Motif ID: IRF1,2,7.p3

Z-value: 5.104


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF7chr11_-_6056490.683.5e-03Click!
IRF1chr5_-_1318543250.581.8e-02Click!
IRF2chr4_-_1856326100.562.4e-02Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_111900650 29.180 NM_001032731
NM_002535
NM_016817
 OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr1_+_78858675 27.465 NM_006820
 IFI44L
interferon-induced protein 44-like
chr21_+_41655786 14.181 NM_002463
 LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_157246305 12.506 NM_005531
 IFI16
interferon, gamma-inducible protein 16
chr17_-_37518213 11.140 NM_024119
 DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr10_+_91082218 10.299 NM_001031683
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_-_25164061 9.785 NM_001031680
 RUNX3
runt-related transcription factor 3
chr4_+_142777172 9.665 NM_000585
NM_172174
 IL15

interleukin 15

chr4_-_169476391 9.251 NM_017631
 DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr1_+_78888064 9.229 NM_006417
 IFI44
interferon-induced protein 44
chr11_-_605920 9.116 IRF7
interferon regulatory factor 7
chr4_+_89597257 9.077 NM_016323
 HERC5
hect domain and RLD 5
chr7_+_128367961 8.974 NM_001098627
 IRF5
interferon regulatory factor 5
chr13_-_42464301 8.640 NM_001002264
NM_033255
 EPSTI1

epithelial stromal interaction 1 (breast)

chr11_-_605998 8.630 NM_001572
NM_004029
 IRF7

interferon regulatory factor 7

chr6_-_27948065 8.186 NM_003533
 HIST1H3I
histone cluster 1, H3i
chr11_+_5667392 8.137 TRIM22
tripartite motif containing 22
chr7_+_150013716 7.960 NM_015660
 GIMAP2
GTPase, IMAP family member 2
chr6_-_31432543 7.837 HLA-B
major histocompatibility complex, class I, B
chr3_+_114733907 7.752 NM_017699
 SIDT1
SID1 transmembrane family, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 70 entries
enrichment   p-value GO term description
13.20 1.98e-02 GO:0019883 antigen processing and presentation of endogenous antigen
11.71 4.86e-14 GO:0060338 regulation of type I interferon-mediated signaling pathway
11.15 4.93e-29 GO:0034340 response to type I interferon
11.09 9.68e-03 GO:0002230 positive regulation of defense response to virus by host
11.03 5.72e-28 GO:0060337 type I interferon-mediated signaling pathway
11.03 5.72e-28 GO:0071357 cellular response to type I interferon
9.95 3.84e-03 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
9.24 3.88e-02 GO:0001916 positive regulation of T cell mediated cytotoxicity
8.70 2.51e-03 GO:0050691 regulation of defense response to virus by host
7.40 1.13e-02 GO:0048002 antigen processing and presentation of peptide antigen
6.26 9.73e-09 GO:0001959 regulation of cytokine-mediated signaling pathway
6.16 1.39e-08 GO:0060759 regulation of response to cytokine stimulus
5.55 4.37e-02 GO:0032480 negative regulation of type I interferon production
5.52 5.96e-19 GO:0009615 response to virus
5.12 1.35e-19 GO:0019221 cytokine-mediated signaling pathway
4.89 7.90e-20 GO:0071345 cellular response to cytokine stimulus
4.89 2.89e-05 GO:0071346 cellular response to interferon-gamma
4.77 2.74e-04 GO:0060333 interferon-gamma-mediated signaling pathway
4.62 1.33e-05 GO:0034341 response to interferon-gamma
4.62 1.49e-02 GO:0032479 regulation of type I interferon production

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
16.18 5.09e-06 GO:0005132 interferon-alpha/beta receptor binding
14.79 2.06e-02 GO:0005143 interleukin-12 receptor binding
7.92 2.56e-02 GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
5.37 1.31e-02 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
3.30 5.81e-07 GO:0005126 cytokine receptor binding
2.69 5.24e-04 GO:0005125 cytokine activity