Motif ID: EWSR1-FLI1.p2

Z-value: 1.238


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FLI1chr11_+_1280675980.185.2e-01Click!
EWSR1chr22_+_27993997-0.136.3e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_10520264 5.097 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_-_10520592 4.456 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chrX_+_107569671 2.423 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr11_-_117628211 2.406 NM_198275
MPZL3
myelin protein zero-like 3
chr1_+_185064654 2.021 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr4_+_183302105 1.729 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr17_-_31146660 1.718 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chrX_-_107569256 1.506 NM_001847
COL4A6
collagen, type IV, alpha 6
chr1_-_6468600 1.420 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr5_-_148422799 1.402 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr16_+_67697622 1.372 NM_138612
HAS3
hyaluronan synthase 3
chr1_-_68071635 1.320 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr1_-_150276064 1.205 S100A11
S100 calcium binding protein A11
chr1_-_68470585 1.192 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr19_+_53466465 1.189 NM_153608
ZNF114
zinc finger protein 114
chr5_+_156819782 1.168 NIPAL4
NIPA-like domain containing 4
chr1_-_150276114 1.127 NM_005620
S100A11
S100 calcium binding protein A11
chr1_-_150276091 1.106 S100A11
S100 calcium binding protein A11
chr20_+_6696744 1.031 NM_001200
BMP2
bone morphogenetic protein 2
chr7_+_16759845 0.973 NM_014399
TSPAN13
tetraspanin 13
chr19_+_12996830 0.938 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_-_71385651 0.925 TRIM47
tripartite motif containing 47
chr19_-_55763091 0.903 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr19_-_242168 0.849 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr1_-_231498081 0.837 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr10_+_119292699 0.835


chr5_+_156819604 0.824 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr10_+_88708267 0.819 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr21_+_38550533 0.758 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr21_+_38550739 0.745 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_-_42282665 0.742 NM_000729
CCK
cholecystokinin
chr1_-_224993498 0.741 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr7_-_106991941 0.739 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr11_+_101485946 0.712 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr17_+_45488356 0.711 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr19_+_12996745 0.663 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_+_2443983 0.663 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr9_+_77695334 0.657 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr3_-_15875932 0.654 NM_015199
ANKRD28
ankyrin repeat domain 28
chr19_-_1966628 0.647 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr1_-_236120844 0.639 NM_021186
ZP4
zona pellucida glycoprotein 4
chr15_+_39310757 0.636 CHP
calcium binding protein P22
chr17_+_45488330 0.633 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr21_+_39099717 0.617 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr4_-_44145580 0.612 NM_198353
KCTD8
potassium channel tetramerisation domain containing 8
chr21_+_39099624 0.596 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr15_+_39310693 0.591 NM_007236
CHP
calcium binding protein P22
chr20_+_42807901 0.586 NM_022358
KCNK15
potassium channel, subfamily K, member 15
chr14_+_69415880 0.580 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr12_+_14409875 0.556 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr10_-_103864579 0.554 LDB1
LIM domain binding 1
chr18_+_54682261 0.551 ZNF532
zinc finger protein 532
chr12_+_10222823 0.549 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr16_-_2848106 0.541 NM_022119
PRSS22
protease, serine, 22
chr6_-_143307976 0.538 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr9_+_34169023 0.526 UBAP1
ubiquitin associated protein 1
chr6_+_139055244 0.526 FLJ46906
hypothetical LOC441172
chr12_+_83954229 0.508 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr9_+_34169036 0.504 UBAP1
ubiquitin associated protein 1
chr6_+_26491302 0.489 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
BTN2A2





butyrophilin, subfamily 2, member A2





chr19_-_242335 0.461 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr8_-_29262240 0.459 NM_057158
DUSP4
dual specificity phosphatase 4
chr2_+_37425240 0.457 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chrX_-_109447954 0.453 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr9_+_34169047 0.452 UBAP1
ubiquitin associated protein 1
chr11_+_9736408 0.449 LOC283104
hypothetical LOC283104
chr2_-_60634271 0.444 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chrX_-_109447970 0.441 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr9_+_34169002 0.435 NM_001171201
NM_001171202
NM_001171203
NM_001171204
NM_016525
UBAP1




ubiquitin associated protein 1




chrX_-_78509662 0.427 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr2_+_113533155 0.423 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr14_-_53493198 0.419 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr9_+_34169058 0.417 UBAP1
ubiquitin associated protein 1
chr3_-_65999548 0.416 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr4_-_96689137 0.415 UNC5C
unc-5 homolog C (C. elegans)
chr11_-_122571198 0.412 NM_024769
CLMP
CXADR-like membrane protein
chr4_+_120029426 0.407 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr10_+_83627422 0.406 NM_001165973
NRG3
neuregulin 3
chr19_-_56164628 0.393 NM_002774
KLK6
kallikrein-related peptidase 6
chr12_-_92489652 0.383 LOC144481
hypothetical protein LOC144481
chr1_-_48235148 0.381 NM_001194986
LOC388630
UPF0632 protein A
chrX_-_49851743 0.367 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr9_-_83494198 0.361 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr3_-_193609531 0.353 NM_021032
FGF12
fibroblast growth factor 12
chr10_+_114700775 0.353 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr10_-_103864651 0.350 NM_003893
LDB1
LIM domain binding 1
chr1_-_202730135 0.347 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr1_+_12627152 0.346 NM_001013630
AADACL4
arylacetamide deacetylase-like 4
chr1_+_117253882 0.344 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr19_-_47450991 0.342 ERF
Ets2 repressor factor
chr19_-_9098625 0.342 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chrX_-_109448083 0.337 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chrX_-_62891712 0.336 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr2_+_182464910 0.330 SSFA2
sperm specific antigen 2
chr11_+_10433241 0.328 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr10_+_104211148 0.327 NM_024789
TMEM180
transmembrane protein 180
chr18_+_44319365 0.324 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr15_+_88345612 0.317 NM_198526
ZNF710
zinc finger protein 710
chr8_-_22982435 0.315 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr17_+_582406 0.302 NM_024792
FAM57A
family with sequence similarity 57, member A
chr7_+_36395913 0.290 NM_018685
ANLN
anillin, actin binding protein
chr10_-_90601655 0.287 NM_144590
ANKRD22
ankyrin repeat domain 22
chr6_+_31698447 0.287


chr19_-_47451119 0.284 NM_006494
ERF
Ets2 repressor factor
chr10_+_104211134 0.282 TMEM180
transmembrane protein 180
chr8_-_111056099 0.282 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr10_+_70553983 0.278 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr17_+_2443652 0.277 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr14_-_93665678 0.272 NM_032036
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr10_+_70553993 0.272 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chrX_-_78509367 0.270 ITM2A
integral membrane protein 2A
chr6_-_24827265 0.269 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr17_-_76919068 0.268 NM_178520
TMEM105
transmembrane protein 105
chr1_-_223907283 0.265 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr11_-_122571046 0.260 CLMP
CXADR-like membrane protein
chr1_-_155336223 0.256 NM_001004341
ETV3L
ets variant 3-like
chr1_-_72521079 0.254


chr2_-_60633908 0.254 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr13_+_46025313 0.251 LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr8_+_30361485 0.246 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr12_-_47464143 0.240 NM_015270
ADCY6
adenylate cyclase 6
chr4_+_84676280 0.238 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr14_-_93665668 0.237 IFI27L2
interferon, alpha-inducible protein 27-like 2
chr18_-_44189625 0.237 ZBTB7C
zinc finger and BTB domain containing 7C
chrX_-_102870207 0.237 NM_001024452
NM_001172285
GLRA4

glycine receptor, alpha 4

chr18_+_41659542 0.234 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chrX_+_56606686 0.231 NM_013444
UBQLN2
ubiquilin 2
chrX_-_108611940 0.230 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr11_-_65244718 0.229 NM_032193
RNASEH2C
ribonuclease H2, subunit C
chr18_-_5620629 0.228 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr8_-_22606653 0.225 NM_004430
EGR3
early growth response 3
chr9_+_124836666 0.221 NM_005294
GPR21
G protein-coupled receptor 21
chrX_-_148394570 0.219 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr1_-_224563461 0.218 LIN9
lin-9 homolog (C. elegans)
chr1_+_151596953 0.209 NM_002965
S100A9
S100 calcium binding protein A9
chr13_+_46025296 0.208 NM_001164211
NM_001164213
NM_015116
LRCH1


leucine-rich repeats and calponin homology (CH) domain containing 1


chr5_-_64100176 0.207 SREK1IP1
SREK1-interacting protein 1
chr1_+_109036431 0.203 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr3_-_109292444 0.197 NM_001777
NM_198793
CD47

CD47 molecule

chr17_+_35390607 0.195 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr1_-_180297372 0.192 NM_001009992
ZNF648
zinc finger protein 648
chr14_-_20636568 0.187 NM_016423
ZNF219
zinc finger protein 219
chr17_+_4784524 0.187 RNF167
ring finger protein 167
chr17_+_24598000 0.187 NM_005208
CRYBA1
crystallin, beta A1
chr5_-_81082699 0.187 NM_012446
SSBP2
single-stranded DNA binding protein 2
chrX_-_85189194 0.181 NM_000390
NM_001145414
CHM

choroideremia (Rab escort protein 1)

chr5_-_146869613 0.175 DPYSL3
dihydropyrimidinase-like 3
chr12_+_52060689 0.171 NM_003109
SP1
Sp1 transcription factor
chr17_+_35390614 0.168 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr4_+_84676414 0.168 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr10_+_70553936 0.166 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr1_-_26070330 0.164 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr5_+_86599350 0.164 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr13_+_46025384 0.164 LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr3_-_133236447 0.163 NM_130808
CPNE4
copine IV
chr10_+_70553945 0.162 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr10_-_35143900 0.161 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr11_-_66897584 0.161 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr7_+_128142661 0.159 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr5_-_64100239 0.159 NM_173829
SREK1IP1
SREK1-interacting protein 1
chr15_-_71712605 0.156 NPTN
neuroplastin
chr11_+_71605466 0.155 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr19_-_6542136 0.155 NM_001252
CD70
CD70 molecule
chr17_+_35390579 0.154 NM_002809
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr12_+_29193399 0.151 FAR2
fatty acyl CoA reductase 2
chr19_-_56178882 0.148 NM_139277
NM_005046
KLK7

kallikrein-related peptidase 7

chr3_-_48446405 0.147 NM_001130082
PLXNB1
plexin B1
chr10_+_70553949 0.146 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr17_+_35390632 0.144 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr12_-_55316350 0.144 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr8_-_93176819 0.144 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_182464713 0.143 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chrX_-_62891730 0.142 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr12_+_54838408 0.140 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr5_-_38631263 0.139 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr2_-_222867171 0.138 PAX3
paired box 3
chr16_-_73292188 0.136 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr3_-_197529434 0.135 NM_152773
TCTEX1D2
Tctex1 domain containing 2
chr10_+_70553862 0.134 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr16_-_79811475 0.134 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr5_+_110587546 0.133 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr19_-_6542082 0.131 CD70
CD70 molecule
chrX_-_62891667 0.131 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr12_-_47637396 0.130 ARF3
ADP-ribosylation factor 3
chr11_-_8788765 0.130 NM_213618
ST5
suppression of tumorigenicity 5
chr1_-_20684858 0.129 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr3_-_193928038 0.128 NM_004113
FGF12
fibroblast growth factor 12
chr17_+_35390641 0.128 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr4_-_57217226 0.127 NM_001145459
NM_139211
HOPX

HOP homeobox

chr10_-_102017327 0.123 NM_018294
CWF19L1
CWF19-like 1, cell cycle control (S. pombe)
chr3_+_77171938 0.123 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr16_-_74126568 0.122 NM_024533
CHST5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
chr11_-_8789457 0.122 NM_139157
ST5
suppression of tumorigenicity 5
chr19_+_43502591 0.120 KCNK6
potassium channel, subfamily K, member 6
chr3_+_188131209 0.119 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr12_+_77781903 0.119 NM_001135805
SYT1
synaptotagmin I
chr1_+_242691295 0.119 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chr16_-_30841938 0.118 NCRNA00095
non-protein coding RNA 95
chr17_-_60483169 0.116 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr1_-_20685314 0.116 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.86 1.23e-02 GO:0048858 cell projection morphogenesis
2.83 1.41e-02 GO:0032990 cell part morphogenesis
2.64 1.84e-02 GO:0000902 cell morphogenesis
2.93 2.24e-02 GO:0048812 neuron projection morphogenesis
2.75 3.41e-02 GO:0000904 cell morphogenesis involved in differentiation
2.93 3.52e-02 GO:0007409 axonogenesis
2.50 4.39e-02 GO:0032989 cellular component morphogenesis

Nothing significant found in compartment category.

Nothing significant found in function category.