Motif ID: POU6F1.p2

Z-value: 1.210


Transcription factors associated with POU6F1.p2:

Gene SymbolEntrez IDGene Name
POU6F1 5463 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU6F1chr12_-_498977430.381.4e-01Click!


Activity profile for motif POU6F1.p2.

activity profile for motif POU6F1.p2


Sorted Z-values histogram for motif POU6F1.p2

Sorted Z-values for motif POU6F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU6F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_65299157 2.397 NM_138737
HEPH
hephaestin
chr6_+_105511615 1.565 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr22_+_38652555 1.548 GRAP2
GRB2-related adaptor protein 2
chr4_-_145281237 1.523 NM_002099
GYPA
glycophorin A (MNS blood group)
chr8_-_13018123 1.260 NM_001164271
DLC1
deleted in liver cancer 1
chr8_-_49996353 1.248 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr12_-_49897743 1.194 POU6F1
POU class 6 homeobox 1
chrX_-_55074125 1.039 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr7_+_91762227 1.017


chr7_-_83662152 0.983 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chrX_+_65299352 0.939 HEPH
hephaestin
chr4_-_145159889 0.923 NM_002100
GYPB
glycophorin B (MNS blood group)
chr18_+_59295123 0.891 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr10_+_4995685 0.859 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_+_71806538 0.829 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr1_+_158603480 0.811 NM_005598
NHLH1
nescient helix loop helix 1
chr17_-_36232366 0.790 NM_000421
KRT10
keratin 10
chr15_-_100280784 0.771 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_+_58899 0.767 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr10_+_4995453 0.764 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr14_-_60022487 0.754 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr3_-_112796855 0.753 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr11_-_57173823 0.752 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr2_-_158439868 0.740 NM_001105
ACVR1
activin A receptor, type I
chr14_+_51025604 0.738 NM_001042481
FRMD6
FERM domain containing 6
chr7_-_107667728 0.736 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr17_-_64462976 0.704 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr15_+_65205107 0.648 NM_001145102
SMAD3
SMAD family member 3
chr1_+_151270301 0.645 NM_003125
SPRR1B
small proline-rich protein 1B
chr7_-_92693716 0.606 NM_001039372
HEPACAM2
HEPACAM family member 2
chr19_+_44591589 0.605


chr9_-_205892 0.579 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr1_+_194887630 0.575 NM_000186
NM_001014975
CFH

complement factor H

chr5_+_125786975 0.569 GRAMD3
GRAM domain containing 3
chr10_+_4995597 0.564 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_+_139869819 0.557


chr6_+_7524691 0.556 DSP
desmoplakin
chr11_+_5466490 0.552 NM_001005163
OR52D1
olfactory receptor, family 52, subfamily D, member 1
chr19_+_61624 0.549 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr9_-_94206648 0.540 NM_014057
NM_033014
OGN

osteoglycin

chr7_+_138469029 0.539 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr8_-_125252884 0.532 C8orf78
chromosome 8 open reading frame 78
chr16_+_33169015 0.521 NM_016212
TP53TG3
TP53 target 3
chr4_-_151990061 0.511 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr19_-_54350457 0.503 NM_002152
HRC
histidine rich calcium binding protein
chr1_+_15145001 0.503 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr1_-_67366807 0.502 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr10_-_5035967 0.497 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr18_+_27281729 0.492 NM_001944
DSG3
desmoglein 3
chr7_+_128136347 0.488 FAM71F1
family with sequence similarity 71, member F1
chr6_-_26216299 0.488 NM_005323
HIST1H1T
histone cluster 1, H1t
chr1_+_109057078 0.485 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr1_-_245120900 0.474 AHCTF1
AT hook containing transcription factor 1
chr11_-_11331411 0.473 CSNK2A1P
casein kinase 2, alpha 1 polypeptide pseudogene
chr22_-_38619739 0.468 NM_152512
ENTHD1
ENTH domain containing 1
chr9_-_124981125 0.460 STRBP
spermatid perinuclear RNA binding protein
chr1_-_191422346 0.454 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr1_+_166516901 0.453 NM_005149
TBX19
T-box 19
chr9_+_80134302 0.453 PSAT1
phosphoserine aminotransferase 1
chr4_-_145046109 0.452 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chr6_-_49942147 0.448 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chrX_-_153698930 0.444 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr8_+_87180248 0.441 NM_152565
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr16_+_33112480 0.440 NM_016212
TP53TG3
TP53 target 3
chr1_+_178466064 0.429 NM_033343
LHX4
LIM homeobox 4
chr14_-_56342097 0.420 NM_172337
OTX2
orthodenticle homeobox 2
chr5_+_86712376 0.414


chrX_-_107569256 0.412 NM_001847
COL4A6
collagen, type IV, alpha 6
chr6_+_134800533 0.411 LOC154092
hypothetical LOC154092
chr3_+_99555387 0.405 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr4_+_95595419 0.397 PDLIM5
PDZ and LIM domain 5
chr12_-_28016182 0.392 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr7_-_83116414 0.389 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr22_+_21116283 0.384


chr8_-_38324809 0.384 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr9_-_106420305 0.383 NM_001001956
OR13C9
olfactory receptor, family 13, subfamily C, member 9
chr16_-_32595553 0.382 NM_016212
TP53TG3
TP53 target 3
chr2_-_200033445 0.377 SATB2
SATB homeobox 2
chr3_+_153074118 0.374 NM_033050
SUCNR1
succinate receptor 1
chrX_+_46938136 0.374 NM_003334
UBA1
ubiquitin-like modifier activating enzyme 1
chr14_+_50096603 0.374 ATL1
atlastin GTPase 1
chr4_+_160408447 0.369 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr6_-_123999640 0.360 NM_006073
TRDN
triadin
chr6_+_152053323 0.358 NM_001122742
ESR1
estrogen receptor 1
chr22_+_21006814 0.355


chr3_+_99350859 0.354 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr15_+_52092392 0.350 NM_001080534
UNC13C
unc-13 homolog C (C. elegans)
chr10_-_30958631 0.347 NM_183058
LYZL2
lysozyme-like 2
chr11_-_123758448 0.347 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr7_+_72034735 0.344 POM121
POM121 membrane glycoprotein
chr1_-_116184846 0.343 NM_001111061
NHLH2
nescient helix loop helix 2
chr2_+_33213111 0.342 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr2_-_27215781 0.341 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr4_-_44348414 0.340 NM_182592
YIPF7
Yip1 domain family, member 7
chr19_+_24061717 0.334 NM_203282
ZNF254
zinc finger protein 254
chr1_+_149299307 0.320 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_+_34448810 0.316 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chrX_+_46938171 0.314 UBA1
ubiquitin-like modifier activating enzyme 1
chr5_-_39238818 0.307 FYB
FYN binding protein
chr2_-_121964373 0.307 CLASP1
cytoplasmic linker associated protein 1
chr18_-_55136673 0.300 NM_181654
CPLX4
complexin 4
chr11_+_69176391 0.299 CCND1
cyclin D1
chr6_-_47362102 0.295 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr5_-_86739683 0.293 CCNH
cyclin H
chr5_-_75954807 0.292 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chrX_+_46938157 0.290 UBA1
ubiquitin-like modifier activating enzyme 1
chr9_-_133944877 0.289 MED27
mediator complex subunit 27
chr11_-_16454493 0.288 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr7_-_135083906 0.286 NM_205855
FAM180A
family with sequence similarity 180, member A
chr8_-_67253234 0.284 NM_000756
CRH
corticotropin releasing hormone
chrX_-_13744933 0.279 GPM6B
glycoprotein M6B
chr3_+_142175329 0.279 SLC25A36
solute carrier family 25, member 36
chr1_+_46151845 0.275 MAST2
microtubule associated serine/threonine kinase 2
chr5_+_150020595 0.275 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr7_-_107930170 0.274 PNPLA8
patatin-like phospholipase domain containing 8
chr7_-_99864220 0.274 NM_017984
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr2_+_178893216 0.273 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr17_+_20712337 0.272


chr6_-_47361921 0.270 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_+_166034402 0.267 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr7_+_18296569 0.265 HDAC9
histone deacetylase 9
chr1_+_103961476 0.264 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chrX_+_46938178 0.263 UBA1
ubiquitin-like modifier activating enzyme 1
chr7_+_106897737 0.262 NM_005295
GPR22
G protein-coupled receptor 22
chr12_-_88573949 0.262 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr10_+_99488223 0.257 NM_001002261
ZFYVE27
zinc finger, FYVE domain containing 27
chr1_+_100776280 0.255 NM_022049
GPR88
G protein-coupled receptor 88
chr1_-_120189301 0.255 NM_001047980
NBPF7
neuroblastoma breakpoint family, member 7
chr1_+_196874759 0.254 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chrX_+_67830204 0.253 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chr12_+_54611212 0.251 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr6_+_88239343 0.251 NM_001168398
NM_006416
SLC35A1

solute carrier family 35 (CMP-sialic acid transporter), member A1

chr12_-_110410730 0.251 ATXN2
ataxin 2
chr12_+_21175394 0.251 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr1_-_158815895 0.251 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr11_-_111636792 0.250 NM_001145024
C11orf34
chromosome 11 open reading frame 34
chr11_-_59390518 0.248 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr3_+_171183203 0.247 SEC62
SEC62 homolog (S. cerevisiae)
chr13_-_43908994 0.246 TSC22D1
TSC22 domain family, member 1
chr7_+_94130673 0.242 PEG10
paternally expressed 10
chr17_+_3326045 0.242 NM_000049
ASPA
aspartoacylase
chr2_-_55090759 0.241 NM_007008
RTN4
reticulon 4
chr11_+_4965996 0.241 NM_021801
MMP26
matrix metallopeptidase 26
chr6_-_2696152 0.240 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr1_+_196874839 0.239 PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_+_90252990 0.238 NM_145715
TIGD2
tigger transposable element derived 2
chr2_-_227952249 0.235 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr5_-_160211623 0.235 NM_025153
ATP10B
ATPase, class V, type 10B
chr4_+_42590038 0.233 NM_001080476
GRXCR1
glutaredoxin, cysteine rich 1
chr7_-_135263737 0.230 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr16_-_85099941 0.229 LOC400550
hypothetical LOC400550
chr7_-_41709191 0.228 NM_002192
INHBA
inhibin, beta A
chr2_-_157890400 0.227 NM_020711
ERMN
ermin, ERM-like protein
chrX_-_32083506 0.225 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr11_-_4924905 0.224 NM_001005329
OR51A4
olfactory receptor, family 51, subfamily A, member 4
chr1_+_109043550 0.223 PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr19_-_58486686 0.222 NM_033341
BIRC8
baculoviral IAP repeat containing 8
chr7_+_143043871 0.221 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr13_-_43908991 0.221 TSC22D1
TSC22 domain family, member 1
chr10_+_38339531 0.218 NM_006954
NM_006974
ZNF33A

zinc finger protein 33A

chr2_+_73911477 0.217 STAMBP
STAM binding protein
chr5_+_125786717 0.215 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr7_-_100262971 0.215 NM_004444
EPHB4
EPH receptor B4
chr5_+_112101454 0.214 NM_000038
NM_001127510
APC

adenomatous polyposis coli

chr12_-_118725672 0.213 CIT
citron (rho-interacting, serine/threonine kinase 21)
chr6_-_155818728 0.212 NM_015718
NOX3
NADPH oxidase 3
chr12_+_16391342 0.212 NM_145792
MGST1
microsomal glutathione S-transferase 1
chr21_-_35153664 0.211 RUNX1
runt-related transcription factor 1
chr1_+_109043711 0.210 PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr11_-_3759886 0.210 NUP98
nucleoporin 98kDa
chr6_+_88239398 0.208 SLC35A1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr12_-_69434330 0.208 PTPRR
protein tyrosine phosphatase, receptor type, R
chr22_-_34566210 0.206 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr13_-_43908995 0.204 TSC22D1
TSC22 domain family, member 1
chr7_-_112217644 0.203 NM_022484
TMEM168
transmembrane protein 168
chr11_+_71605466 0.202 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr14_+_50096492 0.202 NM_015915
NM_181598
ATL1

atlastin GTPase 1

chr6_-_152542293 0.200 NM_133650
SYNE1
spectrin repeat containing, nuclear envelope 1
chr17_+_46176105 0.200 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr1_-_196776697 0.200 NM_133262
NM_133326
ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr5_-_145232723 0.200 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr2_+_169367345 0.198 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr1_+_196874867 0.198 PTPRC
protein tyrosine phosphatase, receptor type, C
chr9_-_94338072 0.196 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr12_+_52126131 0.195 PRR13
proline rich 13
chr1_-_76170563 0.195 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr1_+_559618 0.192


chr1_-_93030538 0.192 NM_005665
EVI5
ecotropic viral integration site 5
chr15_-_91078307 0.190 FAM174B
family with sequence similarity 174, member B
chr13_-_43908985 0.189 TSC22D1
TSC22 domain family, member 1
chr6_-_2785682 0.186 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chrX_+_46938215 0.184 UBA1
ubiquitin-like modifier activating enzyme 1
chr16_-_3291378 0.184 NM_033208
TIGD7
tigger transposable element derived 7
chr22_-_34566276 0.183 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_-_52752935 0.183 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr6_+_45404031 0.183 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr3_-_114047479 0.182 NM_001008784
CD200R1L
CD200 receptor 1-like
chr2_+_38009405 0.182 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr11_-_57927457 0.182 NM_001005469
OR5B3
olfactory receptor, family 5, subfamily B, member 3
chr11_+_48284350 0.180 NM_001004725
OR4S1
olfactory receptor, family 4, subfamily S, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.74 2.06e-12 GO:0007606 sensory perception of chemical stimulus
3.67 2.40e-10 GO:0007608 sensory perception of smell
2.46 6.26e-07 GO:0007600 sensory perception
1.83 3.92e-05 GO:0003008 system process
1.39 5.75e-05 GO:0032501 multicellular organismal process
1.86 5.93e-04 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 4.49e-03 GO:0071944 cell periphery
1.33 1.12e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.75 5.08e-11 GO:0004984 olfactory receptor activity
2.58 3.09e-09 GO:0004930 G-protein coupled receptor activity
1.90 7.13e-05 GO:0004888 transmembrane receptor activity
1.66 1.52e-03 GO:0004872 receptor activity
1.53 8.87e-03 GO:0004871 signal transducer activity
1.53 8.87e-03 GO:0060089 molecular transducer activity
24.99 3.42e-02 GO:0047023 androsterone dehydrogenase activity
24.99 3.42e-02 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity