Motif ID: RUNX1..3.p2

Z-value: 4.453


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251640610.821.1e-04Click!
RUNX1chr21_-_35181956-0.712.0e-03Click!
RUNX2chr6_+_45498262-0.361.7e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_25164061 18.471 NM_001031680
RUNX3
runt-related transcription factor 3
chr1_-_114215768 10.886 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr1_+_204797516 9.648 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr21_-_35343331 9.504 RUNX1
runt-related transcription factor 1
chr9_-_129580732 8.668 NM_170600
SH2D3C
SH2 domain containing 3C
chr16_+_29582069 8.579 NM_003123
SPN
sialophorin
chr21_-_35343500 8.046 RUNX1
runt-related transcription factor 1
chr1_+_204797214 7.953 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr2_-_158008763 7.720 NM_004288
CYTIP
cytohesin 1 interacting protein
chr14_+_92188329 7.422 RIN3
Ras and Rab interactor 3
chr21_-_35343456 7.400 NM_001754
RUNX1
runt-related transcription factor 1
chr9_-_122728173 7.286 TRAF1
TNF receptor-associated factor 1
chr21_-_35343428 7.271 RUNX1
runt-related transcription factor 1
chr21_-_35343448 7.025 RUNX1
runt-related transcription factor 1
chr16_+_29582065 6.759 SPN
sialophorin
chr12_-_101396459 6.504 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chrX_-_30505804 6.448 NM_025159
CXorf21
chromosome X open reading frame 21
chr11_-_66961709 6.320 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr21_-_35343065 6.194 RUNX1
runt-related transcription factor 1
chr6_-_41276901 6.126 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr4_-_1185144 5.832 LOC100130872
hypothetical LOC100130872
chr1_+_207995999 5.759 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr2_-_175170674 5.500 WIPF1
WAS/WASL interacting protein family, member 1
chr14_+_99601517 5.353 EVL
Enah/Vasp-like
chr8_-_21827057 5.343 NM_003974
DOK2
docking protein 2, 56kDa
chr10_+_70517863 5.305 SRGN
serglycin
chr14_+_99601498 5.284 NM_016337
EVL
Enah/Vasp-like
chr10_+_70517823 5.244 NM_002727
SRGN
serglycin
chr19_-_40925151 5.237 NM_024660
TMEM149
transmembrane protein 149
chr2_+_169367345 5.236 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr1_-_205012348 5.209 NM_000572
IL10
interleukin 10
chr3_+_99733432 5.203 NM_005290
GPR15
G protein-coupled receptor 15
chr1_+_202000906 4.996 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr17_-_31441390 4.971 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr16_+_23754822 4.952 PRKCB
protein kinase C, beta
chr1_+_196874867 4.860 PTPRC
protein tyrosine phosphatase, receptor type, C
chr16_+_23754772 4.836 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr13_-_45654296 4.778 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_-_71352090 4.734 UNC13D
unc-13 homolog D (C. elegans)
chr16_+_28413421 4.708 NM_018690
APOBR
apolipoprotein B receptor
chr1_+_190811479 4.692 NM_002922
RGS1
regulator of G-protein signaling 1
chr1_-_205161821 4.678 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr22_+_38627129 4.643 GRAP2
GRB2-related adaptor protein 2
chr12_+_45896511 4.569 FAM113B
family with sequence similarity 113, member B
chr6_-_11490487 4.564 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr17_-_71352017 4.538 UNC13D
unc-13 homolog D (C. elegans)
chr1_-_159306037 4.501 ARHGAP30
Rho GTPase activating protein 30
chr22_+_38627031 4.418 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr13_-_45654292 4.412 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_-_70755023 4.330 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr4_-_113656762 4.266 NM_024019
NEUROG2
neurogenin 2
chr1_+_204797120 4.254 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr14_+_92188546 4.228 RIN3
Ras and Rab interactor 3
chr6_+_31651319 4.180 NM_000594
TNF
tumor necrosis factor
chr2_+_202379442 4.153 NM_139158
CDK15
cyclin-dependent kinase 15
chr17_+_71292535 4.116


chr1_+_204797079 4.099 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr1_+_196874839 4.045 PTPRC
protein tyrosine phosphatase, receptor type, C
chr14_+_75058518 4.016 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr11_+_46339691 3.993 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr5_-_88155360 3.979 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr16_+_29581783 3.963 NM_001030288
SPN
sialophorin
chr6_+_31648071 3.944 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr16_+_23754997 3.909 PRKCB
protein kinase C, beta
chr12_+_25096472 3.879 NM_006152
LRMP
lymphoid-restricted membrane protein
chr6_+_31647854 3.875 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr4_-_38482805 3.868 NM_003263
TLR1
toll-like receptor 1
chr1_+_196874759 3.839 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr14_+_75058591 3.839 BATF
basic leucine zipper transcription factor, ATF-like
chr1_-_159306273 3.739 ARHGAP30
Rho GTPase activating protein 30
chr1_+_32489426 3.725 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr1_-_159306210 3.709 ARHGAP30
Rho GTPase activating protein 30
chrX_-_39921525 3.702 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chrX_+_78087484 3.648 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr7_+_45033757 3.622 NM_001029835
CCM2
cerebral cavernous malformation 2
chr3_+_142587973 3.617


chr11_+_63864263 3.611 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr19_-_60458915 3.598 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr17_+_71292437 3.582 UNK
unkempt homolog (Drosophila)
chr4_-_10295412 3.572 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr1_+_26744929 3.565 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_26744893 3.475 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_157313179 3.474 NM_004833
AIM2
absent in melanoma 2
chr5_+_75734759 3.466 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr19_-_47328399 3.431 NM_002698
POU2F2
POU class 2 homeobox 2
chr16_+_30102426 3.422 CORO1A
coronin, actin binding protein, 1A
chr8_-_102872354 3.400 NCALD
neurocalcin delta
chr1_-_92724181 3.327 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr12_+_25096755 3.326 LRMP
lymphoid-restricted membrane protein
chrX_+_48427137 3.271 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_-_159306369 3.267 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chrX_+_48427103 3.263 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_-_159306327 3.253 ARHGAP30
Rho GTPase activating protein 30
chr8_-_102872372 3.194 NCALD
neurocalcin delta
chr19_+_2240996 3.175


chr19_+_17923110 3.169 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr11_-_58099884 3.152 NM_004811
LPXN
leupaxin
chr14_-_93493519 3.102 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr16_+_23754860 3.075 PRKCB
protein kinase C, beta
chrX_-_135690699 3.066 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr7_+_149761674 3.064 LOC285972
hypothetical LOC285972
chr4_-_38534802 3.040 NM_006068
TLR6
toll-like receptor 6
chr17_+_43165608 3.012 NM_013351
TBX21
T-box 21
chr19_+_16115454 2.933 HSH2D
hematopoietic SH2 domain containing
chr5_+_140871107 2.902


chr5_+_140870881 2.890


chrX_-_135690770 2.858 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr17_+_44643067 2.845 ABI3
ABI family, member 3
chr19_+_17495109 2.841 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr16_+_48857962 2.826 ADCY7
adenylate cyclase 7
chr16_+_28797309 2.820 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr12_+_9713472 2.811 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr18_+_70317802 2.804 NM_001168499
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr19_-_18058632 2.773 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr14_-_104602784 2.729 NM_013345
GPR132
G protein-coupled receptor 132
chr17_-_44642934 2.721 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr15_-_75259714 2.699 PEAK1
NKF3 kinase family member
chr8_-_102872614 2.681 NM_032041
NCALD
neurocalcin delta
chr17_-_71352182 2.663 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr6_-_68655708 2.663


chr19_-_55560686 2.639 NM_004851
NAPSA
napsin A aspartic peptidase
chr12_-_38300109 2.637 NM_005164
ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
chr19_-_45947667 2.606 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr15_-_100280784 2.569 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr14_-_104602809 2.541 GPR132
G protein-coupled receptor 132
chr19_+_60109319 2.485 NM_001145457
NM_001145458
NM_004829
NCR1


natural cytotoxicity triggering receptor 1


chr2_+_102401580 2.479 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr17_-_26665144 2.467 EVI2B
ecotropic viral integration site 2B
chr17_-_26672757 2.450 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr1_+_149395728 2.428 NM_024575
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr22_+_23333610 2.397 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr11_-_5232480 2.384 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr6_-_33028790 2.343 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr10_-_11614279 2.343 NM_001080491
USP6NL
USP6 N-terminal like
chr3_+_47004457 2.342 NBEAL2
neurobeachin-like 2
chr17_-_59363352 2.319 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr3_+_114733907 2.313 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr11_+_60495690 2.306 NM_006725
CD6
CD6 molecule
chr19_+_55627971 2.299 NM_004533
MYBPC2
myosin binding protein C, fast type
chr6_-_149847809 2.290 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr16_-_66590856 2.276 NM_022355
DPEP2
dipeptidase 2
chr9_-_99740243 2.274 NM_197978
HEMGN
hemogen
chr19_-_48976852 2.274 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chrX_-_78509662 2.260 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chrX_-_135691168 2.249 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr5_+_156628929 2.245 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr4_+_39874921 2.241 NM_004310
RHOH
ras homolog gene family, member H
chrX_+_9391314 2.235 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr17_+_69974116 2.224 NM_007261
CD300A
CD300a molecule
chrX_-_111809929 2.224 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr16_+_27346079 2.216 NM_021798
IL21R
interleukin 21 receptor
chr12_-_56432292 2.201 CDK4
cyclin-dependent kinase 4
chr11_-_56761250 2.195 NM_005161
APLNR
apelin receptor
chr1_-_182273114 2.170 GLT25D2
glycosyltransferase 25 domain containing 2
chr9_-_122728993 2.142 NM_005658
TRAF1
TNF receptor-associated factor 1
chr4_-_71751205 2.134 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr11_+_71388619 2.129 NM_001145055
IL18BP
interleukin 18 binding protein
chr5_+_176807931 2.115 NM_001174102
PRR7
proline rich 7 (synaptic)
chr6_+_37511383 2.112


chr17_-_26665194 2.107 EVI2B
ecotropic viral integration site 2B
chr10_+_91082218 2.102 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr4_-_71751070 2.075 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chrX_-_19727775 2.050 SH3KBP1
SH3-domain kinase binding protein 1
chr17_-_26665220 2.047 NM_006495
EVI2B
ecotropic viral integration site 2B
chr22_+_35586950 2.042 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr6_-_31853027 2.041 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr12_+_52697160 2.016 HOXC5
HOXC6
homeobox C5
homeobox C6
chr9_+_129893948 2.013 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chrX_-_78509367 2.011 ITM2A
integral membrane protein 2A
chr2_+_68445936 2.009 PLEK
pleckstrin
chrX_-_19727828 2.006 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr21_+_41655786 2.003 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr17_+_77910411 1.997 NM_207459
TEX19
testis expressed 19
chrX_-_77801480 1.960 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr1_-_182273451 1.937 NM_015101
GLT25D2
glycosyltransferase 25 domain containing 2
chr7_-_92686773 1.932 NM_198151
HEPACAM2
HEPACAM family member 2
chr19_+_61624 1.915 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr6_-_119137923 1.902 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr11_+_71388310 1.891 NM_001145057
IL18BP
interleukin 18 binding protein
chr16_+_31273969 1.877 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr16_+_29982941 1.862 ALDOA
aldolase A, fructose-bisphosphate
chr8_+_144173674 1.856 LY6E
lymphocyte antigen 6 complex, locus E
chr4_+_38740246 1.843 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr16_+_51690564 1.835 CHD9
chromodomain helicase DNA binding protein 9
chr13_-_45654327 1.832 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr16_+_29983029 1.795 NM_184043
ALDOA
aldolase A, fructose-bisphosphate
chr16_-_70475381 1.789 ZNF821
zinc finger protein 821
chr5_+_176717553 1.782


chr15_+_89300973 1.772 RCCD1
RCC1 domain containing 1
chr20_+_54420574 1.762 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr6_-_149847718 1.748 ZC3H12D
zinc finger CCCH-type containing 12D
chr6_-_32892705 1.746 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr12_+_52696908 1.732 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr5_+_176717449 1.724 NM_006480
RGS14
regulator of G-protein signaling 14
chr1_-_159099090 1.722 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr17_-_26665213 1.712 EVI2B
ecotropic viral integration site 2B
chr7_+_120416103 1.710 C7orf58
chromosome 7 open reading frame 58
chr1_-_155788775 1.705 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr6_-_32121784 1.704 NM_032470
TNXB
tenascin XB
chr12_+_15017222 1.702 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 1.71e-06 GO:0050896 response to stimulus
2.02 9.03e-06 GO:0007608 sensory perception of smell
1.93 2.31e-05 GO:0007606 sensory perception of chemical stimulus
1.52 1.05e-04 GO:0002376 immune system process
1.37 4.11e-03 GO:0003008 system process
1.58 5.69e-03 GO:0006955 immune response
1.52 1.81e-02 GO:0007600 sensory perception
1.69 2.02e-02 GO:0001775 cell activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 5.40e-04 GO:0005886 plasma membrane
1.21 6.46e-04 GO:0071944 cell periphery
6.23 1.38e-02 GO:0005833 hemoglobin complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.42 7.74e-07 GO:0004871 signal transducer activity
1.42 7.74e-07 GO:0060089 molecular transducer activity
1.45 5.29e-06 GO:0004872 receptor activity
2.01 8.55e-06 GO:0004984 olfactory receptor activity
1.50 3.42e-05 GO:0004888 transmembrane receptor activity
1.55 1.04e-03 GO:0004930 G-protein coupled receptor activity
3.47 3.08e-02 GO:0003823 antigen binding