Motif ID: ATF4.p2

Z-value: 1.516


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_382465090.126.6e-01Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_32610161 6.079 NM_032514
 MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr7_-_44992729 4.511 C7orf40
chromosome 7 open reading frame 40
chr6_+_139497933 3.591 NM_016217
 HECA
headcase homolog (Drosophila)
chr12_-_121946635 2.846 NM_024667
 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr9_-_109291575 2.621 KLF4
Kruppel-like factor 4 (gut)
chr9_-_109291866 2.571 NM_004235
 KLF4
Kruppel-like factor 4 (gut)
chr20_+_19863716 2.430 RIN2
Ras and Rab interactor 2
chr12_-_121946581 2.400 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr8_-_95343696 2.287 GEM
GTP binding protein overexpressed in skeletal muscle
chr8_-_95343716 2.267 NM_005261
NM_181702
 GEM

GTP binding protein overexpressed in skeletal muscle

chrX_-_83644054 2.235 NM_001177478
NM_001177479
NM_144657
 HDX


highly divergent homeobox


chr7_+_28415495 2.115 LOC401317
hypothetical LOC401317
chr2_-_156897286 2.057 NM_006186
 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr18_+_55718171 2.018 NM_021127
 PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr14_+_75521806 2.008 NM_001102564
NM_052873
 C14orf179

chromosome 14 open reading frame 179

chr4_+_75529716 1.941 NM_001657
 AREG
amphiregulin
chr5_+_60663842 1.924 NM_020928
 ZSWIM6
zinc finger, SWIM-type containing 6
chr4_+_75699652 1.855 NM_001657
 AREG
amphiregulin
chr4_-_48603501 1.828 NM_001014446
NM_152398
 OCIAD2

OCIA domain containing 2

chr7_+_20336849 1.767 ITGB8
integrin, beta 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
5.69 3.19e-02 GO:0010332 response to gamma radiation
3.52 3.82e-02 GO:0006302 double-strand break repair
2.39 8.48e-05 GO:0006281 DNA repair
2.17 1.61e-05 GO:0006974 response to DNA damage stimulus
2.15 2.20e-02 GO:0051329 interphase of mitotic cell cycle
2.11 3.28e-02 GO:0051325 interphase
2.06 2.25e-02 GO:0051301 cell division
1.99 4.30e-07 GO:0033554 cellular response to stress
1.97 2.83e-05 GO:0022403 cell cycle phase
1.97 1.34e-02 GO:0000279 M phase
1.96 4.41e-04 GO:0006259 DNA metabolic process
1.95 6.05e-04 GO:0000278 mitotic cell cycle
1.92 2.78e-02 GO:0060548 negative regulation of cell death
1.90 1.68e-05 GO:0022402 cell cycle process
1.73 1.30e-04 GO:0043067 regulation of programmed cell death
1.73 1.64e-04 GO:0042981 regulation of apoptosis
1.72 1.47e-04 GO:0010941 regulation of cell death
1.72 2.31e-04 GO:0007049 cell cycle
1.63 3.30e-02 GO:0016265 death
1.61 4.92e-02 GO:0008219 cell death

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
2.04 1.42e-04 GO:0044427 chromosomal part
1.90 4.02e-02 GO:0005815 microtubule organizing center
1.87 8.45e-04 GO:0005694 chromosome
1.42 2.43e-03 GO:0031981 nuclear lumen
1.41 6.27e-04 GO:0044428 nuclear part
1.33 6.55e-10 GO:0005634 nucleus
1.23 1.64e-04 GO:0044446 intracellular organelle part
1.23 2.17e-04 GO:0044422 organelle part
1.22 1.14e-10 GO:0043231 intracellular membrane-bounded organelle
1.22 1.48e-10 GO:0043227 membrane-bounded organelle
1.22 5.50e-09 GO:0005737 cytoplasm
1.20 1.09e-10 GO:0043229 intracellular organelle
1.20 1.72e-10 GO:0043226 organelle
1.19 2.42e-15 GO:0044424 intracellular part
1.18 7.98e-16 GO:0005622 intracellular
1.18 6.75e-03 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.25 4.61e-02 GO:0003676 nucleic acid binding
1.24 3.09e-08 GO:0005515 protein binding
1.11 3.77e-05 GO:0005488 binding