Motif ID: SOX2.p2

Z-value: 1.905


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_1829127690.381.5e-01Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_27186400 5.347 NM_153715
 HOXA10
homeobox A10
chr3_-_150533948 5.058 NM_001184723
NM_138786
 TM4SF18

transmembrane 4 L six family member 18

chr12_-_6103945 3.123 NM_000552
 VWF
von Willebrand factor
chr10_+_70517823 3.011 NM_002727
 SRGN
serglycin
chr10_+_70517863 3.002 SRGN
serglycin
chr1_-_171441234 2.891 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr4_+_86918882 2.840 ARHGAP24
Rho GTPase activating protein 24
chrX_+_86659370 2.818 NM_019117
NM_057162
 KLHL4

kelch-like 4 (Drosophila)

chr4_-_101658094 2.696 NM_001159694
NM_016242
 EMCN

endomucin

chr1_+_66570363 2.622 NM_001037339
 PDE4B
phosphodiesterase 4B, cAMP-specific
chr7_+_102340579 2.484 NM_001031692
NM_005824
 LRRC17

leucine rich repeat containing 17

chr2_-_188021117 2.481 NM_005795
 CALCRL
calcitonin receptor-like
chrX_+_15428820 2.419 NM_203281
 BMX
BMX non-receptor tyrosine kinase
chr1_-_32574185 2.399 NM_023009
 MARCKSL1
MARCKS-like 1
chr6_+_153060722 2.397 NM_025107
 MYCT1
myc target 1
chr9_+_18464138 2.385 ADAMTSL1
ADAMTS-like 1
chr10_-_32707549 2.384 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr1_-_197173159 2.370 LOC100131234
familial acute myelogenous leukemia related factor
chr5_+_15553736 2.308 FBXL7
F-box and leucine-rich repeat protein 7
chr17_-_59817456 2.291 PECAM1
platelet/endothelial cell adhesion molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
2.06 4.68e-02 GO:0007156 homophilic cell adhesion
1.80 4.70e-03 GO:0030029 actin filament-based process
1.49 2.92e-03 GO:2000026 regulation of multicellular organismal development
1.40 3.14e-02 GO:0050793 regulation of developmental process
1.35 1.29e-03 GO:0007399 nervous system development
1.29 3.82e-04 GO:0051252 regulation of RNA metabolic process
1.27 2.09e-04 GO:0010468 regulation of gene expression
1.26 2.40e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.26 9.76e-03 GO:0006355 regulation of transcription, DNA-dependent
1.25 8.65e-04 GO:0048731 system development
1.25 3.90e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.24 3.83e-02 GO:0048523 negative regulation of cellular process
1.23 1.37e-03 GO:0048856 anatomical structure development
1.21 2.06e-03 GO:0007275 multicellular organismal development
1.21 4.87e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 3.56e-03 GO:0032502 developmental process
1.19 2.60e-02 GO:0060255 regulation of macromolecule metabolic process
1.18 3.69e-02 GO:0031323 regulation of cellular metabolic process
1.16 1.13e-06 GO:0050794 regulation of cellular process
1.15 1.13e-05 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
5.00 1.49e-02 GO:0010494 stress granule
3.75 4.53e-02 GO:0016460 myosin II complex
3.39 7.85e-03 GO:0000932 cytoplasmic mRNA processing body
3.18 1.86e-02 GO:0042641 actomyosin
2.83 3.68e-03 GO:0035770 RNA granule
2.29 1.29e-03 GO:0030055 cell-substrate junction
2.27 4.36e-03 GO:0005925 focal adhesion
2.16 1.27e-02 GO:0005924 cell-substrate adherens junction
1.68 9.16e-03 GO:0015629 actin cytoskeleton
1.18 1.68e-06 GO:0005634 nucleus
1.06 4.14e-02 GO:0005622 intracellular
1.06 4.54e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.25 3.32e-03 GO:0017124 SH3 domain binding
1.71 2.37e-03 GO:0003779 actin binding
1.49 1.35e-02 GO:0008092 cytoskeletal protein binding
1.40 1.84e-03 GO:0001071 nucleic acid binding transcription factor activity
1.40 1.84e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.33 4.28e-02 GO:0030528 transcription regulator activity
1.26 3.35e-04 GO:0003677 DNA binding
1.24 1.45e-02 GO:0008270 zinc ion binding
1.21 6.82e-04 GO:0003676 nucleic acid binding
1.11 6.94e-03 GO:0005515 protein binding
1.06 2.78e-02 GO:0005488 binding