Motif ID: SOX2.p2

Z-value: 1.905


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_1829127690.381.5e-01Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27186400 5.347 NM_153715
HOXA10
homeobox A10
chr3_-_150533948 5.058 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr12_-_6103945 3.123 NM_000552
VWF
von Willebrand factor
chr10_+_70517823 3.011 NM_002727
SRGN
serglycin
chr10_+_70517863 3.002 SRGN
serglycin
chr1_-_171441234 2.891 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr4_+_86918882 2.840 ARHGAP24
Rho GTPase activating protein 24
chrX_+_86659370 2.818 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr4_-_101658094 2.696 NM_001159694
NM_016242
EMCN

endomucin

chr1_+_66570363 2.622 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr7_+_102340579 2.484 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr2_-_188021117 2.481 NM_005795
CALCRL
calcitonin receptor-like
chrX_+_15428820 2.419 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr1_-_32574185 2.399 NM_023009
MARCKSL1
MARCKS-like 1
chr6_+_153060722 2.397 NM_025107
MYCT1
myc target 1
chr9_+_18464138 2.385 ADAMTSL1
ADAMTS-like 1
chr10_-_32707549 2.384 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr1_-_197173159 2.370 LOC100131234
familial acute myelogenous leukemia related factor
chr5_+_15553736 2.308 FBXL7
F-box and leucine-rich repeat protein 7
chr17_-_59817456 2.291 PECAM1
platelet/endothelial cell adhesion molecule
chr9_+_18464090 2.253 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr13_-_98428244 2.216 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr17_-_59817575 2.207 PECAM1
platelet/endothelial cell adhesion molecule
chr7_+_27190688 2.194


chr2_-_110665188 2.173 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr5_-_111119846 2.143 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr17_-_59817654 2.136 PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_59817722 2.130 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr6_+_130381408 2.084 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr7_-_27190882 2.074 HOXA11
homeobox A11
chr5_+_15553288 2.021 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr3_+_148593911 2.017


chr5_+_15553539 2.006 FBXL7
F-box and leucine-rich repeat protein 7
chr2_+_108637916 1.981 LIMS1
LIMS3
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 3
chr2_+_110013297 1.968 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr8_-_6407882 1.942 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr21_-_38792173 1.935 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr2_-_198248828 1.934 NM_144629
RFTN2
raftlin family member 2
chr2_+_108637698 1.904 NM_001193485
LIMS1
LIM and senescent cell antigen-like domains 1
chr17_-_18890963 1.888 NM_006613
GRAP
GRB2-related adaptor protein
chr6_+_12398514 1.871 NM_001168319
NM_001955
EDN1

endothelin 1

chr7_-_11838260 1.855 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr17_-_59818033 1.833 PECAM1
platelet/endothelial cell adhesion molecule
chr15_-_80125403 1.814 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr15_-_80125514 1.789 MEX3B
mex-3 homolog B (C. elegans)
chr1_+_242281199 1.765 ZNF238
zinc finger protein 238
chr14_+_76298693 1.735 VASH1
vasohibin 1
chr5_-_100266769 1.720 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr2_-_56266408 1.693 LOC100129434
hypothetical LOC100129434
chr9_+_115303527 1.677 NM_130795
RGS3
regulator of G-protein signaling 3
chr13_-_98757634 1.615 NM_004951
GPR183
G protein-coupled receptor 183
chr12_-_68369322 1.601 NM_152439
BEST3
bestrophin 3
chr1_+_22107137 1.589 RPL21
ribosomal protein L21
chr9_+_89302574 1.581 NM_004938
DAPK1
death-associated protein kinase 1
chr7_-_27171673 1.576 NM_152739
HOXA9
homeobox A9
chr6_-_56824371 1.566 DST
dystonin
chr3_+_174598937 1.558 NM_014932
NLGN1
neuroligin 1
chr13_+_110653407 1.558 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr11_+_113436438 1.520 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr11_+_5667494 1.509 NM_006074
TRIM22
tripartite motif containing 22
chr1_-_47468029 1.506 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr2_-_37752272 1.505 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr9_-_72673753 1.504 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr13_-_32658215 1.496 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_+_242283129 1.492 NM_006352
ZNF238
zinc finger protein 238
chr9_+_27099138 1.490 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr6_-_139654807 1.480 NM_153235
TXLNB
taxilin beta
chr18_+_13601664 1.474 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr5_+_15553768 1.445 FBXL7
F-box and leucine-rich repeat protein 7
chr7_-_27180398 1.444 NM_018951
HOXA10
homeobox A10
chr15_+_37330176 1.419 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr9_+_126460511 1.414


chr15_-_68781662 1.377 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr9_+_89302239 1.376 DAPK1
death-associated protein kinase 1
chr8_-_108579270 1.367 NM_001146
ANGPT1
angiopoietin 1
chr16_+_64958086 1.322 CDH5
cadherin 5, type 2 (vascular endothelium)
chr16_+_64958060 1.303 CDH5
cadherin 5, type 2 (vascular endothelium)
chr18_-_21186107 1.302 NM_015461
ZNF521
zinc finger protein 521
chr16_+_64958025 1.297 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr3_-_115826481 1.291 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr3_+_25444753 1.282 NM_016152
RARB
retinoic acid receptor, beta
chr3_+_25444837 1.281 NM_000965
RARB
retinoic acid receptor, beta
chr17_-_44006808 1.265 NM_002146
HOXB3
homeobox B3
chr6_+_21774624 1.255 FLJ22536
hypothetical locus LOC401237
chrX_-_33139349 1.240 NM_004006
DMD
dystrophin
chr9_-_116190038 1.239 AKNA
AT-hook transcription factor
chr3_-_11660395 1.224 NM_001128219
VGLL4
vestigial like 4 (Drosophila)
chr14_-_90953883 1.221 NM_001080414
CCDC88C
coiled-coil domain containing 88C
chr15_+_64781723 1.218 NM_005585
SMAD6
SMAD family member 6
chr15_+_21361546 1.216 NM_005664
MKRN3
makorin ring finger protein 3
chr1_-_85816520 1.213 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr17_-_30783631 1.209 NM_018042
SLFN12
schlafen family member 12
chr13_-_22905822 1.208 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr3_-_115825742 1.205 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr17_+_18971506 1.202 NM_001129778
GRAPL
GRB2-related adaptor protein-like
chr1_-_95165089 1.193 NM_001839
CNN3
calponin 3, acidic
chr5_+_95093267 1.192


chrX_+_28515479 1.168 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr1_-_85703198 1.168 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_-_128138435 1.162 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr15_-_80123935 1.156 MEX3B
mex-3 homolog B (C. elegans)
chrX_+_84385693 1.148 ZNF711
zinc finger protein 711
chrX_+_12904207 1.137 TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr4_-_138673078 1.128 NM_019035
PCDH18
protocadherin 18
chr7_+_134114912 1.126 CALD1
caldesmon 1
chr7_+_93388951 1.123 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr3_+_182900081 1.116 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr4_+_86918870 1.115 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr5_-_88155360 1.110 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr12_-_16650687 1.100 LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_84540921 1.090 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr1_+_43539239 1.088 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr6_+_44295219 1.081 NM_001078174
NM_004955
SLC29A1

solute carrier family 29 (nucleoside transporters), member 1

chr5_-_83715947 1.080 EDIL3
EGF-like repeats and discoidin I-like domains 3
chr6_-_56824672 1.078 DST
dystonin
chr2_+_198377561 1.077 NM_006226
PLCL1
phospholipase C-like 1
chr13_-_73606362 1.077 KLF12
Kruppel-like factor 12
chr6_+_116939500 1.067 NM_153711
FAM26E
family with sequence similarity 26, member E
chr12_-_16650697 1.064 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_192531018 1.061 NM_198152
UTS2D
urotensin 2 domain containing
chr10_+_104525877 1.052 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr7_+_134114957 1.049 CALD1
caldesmon 1
chr1_+_242281175 1.033 NM_205768
ZNF238
zinc finger protein 238
chr11_+_128068982 1.031 NM_002017
FLI1
Friend leukemia virus integration 1
chr13_-_32678142 1.030 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr12_-_101115677 1.029 NM_002674
PMCH
pro-melanin-concentrating hormone
chr9_+_4480193 1.017 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr5_-_39460687 1.014 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr17_-_1195096 1.012 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr11_+_128069165 1.012 FLI1
Friend leukemia virus integration 1
chr3_-_116272911 0.999 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr10_-_88707299 0.995 NM_024756
MMRN2
multimerin 2
chr11_+_128069183 0.993 FLI1
Friend leukemia virus integration 1
chr11_+_128069203 0.992 FLI1
Friend leukemia virus integration 1
chr11_+_111313227 0.992 DIXDC1
DIX domain containing 1
chrX_+_10084984 0.990 NM_001830
CLCN4
chloride channel 4
chr1_+_66570683 0.987 PDE4B
phosphodiesterase 4B, cAMP-specific
chr18_-_24011349 0.974 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr11_+_128069340 0.969 FLI1
Friend leukemia virus integration 1
chr4_-_139382672 0.968 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr1_-_26105954 0.958 NM_203399
STMN1
stathmin 1
chr5_+_88220846 0.957


chrX_+_100692071 0.956 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr5_+_95092384 0.947 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr9_+_112470871 0.947 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr11_+_111313067 0.944 NM_001037954
DIXDC1
DIX domain containing 1
chr15_-_93671314 0.940 LOC400456
hypothetical LOC400456
chr5_-_71838875 0.938 NM_152625
ZNF366
zinc finger protein 366
chr8_-_60194099 0.936 NM_014729
TOX
thymocyte selection-associated high mobility group box
chr3_-_143230124 0.924 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr7_+_106292975 0.919 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr4_-_54119159 0.916 NM_032622
LNX1
ligand of numb-protein X 1
chr14_+_76297885 0.912 NM_014909
VASH1
vasohibin 1
chr1_-_95165037 0.911 CNN3
calponin 3, acidic
chr3_-_58538530 0.909 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr8_+_40130143 0.907 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr1_-_79244948 0.904 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chrX_+_12903145 0.900 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr4_-_54119102 0.896 LNX1
ligand of numb-protein X 1
chr11_-_85108030 0.892 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr7_-_130891861 0.890 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr8_-_124622434 0.887 NM_058229
FBXO32
F-box protein 32
chr3_-_58538110 0.884 FAM107A
family with sequence similarity 107, member A
chr8_-_93184629 0.883 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr12_+_47498778 0.883 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr8_-_93144039 0.882


chr4_+_91035025 0.863 NM_007351
MMRN1
multimerin 1
chr7_+_22733290 0.861 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr4_-_54119123 0.860 LNX1
ligand of numb-protein X 1
chr7_+_106292932 0.859 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr10_+_11087345 0.855 CELF2
CUGBP, Elav-like family member 2
chr12_-_47869067 0.846 NM_006009
TUBA1A
tubulin, alpha 1a
chr11_-_6633427 0.846 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr12_-_10142779 0.845 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr10_+_80672842 0.844 ZMIZ1
zinc finger, MIZ-type containing 1
chr12_-_47869134 0.842 TUBA1A
tubulin, alpha 1a
chr19_-_53941835 0.837 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr5_-_83716346 0.834 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr1_+_61642287 0.832 NFIA
nuclear factor I/A
chr5_-_111120929 0.832 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr15_-_76890626 0.826 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr3_+_44601457 0.823 NM_173658
ZNF660
zinc finger protein 660
chr13_-_37341859 0.823 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr7_+_22733626 0.822 IL6
interleukin 6 (interferon, beta 2)
chr2_-_192419896 0.815 SDPR
serum deprivation response
chr14_+_85066207 0.813 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr14_+_62740878 0.812 NM_020663
RHOJ
ras homolog gene family, member J
chr1_+_211190631 0.806 VASH2
vasohibin 2
chr12_-_69289889 0.804 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr10_+_11087259 0.798 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chrX_+_80344253 0.787 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr5_-_111120817 0.786 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr6_+_121798443 0.783 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_+_211190476 0.777 NM_001136474
NM_001136475
NM_024749
VASH2


vasohibin 2


chr8_+_67201684 0.775 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr10_+_11087280 0.771 CELF2
CUGBP, Elav-like family member 2
chr10_+_22765996 0.770 LOC100289455
hypothetical LOC100289455
chr22_-_20419975 0.768 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr13_-_73605914 0.758 NM_007249
KLF12
Kruppel-like factor 12
chr10_-_92671005 0.758 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 1.13e-06 GO:0050794 regulation of cellular process
1.15 1.13e-05 GO:0050789 regulation of biological process
1.13 2.37e-05 GO:0065007 biological regulation
1.27 2.09e-04 GO:0010468 regulation of gene expression
1.29 3.82e-04 GO:0051252 regulation of RNA metabolic process
1.25 8.65e-04 GO:0048731 system development
1.35 1.29e-03 GO:0007399 nervous system development
1.23 1.37e-03 GO:0048856 anatomical structure development
1.21 2.06e-03 GO:0007275 multicellular organismal development
1.26 2.40e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.49 2.92e-03 GO:2000026 regulation of multicellular organismal development
1.19 3.56e-03 GO:0032502 developmental process
1.25 3.90e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.80 4.70e-03 GO:0030029 actin filament-based process
1.26 9.76e-03 GO:0006355 regulation of transcription, DNA-dependent
1.19 2.60e-02 GO:0060255 regulation of macromolecule metabolic process
1.40 3.14e-02 GO:0050793 regulation of developmental process
1.18 3.69e-02 GO:0031323 regulation of cellular metabolic process
1.24 3.83e-02 GO:0048523 negative regulation of cellular process
2.06 4.68e-02 GO:0007156 homophilic cell adhesion
1.21 4.87e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 1.68e-06 GO:0005634 nucleus
2.29 1.29e-03 GO:0030055 cell-substrate junction
2.83 3.68e-03 GO:0035770 RNA granule
2.27 4.36e-03 GO:0005925 focal adhesion
3.39 7.85e-03 GO:0000932 cytoplasmic mRNA processing body
1.68 9.16e-03 GO:0015629 actin cytoskeleton
2.16 1.27e-02 GO:0005924 cell-substrate adherens junction
5.00 1.49e-02 GO:0010494 stress granule
3.18 1.86e-02 GO:0042641 actomyosin
1.06 4.14e-02 GO:0005622 intracellular
3.75 4.53e-02 GO:0016460 myosin II complex
1.06 4.54e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.26 3.35e-04 GO:0003677 DNA binding
1.21 6.82e-04 GO:0003676 nucleic acid binding
1.40 1.84e-03 GO:0001071 nucleic acid binding transcription factor activity
1.40 1.84e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.71 2.37e-03 GO:0003779 actin binding
2.25 3.32e-03 GO:0017124 SH3 domain binding
1.11 6.94e-03 GO:0005515 protein binding
1.49 1.35e-02 GO:0008092 cytoskeletal protein binding
1.24 1.45e-02 GO:0008270 zinc ion binding
1.06 2.78e-02 GO:0005488 binding
1.33 4.28e-02 GO:0030528 transcription regulator activity