Motif ID: bHLH_family.p2

Z-value: 2.872


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MXI1chr10_+_1119572920.572.1e-02Click!
MLXIPLchr7_-_726767500.552.9e-02Click!
OLIG1chr21_+_33365874-0.421.0e-01Click!
ARNTL2chr12_-_27490824-0.401.2e-01Click!
OLIG2chr21_+_33320080-0.341.9e-01Click!
HEYLchr1_-_39877928-0.332.2e-01Click!
MXD4chr4_-_2233504-0.322.3e-01Click!
MITFchr3_+_69895310-0.282.9e-01Click!
HEY1chr8_-_80842452-0.282.9e-01Click!
CLOCKchr4_-_56107725-0.253.4e-01Click!
ARNTLchr11_+_13255836-0.204.5e-01Click!
NPAS2chr2_+_1008029230.194.9e-01Click!
HES6chr2_-_2388132840.146.0e-01Click!
TFE3chrX_-_48787696-0.126.6e-01Click!
HEY2chr6_+_1261125060.087.7e-01Click!
MNTchr17_-_2250967-0.087.7e-01Click!
MXD3chr5_-_176671437-0.058.5e-01Click!
ID1chr20_+_29656744-0.009.9e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_120289735 5.532 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr16_-_66827449 4.608 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr22_+_38720881 4.540 NM_138435
FAM83F
family with sequence similarity 83, member F
chr8_+_95722448 3.392 ESRP1
epithelial splicing regulatory protein 1
chr8_-_17702991 3.117


chr16_+_67236699 3.115 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr17_-_73636362 3.106 TMC6
transmembrane channel-like 6
chr12_-_56432292 2.989 CDK4
cyclin-dependent kinase 4
chr17_+_9489578 2.942 NM_153210
USP43
ubiquitin specific peptidase 43
chr16_-_23068010 2.815 NM_020718
USP31
ubiquitin specific peptidase 31
chr8_+_95722575 2.734 ESRP1
epithelial splicing regulatory protein 1
chr2_-_172675873 2.694 DLX2
distal-less homeobox 2
chr8_+_95722516 2.690 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr12_-_56432377 2.643 CDK4
cyclin-dependent kinase 4
chr12_-_56432375 2.604 CDK4
cyclin-dependent kinase 4
chr12_-_56432385 2.600 NM_000075
CDK4
cyclin-dependent kinase 4
chr11_+_384199 2.564 NM_007183
PKP3
plakophilin 3
chr5_+_78567604 2.551 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr11_+_384238 2.360 PKP3
plakophilin 3
chr11_+_45900731 2.301 GYLTL1B
glycosyltransferase-like 1B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
1.93 4.26e-02 GO:0042254 ribosome biogenesis
1.80 1.19e-02 GO:0034470 ncRNA processing
1.68 9.50e-03 GO:0034660 ncRNA metabolic process
1.29 1.00e-04 GO:0010467 gene expression
1.26 4.15e-03 GO:0016070 RNA metabolic process
1.24 2.93e-04 GO:0044249 cellular biosynthetic process
1.24 1.31e-02 GO:0044281 small molecule metabolic process
1.23 4.63e-04 GO:0009058 biosynthetic process
1.22 1.38e-02 GO:0090304 nucleic acid metabolic process
1.19 9.94e-04 GO:0034641 cellular nitrogen compound metabolic process
1.19 1.48e-03 GO:0006807 nitrogen compound metabolic process
1.19 3.54e-02 GO:0044267 cellular protein metabolic process
1.18 8.77e-10 GO:0044237 cellular metabolic process
1.18 1.57e-05 GO:0044260 cellular macromolecule metabolic process
1.18 2.73e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 5.25e-09 GO:0044238 primary metabolic process
1.16 1.64e-10 GO:0008152 metabolic process
1.16 1.20e-04 GO:0043170 macromolecule metabolic process
1.09 3.16e-08 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
2.99 4.85e-02 GO:0044452 nucleolar part
1.48 1.55e-03 GO:0005730 nucleolus
1.41 2.16e-02 GO:0030529 ribonucleoprotein complex
1.26 3.27e-06 GO:0031974 membrane-enclosed lumen
1.26 5.02e-06 GO:0043233 organelle lumen
1.26 9.56e-06 GO:0070013 intracellular organelle lumen
1.26 1.76e-04 GO:0031981 nuclear lumen
1.26 6.81e-03 GO:0005654 nucleoplasm
1.25 1.48e-02 GO:0005739 mitochondrion
1.24 1.45e-04 GO:0044428 nuclear part
1.20 1.60e-02 GO:0005829 cytosol
1.15 1.60e-06 GO:0044422 organelle part
1.15 2.31e-06 GO:0044446 intracellular organelle part
1.14 2.40e-06 GO:0044444 cytoplasmic part
1.13 1.02e-10 GO:0005737 cytoplasm
1.10 4.43e-06 GO:0043227 membrane-bounded organelle
1.10 6.21e-06 GO:0043231 intracellular membrane-bounded organelle
1.09 2.26e-11 GO:0005622 intracellular
1.09 4.61e-10 GO:0044424 intracellular part
1.09 1.02e-06 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.39 7.76e-03 GO:0043565 sequence-specific DNA binding
1.24 2.90e-03 GO:0016740 transferase activity
1.11 3.97e-05 GO:0005515 protein binding
1.11 4.04e-02 GO:0003824 catalytic activity