Motif ID: HMX1.p2

Z-value: 1.085


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1



Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_81082699 1.114 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr5_-_81082614 0.971 SSBP2
single-stranded DNA binding protein 2
chr22_-_35970133 0.951 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr7_+_50314801 0.913 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr4_-_11039600 0.901 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr22_-_35970230 0.897 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr11_-_19219000 0.844 NM_024680
E2F8
E2F transcription factor 8
chr1_-_205161821 0.838 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr2_-_6924092 0.807 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr7_+_143683365 0.806 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr1_-_58815415 0.774 TACSTD2
tumor-associated calcium signal transducer 2
chr12_+_4253143 0.762 NM_001759
CCND2
cyclin D2
chr14_-_88328848 0.727 NM_183387
EML5
echinoderm microtubule associated protein like 5
chr18_+_27332024 0.665 NM_001943
DSG2
desmoglein 2
chr3_-_112796855 0.648 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr7_-_143523582 0.647 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr1_+_12149637 0.643 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chrX_+_37429927 0.626 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr1_+_12149662 0.624 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr3_+_46996150 0.603 NM_015175
NBEAL2
neurobeachin-like 2
chr7_-_143622233 0.592 ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chrX_+_48915127 0.585 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr16_-_85099941 0.584 LOC400550
hypothetical LOC400550
chr19_-_10202947 0.580 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chr17_-_7106497 0.569 CLDN7
claudin 7
chr7_-_143622188 0.548 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr5_-_41906459 0.539 NM_000436
OXCT1
3-oxoacid CoA transferase 1
chr12_-_53664722 0.527 NM_001136030
KIAA0748
KIAA0748
chr1_-_158883666 0.514 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr4_-_54152480 0.505 NM_001126328
LNX1
ligand of numb-protein X 1
chr17_+_77582774 0.501 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr22_-_37598160 0.499 CBX6
chromobox homolog 6
chr4_+_91267706 0.498 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr17_-_8809656 0.495 NM_001142633
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr22_-_37598115 0.490 CBX6
chromobox homolog 6
chrX_+_130984912 0.481 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr6_-_13594361 0.480 NM_033069
C6orf114
chromosome 6 open reading frame 114
chrX_+_130985316 0.479 NM_001042452
MST4
serine/threonine protein kinase MST4
chr16_-_65751305 0.474 NM_003789
TRADD
TNFRSF1A-associated via death domain
chrX_-_78509662 0.472 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr11_+_66381451 0.472 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr8_+_82807218 0.466 NM_152284
CHMP4C
chromatin modifying protein 4C
chr9_-_135014343 0.466 NM_001042368
RALGDS
ral guanine nucleotide dissociation stimulator
chr6_+_33697023 0.464 NM_002224
ITPR3
inositol 1,4,5-triphosphate receptor, type 3
chr16_+_11966464 0.461 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr16_-_65751263 0.460 TRADD
TNFRSF1A-associated via death domain
chr17_-_7106987 0.460 NM_001185023
NM_001307
CLDN7

claudin 7

chr14_-_104705753 0.451 JAG2
jagged 2
chr8_+_102574012 0.447 GRHL2
grainyhead-like 2 (Drosophila)
chr19_-_47413733 0.446 DEDD2
death effector domain containing 2
chr9_+_263025 0.446 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr9_+_134843918 0.445 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr1_-_231498081 0.440 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr4_-_54152385 0.437 LNX1
ligand of numb-protein X 1
chr13_+_42046182 0.437 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr19_-_60587414 0.434 NM_001190764
LOC388564
hypothetical protein LOC388564
chr1_-_27159462 0.433 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr5_-_9599157 0.430 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr4_-_109307325 0.427 NM_001166119
LEF1
lymphoid enhancer-binding factor 1
chr6_+_16346759 0.424 NM_006877
GMPR
guanosine monophosphate reductase
chr3_-_13436725 0.422 NUP210
nucleoporin 210kDa
chr19_+_10404110 0.421 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr12_-_47604930 0.420 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr22_-_37598176 0.419 NM_014292
CBX6
chromobox homolog 6
chr5_+_68746694 0.418 NM_001038603
MARVELD2
MARVEL domain containing 2
chr19_+_6723801 0.416


chr3_-_13436802 0.416 NM_024923
NUP210
nucleoporin 210kDa
chr11_+_69602055 0.415 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr17_+_37694007 0.412 STAT5A
signal transducer and activator of transcription 5A
chr15_-_38953628 0.411 NM_133639
RHOV
ras homolog gene family, member V
chr15_+_39032927 0.408 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr4_-_74704964 0.406 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr12_+_56271181 0.405 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr20_+_56897631 0.404 GNAS
GNAS complex locus
chr1_+_166461881 0.400 SFT2D2
SFT2 domain containing 2
chr19_-_50271527 0.399 NM_145288
ZNF296
zinc finger protein 296
chr19_+_43447078 0.398 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr11_+_66580861 0.396 NM_014578
RHOD
ras homolog gene family, member D
chr5_+_176717553 0.396


chr4_-_38460983 0.395 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr19_+_43447262 0.393 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr1_-_31942142 0.393 COL16A1
collagen, type XVI, alpha 1
chr1_-_55039458 0.392 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr1_+_166461865 0.388 SFT2D2
SFT2 domain containing 2
chr7_+_115637795 0.388 NM_015641
TES
testis derived transcript (3 LIM domains)
chr11_-_33847507 0.387 LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_-_2390050 0.387 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr20_+_56897549 0.386 GNAS
GNAS complex locus
chr8_+_102573837 0.383 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr13_+_40929690 0.382 C13orf15
chromosome 13 open reading frame 15
chr11_+_93394025 0.380 NM_001098672
HEPHL1
hephaestin-like 1
chr1_+_166461872 0.378 NM_199344
SFT2D2
SFT2 domain containing 2
chr9_+_123501186 0.378 DAB2IP
DAB2 interacting protein
chr7_-_130443379 0.378 FLJ43663
hypothetical LOC378805
chr11_+_527521 0.375 NM_198075
LRRC56
leucine rich repeat containing 56
chr17_-_59451662 0.375 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr13_+_40929679 0.374 C13orf15
chromosome 13 open reading frame 15
chr2_-_216586488 0.374 NM_018000
MREG
melanoregulin
chr5_-_141238011 0.369


chr19_+_43446937 0.368 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr8_+_144888275 0.366 LOC100128338
hypothetical LOC100128338
chr5_-_41906216 0.366 OXCT1
3-oxoacid CoA transferase 1
chr6_-_13594965 0.363 GFOD1
glucose-fructose oxidoreductase domain containing 1
chrX_-_78509367 0.363 ITM2A
integral membrane protein 2A
chr8_-_144887876 0.359 NM_198488
FAM83H
family with sequence similarity 83, member H
chr13_+_24152548 0.359 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr19_-_47413642 0.359 NM_133328
DEDD2
death effector domain containing 2
chrX_-_48661226 0.355 NM_006875
PIM2
pim-2 oncogene
chr5_+_76150637 0.355 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr15_+_81567327 0.354 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr1_+_26728846 0.353 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_-_12853140 0.350 DNASE2
deoxyribonuclease II, lysosomal
chr1_+_151917674 0.349 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr19_-_62912347 0.347 NM_001085384
ZNF154
zinc finger protein 154
chr1_-_207891264 0.346 NM_001017402
LAMB3
laminin, beta 3
chr1_+_35020425 0.345 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr6_-_136913649 0.345 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr1_+_155130146 0.339 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr4_-_145046109 0.338 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chr12_+_56271259 0.337 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr14_-_54438913 0.336 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr6_-_136913235 0.336 MAP7
microtubule-associated protein 7
chr5_-_139760838 0.335


chr1_+_29113589 0.335 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chrX_-_100332933 0.334 YWHAQP8
YWHAQ pseudogene 8
chr13_+_40929525 0.333 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr7_-_37454933 0.331 NM_014800
ELMO1
engulfment and cell motility 1
chr1_+_26728839 0.326 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr6_-_31658044 0.326 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr19_-_12853249 0.324 NM_001375
DNASE2
deoxyribonuclease II, lysosomal
chr19_+_40299058 0.324 FXYD3
FXYD domain containing ion transport regulator 3
chr7_+_73262188 0.322 LAT2
linker for activation of T cells family, member 2
chr6_-_42017337 0.321 NM_001136125
NM_001760
CCND3

cyclin D3

chr11_-_65895640 0.321 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr3_+_38010618 0.321 VILL
villin-like
chr7_+_73262264 0.320 LAT2
linker for activation of T cells family, member 2
chr8_+_95722448 0.318 ESRP1
epithelial splicing regulatory protein 1
chr5_-_41906257 0.316 OXCT1
3-oxoacid CoA transferase 1
chr2_+_157001159 0.315 GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr17_+_71229191 0.315 ITGB4
integrin, beta 4
chr4_-_73653331 0.314 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr9_-_109290107 0.314 KLF4
Kruppel-like factor 4 (gut)
chr5_+_176717449 0.312 NM_006480
RGS14
regulator of G-protein signaling 14
chr12_+_124044187 0.312 BRI3BP
BRI3 binding protein
chr17_-_38385511 0.311 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr5_+_76150588 0.310 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr2_-_6923215 0.309 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_+_180836050 0.307


chr16_+_716936 0.305 NM_207112
NM_032304
HAGHL

hydroxyacylglutathione hydrolase-like

chr6_+_33151703 0.304 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr1_+_5975345 0.301 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr5_-_88155360 0.299 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr3_-_11736946 0.298 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr1_-_31942206 0.297 NM_001856
COL16A1
collagen, type XVI, alpha 1
chr1_-_6585268 0.296 KLHL21
kelch-like 21 (Drosophila)
chr17_+_71893014 0.296 SPHK1
sphingosine kinase 1
chr9_-_99740243 0.296 NM_197978
HEMGN
hemogen
chr1_-_28376041 0.293 NM_000952
PTAFR
platelet-activating factor receptor
chr8_-_141536992 0.292 TRAPPC9
trafficking protein particle complex 9
chr2_+_102602579 0.291 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr11_+_19095215 0.290 NM_001001483
NM_019028
ZDHHC13

zinc finger, DHHC-type containing 13

chr17_-_71747867 0.290 NM_052916
RNF157
ring finger protein 157
chr6_-_137154859 0.289


chr11_-_605649 0.286 NM_004031
IRF7
interferon regulatory factor 7
chr11_-_33847834 0.283 LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_+_140997171 0.282 RELL2
RELT-like 2
chr11_-_67032125 0.281 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr4_-_90977149 0.277 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr19_-_11352850 0.276 EPOR
erythropoietin receptor
chr9_-_135029096 0.276 NM_021996
GBGT1
RALGDS
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
ral guanine nucleotide dissociation stimulator
chr2_+_185171537 0.275 ZNF804A
zinc finger protein 804A
chr8_-_29263714 0.275 NM_001394
DUSP4
dual specificity phosphatase 4
chr2_+_185171682 0.273 ZNF804A
zinc finger protein 804A
chr9_-_84867604 0.272 RASEF
RAS and EF-hand domain containing
chr15_+_42815851 0.270 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr17_+_19853200 0.270 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr7_+_838663 0.270 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr17_+_71892781 0.268 NM_001142602
SPHK1
sphingosine kinase 1
chr1_-_215377718 0.265 NM_001134285
ESRRG
estrogen-related receptor gamma
chr1_+_27062215 0.264 NM_006142
SFN
stratifin
chr1_-_41100589 0.262 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr12_-_122486920 0.261 RILPL2
Rab interacting lysosomal protein-like 2
chr12_+_63290458 0.259 NM_178169
RASSF3
Ras association (RalGDS/AF-6) domain family member 3
chr2_+_74629654 0.258 NM_001197260
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr6_-_41781655 0.258 TFEB
transcription factor EB
chr1_-_159257567 0.258 F11R
F11 receptor
chr19_-_40146792 0.256 NM_175872
ZNF792
zinc finger protein 792
chrX_-_7076146 0.256 NM_001135565
NM_001178135
NM_001178136
NM_012080
HDHD1



haloacid dehalogenase-like hydrolase domain containing 1



chr1_+_26728827 0.256 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr6_+_31538934 0.256 NM_006674
HCP5
HLA complex P5
chr7_+_73262283 0.255 LAT2
linker for activation of T cells family, member 2
chr12_+_124044104 0.255 NM_080626
BRI3BP
BRI3 binding protein
chr13_-_83354425 0.253 SLITRK1
SLIT and NTRK-like family, member 1
chr1_+_5975286 0.252 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr9_+_115303527 0.248 NM_130795
RGS3
regulator of G-protein signaling 3
chr7_+_156496360 0.247 LOC645249
hypothetical LOC645249
chr21_-_42247007 0.247 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr12_-_56447090 0.247 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr7_+_101245812 0.244 NM_001913
NM_181500
CUX1

cut-like homeobox 1

chr11_-_407324 0.241 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 1.94e-03 GO:0023052 signaling
1.23 7.40e-03 GO:0007165 signal transduction
2.95 3.09e-02 GO:0031294 lymphocyte costimulation
2.95 3.09e-02 GO:0031295 T cell costimulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 3.82e-04 GO:0044459 plasma membrane part
1.13 5.25e-04 GO:0016020 membrane
1.19 3.87e-03 GO:0005886 plasma membrane
1.17 1.11e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 4.07e-03 GO:0005515 protein binding