Motif ID: IKZF2.p2

Z-value: 1.667


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF2chr2_-_213724577-0.068.2e-01Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_74956494 2.647 NM_000700
ANXA1
annexin A1
chr1_+_99884018 2.177 NM_017734
PALMD
palmdelphin
chr14_+_85066265 1.733 FLRT2
fibronectin leucine rich transmembrane protein 2
chr2_+_157822355 1.559 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr2_-_162808123 1.469 NM_004460
FAP
fibroblast activation protein, alpha
chr18_+_3443771 1.452 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr7_-_16471817 1.414 NM_015464
SOSTDC1
sclerostin domain containing 1
chr8_-_72431274 1.345 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr15_+_60838053 1.325 TLN2
talin 2
chr18_-_21184824 1.309


chr4_-_159312973 1.308 FAM198B
family with sequence similarity 198, member B
chr4_+_170817787 1.302 CLCN3
chloride channel 3
chr4_-_89963177 1.279 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr2_-_144994349 1.273 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr7_+_102340579 1.262 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr16_+_81218142 1.242 CDH13
cadherin 13, H-cadherin (heart)
chr1_+_68070573 1.231


chr16_+_81218074 1.215 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr2_-_151052391 1.192 NM_005168
RND3
Rho family GTPase 3
chr3_-_170346760 1.186 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr3_+_46423682 1.185 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr9_-_72673753 1.176 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr11_+_113671744 1.160 NM_006169
NNMT
nicotinamide N-methyltransferase
chr4_-_152366970 1.150 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr1_-_23393808 1.131 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr7_-_13996166 1.113 NM_001163147
NM_004956
ETV1

ets variant 1

chr4_-_115120251 1.102 NM_024590
ARSJ
arylsulfatase family, member J
chr11_+_65027721 1.094


chr1_-_171838802 1.089 NM_178527
SLC9A11
solute carrier family 9, member 11
chr12_-_52939584 1.085 NM_001127322
CBX5
chromobox homolog 5
chr8_-_13416554 1.069 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr3_-_150533948 1.067 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr7_+_93388951 1.066 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr1_-_68470585 1.051 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr12_+_45759634 1.049 FAM113B
family with sequence similarity 113, member B
chr5_+_40877053 1.047 NM_032587
CARD6
caspase recruitment domain family, member 6
chr3_-_11585264 1.034 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr4_-_90197140 1.033 NM_014883
FAM13A
family with sequence similarity 13, member A
chr10_+_111755715 1.024 NM_019903
ADD3
adducin 3 (gamma)
chr7_-_41709191 1.024 NM_002192
INHBA
inhibin, beta A
chr7_+_120416103 1.024 C7orf58
chromosome 7 open reading frame 58
chrX_-_102828238 1.019 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr8_-_133841988 1.015 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr11_-_62229477 1.011 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_-_79244948 1.011 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chrX_+_100692071 1.004 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr6_+_147871477 1.002 NM_001030060
SAMD5
sterile alpha motif domain containing 5
chr1_+_194887630 1.000 NM_000186
NM_001014975
CFH

complement factor H

chr2_-_189752575 0.991 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_-_191422346 0.986 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr18_+_27281729 0.984 NM_001944
DSG3
desmoglein 3
chr12_-_84754112 0.973 RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr21_-_27261276 0.971 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr1_+_160868932 0.965 DDR2
discoidin domain receptor tyrosine kinase 2
chr3_+_29297806 0.957 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr4_-_158111504 0.954 PDGFC
platelet derived growth factor C
chr1_+_160868822 0.949 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr1_+_39569396 0.938 NM_033044
MACF1
microtubule-actin crosslinking factor 1
chr7_+_120415958 0.936 NM_024913
C7orf58
chromosome 7 open reading frame 58
chrX_-_33139349 0.918 NM_004006
DMD
dystrophin
chr17_-_64649608 0.915 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr12_-_48902692 0.914 NM_001113547
LIMA1
LIM domain and actin binding 1
chr7_-_112545847 0.909 LOC401397
hypothetical LOC401397
chr8_-_37847095 0.909 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr6_+_129245978 0.904 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr11_-_95715976 0.902 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr14_+_85066207 0.895 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr16_-_63713382 0.890 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr5_+_96237399 0.888 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr14_+_62740878 0.883 NM_020663
RHOJ
ras homolog gene family, member J
chr6_-_111995213 0.878 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr21_-_26867138 0.876 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr10_+_91077581 0.873 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr18_+_54013575 0.867 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr7_-_91632525 0.858 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr1_+_161305558 0.850 NM_001113381
RGS4
regulator of G-protein signaling 4
chr2_+_202379442 0.846 NM_139158
CDK15
cyclin-dependent kinase 15
chr9_+_129893948 0.843 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr18_-_51219880 0.841 TCF4
transcription factor 4
chr2_-_105381855 0.839 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr1_+_201862845 0.838 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr12_-_47868563 0.836 TUBA1A
tubulin, alpha 1a
chr5_-_59100194 0.835 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_+_94584449 0.832 NM_001013848
EXOC6
exocyst complex component 6
chr4_+_95595419 0.827 PDLIM5
PDZ and LIM domain 5
chr6_+_147568795 0.823 STXBP5
syntaxin binding protein 5 (tomosyn)
chrX_+_102471769 0.818 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr9_+_12764988 0.816 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr4_-_158111916 0.804 PDGFC
platelet derived growth factor C
chr7_-_13992351 0.799 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_-_11887265 0.795 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr4_-_159313167 0.793 NM_016613
FAM198B
family with sequence similarity 198, member B
chr4_+_15080586 0.792 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr7_+_93862137 0.790 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chrX_-_19598912 0.786 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr13_+_48582389 0.782 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr8_-_116750427 0.777 TRPS1
trichorhinophalangeal syndrome I
chr21_-_38792173 0.770 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr6_-_119137923 0.762 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chrX_-_15593074 0.761 NM_020665
TMEM27
transmembrane protein 27
chr1_+_84539876 0.758 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr2_-_40593074 0.748 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr6_-_47117951 0.746 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chrX_+_73080887 0.744 NCRNA00183
non-protein coding RNA 183
chr6_+_116956868 0.742 NM_153036
FAM26D
family with sequence similarity 26, member D
chr20_-_17487480 0.741 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr19_-_36531958 0.740 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chrX_-_153698930 0.737 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr3_-_64648370 0.736 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr10_-_76538859 0.736 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr1_-_143786993 0.733 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_+_74160779 0.731 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr11_+_86189138 0.728 NM_007173
PRSS23
protease, serine, 23
chr4_+_124537334 0.727 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr6_+_121798443 0.726 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr21_-_38210531 0.713 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr2_-_190635566 0.706 NM_005259
MSTN
myostatin
chr9_+_124416768 0.702 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr2_-_192420168 0.698 NM_004657
SDPR
serum deprivation response
chr1_+_22107137 0.698 RPL21
ribosomal protein L21
chr2_-_219404755 0.694 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr10_-_112668679 0.694 NM_001195306
BBIP1
BBSome interacting protein 1
chr18_-_12646730 0.690 NM_001128627
SPIRE1
spire homolog 1 (Drosophila)
chr11_+_33306652 0.689 HIPK3
homeodomain interacting protein kinase 3
chr8_-_49996353 0.687 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr11_+_65026382 0.685


chr5_-_151046638 0.684 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr17_-_44037332 0.678 NM_018952
HOXB6
homeobox B6
chr9_+_112470871 0.677 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chrX_-_73430064 0.672 MIR374AHG
mir-374a-545 cluster host gene (non-protein coding)
chr5_-_58607673 0.669 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_86785346 0.669 NM_012128
CLCA4
chloride channel accessory 4
chr22_-_41685827 0.665 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr5_+_54491702 0.664 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr5_+_155686750 0.662 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr4_+_169654742 0.659 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr9_+_74956614 0.656 ANXA1
annexin A1
chr5_+_140698537 0.656 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr4_+_159351092 0.653 TMEM144
transmembrane protein 144
chr3_+_138132006 0.646 NM_001190796
NCK1
NCK adaptor protein 1
chr4_+_130236731 0.643 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr6_-_68655708 0.642


chr1_-_194844061 0.640 NM_198503
KCNT2
potassium channel, subfamily T, member 2
chr9_+_74956601 0.640 ANXA1
annexin A1
chr14_-_49932366 0.637 NM_004196
CDKL1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr21_-_35174742 0.636 RUNX1
runt-related transcription factor 1
chr1_-_151804929 0.636 NM_005978
S100A2
S100 calcium binding protein A2
chr12_+_10351683 0.635 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr3_-_170864111 0.635 NM_004991
MECOM
MDS1 and EVI1 complex locus
chr3_+_25445071 0.632 RARB
retinoic acid receptor, beta
chr7_+_134226727 0.627 CALD1
caldesmon 1
chr5_-_92942680 0.627 FLJ42709
hypothetical LOC441094
chr12_+_26239755 0.626 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr8_-_42184194 0.620 PLAT
plasminogen activator, tissue
chr18_+_30544193 0.618 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr21_-_35343456 0.618 NM_001754
RUNX1
runt-related transcription factor 1
chr7_-_22518200 0.616 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr2_+_87536174 0.615 NCRNA00152
non-protein coding RNA 152
chr4_-_158111995 0.614 NM_016205
PDGFC
platelet derived growth factor C
chr3_+_69998064 0.613 NM_198177
MITF
microphthalmia-associated transcription factor
chr2_+_33514896 0.610 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr21_-_35343448 0.608 RUNX1
runt-related transcription factor 1
chr1_+_234916376 0.607 NM_001103
ACTN2
actinin, alpha 2
chr8_-_17599438 0.606 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr2_+_108571177 0.603 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr8_-_108579270 0.603 NM_001146
ANGPT1
angiopoietin 1
chr11_+_129484540 0.597 APLP2
amyloid beta (A4) precursor-like protein 2
chr7_-_83662152 0.593 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_+_108571209 0.592 LIMS1
LIM and senescent cell antigen-like domains 1
chr9_+_108665168 0.591 NM_021224
ZNF462
zinc finger protein 462
chr21_-_41479035 0.591 NM_182832
PLAC4
placenta-specific 4
chr15_-_68781662 0.588 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr12_+_32546243 0.587 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_+_100957883 0.579 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr18_+_54039818 0.578 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_+_56772391 0.576 LOC550643
hypothetical LOC550643
chr8_-_102029997 0.574 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr4_+_88187215 0.573 AFF1
AF4/FMR2 family, member 1
chr6_+_136214495 0.572 NM_018945
PDE7B
phosphodiesterase 7B
chr4_+_146820805 0.571 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr18_-_63333487 0.562 DSEL
dermatan sulfate epimerase-like
chr9_+_88953378 0.561 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr2_+_36777406 0.560 VIT
vitrin
chr8_+_70541412 0.556 NM_001128204
NM_015170
SULF1

sulfatase 1

chr3_-_64647325 0.552 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr2_+_102320148 0.552 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr17_+_63338500 0.548 BPTF
bromodomain PHD finger transcription factor
chr2_-_40532651 0.547 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr14_-_22693333 0.544 NM_182728
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr7_+_91762227 0.543


chr9_-_36266930 0.542 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr12_-_51153788 0.542 NM_173086
KRT6C
keratin 6C
chr5_+_86712376 0.541


chr16_+_7322751 0.539 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr3_-_173911467 0.538 NM_001146276
NM_001146277
NM_001146278
NM_020792
NCEH1



neutral cholesterol ester hydrolase 1



chr5_+_92944680 0.537 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_+_160618143 0.536 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr10_+_72642274 0.536 NM_170744
UNC5B
unc-5 homolog B (C. elegans)
chr4_+_160408447 0.531 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr6_-_49712483 0.526 NM_000324
RHAG
Rh-associated glycoprotein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 4.97e-04 GO:0050896 response to stimulus
1.60 1.17e-02 GO:0007606 sensory perception of chemical stimulus

Nothing significant found in compartment category.

Nothing significant found in function category.