Motif ID: ZEB1.p2

Z-value: 3.623


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZEB1chr10_+_31648103-0.811.3e-04Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_22363036 8.870 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr19_+_6415259 8.786 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr19_+_40431359 8.259 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr19_+_40431618 8.197 LSR
lipolysis stimulated lipoprotein receptor
chr1_-_27159462 7.743 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr8_+_120289735 7.661 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr22_+_38720881 7.568 NM_138435
FAM83F
family with sequence similarity 83, member F
chr4_-_35922288 7.358 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr19_+_43447262 6.873 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_40431122 5.969 LSR
lipolysis stimulated lipoprotein receptor
chr8_-_144887876 5.887 NM_198488
FAM83H
family with sequence similarity 83, member H
chr19_+_40431678 5.768 LSR
lipolysis stimulated lipoprotein receptor
chr19_+_43447078 5.661 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr18_+_27332024 5.040 NM_001943
DSG2
desmoglein 2
chr1_-_208046011 5.033 NM_006147
IRF6
interferon regulatory factor 6
chr19_+_43446937 4.957 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_7566698 4.859 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr7_+_26298018 4.853 NM_013322
SNX10
sorting nexin 10
chr17_+_26839143 4.548 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr11_+_32808045 4.384 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr6_-_10527772 4.329 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_1971762 4.228 NM_002744
PRKCZ
protein kinase C, zeta
chr16_-_66827449 4.198 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr19_-_60587414 4.161 NM_001190764
LOC388564
hypothetical protein LOC388564
chr3_+_10832867 4.026 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr11_-_64368616 4.005 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr2_-_166358951 3.973 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr18_-_45975163 3.965 NM_001080467
MYO5B
myosin VB
chr2_-_166359016 3.903 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr2_-_166358792 3.895 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr1_+_60053050 3.859 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr5_+_68746694 3.836 NM_001038603
MARVELD2
MARVEL domain containing 2
chr8_+_95722448 3.747 ESRP1
epithelial splicing regulatory protein 1
chr21_-_42060266 3.693 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr2_+_17585462 3.678 VSNL1
visinin-like 1
chr2_+_17585287 3.639 NM_003385
VSNL1
visinin-like 1
chr7_+_26298136 3.559 SNX10
sorting nexin 10
chr17_-_37196463 3.530 NM_002230
NM_021991
JUP

junction plakoglobin

chr11_-_65895640 3.514 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr21_-_42060334 3.437 RIPK4
receptor-interacting serine-threonine kinase 4
chr1_-_159257595 3.377 NM_016946
F11R
F11 receptor
chr16_+_67328693 3.371 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_-_44269719 3.357 NM_001024845
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr16_+_67328715 3.351 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr21_-_41140908 3.295 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr20_+_48781457 3.272 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr1_-_159257567 3.244 F11R
F11 receptor
chr1_+_24518398 3.174 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr1_-_159257486 3.172 F11R
F11 receptor
chr17_+_35147738 3.151 GRB7
growth factor receptor-bound protein 7
chr5_+_76150637 3.125 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr17_+_71229191 3.076 ITGB4
integrin, beta 4
chr5_+_76150588 3.069 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr1_-_44269615 3.063 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr16_+_67236730 3.024 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr17_+_71229151 3.018 ITGB4
integrin, beta 4
chr17_+_71229110 2.994 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr6_+_7486891 2.988 DSP
desmoplakin
chr16_+_67328805 2.977 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_+_24518501 2.973 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr6_+_7486836 2.961 DSP
desmoplakin
chr8_-_127639647 2.882 FAM84B
family with sequence similarity 84, member B
chr6_+_7486862 2.837 NM_001008844
NM_004415
DSP

desmoplakin

chr19_+_7608010 2.822 STXBP2
syntaxin binding protein 2
chr2_+_47449790 2.822 NM_002354
EPCAM
epithelial cell adhesion molecule
chr16_+_70217564 2.759 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr17_+_71033339 2.756 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr12_-_32940931 2.754 NM_001005242
NM_004572
PKP2

plakophilin 2

chr19_+_7608015 2.716 STXBP2
syntaxin binding protein 2
chr2_-_224410444 2.714 AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr19_+_7607976 2.687 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chrX_+_152562013 2.677 DUSP9
dual specificity phosphatase 9
chr7_+_149651202 2.632 NM_001142928
NM_023942
LRRC61

leucine rich repeat containing 61

chr19_-_7607852 2.615


chr19_+_7608020 2.581 STXBP2
syntaxin binding protein 2
chr14_-_66948523 2.546 NM_016445
PLEK2
pleckstrin 2
chr7_+_29570024 2.541 PRR15
proline rich 15
chr2_+_47449951 2.533 EPCAM
epithelial cell adhesion molecule
chr17_+_35147697 2.519 NM_005310
GRB7
growth factor receptor-bound protein 7
chr14_-_66948612 2.505 PLEK2
pleckstrin 2
chr8_+_144888275 2.500 LOC100128338
hypothetical LOC100128338
chr17_-_6400470 2.480 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr10_-_62163083 2.479 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr16_+_67328737 2.433 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr2_-_224410544 2.428 NM_001039569
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr16_-_65287967 2.368 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr1_+_36544549 2.363 NM_001162530
SH3D21
SH3 domain containing 21
chr19_-_14177980 2.337 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr18_+_59295123 2.329 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr12_+_6926014 2.279 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr8_-_17702991 2.278


chr11_-_550706 2.269 NM_173573
C11orf35
chromosome 11 open reading frame 35
chr7_-_97868101 2.231 BAIAP2L1
BAI1-associated protein 2-like 1
chr20_-_6051562 2.217 FERMT1
fermitin family member 1
chr5_+_68824143 2.196 OCLN
occludin
chr2_-_216586488 2.171 NM_018000
MREG
melanoregulin
chr1_-_158182006 2.163 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr14_-_70345485 2.162 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr21_+_42807052 2.155 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr20_+_13150417 2.145 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr14_-_20636337 2.142 ZNF219
zinc finger protein 219
chr2_-_74522513 2.133 RTKN
rhotekin
chr19_-_6718417 2.111 NM_005490
SH2D3A
SH2 domain containing 3A
chr7_+_147667461 2.105 CNTNAP2
contactin associated protein-like 2
chrX_+_130985316 2.101 NM_001042452
MST4
serine/threonine protein kinase MST4
chr2_-_74522534 2.096 RTKN
rhotekin
chr12_-_51200347 2.095 NM_000424
KRT5
keratin 5
chr2_-_74522563 2.081 NM_001015055
RTKN
rhotekin
chr4_+_75699652 2.079 NM_001657
AREG
amphiregulin
chr8_+_86563382 2.060 NM_000067
CA2
carbonic anhydrase II
chr12_+_56271181 2.051 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr21_-_41140457 2.028 DSCAM
Down syndrome cell adhesion molecule
chr19_-_40693176 2.014 NM_001126059
DMKN
dermokine
chr18_+_45342398 2.008 NM_006033
LIPG
lipase, endothelial
chr1_-_58815415 1.988 TACSTD2
tumor-associated calcium signal transducer 2
chr3_-_45162783 1.975


chr12_+_56271259 1.970 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr6_+_36206239 1.946 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr2_-_121759237 1.945 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr1_+_3360880 1.945 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr7_+_29569978 1.941 PRR15
proline rich 15
chr2_-_36384 1.930 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr1_+_29086206 1.916 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr1_+_29086156 1.914 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr20_-_60375695 1.899 NM_005560
LAMA5
laminin, alpha 5
chr4_+_75529716 1.881 NM_001657
AREG
amphiregulin
chr16_+_751050 1.866 NM_013404
MSLN
mesothelin
chr11_+_45900731 1.863 GYLTL1B
glycosyltransferase-like 1B
chr3_-_45162847 1.841 CDCP1
CUB domain containing protein 1
chr4_+_152549776 1.792 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr12_+_6925997 1.771 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr17_+_35148084 1.771 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr14_-_37134191 1.767 NM_004496
FOXA1
forkhead box A1
chr1_-_58815753 1.754 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr3_-_45162865 1.734 CDCP1
CUB domain containing protein 1
chr1_-_21821597 1.734 RAP1GAP
RAP1 GTPase activating protein
chr14_+_30413393 1.729 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr16_-_11588257 1.725 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr3_+_46996150 1.724 NM_015175
NBEAL2
neurobeachin-like 2
chr22_-_49317408 1.715 ODF3B
outer dense fiber of sperm tails 3B
chr14_-_60817946 1.703


chr3_-_45162901 1.688 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr1_-_27212035 1.667 FAM46B
family with sequence similarity 46, member B
chr6_+_54819527 1.666 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr20_-_62081752 1.663 SAMD10
sterile alpha motif domain containing 10
chr2_+_111594921 1.660 NM_006538
NM_138621
NM_207002
BCL2L11


BCL2-like 11 (apoptosis facilitator)


chr11_+_551449 1.657 NM_001143994
NM_003475
RASSF7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr11_+_75157414 1.656 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr9_-_125070675 1.649 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr12_+_6290127 1.640 PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr8_-_81246215 1.627 NM_001025253
NM_005079
TPD52

tumor protein D52

chr11_+_75157450 1.626 DGAT2
diacylglycerol O-acyltransferase 2
chr17_-_35911340 1.626 NM_032865
TNS4
tensin 4
chr6_+_150505849 1.618 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr8_+_102574012 1.607 GRHL2
grainyhead-like 2 (Drosophila)
chr14_-_37134050 1.601 FOXA1
forkhead box A1
chr8_-_110726063 1.600 SYBU
syntabulin (syntaxin-interacting)
chr19_-_51909416 1.598 NM_001079882
PRKD2
protein kinase D2
chr3_+_188131209 1.578 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr17_+_72789086 1.568 NM_001113491
SEPT9
septin 9
chr14_-_37133927 1.563 FOXA1
forkhead box A1
chr22_-_20314274 1.554 NM_001017964
YDJC
YdjC homolog (bacterial)
chr1_-_27211913 1.553 NM_052943
FAM46B
family with sequence similarity 46, member B
chr12_+_7174230 1.545 NM_014718
CLSTN3
calsyntenin 3
chr19_+_43486640 1.537 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr8_-_110726201 1.536 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr16_+_67236699 1.508 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr14_-_60817663 1.507 TMEM30B
transmembrane protein 30B
chr5_-_168660293 1.502 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr14_-_60817709 1.502 TMEM30B
transmembrane protein 30B
chr11_+_550868 1.494 NM_001143993
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr4_-_82612049 1.490 NM_152545
RASGEF1B
RasGEF domain family, member 1B
chr1_+_64983312 1.485 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr13_-_27092538 1.479 LNX2
ligand of numb-protein X 2
chr1_+_181422016 1.464 LAMC2
laminin, gamma 2
chr1_+_203740391 1.454 CDK18
cyclin-dependent kinase 18
chr6_+_30959839 1.450 NM_001954
DDR1
discoidin domain receptor tyrosine kinase 1
chr18_+_58143499 1.449 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr22_-_30072217 1.442 NM_014323
NM_032050
NM_032051
NM_032052
PATZ1



POZ (BTB) and AT hook containing zinc finger 1



chr4_-_82611995 1.425 RASGEF1B
RasGEF domain family, member 1B
chr2_-_99124466 1.424 NM_182911
TSGA10
testis specific, 10
chr6_+_44203335 1.424 NM_018426
TMEM63B
transmembrane protein 63B
chr14_-_60817621 1.421


chr8_-_95720870 1.417 LOC100288748
hypothetical LOC100288748
chr8_+_95722516 1.410 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr1_+_232107170 1.406 NM_173508
SLC35F3
solute carrier family 35, member F3
chr8_+_95722575 1.404 ESRP1
epithelial splicing regulatory protein 1
chr19_+_60283571 1.402 NM_017729
EPS8L1
EPS8-like 1
chr15_-_20637731 1.398 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr19_+_45811856 1.393 LTBP4
latent transforming growth factor beta binding protein 4
chr5_-_60175798 1.387 NM_001104558
NM_024930
ELOVL7

ELOVL family member 7, elongation of long chain fatty acids (yeast)

chr1_+_181421984 1.386 LAMC2
laminin, gamma 2
chr10_-_21502993 1.385 NEBL
nebulette
chr6_-_47385205 1.381 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr7_+_149651481 1.379 LRRC61
leucine rich repeat containing 61
chr17_-_40866062 1.372 NM_174919
SH3D20
SH3 domain containing 20
chr19_-_48835783 1.367 NM_145296
CADM4
cell adhesion molecule 4
chr7_-_149651594 1.361 NM_001164458
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr1_+_32979930 1.360 NM_020888
KIAA1522
KIAA1522
chr11_-_114880275 1.359 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 4.33e-04 GO:0008152 metabolic process
1.11 3.00e-03 GO:0044238 primary metabolic process
1.11 4.09e-03 GO:0044237 cellular metabolic process
1.06 6.25e-03 GO:0009987 cellular process
1.31 2.38e-02 GO:0006793 phosphorus metabolic process
1.31 2.38e-02 GO:0006796 phosphate metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 2.94e-12 GO:0005737 cytoplasm
1.07 6.39e-07 GO:0005622 intracellular
1.13 9.61e-06 GO:0044444 cytoplasmic part
1.07 1.06e-05 GO:0044424 intracellular part
1.23 1.75e-04 GO:0005829 cytosol
1.11 6.29e-03 GO:0044446 intracellular organelle part
1.23 6.62e-03 GO:0012505 endomembrane system
1.10 1.77e-02 GO:0044422 organelle part
1.28 1.99e-02 GO:0005794 Golgi apparatus
1.17 4.20e-02 GO:0031090 organelle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 1.19e-06 GO:0005515 protein binding
1.39 3.98e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.26 1.24e-04 GO:0016740 transferase activity
1.37 1.26e-03 GO:0016301 kinase activity
1.23 1.28e-03 GO:0032553 ribonucleotide binding
1.23 1.28e-03 GO:0032555 purine ribonucleotide binding
1.23 1.31e-03 GO:0017076 purine nucleotide binding
1.22 3.07e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.35 1.30e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.18 1.98e-02 GO:0000166 nucleotide binding
1.22 2.16e-02 GO:0030554 adenyl nucleotide binding
1.11 2.23e-02 GO:0003824 catalytic activity
1.22 2.37e-02 GO:0032559 adenyl ribonucleotide binding
1.22 3.56e-02 GO:0005524 ATP binding