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• Activity deltas table
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Motif ID: SOX2.p2

Z-value: 1.905

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_-_27186400	5.347	NM_153715	HOXA10	homeobox A10
chr3_-_150533948	5.058	NM_001184723 NM_138786	TM4SF18	transmembrane 4 L six family member 18
chr12_-_6103945	3.123	NM_000552	VWF	von Willebrand factor
chr10_+_70517823	3.011	NM_002727	SRGN	serglycin
chr10_+_70517863	3.002		SRGN	serglycin
chr1_-_171441234	2.891		TNFSF4	tumor necrosis factor (ligand) superfamily, member 4
chr4_+_86918882	2.840		ARHGAP24	Rho GTPase activating protein 24
chrX_+_86659370	2.818	NM_019117 NM_057162	KLHL4	kelch-like 4 (Drosophila)
chr4_-_101658094	2.696	NM_001159694 NM_016242	EMCN	endomucin
chr1_+_66570363	2.622	NM_001037339	PDE4B	phosphodiesterase 4B, cAMP-specific
chr7_+_102340579	2.484	NM_001031692 NM_005824	LRRC17	leucine rich repeat containing 17
chr2_-_188021117	2.481	NM_005795	CALCRL	calcitonin receptor-like
chrX_+_15428820	2.419	NM_203281	BMX	BMX non-receptor tyrosine kinase
chr1_-_32574185	2.399	NM_023009	MARCKSL1	MARCKS-like 1
chr6_+_153060722	2.397	NM_025107	MYCT1	myc target 1
chr9_+_18464138	2.385		ADAMTSL1	ADAMTS-like 1
chr10_-_32707549	2.384		EPC1	enhancer of polycomb homolog 1 (Drosophila)
chr1_-_197173159	2.370		LOC100131234	familial acute myelogenous leukemia related factor
chr5_+_15553736	2.308		FBXL7	F-box and leucine-rich repeat protein 7
chr17_-_59817456	2.291		PECAM1	platelet/endothelial cell adhesion molecule
chr9_+_18464090	2.253	NM_001040272 NM_052866	ADAMTSL1	ADAMTS-like 1
chr13_-_98428244	2.216	NM_001130048 NM_001130050	DOCK9	dedicator of cytokinesis 9
chr17_-_59817575	2.207		PECAM1	platelet/endothelial cell adhesion molecule
chr7_+_27190688	2.194
chr2_-_110665188	2.173	NM_033514	LIMS3-LOC440895 LIMS3	LIMS3-LOC440895 read-through LIM and senescent cell antigen-like domains 3
chr5_-_111119846	2.143	NM_001142483	C5orf13	chromosome 5 open reading frame 13
chr17_-_59817654	2.136		PECAM1	platelet/endothelial cell adhesion molecule
chr17_-_59817722	2.130	NM_000442	PECAM1	platelet/endothelial cell adhesion molecule
chr6_+_130381408	2.084	NM_001007102 NM_032438	L3MBTL3	l(3)mbt-like 3 (Drosophila)
chr7_-_27190882	2.074		HOXA11	homeobox A11
chr5_+_15553288	2.021	NM_012304	FBXL7	F-box and leucine-rich repeat protein 7
chr3_+_148593911	2.017
chr5_+_15553539	2.006		FBXL7	F-box and leucine-rich repeat protein 7
chr2_+_108637916	1.981		LIMS1 LIMS3	LIM and senescent cell antigen-like domains 1 LIM and senescent cell antigen-like domains 3
chr2_+_110013297	1.968	NM_033514	LIMS3-LOC440895 LIMS3	LIMS3-LOC440895 read-through LIM and senescent cell antigen-like domains 3
chr8_-_6407882	1.942	NM_001118887 NM_001118888 NM_001147	ANGPT2	angiopoietin 2
chr21_-_38792173	1.935	NM_001136155 NM_182918	ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr2_-_198248828	1.934	NM_144629	RFTN2	raftlin family member 2
chr2_+_108637698	1.904	NM_001193485	LIMS1	LIM and senescent cell antigen-like domains 1
chr17_-_18890963	1.888	NM_006613	GRAP	GRB2-related adaptor protein
chr6_+_12398514	1.871	NM_001168319 NM_001955	EDN1	endothelin 1
chr7_-_11838260	1.855	NM_015204	THSD7A	thrombospondin, type I, domain containing 7A
chr17_-_59818033	1.833		PECAM1	platelet/endothelial cell adhesion molecule
chr15_-_80125403	1.814	NM_032246	MEX3B	mex-3 homolog B (C. elegans)
chr15_-_80125514	1.789		MEX3B	mex-3 homolog B (C. elegans)
chr1_+_242281199	1.765		ZNF238	zinc finger protein 238
chr14_+_76298693	1.735		VASH1	vasohibin 1
chr5_-_100266769	1.720	NM_175052 NM_005668	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr2_-_56266408	1.693		LOC100129434	hypothetical LOC100129434
chr9_+_115303527	1.677	NM_130795	RGS3	regulator of G-protein signaling 3
chr13_-_98757634	1.615	NM_004951	GPR183	G protein-coupled receptor 183
chr12_-_68369322	1.601	NM_152439	BEST3	bestrophin 3
chr1_+_22107137	1.589		RPL21	ribosomal protein L21
chr9_+_89302574	1.581	NM_004938	DAPK1	death-associated protein kinase 1
chr7_-_27171673	1.576	NM_152739	HOXA9	homeobox A9
chr6_-_56824371	1.566		DST	dystonin
chr3_+_174598937	1.558	NM_014932	NLGN1	neuroligin 1
chr13_+_110653407	1.558		ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7
chr11_+_113436438	1.520	NM_001018011	ZBTB16	zinc finger and BTB domain containing 16
chr11_+_5667494	1.509	NM_006074	TRIM22	tripartite motif containing 22
chr1_-_47468029	1.506	NM_003189	TAL1	T-cell acute lymphocytic leukemia 1
chr2_-_37752272	1.505		CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3
chr9_-_72673753	1.504	NM_001007470 NM_020952 NM_024971 NM_206944 NM_206945 NM_206946 NM_206947 NM_206948	TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr13_-_32658215	1.496	NM_178007	STARD13	StAR-related lipid transfer (START) domain containing 13
chr1_+_242283129	1.492	NM_006352	ZNF238	zinc finger protein 238
chr9_+_27099138	1.490	NM_000459	TEK	TEK tyrosine kinase, endothelial
chr6_-_139654807	1.480	NM_153235	TXLNB	taxilin beta
chr18_+_13601664	1.474	NM_001003674 NM_001003675	C18orf1	chromosome 18 open reading frame 1
chr5_+_15553768	1.445		FBXL7	F-box and leucine-rich repeat protein 7
chr7_-_27180398	1.444	NM_018951	HOXA10	homeobox A10
chr15_+_37330176	1.419	NM_207445	C15orf54	chromosome 15 open reading frame 54
chr9_+_126460511	1.414
chr15_-_68781662	1.377	NM_001008224	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats
chr9_+_89302239	1.376		DAPK1	death-associated protein kinase 1
chr8_-_108579270	1.367	NM_001146	ANGPT1	angiopoietin 1
chr16_+_64958086	1.322		CDH5	cadherin 5, type 2 (vascular endothelium)
chr16_+_64958060	1.303		CDH5	cadherin 5, type 2 (vascular endothelium)
chr18_-_21186107	1.302	NM_015461	ZNF521	zinc finger protein 521
chr16_+_64958025	1.297	NM_001795	CDH5	cadherin 5, type 2 (vascular endothelium)
chr3_-_115826481	1.291	NM_001164346	ZBTB20	zinc finger and BTB domain containing 20
chr3_+_25444753	1.282	NM_016152	RARB	retinoic acid receptor, beta
chr3_+_25444837	1.281	NM_000965	RARB	retinoic acid receptor, beta
chr17_-_44006808	1.265	NM_002146	HOXB3	homeobox B3
chr6_+_21774624	1.255		FLJ22536	hypothetical locus LOC401237
chrX_-_33139349	1.240	NM_004006	DMD	dystrophin
chr9_-_116190038	1.239		AKNA	AT-hook transcription factor
chr3_-_11660395	1.224	NM_001128219	VGLL4	vestigial like 4 (Drosophila)
chr14_-_90953883	1.221	NM_001080414	CCDC88C	coiled-coil domain containing 88C
chr15_+_64781723	1.218	NM_005585	SMAD6	SMAD family member 6
chr15_+_21361546	1.216	NM_005664	MKRN3	makorin ring finger protein 3
chr1_-_85816520	1.213	NM_001134445	DDAH1	dimethylarginine dimethylaminohydrolase 1
chr17_-_30783631	1.209	NM_018042	SLFN12	schlafen family member 12
chr13_-_22905822	1.208	NM_014363	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)
chr3_-_115825742	1.205	NM_001164347	ZBTB20	zinc finger and BTB domain containing 20
chr17_+_18971506	1.202	NM_001129778	GRAPL	GRB2-related adaptor protein-like
chr1_-_95165089	1.193	NM_001839	CNN3	calponin 3, acidic
chr5_+_95093267	1.192
chrX_+_28515479	1.168	NM_014271	IL1RAPL1	interleukin 1 receptor accessory protein-like 1
chr1_-_85703198	1.168		DDAH1	dimethylarginine dimethylaminohydrolase 1
chr2_-_128138435	1.162	NM_017980	LIMS2	LIM and senescent cell antigen-like domains 2
chr15_-_80123935	1.156		MEX3B	mex-3 homolog B (C. elegans)
chrX_+_84385693	1.148		ZNF711	zinc finger protein 711
chrX_+_12904207	1.137		TMSB4X TMSL3	thymosin beta 4, X-linked thymosin-like 3
chr4_-_138673078	1.128	NM_019035	PCDH18	protocadherin 18
chr7_+_134114912	1.126		CALD1	caldesmon 1
chr7_+_93388951	1.123	NM_004126	GNG11	guanine nucleotide binding protein (G protein), gamma 11
chr3_+_182900081	1.116		SOX2OT	SOX2 overlapping transcript (non-protein coding)
chr4_+_86918870	1.115	NM_001042669	ARHGAP24	Rho GTPase activating protein 24
chr5_-_88155360	1.110	NM_001193348 NM_001193349	MEF2C	myocyte enhancer factor 2C
chr12_-_16650687	1.100		LMO3	LIM domain only 3 (rhombotin-like 2)
chr1_+_84540921	1.090	NM_001134664	SAMD13	sterile alpha motif domain containing 13
chr1_+_43539239	1.088	NM_005424	TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr6_+_44295219	1.081	NM_001078174 NM_004955	SLC29A1	solute carrier family 29 (nucleoside transporters), member 1
chr5_-_83715947	1.080		EDIL3	EGF-like repeats and discoidin I-like domains 3
chr6_-_56824672	1.078		DST	dystonin
chr2_+_198377561	1.077	NM_006226	PLCL1	phospholipase C-like 1
chr13_-_73606362	1.077		KLF12	Kruppel-like factor 12
chr6_+_116939500	1.067	NM_153711	FAM26E	family with sequence similarity 26, member E
chr12_-_16650697	1.064	NM_018640	LMO3	LIM domain only 3 (rhombotin-like 2)
chr3_-_192531018	1.061	NM_198152	UTS2D	urotensin 2 domain containing
chr10_+_104525877	1.052	NM_017787	C10orf26	chromosome 10 open reading frame 26
chr7_+_134114957	1.049		CALD1	caldesmon 1
chr1_+_242281175	1.033	NM_205768	ZNF238	zinc finger protein 238
chr11_+_128068982	1.031	NM_002017	FLI1	Friend leukemia virus integration 1
chr13_-_32678142	1.030	NM_052851	STARD13	StAR-related lipid transfer (START) domain containing 13
chr12_-_101115677	1.029	NM_002674	PMCH	pro-melanin-concentrating hormone
chr9_+_4480193	1.017	NM_004170	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr5_-_39460687	1.014		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr17_-_1195096	1.012		PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr11_+_128069165	1.012		FLI1	Friend leukemia virus integration 1
chr3_-_116272911	0.999	NM_001164343	ZBTB20	zinc finger and BTB domain containing 20
chr10_-_88707299	0.995	NM_024756	MMRN2	multimerin 2
chr11_+_128069183	0.993		FLI1	Friend leukemia virus integration 1
chr11_+_128069203	0.992		FLI1	Friend leukemia virus integration 1
chr11_+_111313227	0.992		DIXDC1	DIX domain containing 1
chrX_+_10084984	0.990	NM_001830	CLCN4	chloride channel 4
chr1_+_66570683	0.987		PDE4B	phosphodiesterase 4B, cAMP-specific
chr18_-_24011349	0.974	NM_001792	CDH2	cadherin 2, type 1, N-cadherin (neuronal)
chr11_+_128069340	0.969		FLI1	Friend leukemia virus integration 1
chr4_-_139382672	0.968	NM_014331	SLC7A11	solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr1_-_26105954	0.958	NM_203399	STMN1	stathmin 1
chr5_+_88220846	0.957
chrX_+_100692071	0.956	NM_016608	ARMCX1	armadillo repeat containing, X-linked 1
chr5_+_95092384	0.947	NM_014899	RHOBTB3	Rho-related BTB domain containing 3
chr9_+_112470871	0.947	NM_001166280 NM_001166281 NM_005592	MUSK	muscle, skeletal, receptor tyrosine kinase
chr11_+_111313067	0.944	NM_001037954	DIXDC1	DIX domain containing 1
chr15_-_93671314	0.940		LOC400456	hypothetical LOC400456
chr5_-_71838875	0.938	NM_152625	ZNF366	zinc finger protein 366
chr8_-_60194099	0.936	NM_014729	TOX	thymocyte selection-associated high mobility group box
chr3_-_143230124	0.924	NM_001178141 NM_001178142 NM_006286	TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)
chr7_+_106292975	0.919		PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr4_-_54119159	0.916	NM_032622	LNX1	ligand of numb-protein X 1
chr14_+_76297885	0.912	NM_014909	VASH1	vasohibin 1
chr1_-_95165037	0.911		CNN3	calponin 3, acidic
chr3_-_58538530	0.909	NM_001076778 NM_007177	FAM107A	family with sequence similarity 107, member A
chr8_+_40130143	0.907	NM_020130	C8orf4	chromosome 8 open reading frame 4
chr1_-_79244948	0.904	NM_022159	ELTD1	EGF, latrophilin and seven transmembrane domain containing 1
chrX_+_12903145	0.900	NM_021109 NM_183049	TMSB4X TMSL3	thymosin beta 4, X-linked thymosin-like 3
chr4_-_54119102	0.896		LNX1	ligand of numb-protein X 1
chr11_-_85108030	0.892	NM_001162952 NM_206930	SYTL2	synaptotagmin-like 2
chr7_-_130891861	0.890	NM_001018111 NM_005397	PODXL	podocalyxin-like
chr8_-_124622434	0.887	NM_058229	FBXO32	F-box protein 32
chr3_-_58538110	0.884		FAM107A	family with sequence similarity 107, member A
chr8_-_93184629	0.883	NM_001198633 NM_175634	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_+_47498778	0.883	NM_000725	CACNB3	calcium channel, voltage-dependent, beta 3 subunit
chr8_-_93144039	0.882
chr4_+_91035025	0.863	NM_007351	MMRN1	multimerin 1
chr7_+_22733290	0.861	NM_000600	IL6	interleukin 6 (interferon, beta 2)
chr4_-_54119123	0.860		LNX1	ligand of numb-protein X 1
chr7_+_106292932	0.859		PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr10_+_11087345	0.855		CELF2	CUGBP, Elav-like family member 2
chr12_-_47869067	0.846	NM_006009	TUBA1A	tubulin, alpha 1a
chr11_-_6633427	0.846	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr12_-_10142779	0.845	NM_016511	CLEC1A	C-type lectin domain family 1, member A
chr10_+_80672842	0.844		ZMIZ1	zinc finger, MIZ-type containing 1
chr12_-_47869134	0.842		TUBA1A	tubulin, alpha 1a
chr19_-_53941835	0.837	NM_182575	IZUMO1	izumo sperm-egg fusion 1
chr5_-_83716346	0.834	NM_005711	EDIL3	EGF-like repeats and discoidin I-like domains 3
chr1_+_61642287	0.832		NFIA	nuclear factor I/A
chr5_-_111120929	0.832	NM_001142482 NM_001142481	C5orf13	chromosome 5 open reading frame 13
chr15_-_76890626	0.826	NM_014272	ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr3_+_44601457	0.823	NM_173658	ZNF660	zinc finger protein 660
chr13_-_37341859	0.823	NM_001135955 NM_001135956 NM_001135957 NM_001135958 NM_003306 NM_016179	TRPC4	transient receptor potential cation channel, subfamily C, member 4
chr7_+_22733626	0.822		IL6	interleukin 6 (interferon, beta 2)
chr2_-_192419896	0.815		SDPR	serum deprivation response
chr14_+_85066207	0.813	NM_013231	FLRT2	fibronectin leucine rich transmembrane protein 2
chr14_+_62740878	0.812	NM_020663	RHOJ	ras homolog gene family, member J
chr1_+_211190631	0.806		VASH2	vasohibin 2
chr12_-_69289889	0.804	NM_002837	PTPRB	protein tyrosine phosphatase, receptor type, B
chr10_+_11087259	0.798	NM_001025077	CELF2	CUGBP, Elav-like family member 2
chrX_+_80344253	0.787		SH3BGRL	SH3 domain binding glutamic acid-rich protein like
chr5_-_111120817	0.786	NM_004772	C5orf13	chromosome 5 open reading frame 13
chr6_+_121798443	0.783	NM_000165	GJA1	gap junction protein, alpha 1, 43kDa
chr1_+_211190476	0.777	NM_001136474 NM_001136475 NM_024749	VASH2	vasohibin 2
chr8_+_67201684	0.775	NM_033058 NM_184085 NM_184086 NM_184087	TRIM55	tripartite motif containing 55
chr10_+_11087280	0.771		CELF2	CUGBP, Elav-like family member 2
chr10_+_22765996	0.770		LOC100289455	hypothetical LOC100289455
chr22_-_20419975	0.768	NM_013313	YPEL1	yippee-like 1 (Drosophila)
chr13_-_73605914	0.758	NM_007249	KLF12	Kruppel-like factor 12
chr10_-_92671005	0.758	NM_014391	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.16	1.13e-06	GO:0050794	regulation of cellular process
1.15	1.13e-05	GO:0050789	regulation of biological process
1.13	2.37e-05	GO:0065007	biological regulation
1.27	2.09e-04	GO:0010468	regulation of gene expression
1.29	3.82e-04	GO:0051252	regulation of RNA metabolic process
1.25	8.65e-04	GO:0048731	system development
1.35	1.29e-03	GO:0007399	nervous system development
1.23	1.37e-03	GO:0048856	anatomical structure development
1.21	2.06e-03	GO:0007275	multicellular organismal development
1.26	2.40e-03	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.49	2.92e-03	GO:2000026	regulation of multicellular organismal development
1.19	3.56e-03	GO:0032502	developmental process
1.25	3.90e-03	GO:0010556	regulation of macromolecule biosynthetic process
1.80	4.70e-03	GO:0030029	actin filament-based process
1.26	9.76e-03	GO:0006355	regulation of transcription, DNA-dependent
1.19	2.60e-02	GO:0060255	regulation of macromolecule metabolic process
1.40	3.14e-02	GO:0050793	regulation of developmental process
1.18	3.69e-02	GO:0031323	regulation of cellular metabolic process
1.24	3.83e-02	GO:0048523	negative regulation of cellular process
2.06	4.68e-02	GO:0007156	homophilic cell adhesion
1.21	4.87e-02	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.18	1.68e-06	GO:0005634	nucleus
2.29	1.29e-03	GO:0030055	cell-substrate junction
2.83	3.68e-03	GO:0035770	RNA granule
2.27	4.36e-03	GO:0005925	focal adhesion
3.39	7.85e-03	GO:0000932	cytoplasmic mRNA processing body
1.68	9.16e-03	GO:0015629	actin cytoskeleton
2.16	1.27e-02	GO:0005924	cell-substrate adherens junction
5.00	1.49e-02	GO:0010494	stress granule
3.18	1.86e-02	GO:0042641	actomyosin
1.06	4.14e-02	GO:0005622	intracellular
3.75	4.53e-02	GO:0016460	myosin II complex
1.06	4.54e-02	GO:0044424	intracellular part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.26	3.35e-04	GO:0003677	DNA binding
1.21	6.82e-04	GO:0003676	nucleic acid binding
1.40	1.84e-03	GO:0001071	nucleic acid binding transcription factor activity
1.40	1.84e-03	GO:0003700	sequence-specific DNA binding transcription factor activity
1.71	2.37e-03	GO:0003779	actin binding
2.25	3.32e-03	GO:0017124	SH3 domain binding
1.11	6.94e-03	GO:0005515	protein binding
1.49	1.35e-02	GO:0008092	cytoskeletal protein binding
1.24	1.45e-02	GO:0008270	zinc ion binding
1.06	2.78e-02	GO:0005488	binding
1.33	4.28e-02	GO:0030528	transcription regulator activity