Motif ID: IRF1,2,7.p3

Z-value: 5.104


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF7chr11_-_6056490.683.5e-03Click!
IRF1chr5_-_1318543250.581.8e-02Click!
IRF2chr4_-_1856326100.562.4e-02Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_111900650 29.180 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr1_+_78858675 27.465 NM_006820
IFI44L
interferon-induced protein 44-like
chr21_+_41655786 14.181 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_157246305 12.506 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr17_-_37518213 11.140 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr10_+_91082218 10.299 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_-_25164061 9.785 NM_001031680
RUNX3
runt-related transcription factor 3
chr4_+_142777172 9.665 NM_000585
NM_172174
IL15

interleukin 15

chr4_-_169476391 9.251 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr1_+_78888064 9.229 NM_006417
IFI44
interferon-induced protein 44
chr11_-_605920 9.116 IRF7
interferon regulatory factor 7
chr4_+_89597257 9.077 NM_016323
HERC5
hect domain and RLD 5
chr7_+_128367961 8.974 NM_001098627
IRF5
interferon regulatory factor 5
chr13_-_42464301 8.640 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr11_-_605998 8.630 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr6_-_27948065 8.186 NM_003533
HIST1H3I
histone cluster 1, H3i
chr11_+_5667392 8.137 TRIM22
tripartite motif containing 22
chr7_+_150013716 7.960 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr6_-_31432543 7.837 HLA-B
major histocompatibility complex, class I, B
chr3_+_114733907 7.752 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr3_+_188568861 7.570 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr6_+_6533932 7.316 NM_004271
LY86
lymphocyte antigen 86
chr9_+_5500544 7.225 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr11_+_1830763 7.197 NM_002339
LSP1
lymphocyte-specific protein 1
chr22_-_34886727 7.175 NM_145640
APOL3
apolipoprotein L, 3
chr7_+_73826244 7.034 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr7_-_76667045 6.988 NM_006682
FGL2
fibrinogen-like 2
chr6_-_32920167 6.978 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr17_+_6600080 6.963 XAF1
XIAP associated factor 1
chr5_-_149772528 6.940


chr5_-_149772469 6.930 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr1_+_938709 6.890 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr19_-_7672978 6.815 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr12_+_25096755 6.714 LRMP
lymphoid-restricted membrane protein
chr16_-_88358946 6.643 FANCA
Fanconi anemia, complementation group A
chr16_+_55580910 6.442 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr6_-_32919751 6.407 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr16_+_10878539 6.402 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr10_+_22765996 6.333 LOC100289455
hypothetical LOC100289455
chr17_+_6599879 6.161 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr21_+_41719847 6.076 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr12_+_12115668 6.024 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr11_-_605649 5.964 NM_004031
IRF7
interferon regulatory factor 7
chr16_-_49272617 5.939 SNX20
sorting nexin 20
chr6_+_32929902 5.904 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr11_+_5602782 5.873 NM_021616
TRIM34
tripartite motif containing 34
chr15_+_42790951 5.837 NM_004048
B2M
beta-2-microglobulin
chr1_-_159306369 5.771 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr12_+_6431437 5.749 NM_018009
TAPBPL
TAP binding protein-like
chr7_+_134483305 5.722 NM_018295
TMEM140
transmembrane protein 140
chr16_-_49272741 5.580 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr5_+_131774478 5.580 NM_001013717
C5orf56
chromosome 5 open reading frame 56
chr1_-_159306327 5.569 ARHGAP30
Rho GTPase activating protein 30
chr4_+_37569093 5.511 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr6_+_37081387 5.448 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr12_+_93066370 5.419 NM_005761
PLXNC1
plexin C1
chr6_+_31648071 5.411 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_-_2486313 5.386 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr6_-_32929390 5.379 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_230792844 5.367 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr17_+_38719371 5.357 NM_145041
TMEM106A
FLJ77644
transmembrane protein 106A
hypothetical LOC728772
chr6_+_26548678 5.340 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr9_+_5440455 5.323 NM_014143
CD274
CD274 molecule
chr11_-_60475558 5.320 NM_016582
SLC15A3
solute carrier family 15, member 3
chr7_-_149960218 5.301 GIMAP6
GTPase, IMAP family member 6
chr1_-_9052207 5.271 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr17_-_30783631 5.256 NM_018042
SLFN12
schlafen family member 12
chr5_-_149772563 5.231 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr15_+_86983038 5.213 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr6_-_32929570 5.149 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_-_49826221 5.127 UBA7
ubiquitin-like modifier activating enzyme 7
chr22_-_16080265 5.114 CECR1
cat eye syndrome chromosome region, candidate 1
chr3_-_49826360 5.093 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr1_-_9052170 5.036 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr6_-_32929721 5.013 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr15_-_42790805 4.928


chr10_+_115429622 4.891 CASP7
caspase 7, apoptosis-related cysteine peptidase
chr20_-_55628852 4.885 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr1_+_157067729 4.868 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr10_+_91142301 4.862 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr16_-_11783908 4.848 NM_014153
ZC3H7A
zinc finger CCCH-type containing 7A
chr17_+_44643067 4.818 ABI3
ABI family, member 3
chr10_+_63478974 4.788 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr19_-_55091942 4.785 NM_152899
IL4I1
interleukin 4 induced 1
chr10_+_97505398 4.726 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr19_-_18058632 4.723 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr9_-_32516164 4.679 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_+_111829121 4.664 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr17_-_44642934 4.647 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr21_-_42219849 4.642 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr7_-_92615593 4.600 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr17_+_75851984 4.500


chr6_-_30289092 4.462 NM_003449
TRIM26
tripartite motif containing 26
chr18_-_6404900 4.415 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr10_+_91051685 4.315 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr17_+_22982344 4.251 LGALS9
lectin, galactoside-binding, soluble, 9
chr17_+_22982372 4.250 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_89303478 4.249 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr17_+_22982383 4.249 LGALS9
lectin, galactoside-binding, soluble, 9
chr17_+_22982319 4.185 LGALS9
lectin, galactoside-binding, soluble, 9
chr6_+_32713160 4.178 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr1_-_89261021 4.151 NM_018284
GBP3
guanylate binding protein 3
chr3_+_123882355 4.116 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr12_+_25096472 4.109 NM_006152
LRMP
lymphoid-restricted membrane protein
chr17_+_22982278 4.108 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr22_+_17012841 4.097 USP18
ubiquitin specific peptidase 18
chr2_-_6923215 4.096 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr19_+_10058023 4.010 C19orf66
chromosome 19 open reading frame 66
chr10_+_115429415 3.983 NM_001227
NM_033338
NM_033339
CASP7


caspase 7, apoptosis-related cysteine peptidase


chr3_+_161189322 3.969 NM_000882
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr17_+_69974361 3.945 CD300A
CD300a molecule
chr20_-_24986501 3.880 ACSS1
acyl-CoA synthetase short-chain family member 1
chr19_+_10057972 3.854 C19orf66
chromosome 19 open reading frame 66
chr17_-_40695216 3.853 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr7_-_76883642 3.823 NM_017439
PION
pigeon homolog (Drosophila)
chr12_+_12115139 3.793 NM_138723
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr1_+_159334774 3.758 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr11_+_32069183 3.687 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr22_+_17012704 3.669 NM_017414
USP18
ubiquitin specific peptidase 18
chr8_-_145132551 3.660 PARP10
poly (ADP-ribose) polymerase family, member 10
chr2_+_218641982 3.563 NM_198483
RUFY4
RUN and FYVE domain containing 4
chr4_-_157094443 3.517 NM_001334
CTSO
cathepsin O
chr8_-_145132582 3.435 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr22_+_34374358 3.403 NM_030641
APOL6
apolipoprotein L, 6
chr11_-_57091656 3.401 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr11_-_104274606 3.387 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr19_-_17377383 3.379 NM_004335
BST2
bone marrow stromal cell antigen 2
chr20_+_44180355 3.350 CD40
CD40 molecule, TNF receptor superfamily member 5
chr2_-_242449662 3.331 NM_005018
PDCD1
programmed cell death 1
chr16_+_29739256 3.322 MVP
major vault protein
chr19_+_17377502 3.304 LOC100507535
hypothetical LOC100507535
chr10_-_6059460 3.299 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr21_+_41714311 3.283 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_-_9052253 3.271 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr2_+_68445821 3.253 NM_002664
PLEK
pleckstrin
chr6_+_30018287 3.249 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr3_+_48482625 3.157 TREX1
three prime repair exonuclease 1
chr2_-_88946767 3.104


chr22_+_37747063 3.099 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr6_-_133126278 3.088 NM_078488
VNN2
vanin 2
chr11_-_104421240 3.083 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr4_-_38460983 3.078 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr4_-_138673078 3.075 NM_019035
PCDH18
protocadherin 18
chr2_-_227737009 3.058 COL4A4
collagen, type IV, alpha 4
chr2_+_33555182 3.049 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_+_18320822 3.040 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr2_+_230900121 3.034 NM_138402
SP140L
SP140 nuclear body protein-like
chr7_+_154351087 3.020 LOC100132707
hypothetical LOC100132707
chr17_-_41018291 3.010


chr1_+_208568811 3.001 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chrX_+_37524250 2.941 CYBB
cytochrome b-245, beta polypeptide
chr21_+_42807052 2.918 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr22_+_34979118 2.916 APOL1
apolipoprotein L, 1
chr1_+_63831479 2.911 NM_002633
PGM1
phosphoglucomutase 1
chr5_-_95184121 2.870 GLRX
glutaredoxin (thioltransferase)
chr19_+_10057757 2.867 NM_018381
C19orf66
chromosome 19 open reading frame 66
chr16_+_29739215 2.862 NM_005115
NM_017458
MVP

major vault protein

chr2_-_37237530 2.848 EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr9_-_21375258 2.843 NM_000605
IFNA2
interferon, alpha 2
chr17_+_44642587 2.836 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr5_+_156628929 2.811 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr19_+_59866217 2.751 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr1_-_152847301 2.749 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr2_-_191587169 2.734 NM_007315
NM_139266
STAT1

signal transducer and activator of transcription 1, 91kDa

chrX_+_37524190 2.733 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr2_+_33554824 2.731 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_-_74244539 2.727


chr2_+_68445936 2.717 PLEK
pleckstrin
chr3_-_173723754 2.713 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr6_+_116889248 2.711 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr18_+_19848749 2.704 TTC39C
tetratricopeptide repeat domain 39C
chr15_+_73278285 2.694 C15orf39
chromosome 15 open reading frame 39
chr2_-_191587128 2.691 STAT1
signal transducer and activator of transcription 1, 91kDa
chr19_+_59866237 2.684 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr11_+_71388310 2.680 NM_001145057
IL18BP
interleukin 18 binding protein
chr12_+_9713472 2.675 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr1_-_152847105 2.673 ADAR
adenosine deaminase, RNA-specific
chr13_+_48968097 2.671 PHF11
PHD finger protein 11
chr2_-_191587153 2.663 STAT1
signal transducer and activator of transcription 1, 91kDa
chr22_+_36008465 2.657 CYTH4
cytohesin 4
chr8_+_79740813 2.621 NM_016010
FAM164A
family with sequence similarity 164, member A
chr2_-_191587127 2.612 STAT1
signal transducer and activator of transcription 1, 91kDa
chr13_+_30207668 2.609 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr6_-_138231006 2.602


chr2_-_37237651 2.588 NM_001135651
NM_002759
EIF2AK2

eukaryotic translation initiation factor 2-alpha kinase 2

chr11_-_104344473 2.585 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr13_+_42046182 2.537 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr1_+_154390939 2.534 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr11_-_63087430 2.522 NM_017878
HRASLS2
HRAS-like suppressor 2
chr6_+_37509028 2.520 FTSJD2
FtsJ methyltransferase domain containing 2
chr4_+_89519134 2.519 HERC6
hect domain and RLD 6
chr1_+_157167965 2.513 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr5_-_95184221 2.510 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr20_+_44180296 2.503 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr1_-_159306210 2.494 ARHGAP30
Rho GTPase activating protein 30
chr11_-_60880799 2.493 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr22_+_37823174 2.480 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr6_+_32919873 2.467


chr22_+_34979062 2.463 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr12_+_11694172 2.442 ETV6
ets variant 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
11.15 4.93e-29 GO:0034340 response to type I interferon
11.03 5.72e-28 GO:0060337 type I interferon-mediated signaling pathway
11.03 5.72e-28 GO:0071357 cellular response to type I interferon
3.14 4.21e-26 GO:0006955 immune response
2.51 4.69e-24 GO:0002376 immune system process
4.06 3.82e-23 GO:0045087 innate immune response
4.89 7.90e-20 GO:0071345 cellular response to cytokine stimulus
5.12 1.35e-19 GO:0019221 cytokine-mediated signaling pathway
5.52 5.96e-19 GO:0009615 response to virus
2.71 9.19e-19 GO:0006952 defense response
3.92 5.93e-17 GO:0034097 response to cytokine stimulus
11.71 4.86e-14 GO:0060338 regulation of type I interferon-mediated signaling pathway
2.26 2.44e-11 GO:0051704 multi-organism process
2.97 3.32e-11 GO:0051707 response to other organism
1.67 1.11e-10 GO:0006950 response to stress
2.63 9.75e-10 GO:0009607 response to biotic stimulus
1.33 1.36e-09 GO:0050896 response to stimulus
2.34 1.86e-09 GO:0002682 regulation of immune system process
3.06 2.55e-09 GO:0031347 regulation of defense response
6.26 9.73e-09 GO:0001959 regulation of cytokine-mediated signaling pathway
6.16 1.39e-08 GO:0060759 regulation of response to cytokine stimulus
2.29 7.57e-08 GO:0071310 cellular response to organic substance
2.55 1.37e-07 GO:0050776 regulation of immune response
3.61 2.22e-07 GO:0045088 regulation of innate immune response
2.31 3.25e-06 GO:0080134 regulation of response to stress
1.41 9.16e-06 GO:0007165 signal transduction
1.36 1.10e-05 GO:0051716 cellular response to stimulus
4.62 1.33e-05 GO:0034341 response to interferon-gamma
4.89 2.89e-05 GO:0071346 cellular response to interferon-gamma
3.00 2.38e-04 GO:0050867 positive regulation of cell activation
3.41 2.43e-04 GO:0001819 positive regulation of cytokine production
1.35 2.53e-04 GO:0023052 signaling
4.77 2.74e-04 GO:0060333 interferon-gamma-mediated signaling pathway
2.59 3.31e-04 GO:0001817 regulation of cytokine production
1.79 3.48e-04 GO:0070887 cellular response to chemical stimulus
1.54 3.50e-04 GO:0007166 cell surface receptor linked signaling pathway
4.21 3.56e-04 GO:0043900 regulation of multi-organism process
1.52 4.48e-04 GO:0048583 regulation of response to stimulus
2.93 1.65e-03 GO:0051251 positive regulation of lymphocyte activation
3.17 1.73e-03 GO:0050870 positive regulation of T cell activation
2.13 1.76e-03 GO:0002684 positive regulation of immune system process
2.26 1.88e-03 GO:0044419 interspecies interaction between organisms
2.84 1.98e-03 GO:0002696 positive regulation of leukocyte activation
8.70 2.51e-03 GO:0050691 regulation of defense response to virus by host
2.50 3.68e-03 GO:0050865 regulation of cell activation
9.95 3.84e-03 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
2.59 5.31e-03 GO:0051249 regulation of lymphocyte activation
1.38 5.68e-03 GO:0048518 positive regulation of biological process
1.18 6.91e-03 GO:0050789 regulation of biological process
2.79 7.04e-03 GO:0050863 regulation of T cell activation
1.19 9.11e-03 GO:0050794 regulation of cellular process
11.09 9.68e-03 GO:0002230 positive regulation of defense response to virus by host
1.57 1.03e-02 GO:0010033 response to organic substance
7.40 1.13e-02 GO:0048002 antigen processing and presentation of peptide antigen
2.43 1.31e-02 GO:0002694 regulation of leukocyte activation
3.33 1.36e-02 GO:0050670 regulation of lymphocyte proliferation
4.62 1.49e-02 GO:0032479 regulation of type I interferon production
4.29 1.51e-02 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
3.30 1.57e-02 GO:0032944 regulation of mononuclear cell proliferation
4.22 1.85e-02 GO:0002819 regulation of adaptive immune response
1.48 1.92e-02 GO:0023051 regulation of signaling
13.20 1.98e-02 GO:0019883 antigen processing and presentation of endogenous antigen
3.20 2.40e-02 GO:0070663 regulation of leukocyte proliferation
1.51 2.62e-02 GO:0009966 regulation of signal transduction
2.77 3.00e-02 GO:0002697 regulation of immune effector process
2.81 3.62e-02 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
9.24 3.88e-02 GO:0001916 positive regulation of T cell mediated cytotoxicity
2.26 4.28e-02 GO:0010740 positive regulation of intracellular protein kinase cascade
5.55 4.37e-02 GO:0032480 negative regulation of type I interferon production
1.59 4.57e-02 GO:0043067 regulation of programmed cell death

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.30 5.81e-07 GO:0005126 cytokine receptor binding
16.18 5.09e-06 GO:0005132 interferon-alpha/beta receptor binding
2.69 5.24e-04 GO:0005125 cytokine activity
5.37 1.31e-02 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
14.79 2.06e-02 GO:0005143 interleukin-12 receptor binding
7.92 2.56e-02 GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor