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• Activity deltas table
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• Motifs sorted by significance (text)
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Motif ID: bHLH_family.p2

Z-value: 2.872

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_+_120289735	5.532	NM_052886	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
chr16_-_66827449	4.608	NM_024939	ESRP2	epithelial splicing regulatory protein 2
chr22_+_38720881	4.540	NM_138435	FAM83F	family with sequence similarity 83, member F
chr8_+_95722448	3.392		ESRP1	epithelial splicing regulatory protein 1
chr8_-_17702991	3.117
chr16_+_67236699	3.115		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr17_-_73636362	3.106		TMC6	transmembrane channel-like 6
chr12_-_56432292	2.989		CDK4	cyclin-dependent kinase 4
chr17_+_9489578	2.942	NM_153210	USP43	ubiquitin specific peptidase 43
chr16_-_23068010	2.815	NM_020718	USP31	ubiquitin specific peptidase 31
chr8_+_95722575	2.734		ESRP1	epithelial splicing regulatory protein 1
chr2_-_172675873	2.694		DLX2	distal-less homeobox 2
chr8_+_95722516	2.690	NM_001034915 NM_001122825 NM_001122826 NM_001122827 NM_017697	ESRP1	epithelial splicing regulatory protein 1
chr12_-_56432377	2.643		CDK4	cyclin-dependent kinase 4
chr12_-_56432375	2.604		CDK4	cyclin-dependent kinase 4
chr12_-_56432385	2.600	NM_000075	CDK4	cyclin-dependent kinase 4
chr11_+_384199	2.564	NM_007183	PKP3	plakophilin 3
chr5_+_78567604	2.551	NM_152405	JMY	junction mediating and regulatory protein, p53 cofactor
chr11_+_384238	2.360		PKP3	plakophilin 3
chr11_+_45900731	2.301		GYLTL1B	glycosyltransferase-like 1B
chr17_+_35148084	2.295	NM_001030002	GRB7	growth factor receptor-bound protein 7
chr5_+_78568094	2.275
chr2_-_172675480	2.257	NM_004405	DLX2	distal-less homeobox 2
chr19_+_40431122	2.216		LSR	lipolysis stimulated lipoprotein receptor
chr19_-_5291700	2.177	NM_002850 NM_130853 NM_130854 NM_130855	PTPRS	protein tyrosine phosphatase, receptor type, S
chrX_+_152562013	2.175		DUSP9	dual specificity phosphatase 9
chr11_-_118757477	2.123		USP2	ubiquitin specific peptidase 2
chr17_+_35147697	2.117	NM_005310	GRB7	growth factor receptor-bound protein 7
chr6_+_138230045	2.098	NM_006290	TNFAIP3	tumor necrosis factor, alpha-induced protein 3
chr17_+_35147738	2.094		GRB7	growth factor receptor-bound protein 7
chr17_-_35510074	2.056		NR1D1	nuclear receptor subfamily 1, group D, member 1
chr2_+_27518736	1.962	NM_001168364 NM_173853	KRTCAP3	keratinocyte associated protein 3
chr17_-_35510431	1.898	NM_021724	NR1D1	nuclear receptor subfamily 1, group D, member 1
chr1_-_159257486	1.896		F11R	F11 receptor
chr1_-_159257567	1.892		F11R	F11 receptor
chr16_+_70217564	1.864	NM_001017967 NM_052858	MARVELD3	MARVEL domain containing 3
chr8_-_75396016	1.826	NM_020647	JPH1	junctophilin 1
chr7_-_1562272	1.814	NM_001097620	TMEM184A	transmembrane protein 184A
chr16_-_5023914	1.801		NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr16_-_5023934	1.791	NM_016256	NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr19_+_40431359	1.756	NM_015925 NM_205834 NM_205835	LSR	lipolysis stimulated lipoprotein receptor
chr2_-_172572993	1.739
chr7_-_22363036	1.711	NM_012294	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr16_+_67236730	1.680		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr3_-_57088332	1.671	NM_001128615	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3
chr14_+_102458745	1.667	NM_030943	AMN	amnionless homolog (mouse)
chr9_-_126309510	1.654	NM_004959	NR5A1	nuclear receptor subfamily 5, group A, member 1
chr17_-_38979178	1.651	NM_001079675	ETV4	ets variant 4
chr17_-_73636386	1.645	NM_001127198	TMC6	transmembrane channel-like 6
chr2_+_172573049	1.633	NM_199227	METAP1D	methionyl aminopeptidase type 1D (mitochondrial)
chr6_-_47385205	1.616		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr1_-_159459999	1.576	NM_001643	APOA2	apolipoprotein A-II
chr7_+_16759845	1.561	NM_014399	TSPAN13	tetraspanin 13
chr19_+_40431618	1.554		LSR	lipolysis stimulated lipoprotein receptor
chr1_-_159257595	1.552	NM_016946	F11R	F11 receptor
chr6_-_33493792	1.548		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr6_-_43305156	1.544	NM_006443 NM_199184	C6orf108	chromosome 6 open reading frame 108
chr14_+_23855291	1.542		LTB4R	leukotriene B4 receptor
chr11_+_119586879	1.496	NM_178507	OAF	OAF homolog (Drosophila)
chr1_-_199635057	1.494		LAD1	ladinin 1
chr1_-_1840564	1.489	NM_178545	TMEM52	transmembrane protein 52
chrX_+_130985316	1.476	NM_001042452	MST4	serine/threonine protein kinase MST4
chr16_+_5023672	1.452		LOC100507589	hypothetical LOC100507589
chr1_-_199635240	1.450	NM_005558	LAD1	ladinin 1
chr17_-_17050326	1.438		PLD6	phospholipase D family, member 6
chr17_+_77478858	1.438		LOC92659	hypothetical LOC92659
chr1_+_42920946	1.436		YBX1	Y box binding protein 1
chr16_+_84204424	1.436	NM_014615	KIAA0182	KIAA0182
chr1_+_181422016	1.432		LAMC2	laminin, gamma 2
chr16_-_5023562	1.417		NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr2_+_241903395	1.415	NM_001008491 NM_006155	SEPT2	septin 2
chr7_-_110989582	1.413	NM_032549	IMMP2L	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr6_-_47385313	1.400		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr6_+_41622267	1.399		FOXP4	forkhead box P4
chr17_-_35911340	1.399	NM_032865	TNS4	tensin 4
chr2_+_46779553	1.382	NM_014011	SOCS5	suppressor of cytokine signaling 5
chr6_-_53517397	1.380		GCLC	glutamate-cysteine ligase, catalytic subunit
chr1_-_199635339	1.380		LAD1	ladinin 1
chr9_-_99994704	1.379	NM_052820	CORO2A	coronin, actin binding protein, 2A
chr17_-_7078446	1.373	NM_004422	DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr19_+_12966970	1.358	NM_002501	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)
chr12_+_52713098	1.351	NM_018953	HOXC5	homeobox C5
chr17_-_7078304	1.347		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr11_-_118757574	1.338	NM_004205	USP2	ubiquitin specific peptidase 2
chr17_-_7078399	1.333		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr1_+_29113589	1.319	NM_001166006	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr11_-_125586733	1.316	NM_001144827 NM_032795	RPUSD4	RNA pseudouridylate synthase domain containing 4
chr1_+_1971762	1.312	NM_002744	PRKCZ	protein kinase C, zeta
chr17_-_17050355	1.296	NM_178836	PLD6	phospholipase D family, member 6
chr13_-_19665036	1.295		GJB2	gap junction protein, beta 2, 26kDa
chr12_-_61614930	1.287	NM_020700	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr8_-_110726063	1.281		SYBU	syntabulin (syntaxin-interacting)
chr6_+_32090516	1.275	NM_007293 NM_001002029	C4A C4B	complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr14_-_23106372	1.268		AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr20_+_48781457	1.257	NM_032521	PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)
chr12_+_52653176	1.256	NM_014212	HOXC11	homeobox C11
chr13_+_112999538	1.250		LAMP1	lysosomal-associated membrane protein 1
chr12_-_61615124	1.244		PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr3_+_46996150	1.243	NM_015175	NBEAL2	neurobeachin-like 2
chr7_+_150390566	1.236		SLC4A2	solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr11_+_125586828	1.229	NM_024556	FAM118B	family with sequence similarity 118, member B
chr7_-_23476497	1.224	NM_006547	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3
chr6_-_33493898	1.213		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr1_-_12599934	1.211	NM_004753	DHRS3	dehydrogenase/reductase (SDR family) member 3
chr6_-_10527772	1.210	NM_001042425	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr19_+_7608010	1.196		STXBP2	syntaxin binding protein 2
chr13_+_112999590	1.186		LAMP1	lysosomal-associated membrane protein 1
chr2_+_17585287	1.169	NM_003385	VSNL1	visinin-like 1
chr2_-_220116508	1.168	NM_024536	CHPF	chondroitin polymerizing factor
chr6_-_138862271	1.161	NM_001144060	NHSL1	NHS-like 1
chr2_-_171999473	1.159	NM_024770	METTL8	methyltransferase like 8
chr14_-_54438913	1.158	NM_000161 NM_001024024 NM_001024070 NM_001024071	GCH1	GTP cyclohydrolase 1
chr8_-_144887876	1.156	NM_198488	FAM83H	family with sequence similarity 83, member H
chr2_+_218992053	1.155	NM_007127	VIL1	villin 1
chr2_+_17585462	1.154		VSNL1	visinin-like 1
chr1_-_21868380	1.153	NM_001145657 NM_002885	RAP1GAP	RAP1 GTPase activating protein
chr1_-_158182006	1.151	NM_001135050 NM_020789	IGSF9	immunoglobulin superfamily, member 9
chr6_-_53517466	1.146		GCLC	glutamate-cysteine ligase, catalytic subunit
chr12_-_83830700	1.143		SLC6A15	solute carrier family 6 (neutral amino acid transporter), member 15
chr1_+_65385799	1.142	NM_203464 NM_001005353	AK4	adenylate kinase 4
chr5_+_3649167	1.141	NM_024337	IRX1	iroquois homeobox 1
chr19_+_7608015	1.138		STXBP2	syntaxin binding protein 2
chr17_-_34084682	1.137	NM_001130677	C17orf96	chromosome 17 open reading frame 96
chr6_+_41622111	1.136	NM_001012426 NM_001012427 NM_138457	FOXP4	forkhead box P4
chr12_+_52618815	1.136	NM_017410	HOXC13	homeobox C13
chr20_+_43953606	1.135		CTSA	cathepsin A
chr6_+_160310118	1.122	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr16_+_29726195	1.112		MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_+_105511615	1.109	NM_001004317	LIN28B	lin-28 homolog B (C. elegans)
chr12_-_83830710	1.109	NM_001146335 NM_018057 NM_182767	SLC6A15	solute carrier family 6 (neutral amino acid transporter), member 15
chr19_-_38485161	1.107
chr17_-_68769613	1.104	NM_001129885	CPSF4L	cleavage and polyadenylation specific factor 4-like
chr1_-_11042555	1.097		SRM	spermidine synthase
chr3_-_49916304	1.095	NM_002447	MST1R	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
chr19_+_7607976	1.094	NM_001127396 NM_006949	STXBP2	syntaxin binding protein 2
chr12_-_83830670	1.092		SLC6A15	solute carrier family 6 (neutral amino acid transporter), member 15
chr17_+_36599664	1.090	NM_001190460	KRTAP9-1	keratin associated protein 9-1
chr5_+_70918856	1.090	NM_022132	MCCC2	methylcrotonoyl-CoA carboxylase 2 (beta)
chr1_+_181421984	1.088		LAMC2	laminin, gamma 2
chr17_-_41625921	1.087	NM_001193466	KIAA1267	KIAA1267
chr1_+_61320213	1.087	NM_001134673 NM_005595	NFIA	nuclear factor I/A
chr16_-_21221872	1.075	NM_001014444 NM_001888	CRYM	crystallin, mu
chr17_-_18848713	1.074	NM_001039999	FAM83G	family with sequence similarity 83, member G
chr2_+_219751230	1.073		FAM134A	family with sequence similarity 134, member A
chr8_-_110726201	1.066	NM_001099753 NM_001099754 NM_001099755	SYBU	syntabulin (syntaxin-interacting)
chr2_-_178645718	1.066	NM_016953	PDE11A	phosphodiesterase 11A
chr1_+_3360880	1.064	NM_014448	ARHGEF16	Rho guanine nucleotide exchange factor (GEF) 16
chr6_-_47385470	1.059		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr6_-_138231006	1.055
chr11_-_116168316	1.051	NM_001166598 NM_052968	APOA5	apolipoprotein A-V
chr3_+_160002571	1.044		MFSD1	major facilitator superfamily domain containing 1
chr6_+_7486862	1.040	NM_001008844 NM_004415	DSP	desmoplakin
chr19_-_12747421	1.039	NM_001100176 NM_013312	HOOK2	hook homolog 2 (Drosophila)
chr6_-_47385605	1.038	NM_014452	TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr17_+_45911179	1.037	NM_018346	RSAD1	radical S-adenosyl methionine domain containing 1
chr6_+_7486836	1.033		DSP	desmoplakin
chr6_-_47385599	1.030		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr12_-_63439449	1.030		GNS	glucosamine (N-acetyl)-6-sulfatase
chr16_+_56616782	1.029	NM_002428	MMP15	matrix metallopeptidase 15 (membrane-inserted)
chr17_+_45911216	1.029		RSAD1	radical S-adenosyl methionine domain containing 1
chr1_-_27113018	1.028	NM_021969	NR0B2	nuclear receptor subfamily 0, group B, member 2
chr6_-_35996915	1.027	NM_003137	SRPK1	SRSF protein kinase 1
chr6_-_47385604	1.027		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr6_+_87921980	1.023	NM_015021	ZNF292	zinc finger protein 292
chr17_-_42250961	1.023	NM_030753	WNT3	wingless-type MMTV integration site family, member 3
chr17_+_69939806	1.022		GPRC5C	G protein-coupled receptor, family C, group 5, member C
chr16_+_65471881	1.021	NM_020786	PDP2	pyruvate dehyrogenase phosphatase catalytic subunit 2
chr20_+_46971618	1.019	NM_006420	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr16_+_68353738	1.015	NM_007014 NM_199423	WWP2	WW domain containing E3 ubiquitin protein ligase 2
chr19_+_7608020	1.014		STXBP2	syntaxin binding protein 2
chr2_-_220116062	1.006	NM_001195731	CHPF	chondroitin polymerizing factor
chr20_+_43953331	1.002		CTSA	cathepsin A
chr5_+_70918888	0.998		MCCC2	methylcrotonoyl-CoA carboxylase 2 (beta)
chr3_+_10832867	0.998	NM_014229	SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr11_+_76171780	0.992	NM_015516	TSKU	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr6_-_28999388	0.990		TRIM27	tripartite motif containing 27
chr22_-_36907638	0.989	NM_001004426 NM_003560	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)
chr20_+_43028533	0.987	NM_006282	STK4	serine/threonine kinase 4
chr20_+_43953428	0.985		CTSA	cathepsin A
chr6_-_138862273	0.984
chr6_-_53517793	0.981		GCLC	glutamate-cysteine ligase, catalytic subunit
chr19_-_7607852	0.976
chr3_-_15875932	0.972	NM_015199	ANKRD28	ankyrin repeat domain 28
chr6_-_30151526	0.966	NM_170769 NM_025236	RNF39	ring finger protein 39
chr2_-_208342296	0.964	NM_003468	FZD5	frizzled homolog 5 (Drosophila)
chr1_-_24307514	0.961		MYOM3	myomesin family, member 3
chr6_-_35996867	0.959		SRPK1	SRSF protein kinase 1
chr6_+_32229771	0.959		PPT2-EGFL8 PPT2	PPT2-EGFL8 read-through transcript palmitoyl-protein thioesterase 2
chr12_-_63439456	0.955	NM_002076	GNS	glucosamine (N-acetyl)-6-sulfatase
chr3_-_69674412	0.952		FRMD4B	FERM domain containing 4B
chr1_+_27541049	0.951	NM_001193308 NM_032872	SYTL1	synaptotagmin-like 1
chr2_+_219751207	0.950		FAM134A	family with sequence similarity 134, member A
chr10_+_5478521	0.949	NM_005863	NET1	neuroepithelial cell transforming 1
chr12_-_63439415	0.948		GNS	glucosamine (N-acetyl)-6-sulfatase
chr2_+_74610039	0.948	NM_013247 NM_145074	HTRA2	HtrA serine peptidase 2
chr1_+_27541086	0.947		SYTL1	synaptotagmin-like 1
chr16_+_29726962	0.946		MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_-_74522513	0.945		RTKN	rhotekin
chr16_+_57106883	0.944	NM_001160305 NM_024860	SETD6	SET domain containing 6
chrX_+_130984912	0.943	NM_001042453 NM_016542	MST4	serine/threonine protein kinase MST4

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.16	1.64e-10	GO:0008152	metabolic process
1.18	8.77e-10	GO:0044237	cellular metabolic process
1.17	5.25e-09	GO:0044238	primary metabolic process
1.09	3.16e-08	GO:0009987	cellular process
1.18	1.57e-05	GO:0044260	cellular macromolecule metabolic process
1.29	1.00e-04	GO:0010467	gene expression
1.16	1.20e-04	GO:0043170	macromolecule metabolic process
1.24	2.93e-04	GO:0044249	cellular biosynthetic process
1.23	4.63e-04	GO:0009058	biosynthetic process
1.19	9.94e-04	GO:0034641	cellular nitrogen compound metabolic process
1.19	1.48e-03	GO:0006807	nitrogen compound metabolic process
1.26	4.15e-03	GO:0016070	RNA metabolic process
1.68	9.50e-03	GO:0034660	ncRNA metabolic process
1.80	1.19e-02	GO:0034470	ncRNA processing
1.24	1.31e-02	GO:0044281	small molecule metabolic process
1.22	1.38e-02	GO:0090304	nucleic acid metabolic process
1.18	2.73e-02	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19	3.54e-02	GO:0044267	cellular protein metabolic process
1.93	4.26e-02	GO:0042254	ribosome biogenesis

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.09	2.26e-11	GO:0005622	intracellular
1.13	1.02e-10	GO:0005737	cytoplasm
1.09	4.61e-10	GO:0044424	intracellular part
1.09	1.02e-06	GO:0043226	organelle
1.15	1.60e-06	GO:0044422	organelle part
1.09	2.26e-06	GO:0043229	intracellular organelle
1.15	2.31e-06	GO:0044446	intracellular organelle part
1.14	2.40e-06	GO:0044444	cytoplasmic part
1.26	3.27e-06	GO:0031974	membrane-enclosed lumen
1.10	4.43e-06	GO:0043227	membrane-bounded organelle
1.26	5.02e-06	GO:0043233	organelle lumen
1.10	6.21e-06	GO:0043231	intracellular membrane-bounded organelle
1.26	9.56e-06	GO:0070013	intracellular organelle lumen
1.24	1.45e-04	GO:0044428	nuclear part
1.26	1.76e-04	GO:0031981	nuclear lumen
1.48	1.55e-03	GO:0005730	nucleolus
1.26	6.81e-03	GO:0005654	nucleoplasm
1.25	1.48e-02	GO:0005739	mitochondrion
1.20	1.60e-02	GO:0005829	cytosol
1.41	2.16e-02	GO:0030529	ribonucleoprotein complex
2.99	4.85e-02	GO:0044452	nucleolar part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.11	3.97e-05	GO:0005515	protein binding
1.24	2.90e-03	GO:0016740	transferase activity
1.39	7.76e-03	GO:0043565	sequence-specific DNA binding
1.11	4.04e-02	GO:0003824	catalytic activity