Motif ID: GFI1.p2

Z-value: 2.093


Transcription factors associated with GFI1.p2:

Gene SymbolEntrez IDGene Name
GFI1 2672 growth factor independent 1 transcription repressor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GFI1chr1_-_92724181-0.292.7e-01Click!


Activity profile for motif GFI1.p2.

activity profile for motif GFI1.p2


Sorted Z-values histogram for motif GFI1.p2

Sorted Z-values for motif GFI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GFI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_183302105 5.292 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr5_+_66160359 4.193 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_-_127897098 3.791 ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr1_+_112740378 3.397


chr1_+_112740322 3.336 NM_018704
CTTNBP2NL
CTTNBP2 N-terminal like
chr6_-_166960649 3.283 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_+_112740380 3.182 LOC100129406
CTTNBP2NL
hypothetical protein LOC100129406
CTTNBP2 N-terminal like
chr7_-_27162688 3.084 NM_006896
HOXA7
homeobox A7
chr3_+_112876212 2.758 NM_001185106
NM_153268
PLCXD2

phosphatidylinositol-specific phospholipase C, X domain containing 2

chr9_-_23816062 2.739 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_-_166960496 2.667 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr11_-_127897271 2.663 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr6_+_26333361 2.657 NM_003532
HIST1H3E
histone cluster 1, H3e
chr10_+_102782156 2.633 SFXN3
sideroflexin 3
chr6_-_26379567 2.625 NM_003534
HIST1H3G
histone cluster 1, H3g
chr2_-_189752575 2.573 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_-_166960690 2.508 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr8_-_49996353 2.492 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr8_+_42129620 2.426 NM_001134296
NM_006803
AP3M2

adaptor-related protein complex 3, mu 2 subunit

chr2_-_45090025 2.353 NM_016932
SIX2
SIX homeobox 2
chr10_+_102782151 2.293 SFXN3
sideroflexin 3
chr5_+_174084137 2.282 NM_002449
MSX2
msh homeobox 2
chr5_-_124108672 2.250 NM_020747
ZNF608
zinc finger protein 608
chr6_+_26153590 2.238 NM_003531
HIST1H3C
histone cluster 1, H3c
chr4_-_115120251 2.224 NM_024590
ARSJ
arylsulfatase family, member J
chr17_-_17816425 2.197 NM_001033551
NM_001082968
TOM1L2

target of myb1-like 2 (chicken)

chr18_+_42780784 2.190 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr7_-_121571472 2.149 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr16_+_81218074 2.131 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr11_-_8849485 2.102 ST5
suppression of tumorigenicity 5
chr1_-_68470585 2.066 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr4_-_122063118 2.008 NM_018699
PRDM5
PR domain containing 5
chr1_+_101474892 1.968 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr8_-_41286088 1.966 NM_003012
SFRP1
secreted frizzled-related protein 1
chr3_-_87122958 1.879 VGLL3
vestigial like 3 (Drosophila)
chr5_+_102229612 1.836 PAM
peptidylglycine alpha-amidating monooxygenase
chr1_-_93919789 1.818 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr19_-_11352850 1.796 EPOR
erythropoietin receptor
chr3_-_87122936 1.794 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr12_+_4300607 1.785 NM_020375
C12orf5
chromosome 12 open reading frame 5
chr4_+_167013859 1.764 NM_012464
TLL1
tolloid-like 1
chr1_+_101475149 1.759 S1PR1
sphingosine-1-phosphate receptor 1
chr6_-_30289092 1.706 NM_003449
TRIM26
tripartite motif containing 26
chr3_+_173951163 1.681 ECT2
epithelial cell transforming sequence 2 oncogene
chr1_-_95165037 1.672 CNN3
calponin 3, acidic
chrX_+_56275510 1.665 NM_007250
NM_001159296
KLF8

Kruppel-like factor 8

chr1_-_95165089 1.639 NM_001839
CNN3
calponin 3, acidic
chr4_+_77829634 1.628 SHROOM3
shroom family member 3
chr17_+_17816851 1.624 NM_001130090
NM_001130091
NM_001130092
NM_031294
LRRC48



leucine rich repeat containing 48



chrX_+_17665483 1.623 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr5_+_142130475 1.608 NM_001135608
NM_015071
ARHGAP26

Rho GTPase activating protein 26

chr11_+_43658718 1.579 NM_016142
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
chr5_-_127901633 1.576 NM_001999
FBN2
fibrillin 2
chr5_+_102229425 1.562 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr3_+_50248749 1.522 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr3_-_115960807 1.514 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chrX_-_10548458 1.511 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr12_-_45759691 1.501 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr5_-_112658456 1.498 NM_002387
MCC
mutated in colorectal cancers
chr11_-_72111027 1.468 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr4_+_47181987 1.464 NM_020453
ATP10D
ATPase, class V, type 10D
chr12_+_52733927 1.458 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr1_-_36688556 1.453 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr7_+_65307816 1.449 TPST1
tyrosylprotein sulfotransferase 1
chr5_+_142130154 1.444 ARHGAP26
Rho GTPase activating protein 26
chr21_-_42789369 1.440 NM_080860
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr5_+_140835788 1.435 PCDHGC3
protocadherin gamma subfamily C, 3
chr22_-_26527469 1.430 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr4_-_83938920 1.428 NM_001037582
NM_024906
SCD5

stearoyl-CoA desaturase 5

chr17_+_65677255 1.413 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chrX_-_62891667 1.390 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr3_+_113060826 1.384 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr22_+_31080871 1.372 NM_006604
RFPL3
ret finger protein-like 3
chr4_-_5761194 1.371 NM_147127
EVC2
Ellis van Creveld syndrome 2
chr11_+_13255925 1.364 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr3_-_116348780 1.361 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chrX_+_103103848 1.348 NM_194324
TMSB15B
thymosin beta 15B
chr7_-_42243318 1.346 GLI3
GLI family zinc finger 3
chr17_-_30783631 1.345 NM_018042
SLFN12
schlafen family member 12
chr11_+_13255836 1.344 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr4_+_77829743 1.338 SHROOM3
shroom family member 3
chr5_+_140835727 1.331 NM_002588
NM_032402
NM_032403
PCDHGC3


protocadherin gamma subfamily C, 3


chrX_-_62891730 1.326 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr11_+_13255967 1.323 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr15_-_81744469 1.323 NM_001717
BNC1
basonuclin 1
chr1_+_66570683 1.320 PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_-_112658200 1.315 MCC
mutated in colorectal cancers
chr11_+_13255905 1.311 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr4_+_95898098 1.309 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr11_+_58631190 1.308 NM_001142703
NM_001142704
NM_198947
FAM111B


family with sequence similarity 111, member B


chr16_+_67236730 1.304 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr4_-_186537145 1.300 NM_018409
LRP2BP
LRP2 binding protein
chr17_-_67628523 1.294 FLJ37644
hypothetical LOC400618
chr3_-_64186151 1.290 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chrX_-_62891712 1.289 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr9_-_83494198 1.289 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr11_+_13255913 1.283 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr3_-_147361912 1.282 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr10_-_101680645 1.279 DNMBP
dynamin binding protein
chr5_-_92942680 1.274 FLJ42709
hypothetical LOC441094
chrX_-_103060777 1.271 LOC100128594
hypothetical LOC100128594
chr17_+_67628772 1.266 SOX9
SRY (sex determining region Y)-box 9
chr17_+_67628749 1.262 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr22_-_35502059 1.256 NM_001177701
NM_006860
IFT27

intraflagellar transport 27 homolog (Chlamydomonas)

chr3_-_71196696 1.255 FOXP1
forkhead box P1
chr7_-_42243142 1.243 NM_000168
GLI3
GLI family zinc finger 3
chr4_-_40911212 1.237 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr4_+_120167264 1.235 SYNPO2
synaptopodin 2
chr11_-_117640407 1.228 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr16_+_67236699 1.220 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr10_-_123346148 1.217 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr5_-_171643399 1.206 NM_152277
UBTD2
ubiquitin domain containing 2
chr11_+_13255948 1.202 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr6_-_134540666 1.201 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr14_-_90596665 1.200 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr10_-_71576458 1.194 NM_001040273
NM_173555
TYSND1

trypsin domain containing 1

chr9_+_81376666 1.194 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr9_+_129605275 1.194 NM_001018078
FPGS
folylpolyglutamate synthase
chr7_+_65307691 1.193 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr1_+_85300580 1.192 NM_145172
WDR63
WD repeat domain 63
chr5_+_60663842 1.181 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr6_+_114285209 1.174 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr6_+_32970477 1.163 LOC100294145
hypothetical LOC100294145
chr4_-_138673014 1.156 PCDH18
protocadherin 18
chr2_+_98070026 1.150 NM_144992
VWA3B
von Willebrand factor A domain containing 3B
chr8_+_102573837 1.149 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr18_+_19706979 1.141 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr19_+_627346 1.140 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr12_-_28016182 1.138 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr4_+_38860418 1.135 NM_025132
WDR19
WD repeat domain 19
chr3_-_69517913 1.135 FRMD4B
FERM domain containing 4B
chr11_+_13255952 1.126 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr1_+_66570363 1.125 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_-_54866126 1.125 NM_003711
NM_176895
RNF138P1
PPAP2A

ring finger protein 138 pseudogene 1
phosphatidic acid phosphatase type 2A

chr6_-_26125939 1.118 NM_005325
HIST1H1A
histone cluster 1, H1a
chr9_+_129605349 1.116 FPGS
folylpolyglutamate synthase
chr8_-_98359248 1.112 TSPYL5
TSPY-like 5
chr12_+_83954229 1.107 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr5_-_171643247 1.106 UBTD2
ubiquitin domain containing 2
chr8_+_102574012 1.106 GRHL2
grainyhead-like 2 (Drosophila)
chr3_+_50248678 1.105 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr7_-_27153892 1.101 NM_024014
HOXA6
homeobox A6
chr1_-_46370837 1.096 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr1_+_162795328 1.094 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr20_+_43874735 1.091 UBE2C
ubiquitin-conjugating enzyme E2C
chrX_-_47394808 1.091 ELK1
ELK1, member of ETS oncogene family
chr9_-_34319151 1.090 NM_194313
KIF24
kinesin family member 24
chr12_-_47869067 1.089 NM_006009
TUBA1A
tubulin, alpha 1a
chr14_+_64948332 1.087 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr8_-_28403652 1.086 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr4_-_159313613 1.082 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr7_-_133794344 1.081 AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chrX_-_131451675 1.075 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr3_+_113060716 1.074 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr7_-_94123308 1.073 SGCE
sarcoglycan, epsilon
chr17_+_67628763 1.073 SOX9
SRY (sex determining region Y)-box 9
chr15_+_83724743 1.069 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chrX_-_33139349 1.069 NM_004006
DMD
dystrophin
chr5_-_73973004 1.068 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr6_+_21701942 1.066 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr3_+_114414064 1.061 NM_033254
BOC
Boc homolog (mouse)
chr1_+_218768423 1.061 MARK1
MAP/microtubule affinity-regulating kinase 1
chr3_-_173911467 1.054 NM_001146276
NM_001146277
NM_001146278
NM_020792
NCEH1



neutral cholesterol ester hydrolase 1



chr14_-_92284626 1.054 NM_001008530
NM_005606
LGMN

legumain

chr9_-_35062545 1.052 VCP
valosin containing protein
chr12_-_47869134 1.052 TUBA1A
tubulin, alpha 1a
chr3_-_147361626 1.044 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr8_-_78074851 1.043 NM_000318
NM_001079867
PEX2

peroxisomal biogenesis factor 2

chr8_-_42184350 1.040 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr12_+_77782719 1.033 SYT1
synaptotagmin I
chr9_+_34319503 1.032 NM_001161
NM_147172
NM_147173
NUDT2


nudix (nucleoside diphosphate linked moiety X)-type motif 2


chr7_-_94123413 1.028 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr6_-_10520264 1.027 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr2_+_149895274 1.027 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr20_+_43875078 1.024 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr19_+_20897898 1.023 NM_003429
ZNF85
zinc finger protein 85
chr6_+_46728590 1.020 NM_004277
SLC25A27
solute carrier family 25, member 27
chr9_+_129604962 1.019 NM_004957
FPGS
folylpolyglutamate synthase
chr3_+_115258348 1.018 QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr7_-_94123362 1.015 SGCE
sarcoglycan, epsilon
chr19_-_63643400 1.013 NM_003433
ZNF132
zinc finger protein 132
chr7_-_133794404 1.012 NM_001628
AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr4_+_321607 1.009 ZNF141
zinc finger protein 141
chr4_+_321587 1.002 NM_003441
ZNF141
zinc finger protein 141
chr19_+_13767207 1.002 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr3_+_50248652 0.998 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr20_+_43874654 0.997 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr13_-_66702433 0.990 NM_020403
NM_203487
PCDH9

protocadherin 9

chr4_+_8251818 0.989 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr4_-_76774594 0.985 NM_003948
CDKL2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr3_+_50248639 0.979 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr1_-_20931288 0.976 SH2D5
SH2 domain containing 5
chr14_-_52487558 0.976 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr9_-_20612476 0.976 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr8_-_119192985 0.974 NM_000127
EXT1
exostosin 1
chr18_-_43711143 0.972 SMAD2
SMAD family member 2
chr4_+_86968069 0.970 ARHGAP24
Rho GTPase activating protein 24
chr4_-_138673078 0.953 NM_019035
PCDH18
protocadherin 18
chr17_-_1566223 0.948 C17orf91
chromosome 17 open reading frame 91
chr8_-_98359347 0.944 NM_033512
TSPYL5
TSPY-like 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 6.14e-03 GO:0009987 cellular process
1.98 1.66e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.63 1.67e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.53 2.78e-02 GO:0045595 regulation of cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 2.54e-07 GO:0005634 nucleus
1.11 5.83e-06 GO:0043229 intracellular organelle
1.11 9.49e-06 GO:0043226 organelle
1.09 1.51e-05 GO:0005622 intracellular
1.12 3.50e-05 GO:0043227 membrane-bounded organelle
1.12 3.52e-05 GO:0043231 intracellular membrane-bounded organelle
1.08 1.50e-04 GO:0044424 intracellular part
1.43 1.11e-02 GO:0042995 cell projection

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.07 5.49e-03 GO:0005488 binding
1.12 1.09e-02 GO:0005515 protein binding
1.25 4.81e-02 GO:0008270 zinc ion binding