Motif ID: JUN.p2

Z-value: 1.954


Transcription factors associated with JUN.p2:

Gene SymbolEntrez IDGene Name
JUN 3725 jun oncogene
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
JUNchr1_-_590222750.514.4e-02Click!
JUNDchr19_-_182534130.411.1e-01Click!
JUNBchr19_+_127632950.273.1e-01Click!


Activity profile for motif JUN.p2.

activity profile for motif JUN.p2


Sorted Z-values histogram for motif JUN.p2

Sorted Z-values for motif JUN.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of JUN.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_13445942 3.561 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr3_+_129690735 2.962


chr19_-_53941835 2.660 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr3_+_142569988 2.532 ZBTB38
zinc finger and BTB domain containing 38
chr20_+_32610161 2.391 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr11_-_1549719 2.295 NM_004420
DUSP8
dual specificity phosphatase 8
chr2_+_74635354 2.262 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr14_+_100362236 2.191 MEG3
maternally expressed 3 (non-protein coding)
chr14_+_100362204 2.131 MEG3
maternally expressed 3 (non-protein coding)
chr11_-_68537243 2.046 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr11_-_118740069 1.979 NM_171997
USP2
ubiquitin specific peptidase 2
chr9_+_131291224 1.976 LOC100506190
hypothetical LOC100506190
chr2_+_238200922 1.955 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr4_-_186693574 1.933 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr1_-_1283770 1.912 NM_032348
MXRA8
matrix-remodelling associated 8
chr9_+_34980266 1.885 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr9_+_131291144 1.846


chr11_-_118739838 1.824 USP2
ubiquitin specific peptidase 2
chr1_+_110328850 1.804 AHCYL1
adenosylhomocysteinase-like 1
chr4_-_111777584 1.777 PITX2
paired-like homeodomain 2
chr9_+_133154896 1.768 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr11_+_12652427 1.759 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr6_-_91063301 1.744 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr9_+_138341752 1.743 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr4_-_111777651 1.737 PITX2
paired-like homeodomain 2
chr13_-_27967215 1.729 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr2_+_30307900 1.706 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr2_+_74635019 1.688 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr5_+_71438796 1.688 NM_005909
MAP1B
microtubule-associated protein 1B
chr4_-_111763655 1.683 NM_000325
PITX2
paired-like homeodomain 2
chr6_+_39868116 1.652


chr6_+_39868126 1.610 DAAM2
dishevelled associated activator of morphogenesis 2
chr19_-_10202947 1.607 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chr3_+_171558188 1.589 SKIL
SKI-like oncogene
chr3_+_171558215 1.570 SKIL
SKI-like oncogene
chr6_-_53321658 1.565 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr17_+_35751796 1.560 NM_001024809
RARA
retinoic acid receptor, alpha
chr19_-_55671273 1.558 FAM71E1
family with sequence similarity 71, member E1
chr1_-_152394215 1.544 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr7_+_120378052 1.509 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr10_+_35524835 1.468 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr6_+_139497933 1.466 NM_016217
HECA
headcase homolog (Drosophila)
chr16_+_30903963 1.456 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr16_+_85101605 1.441 NM_001451
FOXF1
forkhead box F1
chr21_-_42303517 1.440 NM_001098402
NM_001098403
NM_020727
ZNF295


zinc finger protein 295


chr9_-_72218098 1.438 KLF9
Kruppel-like factor 9
chr3_+_171558143 1.432 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr7_-_8268206 1.413 NM_022307
ICA1
islet cell autoantigen 1, 69kDa
chr8_+_23442331 1.377 SLC25A37
solute carrier family 25, member 37
chr1_+_99502655 1.369 LPPR4
lipid phosphate phosphatase-related protein type 4
chr3_+_158026769 1.347 NM_001004316
NM_001193283
LEKR1

leucine, glutamate and lysine rich 1

chr1_+_110328941 1.342 AHCYL1
adenosylhomocysteinase-like 1
chr10_-_62373828 1.320 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr4_-_111763356 1.306 PITX2
paired-like homeodomain 2
chr6_-_53321706 1.306 NM_021814
ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr21_-_43671355 1.300 NM_173354
SIK1
salt-inducible kinase 1
chr6_-_91063181 1.291 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr15_-_80125514 1.283 MEX3B
mex-3 homolog B (C. elegans)
chr3_-_101077605 1.276 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr8_-_41641881 1.266 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr2_-_74634569 1.264 NM_032603
LOXL3
lysyl oxidase-like 3
chr10_-_131652364 1.254 EBF3
early B-cell factor 3
chr2_-_156897286 1.230 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr7_+_28415495 1.228 LOC401317
hypothetical LOC401317
chr13_+_110653407 1.220 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr19_+_55671600 1.214 C19orf63
chromosome 19 open reading frame 63
chr7_-_8268292 1.214 NM_001136020
ICA1
islet cell autoantigen 1, 69kDa
chr7_-_44992729 1.208 C7orf40
chromosome 7 open reading frame 40
chr1_+_99502435 1.203 NM_001166252
NM_014839
LPPR4

lipid phosphate phosphatase-related protein type 4

chr2_+_10101822 1.188 NM_001177718
KLF11
Kruppel-like factor 11
chr17_-_44026042 1.186 NM_002147
HOXB5
homeobox B5
chr19_+_16048306 1.178 TPM4
tropomyosin 4
chr9_+_34979674 1.176 NM_001135004
NM_012266
DNAJB5

DnaJ (Hsp40) homolog, subfamily B, member 5

chrX_+_153325684 1.171 FAM50A
family with sequence similarity 50, member A
chr7_+_134483305 1.169 NM_018295
TMEM140
transmembrane protein 140
chr1_+_165330710 1.168 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr9_-_128924782 1.168 ANGPTL2
angiopoietin-like 2
chr3_+_25444753 1.139 NM_016152
RARB
retinoic acid receptor, beta
chr6_-_53321545 1.131 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr22_+_40286957 1.119 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr11_-_118693021 1.117 NM_006500
MCAM
melanoma cell adhesion molecule
chr22_+_36927884 1.114 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr6_-_29703725 1.113 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr2_+_5750229 1.113 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr16_+_415630 1.109 NM_014700
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr19_+_16048266 1.108 TPM4
tropomyosin 4
chr9_-_128924706 1.105 ANGPTL2
angiopoietin-like 2
chr3_+_25444837 1.102 NM_000965
RARB
retinoic acid receptor, beta
chr16_+_85101734 1.098 FOXF1
forkhead box F1
chr5_+_14493905 1.097 TRIO
triple functional domain (PTPRF interacting)
chrX_+_153325643 1.097 NM_004699
FAM50A
family with sequence similarity 50, member A
chr7_-_112515068 1.090 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr9_-_128924819 1.090 NM_012098
ANGPTL2
angiopoietin-like 2
chr19_-_7459867 1.089 NM_080662
PEX11G
peroxisomal biogenesis factor 11 gamma
chr11_-_88864061 1.089 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr7_-_112515035 1.076 GPR85
G protein-coupled receptor 85
chr2_+_33025872 1.073 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr11_+_116575249 1.070 NM_001001522
NM_003186
TAGLN

transgelin

chr1_+_110328830 1.069 NM_006621
AHCYL1
adenosylhomocysteinase-like 1
chr7_-_45095017 1.068 NM_001146334
NACAD
NAC alpha domain containing
chr8_+_23442307 1.062 NM_016612
SLC25A37
solute carrier family 25, member 37
chr19_+_55671468 1.054 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr7_-_112514990 1.050 GPR85
G protein-coupled receptor 85
chr9_-_72219359 1.036 NM_001206
KLF9
Kruppel-like factor 9
chr12_+_105692466 1.030 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr3_-_188946168 1.023 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr16_+_415606 1.015 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr7_-_137337354 1.006 NM_194071
CREB3L2
cAMP responsive element binding protein 3-like 2
chr10_+_31648103 1.001 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr1_+_9522133 0.995 SLC25A33
solute carrier family 25, member 33
chr1_+_110328955 0.994 AHCYL1
adenosylhomocysteinase-like 1
chr2_+_219991342 0.993 NM_001927
DES
desmin
chr7_-_137337352 0.992 CREB3L2
cAMP responsive element binding protein 3-like 2
chr5_-_172130766 0.988 NM_004417
DUSP1
dual specificity phosphatase 1
chr7_+_44612705 0.988 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr7_+_100302885 0.965 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr10_+_104525877 0.963 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr1_+_9522107 0.948 NM_032315
SLC25A33
solute carrier family 25, member 33
chr1_+_110328922 0.934 AHCYL1
adenosylhomocysteinase-like 1
chr11_-_8982107 0.932 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr2_+_151922350 0.931 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_+_9950474 0.925 CRELD1
cysteine-rich with EGF-like domains 1
chr11_-_61341011 0.922 NM_013402
FADS1
fatty acid desaturase 1
chr4_-_140696740 0.920 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr19_+_50041400 0.920 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr21_-_38210531 0.918 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr10_+_50177192 0.912 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr7_+_44612693 0.906 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chrX_+_12903145 0.896 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr19_+_55671594 0.893 C19orf63
chromosome 19 open reading frame 63
chr7_+_5598979 0.888 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr19_+_50041387 0.883 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr3_-_8518327 0.882 LOC100288428
hypothetical LOC100288428
chr19_+_55671584 0.880 C19orf63
chromosome 19 open reading frame 63
chr4_+_55956520 0.879


chr3_+_25445071 0.877 RARB
retinoic acid receptor, beta
chr7_-_137337318 0.872 CREB3L2
cAMP responsive element binding protein 3-like 2
chr7_+_22733290 0.870 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr15_-_80125403 0.868 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chrX_-_151996613 0.867 NM_032882
PNMA6A
paraneoplastic antigen like 6A
chr15_+_47502666 0.863 NM_002009
FGF7
fibroblast growth factor 7
chr2_-_96899396 0.862 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr4_-_142273881 0.858 NM_020724
RNF150
ring finger protein 150
chr1_+_26368969 0.851 NM_015871
ZNF593
zinc finger protein 593
chr16_-_4837266 0.847 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr1_-_59022275 0.845 NM_002228
JUN
jun proto-oncogene
chr6_+_118976134 0.844 NM_002667
PLN
phospholamban
chr22_-_42589543 0.842 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chrX_+_151991474 0.837 NM_001170944
NM_032882
LOC100287428
PNMA6A
paraneoplastic antigen-like protein 6A related gene
paraneoplastic antigen like 6A
chr7_+_44612745 0.835 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr17_-_44058612 0.832 NM_024017
HOXB9
homeobox B9
chr8_+_38363150 0.832 NM_144652
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr11_+_124539814 0.831 PKNOX2
PBX/knotted 1 homeobox 2
chr7_+_44612714 0.831 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr3_-_64186151 0.831 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr17_+_1580504 0.831 WDR81
WD repeat domain 81
chr20_+_42644633 0.828 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr5_-_175897430 0.827 RNF44
ring finger protein 44
chr17_+_20165049 0.825 CCDC144C
coiled-coil domain containing 144C
chr2_-_237987509 0.825 COL6A3
collagen, type VI, alpha 3
chr11_+_119701047 0.824 NM_001198670
NM_001198671
NM_001198672
NM_001198673
NM_001198674
NM_001198675
NM_174926
TMEM136






transmembrane protein 136






chr9_+_17568952 0.823 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr3_-_188945921 0.821 BCL6
B-cell CLL/lymphoma 6
chr6_+_136214495 0.818 NM_018945
PDE7B
phosphodiesterase 7B
chr12_+_131194962 0.815


chr3_+_8518539 0.814 LMCD1
LIM and cysteine-rich domains 1
chr17_-_18469569 0.814 CCDC144B
coiled-coil domain containing 144B
chr2_-_96899326 0.808 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr19_-_40938251 0.808 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr9_+_129900590 0.806 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr7_+_44612722 0.802 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr17_+_56884560 0.794 TBX4
T-box 4
chr17_-_1029758 0.793 NM_021962
ABR
active BCR-related gene
chr9_+_101623957 0.791 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr13_-_35769968 0.789 NM_001198910
NM_001144981
NM_001144982
NM_001144983
NM_001144984
NM_001144985
NM_001144986
NM_001198908
C13orf38-SOHLH2
C13orf38






C13orf38-SOHLH2 readthrough
chromosome 13 open reading frame 38






chr3_+_9950513 0.785 NM_015513
NM_001031717
NM_001077415
CRELD1


cysteine-rich with EGF-like domains 1


chr2_+_28469275 0.784 NM_005253
FOSL2
FOS-like antigen 2
chr3_+_8518508 0.781 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chrX_-_13866565 0.777 NM_001001994
GPM6B
glycoprotein M6B
chr19_+_16048315 0.776 TPM4
tropomyosin 4
chr7_+_5598964 0.775 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr12_-_113328271 0.773 NM_181486
TBX5
T-box 5
chr19_+_11510578 0.772 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr21_-_35343500 0.760 RUNX1
runt-related transcription factor 1
chr17_+_45940743 0.758 NM_032133
MYCBPAP
MYCBP associated protein
chr8_-_145983457 0.756 NM_030580
ZNF34
zinc finger protein 34
chr6_-_3172775 0.756 NM_178012
TUBB2B
tubulin, beta 2B
chr10_+_123913094 0.755 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr7_+_30927439 0.755 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr8_-_98359347 0.754 NM_033512
TSPYL5
TSPY-like 5
chr13_-_35769882 0.754 C13orf38
chromosome 13 open reading frame 38
chr19_+_1199548 0.753 NM_177401
MIDN
midnolin
chr1_+_46151845 0.746 MAST2
microtubule associated serine/threonine kinase 2
chr12_+_131194931 0.743 NM_024078
NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr11_+_18676857 0.743 TMEM86A
transmembrane protein 86A
chr22_+_36928011 0.742 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr8_-_108579270 0.742 NM_001146
ANGPT1
angiopoietin 1
chrX_+_48317772 0.739 NM_006743
RBM3
RNA binding motif (RNP1, RRM) protein 3
chr18_+_75540786 0.739 NM_004715
NM_048368
CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

chr12_+_12829807 0.738 NM_030817
APOLD1
apolipoprotein L domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.41 1.39e-04 GO:0048523 negative regulation of cellular process
1.37 5.05e-04 GO:0048519 negative regulation of biological process
1.61 6.81e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.29 1.56e-03 GO:0060255 regulation of macromolecule metabolic process
2.81 1.86e-03 GO:0051789 response to protein stimulus
1.16 2.95e-03 GO:0050794 regulation of cellular process
1.34 3.91e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.33 4.10e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.33 4.91e-03 GO:0048522 positive regulation of cellular process
1.26 5.48e-03 GO:0031323 regulation of cellular metabolic process
1.34 7.79e-03 GO:0051252 regulation of RNA metabolic process
1.15 7.81e-03 GO:0050789 regulation of biological process
1.30 1.16e-02 GO:0031326 regulation of cellular biosynthetic process
1.24 1.21e-02 GO:0032502 developmental process
1.31 1.24e-02 GO:0010468 regulation of gene expression
1.30 1.32e-02 GO:0009889 regulation of biosynthetic process
3.40 1.42e-02 GO:0006986 response to unfolded protein
1.25 1.64e-02 GO:0007275 multicellular organismal development
1.13 2.30e-02 GO:0065007 biological regulation
1.24 2.98e-02 GO:0080090 regulation of primary metabolic process
1.67 3.16e-02 GO:0010629 negative regulation of gene expression
1.27 4.09e-02 GO:0048731 system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.60 3.16e-03 GO:0043292 contractile fiber
2.65 3.48e-03 GO:0030016 myofibril
1.17 5.94e-03 GO:0005634 nucleus
2.75 7.12e-03 GO:0030017 sarcomere
2.49 2.18e-02 GO:0044449 contractile fiber part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 1.24e-05 GO:0005515 protein binding
1.56 4.90e-04 GO:0030528 transcription regulator activity
2.00 3.77e-03 GO:0008134 transcription factor binding
1.49 7.66e-03 GO:0001071 nucleic acid binding transcription factor activity
1.49 7.66e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.90 1.07e-02 GO:0016563 transcription activator activity
1.64 2.89e-02 GO:0008092 cytoskeletal protein binding