Motif ID: NHLH1,2.p2

Z-value: 3.041


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH1chr1_+_158603480-0.601.4e-02Click!
NHLH2chr1_-_1161852150.068.3e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_109112428 8.359 NM_001099289
 SH3RF3
SH3 domain containing ring finger 3
chr7_+_17304707 6.231 NM_001621
 AHR
aryl hydrocarbon receptor
chr9_-_83493415 4.432 NM_005077
 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr12_-_74710741 4.404 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr3_-_73756668 4.339 NM_015009
 PDZRN3
PDZ domain containing ring finger 3
chr2_-_229844198 4.278 NM_001100818
NM_017933
 PID1

phosphotyrosine interaction domain containing 1

chr9_+_17124974 4.125 NM_001114395
NM_017738
 CNTLN

centlein, centrosomal protein

chr11_-_6298284 3.862 NM_145040
 PRKCDBP
protein kinase C, delta binding protein
chr13_-_25523164 3.604 NM_001007538
 SHISA2
shisa homolog 2 (Xenopus laevis)
chr4_-_40911212 3.430 NM_001166050
NM_004307
NM_173075
 APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr19_+_10597167 3.209 NM_020428
 SLC44A2
solute carrier family 44, member 2
chr3_-_87122936 3.150 NM_016206
 VGLL3
vestigial like 3 (Drosophila)
chr3_-_87122958 3.023 VGLL3
vestigial like 3 (Drosophila)
chr9_-_21549696 2.978 LOC554202
hypothetical LOC554202
chr7_-_45927263 2.928 NM_000598
NM_001013398
 IGFBP3

insulin-like growth factor binding protein 3

chr13_-_43259032 2.878 NM_017993
 ENOX1
ecto-NOX disulfide-thiol exchanger 1
chrX_-_106846253 2.839 NM_001015881
 TSC22D3
TSC22 domain family, member 3
chr13_+_113546841 2.809 NM_000820
 GAS6
growth arrest-specific 6
chr17_+_56832492 2.762 TBX2
T-box 2
chr7_+_129919330 2.738 MEST
mesoderm specific transcript homolog (mouse)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 56 entries
enrichment   p-value GO term description
1.87 2.07e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.69 3.18e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.69 7.92e-05 GO:0001944 vasculature development
1.63 2.46e-03 GO:0001568 blood vessel development
1.62 3.01e-02 GO:0048514 blood vessel morphogenesis
1.61 6.59e-06 GO:0007409 axonogenesis
1.60 5.57e-06 GO:0048812 neuron projection morphogenesis
1.60 5.90e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.60 6.01e-04 GO:0007411 axon guidance
1.60 4.16e-03 GO:0061061 muscle structure development
1.57 9.44e-06 GO:0072358 cardiovascular system development
1.57 9.44e-06 GO:0072359 circulatory system development
1.55 1.70e-05 GO:0000904 cell morphogenesis involved in differentiation
1.54 1.78e-05 GO:0048858 cell projection morphogenesis
1.53 3.44e-05 GO:0032990 cell part morphogenesis
1.52 8.74e-05 GO:0031175 neuron projection development
1.48 1.22e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.48 7.47e-05 GO:0048666 neuron development
1.47 2.93e-05 GO:0032989 cellular component morphogenesis
1.47 9.81e-05 GO:0000902 cell morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.99 3.16e-03 GO:0001726 ruffle
1.89 5.66e-03 GO:0005924 cell-substrate adherens junction
1.84 2.27e-02 GO:0005925 focal adhesion
1.83 3.36e-05 GO:0031252 cell leading edge
1.82 5.35e-04 GO:0005912 adherens junction
1.82 1.68e-02 GO:0030055 cell-substrate junction
1.70 4.63e-03 GO:0070161 anchoring junction
1.32 3.33e-02 GO:0030054 cell junction
1.17 1.79e-02 GO:0044459 plasma membrane part
1.10 4.39e-07 GO:0005737 cytoplasm
1.06 3.01e-05 GO:0044424 intracellular part
1.06 3.36e-05 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
1.51 4.82e-03 GO:0003779 actin binding
1.39 3.31e-02 GO:0019904 protein domain specific binding
1.37 1.15e-02 GO:0008092 cytoskeletal protein binding
1.30 2.15e-02 GO:0019899 enzyme binding
1.11 2.40e-06 GO:0005515 protein binding
1.05 6.81e-04 GO:0005488 binding