH3 interacting domain death agonist

chr19_+_61344341 0.469 NM_018337
ZNF444
zinc finger protein 444
chr22_-_21231421 0.467 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr20_+_34667566 0.454 NM_018840
NM_199483
C20orf24

chromosome 20 open reading frame 24

chr22_+_21852551 0.451 NM_004327
NM_021574
BCR

breakpoint cluster region

chr8_-_145672525 0.448 NM_003923
FOXH1
forkhead box H1
chr2_+_74610666 0.448 HTRA2
HtrA serine peptidase 2
chr3_-_24511456 0.444 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr1_+_114249549 0.440 DCLRE1B
DNA cross-link repair 1B
chr20_+_34667624 0.436 C20orf24
chromosome 20 open reading frame 24
chr2_+_197212522 0.434 NM_001080539
CCDC150
coiled-coil domain containing 150
chr9_+_80101810 0.432 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr1_+_114249429 0.432 NM_022836
DCLRE1B
DNA cross-link repair 1B
chrX_-_152938441 0.430 IRAK1
interleukin-1 receptor-associated kinase 1
chr14_+_67156386 0.429 ARG2
arginase, type II
chrX_+_38548373 0.429 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr1_+_3679168 0.429 NM_001163724
LOC388588
hypothetical protein LOC388588
chr9_-_114814286 0.427 NM_001101338
ZNF883
zinc finger protein 883
chr19_-_57981827 0.425 NM_198457
ZNF600
zinc finger protein 600
chr2_+_74610039 0.425 NM_013247
NM_145074
HTRA2

HtrA serine peptidase 2

chr19_+_17766609 0.423 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr2_+_169021039 0.421 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr2_+_74610635 0.416 HTRA2
HtrA serine peptidase 2
chr17_-_58877276 0.415 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr11_+_3833495 0.415 NM_003156
STIM1
stromal interaction molecule 1
chr14_+_67156323 0.413 NM_001172
ARG2
arginase, type II
chrX_+_38548316 0.413 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr10_+_5556923 0.412 NM_005185
CALML3
calmodulin-like 3
chr20_+_34667590 0.405 C20orf24
chromosome 20 open reading frame 24
chr15_-_62242352 0.399 NM_000942
PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr1_+_45578464 0.397 TOE1
target of EGR1, member 1 (nuclear)
chr1_-_149004852 0.394 CTSS
cathepsin S
chr19_+_49866563 0.393 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr14_+_35072998 0.392 NM_032594
INSM2
insulinoma-associated 2
chr5_-_176763789 0.391 F12
coagulation factor XII (Hageman factor)
chr4_-_9727542 0.388 WDR1
WD repeat domain 1
chr2_+_169021001 0.385 LASS6
LAG1 homolog, ceramide synthase 6
chr12_-_112257217 0.383 SLC24A6
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
chr3_+_32123004 0.382 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr14_-_91372365 0.382 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chr22_-_18687511 0.379 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr19_+_34994701 0.376 NM_001238
CCNE1
cyclin E1
chr20_-_43022286 0.375 NM_006809
TOMM34
translocase of outer mitochondrial membrane 34
chr11_+_66927955 0.372 TBC1D10C
TBC1 domain family, member 10C
chr11_-_64327197 0.366 NM_004579
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr16_-_87244896 0.361 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr19_-_52426055 0.360 NM_014417
BBC3
BCL2 binding component 3
chr7_-_100077072 0.360 NM_003227
TFR2
transferrin receptor 2
chr10_-_46593923 0.357 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr3_+_9919511 0.356 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr5_-_10360873 0.356 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr1_+_45578370 0.354 TOE1
target of EGR1, member 1 (nuclear)
chr12_-_46385991 0.352 RPAP3
RNA polymerase II associated protein 3
chr1_+_84536636 0.352 NM_001010971
SAMD13
sterile alpha motif domain containing 13
chr19_-_16998449 0.351 NM_015692
CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chrX_-_152938456 0.350 IRAK1
interleukin-1 receptor-associated kinase 1
chr1_-_158334983 0.349 NM_052868
IGSF8
immunoglobulin superfamily, member 8
chr1_-_154977526 0.346 NM_024540
NM_145729
MRPL24

mitochondrial ribosomal protein L24

chr1_-_154977479 0.346 MRPL24
mitochondrial ribosomal protein L24
chr14_+_67156405 0.343 ARG2
arginase, type II
chr10_-_21502993 0.341 NEBL
nebulette
chr17_+_75849221 0.340 NM_020914
NM_020954
RNF213

ring finger protein 213

chr20_-_47238310 0.340 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr19_-_6432765 0.338 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr19_-_2407954 0.337 NM_032737
LMNB2
lamin B2
chr1_-_247119516 0.336 NM_001136036
ZNF692
zinc finger protein 692
chr1_+_54291847 0.332 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr17_-_28228184 0.332 MYO1D
myosin ID
chr4_-_9727476 0.330 WDR1
WD repeat domain 1
chr1_+_3597092 0.329 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr12_-_14887648 0.321 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr1_-_207892420 0.320 NM_000228
LAMB3
laminin, beta 3
chr1_+_232107170 0.318 NM_173508
SLC35F3
solute carrier family 35, member F3
chr17_-_43273639 0.317 NM_001145023
NM_138355
SCRN2

secernin 2

chr19_+_16860871 0.313 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr11_+_85017269 0.312 NM_001193537
NM_001193538
NM_018480
TMEM126B


transmembrane protein 126B


chrX_+_152565849 0.311 DUSP9
dual specificity phosphatase 9
chr15_+_38843535 0.311 NM_005258
GCHFR
GTP cyclohydrolase I feedback regulator
chr2_-_26058941 0.309 NM_002254
KIF3C
kinesin family member 3C
chr16_-_10943803 0.306 DEXI
Dexi homolog (mouse)
chr2_+_171999082 0.302 DCAF17
DDB1 and CUL4 associated factor 17
chr5_+_141328805 0.302 NM_004290
NM_183398
NM_183400
RNF14


ring finger protein 14


chr2_-_26058831 0.301 KIF3C
kinesin family member 3C
chr1_-_54291634 0.298 NM_004872
TMEM59
transmembrane protein 59
chr5_-_10361167 0.298 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr16_+_87047159 0.297 ZFPM1
zinc finger protein, multitype 1
chr4_+_48683021 0.296 NM_025087
CWH43
cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
chr16_-_10943778 0.296 DEXI
Dexi homolog (mouse)
chr12_+_54784681 0.295 PA2G4
proliferation-associated 2G4, 38kDa
chr12_-_121277972 0.295 NM_019887
NM_138929
DIABLO

diablo homolog (Drosophila)

chr15_+_89300973 0.293 RCCD1
RCC1 domain containing 1
chr22_+_18085891 0.292 SEPT5
septin 5
chr9_-_168913 0.292 NM_001145355
NM_001145356
NM_018491
CBWD2
CBWD1


COBW domain containing 2
COBW domain containing 1


chr3_-_44494160 0.291 NM_181489
ZNF445
zinc finger protein 445
chr6_+_36206239 0.289 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr19_-_12807221 0.288 NM_031429
RTBDN
retbindin
chr19_-_2002222 0.286 NM_017572
NM_199054
MKNK2

MAP kinase interacting serine/threonine kinase 2

chr17_-_43273630 0.286 SCRN2
secernin 2
chr4_-_9727456 0.285 WDR1
WD repeat domain 1
chr20_-_52223918 0.282 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr12_+_54784614 0.281 PA2G4
proliferation-associated 2G4, 38kDa
chr3_-_44494108 0.281 ZNF445
zinc finger protein 445
chr6_+_26307691 0.281 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr1_+_45578256 0.281 TOE1
target of EGR1, member 1 (nuclear)
chr20_-_33007242 0.280 GSS
glutathione synthetase
chr6_-_166502119 0.278 NM_003181
T
T, brachyury homolog (mouse)
chr10_-_91394881 0.278 PANK1
pantothenate kinase 1
chr20_+_56899904 0.277 GNAS
GNAS complex locus
chr19_-_15869870 0.275 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr20_-_33007243 0.275 NM_000178
GSS
glutathione synthetase
chr12_+_131577229 0.273 NM_001142641
FBRSL1
fibrosin-like 1
chr1_-_247119908 0.273 NM_001193328
NM_017865
ZNF692

zinc finger protein 692

chr1_+_117711575 0.273 NM_006699
MAN1A2
mannosidase, alpha, class 1A, member 2
chr20_-_33007209 0.272 GSS
glutathione synthetase
chr6_-_26307418 0.272 NM_021065
NM_003530
HIST1H2AD
HIST1H3D
histone cluster 1, H2ad
histone cluster 1, H3d

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 2.61e-05 GO:0044444 cytoplasmic part
1.65 1.14e-04 GO:0012505 endomembrane system
1.53 1.61e-04 GO:0031090 organelle membrane
1.18 1.08e-03 GO:0005737 cytoplasm
1.23 1.38e-02 GO:0044446 intracellular organelle part
1.22 1.51e-02 GO:0044422 organelle part

Nothing significant found in function category.