Motif ID: HOXA9_MEIS1.p2

Z-value: 1.092


Transcription factors associated with HOXA9_MEIS1.p2:

Gene SymbolEntrez IDGene Name
HOXA9 3205 homeobox A9
MEIS1 4211 Meis homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA9chr7_-_27171673-0.601.5e-02Click!
MEIS1chr2_+_66516020-0.591.6e-02Click!


Activity profile for motif HOXA9_MEIS1.p2.

activity profile for motif HOXA9_MEIS1.p2


Sorted Z-values histogram for motif HOXA9_MEIS1.p2

Sorted Z-values for motif HOXA9_MEIS1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA9_MEIS1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_29597965 3.179 QPRT
quinolinate phosphoribosyltransferase
chr18_+_9875722 2.965 NM_001098529
NM_032243
TXNDC2

thioredoxin domain containing 2 (spermatozoa)

chr1_+_196874839 2.468 PTPRC
protein tyrosine phosphatase, receptor type, C
chr15_+_42815851 2.080 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr16_+_29597829 1.931 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr4_-_40211324 1.818 RBM47
RNA binding motif protein 47
chr9_-_99740243 1.490 NM_197978
HEMGN
hemogen
chr2_+_68445821 1.392 NM_002664
PLEK
pleckstrin
chr6_-_25044156 1.355 FAM65B
family with sequence similarity 65, member B
chr1_+_144152864 1.311 TXNIP
thioredoxin interacting protein
chr1_+_196874867 1.286 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_-_130792297 1.233 LOC286467
hypothetical LOC286467
chr1_+_196874759 1.165 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr4_+_123311207 1.079 NM_015312
KIAA1109
KIAA1109
chr7_+_72883128 1.047 NM_001305
CLDN4
claudin 4
chr19_+_61624 1.015 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr3_-_173723754 1.003 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr1_-_611896 1.002 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr12_-_107551783 0.989 NM_003006
SELPLG
selectin P ligand
chr10_+_70517823 0.954 NM_002727
SRGN
serglycin
chr1_+_58899 0.868 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr1_+_357502 0.862 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr6_+_29382381 0.859 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr15_+_64481270 0.845 MAP2K1
mitogen-activated protein kinase kinase 1
chr7_+_143457083 0.824 NM_001001659
OR2A14
olfactory receptor, family 2, subfamily A, member 14
chr1_-_157313179 0.823 NM_004833
AIM2
absent in melanoma 2
chr8_-_107023 0.822 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr12_-_101115677 0.817 NM_002674
PMCH
pro-melanin-concentrating hormone
chr2_+_169631777 0.817 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_200397300 0.808 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr12_-_49708279 0.802 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr1_-_148854503 0.792


chr2_+_68445936 0.782 PLEK
pleckstrin
chr4_+_39084936 0.758 KLB
klotho beta
chr15_-_100280784 0.733 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_-_167822248 0.729 F5
coagulation factor V (proaccelerin, labile factor)
chr22_-_25205376 0.720 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr15_-_56093477 0.716 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr11_-_62145952 0.704 NM_012200
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr1_-_153477511 0.689 GBA
glucosidase, beta, acid
chr12_-_107551694 0.658 SELPLG
selectin P ligand
chr4_+_39084867 0.655 NM_175737
KLB
klotho beta
chr20_-_44575599 0.643 NM_018102
NM_199441
ZNF334

zinc finger protein 334

chr11_+_63627816 0.639 NM_013280
FLRT1
fibronectin leucine rich transmembrane protein 1
chr3_+_123279439 0.632 NM_006889
CD86
CD86 molecule
chr17_-_35464414 0.602 NM_001079518
NM_014815
MED24

mediator complex subunit 24

chr17_+_53587492 0.594 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr12_-_9159780 0.593 A2M
alpha-2-macroglobulin
chr14_-_93926679 0.586 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr6_-_49712483 0.574 NM_000324
RHAG
Rh-associated glycoprotein
chr18_+_2645885 0.564 NM_015295
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr13_+_51334117 0.536 NM_031290
CCDC70
coiled-coil domain containing 70
chr11_-_4675524 0.531 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr2_-_165133239 0.511 GRB14
growth factor receptor-bound protein 14
chr1_+_938709 0.510 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr12_+_7348194 0.508 NM_001080454
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr6_-_32665409 0.501 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr7_+_104468614 0.500 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr15_-_23204887 0.493 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr12_-_107551744 0.492 SELPLG
selectin P ligand
chr6_+_35308605 0.487 SCUBE3
signal peptide, CUB domain, EGF-like 3
chr1_-_167822334 0.484 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr7_+_115650240 0.466 NM_152829
TES
testis derived transcript (3 LIM domains)
chr14_+_77939845 0.464 NM_004796
NRXN3
neurexin 3
chrX_-_131181141 0.460 RAP2C
RAP2C, member of RAS oncogene family
chr7_+_128365482 0.457 NM_032643
IRF5
interferon regulatory factor 5
chr20_+_5935897 0.453 NM_001127458
CRLS1
cardiolipin synthase 1
chr1_+_67404756 0.433 NM_144701
IL23R
interleukin 23 receptor
chr18_+_70317548 0.417 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr10_+_70517863 0.414 SRGN
serglycin
chrX_-_105169370 0.406 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr4_-_83566802 0.404 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr1_-_245237925 0.401 ZNF695
zinc finger protein 695
chr12_-_51629874 0.383 KRT8
keratin 8
chr1_-_245237977 0.382 NM_020394
ZNF695
zinc finger protein 695
chr2_-_135498716 0.379 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chrX_-_77469635 0.378 NM_006639
CYSLTR1
cysteinyl leukotriene receptor 1
chr3_-_139960874 0.375 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr6_+_31782618 0.369 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr12_-_9159742 0.365 A2M
alpha-2-macroglobulin
chr14_+_19473606 0.356 NM_001004063
OR4K1
olfactory receptor, family 4, subfamily K, member 1
chr6_-_25940247 0.355 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr1_+_13903936 0.343 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr1_-_153477673 0.337 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr6_+_28032997 0.328 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr11_+_5862076 0.319 NM_001005165
OR52E4
olfactory receptor, family 52, subfamily E, member 4
chr19_+_44681443 0.316 DLL3
delta-like 3 (Drosophila)
chr17_-_36444626 0.315 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr2_-_74634569 0.309 NM_032603
LOXL3
lysyl oxidase-like 3
chr12_+_61645361 0.309 RPL14
ribosomal protein L14
chr17_-_39094787 0.291 NM_001040002
MEOX1
mesenchyme homeobox 1
chr7_-_84589182 0.291 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr3_+_112743729 0.291 CD96
CD96 molecule
chr19_+_10689725 0.283 NM_001005360
NM_001005361
NM_001005362
NM_001190716
NM_004945
DNM2




dynamin 2




chr12_-_85756766 0.281 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_-_93172119 0.278


chr22_+_21393107 0.274 IGLJ3
immunoglobulin lambda joining 3
chr19_+_44681374 0.273 NM_016941
NM_203486
DLL3

delta-like 3 (Drosophila)

chr15_+_36776090 0.271 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr1_-_167865973 0.267 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chrX_+_123062143 0.263 STAG2
stromal antigen 2
chr11_-_5964790 0.262 NM_001005173
OR52L1
olfactory receptor, family 52, subfamily L, member 1
chr17_-_26665194 0.260 EVI2B
ecotropic viral integration site 2B
chr4_+_71713324 0.258 NM_031889
ENAM
enamelin
chr16_-_24850163 0.257 ARHGAP17
Rho GTPase activating protein 17
chrX_-_30505804 0.254 NM_025159
CXorf21
chromosome X open reading frame 21
chr3_+_82117978 0.252


chr5_-_142795269 0.251 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr5_-_176671897 0.249 NM_001142935
NM_031300
MXD3

MAX dimerization protein 3

chr8_-_13018123 0.249 NM_001164271
DLC1
deleted in liver cancer 1
chr10_+_98730977 0.244 NM_015652
C10orf12
chromosome 10 open reading frame 12
chr6_-_159386007 0.244 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr2_-_207291364 0.244 NM_001093730
DYTN
dystrotelin
chr7_+_90177082 0.237 CDK14
cyclin-dependent kinase 14
chr10_+_129237602 0.236 NM_001030013
NPS
neuropeptide S
chr6_+_70633168 0.235 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr21_-_33107813 0.231 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr2_+_61243132 0.229 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr4_+_159351092 0.226 TMEM144
transmembrane protein 144
chr11_-_116168316 0.225 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr17_+_16061190 0.220 NM_004278
PIGL
phosphatidylinositol glycan anchor biosynthesis, class L
chr17_+_38247493 0.219 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr5_-_22889192 0.217 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr5_+_128328685 0.214 SLC27A6
solute carrier family 27 (fatty acid transporter), member 6
chr21_+_44941514 0.213 NM_198699
KRTAP10-12
keratin associated protein 10-12
chr18_+_70318001 0.212 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr6_-_28327980 0.211 NM_019110
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr2_-_2313894 0.208 NM_015025
MYT1L
myelin transcription factor 1-like
chr15_-_74091817 0.207 NM_138573
NRG4
neuregulin 4
chr6_-_43054865 0.207 PEX6
peroxisomal biogenesis factor 6
chr5_+_180726874 0.206 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr1_-_109651140 0.206 NM_001010985
MYBPHL
myosin binding protein H-like
chr7_+_44612645 0.204 NM_001003941
NM_001165036
NM_002541
OGDH


oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)


chr10_-_76488277 0.202 NM_001003892
DUPD1
dual specificity phosphatase and pro isomerase domain containing 1
chr6_+_32254108 0.200 NM_006913
RNF5
ring finger protein 5
chr18_-_59137948 0.193 BCL2
B-cell CLL/lymphoma 2
chr21_-_46849413 0.191 NM_006272
S100B
S100 calcium binding protein B
chr9_+_129951552 0.190 NM_005564
LCN2
lipocalin 2
chr12_+_63084317 0.190 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr1_-_246525502 0.190 NM_001004692
OR2T12
olfactory receptor, family 2, subfamily T, member 12
chr2_-_6924092 0.187 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr18_-_29882555 0.187 NM_001198549
NOL4
nucleolar protein 4
chr5_-_179040580 0.186 NM_001164444
CBY3
chibby homolog 3 (Drosophila)
chr21_+_39745649 0.185 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr10_+_35524835 0.185 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr3_+_153468518 0.184 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr6_+_64414389 0.183 NM_015153
PHF3
PHD finger protein 3
chr9_+_92629525 0.182 NM_001174167
SYK
spleen tyrosine kinase
chr3_+_112743615 0.182 NM_005816
NM_198196
CD96

CD96 molecule

chr9_+_95886558 0.181 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr8_-_27997306 0.180 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr9_+_102987137 0.179 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr1_-_245237952 0.178 ZNF695
zinc finger protein 695
chr1_+_57093030 0.176 NM_000562
C8A
complement component 8, alpha polypeptide
chr6_-_166716353 0.173 BRP44L
brain protein 44-like
chr5_+_141326620 0.168 NM_183399
RNF14
ring finger protein 14
chr10_-_46039941 0.167 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr3_-_52544061 0.166 NM_022908
NT5DC2
5'-nucleotidase domain containing 2
chr22_+_29696662 0.158


chr11_+_56862395 0.157 NM_002559
P2RX3
purinergic receptor P2X, ligand-gated ion channel, 3
chr12_-_9159789 0.155 NM_000014
A2M
alpha-2-macroglobulin
chr7_+_26644014 0.154 NM_001145531
C7orf71
chromosome 7 open reading frame 71
chr8_-_102034370 0.153 NM_001135699
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_+_58459131 0.153 NM_153331
KCTD6
potassium channel tetramerisation domain containing 6
chr21_-_44836811 0.150 NM_198688
KRTAP10-6
keratin associated protein 10-6
chr11_-_16387001 0.150 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr17_+_17548888 0.148


chr19_+_44681425 0.147 DLL3
delta-like 3 (Drosophila)
chr9_-_124280025 0.146 NM_001004451
OR1J1
olfactory receptor, family 1, subfamily J, member 1
chr7_-_143560850 0.146 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr9_+_95886625 0.145 PTPDC1
protein tyrosine phosphatase domain containing 1
chrX_+_64625339 0.144 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chrX_-_110541029 0.144 NM_000555
DCX
doublecortin
chr5_+_161208475 0.142 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_+_32021899 0.141 CFB
complement factor B
chr20_-_62071584 0.138 NM_020713
ZNF512B
zinc finger protein 512B
chr10_-_50402148 0.137 NM_170753
PGBD3
piggyBac transposable element derived 3
chr12_-_119826433 0.136 NM_139015
SPPL3
signal peptide peptidase 3
chr14_+_19735334 0.135 NM_001005503
OR11G2
olfactory receptor, family 11, subfamily G, member 2
chr17_+_35471971 0.135 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr12_-_21439637 0.135 NM_134431
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr6_-_11219932 0.132 NM_207582
ERVFRDE1
HERV-FRD provirus ancestral Env polyprotein
chr18_-_3001944 0.132 NM_014646
LPIN2
lipin 2
chr6_+_26705110 0.132 NM_013375
ABT1
activator of basal transcription 1
chr15_+_97990705 0.132 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr19_+_9222605 0.130 NM_001079935
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr5_-_169749215 0.130 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr14_+_19598043 0.127 NM_001004717
OR4L1
olfactory receptor, family 4, subfamily L, member 1
chr12_-_119961143 0.127 NM_003733
NM_198213
OASL

2'-5'-oligoadenylate synthetase-like

chr1_-_9052207 0.127 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr7_+_143646150 0.127 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr6_-_27988152 0.127 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr1_+_227506751 0.123 NM_006542
SPHAR
S-phase response (cyclin related)
chr4_-_68511738 0.123 NM_001114387
NM_182606
TMPRSS11A

transmembrane protease, serine 11A

chr17_+_63338500 0.121 BPTF
bromodomain PHD finger transcription factor
chr1_+_144374513 0.121 RNF115
ring finger protein 115
chr1_+_151498802 0.119 NM_000427
LOR
loricrin
chr4_+_95595419 0.118 PDLIM5
PDZ and LIM domain 5
chr11_+_62813947 0.116 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr1_-_150564302 0.116 NM_002016
FLG
filaggrin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.06 5.29e-12 GO:0007608 sensory perception of smell
4.66 2.45e-11 GO:0007606 sensory perception of chemical stimulus
3.07 1.98e-07 GO:0007600 sensory perception
2.22 2.65e-06 GO:0003008 system process
2.39 3.24e-06 GO:0050877 neurological system process
1.40 1.37e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 7.93e-04 GO:0005886 plasma membrane
6.54 1.46e-03 GO:0045095 keratin filament
1.47 1.51e-03 GO:0071944 cell periphery
1.36 5.95e-03 GO:0016021 integral to membrane
1.34 1.49e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.30 3.08e-13 GO:0004984 olfactory receptor activity
2.74 5.13e-06 GO:0004930 G-protein coupled receptor activity
2.20 8.90e-05 GO:0004888 transmembrane receptor activity
1.98 1.39e-04 GO:0004872 receptor activity
1.74 3.00e-03 GO:0004871 signal transducer activity
1.74 3.00e-03 GO:0060089 molecular transducer activity