Motif ID: HIF1A.p2

Z-value: 1.480


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_612317950.185.0e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_38720881 2.033 NM_138435
FAM83F
family with sequence similarity 83, member F
chr10_-_88720908 1.811 LOC100133190
hypothetical LOC100133190
chr13_-_43259032 1.798 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr1_+_231816372 1.409 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr10_+_112247614 1.319 NM_004419
DUSP5
dual specificity phosphatase 5
chr1_+_13899272 1.260 NM_001135610
PRDM2
PR domain containing 2, with ZNF domain
chr3_-_180651874 1.231 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr11_+_20341835 1.224 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr11_+_12088639 1.206 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr11_+_20341806 1.172 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr11_+_20341900 1.126 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr3_-_180652024 1.124 NM_021629
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr4_+_321607 1.095 ZNF141
zinc finger protein 141
chr19_-_53516962 1.089 CCDC114
coiled-coil domain containing 114
chr4_+_321587 1.077 NM_003441
ZNF141
zinc finger protein 141
chr6_+_73388713 1.054 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr1_+_231816540 1.052 KCNK1
potassium channel, subfamily K, member 1
chr11_+_94141151 0.985 NM_130847
AMOTL1
angiomotin like 1
chr10_+_3099708 0.962 NM_002627
PFKP
phosphofructokinase, platelet
chr6_+_33697023 0.956 NM_002224
ITPR3
inositol 1,4,5-triphosphate receptor, type 3
chr5_+_49998677 0.945 PARP8
poly (ADP-ribose) polymerase family, member 8
chr10_-_43390014 0.933 NM_001099282
NM_001099283
NM_001099284
ZNF239


zinc finger protein 239


chr3_-_129024665 0.926 NM_001003794
MGLL
monoglyceride lipase
chr19_-_51608665 0.899 NM_032040
CCDC8
coiled-coil domain containing 8
chr1_+_148521852 0.894 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr12_+_129922589 0.889 RAN
RAN, member RAS oncogene family
chr4_-_10068055 0.876 NM_053042
ZNF518B
zinc finger protein 518B
chrX_+_16714452 0.869 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr3_-_129023850 0.857 NM_007283
MGLL
monoglyceride lipase
chr12_+_129922570 0.857 RAN
RAN, member RAS oncogene family
chr21_+_25856311 0.852 MIR155HG
MIR155 host gene (non-protein coding)
chr17_-_7996409 0.850 NM_002616
PER1
period homolog 1 (Drosophila)
chrX_-_47394808 0.847 ELK1
ELK1, member of ETS oncogene family
chr8_+_95722448 0.840 ESRP1
epithelial splicing regulatory protein 1
chr2_-_235070431 0.836 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr4_+_183302105 0.814 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr1_-_158161877 0.814 TAGLN2
transgelin 2
chr11_+_13646806 0.810 FAR1
fatty acyl CoA reductase 1
chrX_-_47394937 0.806 NM_001114123
NM_005229
ELK1

ELK1, member of ETS oncogene family

chr2_-_225615556 0.802 NM_014689
DOCK10
dedicator of cytokinesis 10
chr1_-_158161902 0.802 NM_003564
TAGLN2
transgelin 2
chrX_-_135161185 0.784 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr11_-_124871258 0.777 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr1_-_208046011 0.775 NM_006147
IRF6
interferon regulatory factor 6
chr19_-_19599973 0.772 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr11_+_13646727 0.770 NM_032228
FAR1
fatty acyl CoA reductase 1
chrX_-_13866366 0.767


chr19_-_63550712 0.763 A1BG
alpha-1-B glycoprotein
chr7_+_115637795 0.758 NM_015641
TES
testis derived transcript (3 LIM domains)
chr5_+_17270781 0.758 BASP1
brain abundant, membrane attached signal protein 1
chr1_+_12046020 0.750 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr9_-_109291575 0.748 KLF4
Kruppel-like factor 4 (gut)
chr1_-_35957030 0.715 C1orf216
chromosome 1 open reading frame 216
chr3_-_185025989 0.710 NM_024871
MAP6D1
MAP6 domain containing 1
chr17_-_58877276 0.710 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr11_+_69602055 0.706 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr5_+_110587546 0.700 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr12_-_21701985 0.694 NM_001174097
LDHB
lactate dehydrogenase B
chrX_+_148430424 0.692 NM_001171907
NM_001171908
NM_178124
CXorf40A


chromosome X open reading frame 40A


chr5_-_159730196 0.690 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr9_-_109291866 0.687 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr1_+_222870573 0.687 CNIH3
cornichon homolog 3 (Drosophila)
chr12_+_68923043 0.684 NM_014515
CNOT2
CCR4-NOT transcription complex, subunit 2
chr12_-_21702036 0.683 LDHB
lactate dehydrogenase B
chrX_+_135057202 0.682 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr12_-_21702021 0.679 LDHB
lactate dehydrogenase B
chrX_+_64804235 0.669 NM_002444
MSN
moesin
chr10_+_17312654 0.669 VIM
vimentin
chr12_-_75983329 0.660 NM_203394
E2F7
E2F transcription factor 7
chr15_+_46957556 0.657 NM_014335
EID1
EP300 interacting inhibitor of differentiation 1
chr1_-_35956979 0.651 C1orf216
chromosome 1 open reading frame 216
chr3_+_23219707 0.649 NM_152653
UBE2E2
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
chr7_+_2525922 0.647 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr12_+_38905053 0.644 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr16_-_30504309 0.644 NM_152458
ZNF785
zinc finger protein 785
chr12_-_21702000 0.641 LDHB
lactate dehydrogenase B
chr5_+_3649167 0.640 NM_024337
IRX1
iroquois homeobox 1
chr6_+_56927665 0.640 NM_152731
BEND6
BEN domain containing 6
chr3_-_16530132 0.638 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr1_-_173428455 0.638 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr6_+_56927882 0.632 BEND6
BEN domain containing 6
chrX_-_148430250 0.630 LOC100131434
hypothetical LOC100131434
chr17_-_44010543 0.627 NM_024015
HOXB4
homeobox B4
chrX_-_13866451 0.626 GPM6B
glycoprotein M6B
chr13_-_35818491 0.623 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr18_+_42167904 0.619 RNF165
ring finger protein 165
chr13_-_35818777 0.615 NM_001142295
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr3_-_16529996 0.612 RFTN1
raftlin, lipid raft linker 1
chr3_-_73756668 0.609 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr2_-_96174502 0.602 DUSP2
dual specificity phosphatase 2
chr9_-_21984414 0.597 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr3_+_23219490 0.594 UBE2E2
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
chr4_-_119493322 0.593 NM_003619
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr1_+_222870798 0.591 NM_152495
CNIH3
cornichon homolog 3 (Drosophila)
chr13_-_35818396 0.587 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr14_-_87529222 0.587 GALC
galactosylceramidase
chr8_+_26296439 0.586 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr7_-_72609957 0.585 NM_001197244
NM_001707
BCL7B

B-cell CLL/lymphoma 7B

chr2_+_190981257 0.581 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr12_-_21702046 0.576 NM_002300
LDHB
lactate dehydrogenase B
chr17_-_40263124 0.576 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr14_-_87529212 0.574 GALC
galactosylceramidase
chr1_-_180840016 0.574 NM_002928
RGS16
regulator of G-protein signaling 16
chr2_-_213724577 0.572 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr2_-_96174865 0.570 NM_004418
DUSP2
dual specificity phosphatase 2
chr1_+_117253882 0.560 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr13_-_35818603 0.559 NM_001142296
NM_015087
SPG20

spastic paraplegia 20 (Troyer syndrome)

chrX_+_64804259 0.559 MSN
moesin
chr4_-_122063118 0.558 NM_018699
PRDM5
PR domain containing 5
chr22_-_30016707 0.555 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr1_-_84237316 0.553 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr1_-_8861278 0.552 ENO1
enolase 1, (alpha)
chrX_-_13866565 0.547 NM_001001994
GPM6B
glycoprotein M6B
chr3_-_52065130 0.546 NM_001947
DUSP7
dual specificity phosphatase 7
chr15_+_61356801 0.545 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr22_+_16020241 0.545 CECR4
cat eye syndrome chromosome region, candidate 4 (non-protein coding)
chr8_+_22479115 0.539 NM_001018003
SORBS3
sorbin and SH3 domain containing 3
chr2_-_144991386 0.538 ZEB2
zinc finger E-box binding homeobox 2
chr1_+_181025494 0.538 NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr8_+_49083522 0.537 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr12_+_52806103 0.535 LOC400043
hypothetical LOC400043
chr1_+_199975563 0.535 NM_001167738
NAV1
neuron navigator 1
chr7_-_72609804 0.534 BCL7B
B-cell CLL/lymphoma 7B
chr4_-_143987053 0.532 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chrX_-_148430357 0.532 LOC100131434
hypothetical LOC100131434
chr11_-_66092534 0.526 NM_003793
CTSF
cathepsin F
chr2_+_74502364 0.526 NM_032118
WDR54
WD repeat domain 54
chr17_-_8000362 0.517 PER1
period homolog 1 (Drosophila)
chr15_-_81744469 0.516 NM_001717
BNC1
basonuclin 1
chr6_-_121697305 0.513 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr7_+_27102197 0.510


chr3_-_36961539 0.509 NM_014831
TRANK1
tetratricopeptide repeat and ankyrin repeat containing 1
chr5_+_176493488 0.507 NSD1
nuclear receptor binding SET domain protein 1
chr5_+_17270474 0.503 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr7_+_39739690 0.492 NCRNA00265
non-protein coding RNA 265
chr7_+_48041632 0.490 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr10_+_80740584 0.489 ZMIZ1
zinc finger, MIZ-type containing 1
chr7_+_154720547 0.487 INSIG1
insulin induced gene 1
chr14_+_104523660 0.486 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr1_-_146398501 0.484 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr19_-_11352850 0.477 EPOR
erythropoietin receptor
chr8_-_9046460 0.477 PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr19_-_36531958 0.473 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr8_+_94998258 0.468 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr18_+_54682261 0.465 ZNF532
zinc finger protein 532
chr8_+_145718702 0.464


chr9_-_139316523 0.458 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr9_+_90193058 0.456 NM_006717
SPIN1
spindlin 1
chr3_+_114414064 0.456 NM_033254
BOC
Boc homolog (mouse)
chr16_+_88169612 0.454 NM_014427
NM_153636
CPNE7

copine VII

chr6_+_1336077 0.452


chr5_+_148717806 0.449 PCYOX1L
prenylcysteine oxidase 1 like
chr9_+_132874324 0.448 NM_006059
LAMC3
laminin, gamma 3
chr19_+_43502380 0.447 KCNK6
potassium channel, subfamily K, member 6
chr8_-_72918697 0.446 MSC
musculin
chr8_-_124123772 0.445 NM_001134671
NM_024295
DERL1

Der1-like domain family, member 1

chr7_+_55054416 0.442 EGFR
epidermal growth factor receptor
chr5_-_127447197 0.441 FLJ33630
hypothetical LOC644873
chr7_-_87687302 0.441 NM_003130
SRI
sorcin
chr1_+_182622987 0.441 C1orf21
chromosome 1 open reading frame 21
chr22_-_22511173 0.438 NM_001002862
NM_001135751
NM_198440
DERL3


Der1-like domain family, member 3


chr8_+_98725505 0.437 NM_178812
MTDH
metadherin
chr3_-_81893308 0.437 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr18_+_40513889 0.437 NM_001130110
SETBP1
SET binding protein 1
chr5_+_176493233 0.435 NM_022455
NSD1
nuclear receptor binding SET domain protein 1
chr1_-_68071635 0.435 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr16_-_79395379 0.434 NM_152342
CDYL2
chromodomain protein, Y-like 2
chrX_+_101267315 0.434 NM_080390
TCEAL2
transcription elongation factor A (SII)-like 2
chr5_+_148717762 0.433 NM_024028
PCYOX1L
prenylcysteine oxidase 1 like
chr9_-_21984379 0.432 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr2_-_84961749 0.428 NM_001080824
C2orf89
chromosome 2 open reading frame 89
chr7_+_44802691 0.423 NM_021130
PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr9_+_111582317 0.422 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr1_-_143232344 0.419 LOC728855
hypothetical LOC728855
chr8_-_124123707 0.418 DERL1
Der1-like domain family, member 1
chr1_-_158161898 0.418 TAGLN2
transgelin 2
chr6_-_116799548 0.417 LOC100287467
hypothetical LOC100287467
chrX_+_11686198 0.417 NM_078628
NM_078629
MSL3

male-specific lethal 3 homolog (Drosophila)

chr20_-_57015698 0.417 NM_001336
CTSZ
cathepsin Z
chr1_-_8861374 0.415 ENO1
enolase 1, (alpha)
chr3_-_109292444 0.414 NM_001777
NM_198793
CD47

CD47 molecule

chr9_+_81376666 0.412 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr22_+_48971067 0.410 TRABD
TraB domain containing
chr11_+_65357972 0.409 NM_152760
SNX32
sorting nexin 32
chr8_-_116750277 0.408 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr1_+_207915617 0.408 G0S2
G0/G1switch 2
chr1_-_143232464 0.408


chrX_+_64804318 0.408 MSN
moesin
chr11_+_32069183 0.407 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr14_-_87529600 0.405 NM_000153
NM_001037525
GALC

galactosylceramidase

chr13_-_98536640 0.405 NM_001130049
NM_015296
DOCK9

dedicator of cytokinesis 9

chr8_-_124123721 0.404 DERL1
Der1-like domain family, member 1
chr6_-_97391779 0.403 NM_001143957
NM_030784
GPR63

G protein-coupled receptor 63

chr5_+_148941228 0.403 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr7_-_27102049 0.402 NM_005522
NM_153620
HOXA1

homeobox A1

chr7_-_87687276 0.400 SRI
sorcin
chr2_-_217267742 0.398 IGFBP5
insulin-like growth factor binding protein 5
chr8_-_101804114 0.396 PABPC1
poly(A) binding protein, cytoplasmic 1
chr1_-_35957314 0.396 NM_152374
C1orf216
chromosome 1 open reading frame 216
chr2_+_222997456 0.396 SGPP2
sphingosine-1-phosphate phosphatase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.45 1.35e-04 GO:0006913 nucleocytoplasmic transport
2.42 1.91e-04 GO:0051169 nuclear transport
1.22 5.35e-04 GO:0044260 cellular macromolecule metabolic process
1.15 1.32e-02 GO:0044237 cellular metabolic process
1.58 2.37e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.30 4.54e-02 GO:0043412 macromolecule modification

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 2.12e-14 GO:0044424 intracellular part
1.13 1.86e-13 GO:0005622 intracellular
1.15 7.47e-08 GO:0043231 intracellular membrane-bounded organelle
1.15 1.00e-07 GO:0043227 membrane-bounded organelle
1.13 4.03e-07 GO:0043226 organelle
1.13 6.43e-07 GO:0043229 intracellular organelle
1.21 9.77e-07 GO:0005634 nucleus
1.14 4.84e-06 GO:0005737 cytoplasm
2.15 4.90e-05 GO:0005635 nuclear envelope
1.05 1.91e-04 GO:0044464 cell part
1.05 1.98e-04 GO:0005623 cell
1.15 1.14e-03 GO:0044444 cytoplasmic part
1.30 2.16e-03 GO:0005829 cytosol
1.28 6.07e-03 GO:0044428 nuclear part
2.16 1.35e-02 GO:0031965 nuclear membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 3.23e-03 GO:0005515 protein binding
1.07 4.83e-03 GO:0005488 binding
1.29 3.67e-02 GO:0016740 transferase activity
1.25 3.88e-02 GO:0000166 nucleotide binding
1.20 4.09e-02 GO:0003676 nucleic acid binding