Motif ID: EWSR1-FLI1.p2

Z-value: 1.238


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FLI1chr11_+_1280675980.185.2e-01Click!
EWSR1chr22_+_27993997-0.136.3e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_10520264 5.097 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_-_10520592 4.456 NM_001032280
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chrX_+_107569671 2.423 NM_000495
NM_033380
 COL4A5

collagen, type IV, alpha 5

chr11_-_117628211 2.406 NM_198275
 MPZL3
myelin protein zero-like 3
chr1_+_185064654 2.021 NM_024420
 PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr4_+_183302105 1.729 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr17_-_31146660 1.718 NM_001032278
NM_024302
 MMP28

matrix metallopeptidase 28

chrX_-_107569256 1.506 NM_001847
 COL4A6
collagen, type IV, alpha 6
chr1_-_6468600 1.420 NM_001042665
 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr5_-_148422799 1.402 NM_024577
 SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr16_+_67697622 1.372 NM_138612
 HAS3
hyaluronan synthase 3
chr1_-_68071635 1.320 NM_018841
 GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr1_-_150276064 1.205 S100A11
S100 calcium binding protein A11
chr1_-_68470585 1.192 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr19_+_53466465 1.189 NM_153608
 ZNF114
zinc finger protein 114
chr5_+_156819782 1.168 NIPAL4
NIPA-like domain containing 4
chr1_-_150276114 1.127 NM_005620
 S100A11
S100 calcium binding protein A11
chr1_-_150276091 1.106 S100A11
S100 calcium binding protein A11
chr20_+_6696744 1.031 NM_001200
 BMP2
bone morphogenetic protein 2
chr7_+_16759845 0.973 NM_014399
 TSPAN13
tetraspanin 13

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
2.93 2.24e-02 GO:0048812 neuron projection morphogenesis
2.93 3.52e-02 GO:0007409 axonogenesis
2.86 1.23e-02 GO:0048858 cell projection morphogenesis
2.83 1.41e-02 GO:0032990 cell part morphogenesis
2.75 3.41e-02 GO:0000904 cell morphogenesis involved in differentiation
2.64 1.84e-02 GO:0000902 cell morphogenesis
2.50 4.39e-02 GO:0032989 cellular component morphogenesis

Nothing significant found in compartment category.

Nothing significant found in function category.