Motif ID: LHX3,4.p2

Z-value: 0.779


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LHX3chr9_-_138234707-0.234.0e-01Click!
LHX4chr1_+_1784660640.117.0e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_88155360 2.771 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr19_-_56612653 2.023 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr2_-_175170674 1.451 WIPF1
WAS/WASL interacting protein family, member 1
chr17_+_19917420 1.290 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr13_+_23042722 1.234 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr16_+_11966464 1.197 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr18_+_59767567 1.148 NM_001123366
HMSD
histocompatibility (minor) serpin domain containing
chr1_+_196874839 1.126 PTPRC
protein tyrosine phosphatase, receptor type, C
chr6_-_32265489 1.093 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr12_-_101396459 1.036 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_114215768 0.970 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr3_-_57209319 0.965 NM_003865
HESX1
HESX homeobox 1
chr19_+_14554895 0.948 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr1_-_92725017 0.876 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr20_-_51633042 0.870 NM_006526
ZNF217
zinc finger protein 217
chr7_-_25234582 0.870 NM_022150
NPVF
neuropeptide VF precursor
chr7_+_90177082 0.829 CDK14
cyclin-dependent kinase 14
chr5_+_67622242 0.821 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_38087366 0.796 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr22_+_38627129 0.782 GRAP2
GRB2-related adaptor protein 2
chr8_-_42742729 0.743 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr22_+_38627031 0.739 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr1_+_166516901 0.722 NM_005149
TBX19
T-box 19
chr6_+_31538934 0.715 NM_006674
HCP5
HLA complex P5
chr3_+_99733432 0.707 NM_005290
GPR15
G protein-coupled receptor 15
chr2_-_158008763 0.675 NM_004288
CYTIP
cytohesin 1 interacting protein
chr11_+_22646229 0.635 NM_177553
GAS2
growth arrest-specific 2
chr6_-_144427340 0.631 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr11_+_59979857 0.625 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr10_-_50066386 0.602 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr2_-_215711313 0.592 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr7_-_92615593 0.589 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr3_-_143230124 0.580 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr13_-_83354425 0.552 SLITRK1
SLIT and NTRK-like family, member 1
chr7_+_128802719 0.552 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr12_-_51887266 0.551 NM_000889
ITGB7
integrin, beta 7
chr1_+_196874867 0.551 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_+_91620749 0.539 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr5_+_156628929 0.529 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_161981138 0.526 TBR1
T-box, brain, 1
chr1_-_158815895 0.524 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr3_+_46386636 0.520 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr12_-_52281050 0.501 NM_001130059
ATF7
activating transcription factor 7
chr12_+_52697160 0.498 HOXC5
HOXC6
homeobox C5
homeobox C6
chr3_-_168674502 0.492 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_+_117345894 0.489 NM_004258
CD101
CD101 molecule
chrX_-_13744933 0.486 GPM6B
glycoprotein M6B
chr9_-_205892 0.484 NM_152569
C9orf66
chromosome 9 open reading frame 66
chrX_+_37524190 0.473 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr12_-_51887318 0.466 ITGB7
integrin, beta 7
chr2_+_161980865 0.458 NM_006593
TBR1
T-box, brain, 1
chr2_-_65013070 0.446 LOC400958
hypothetical LOC400958
chr2_+_161981046 0.429 TBR1
T-box, brain, 1
chr10_+_91488704 0.422 KIF20B
kinesin family member 20B
chr19_-_53841064 0.416 NM_001217
CA11
carbonic anhydrase XI
chr11_-_58099884 0.412 NM_004811
LPXN
leupaxin
chr12_+_15590811 0.407 PTPRO
protein tyrosine phosphatase, receptor type, O
chr13_+_52500830 0.405 NM_006418
OLFM4
olfactomedin 4
chr1_-_152845399 0.404 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chrX_+_37524250 0.403 CYBB
cytochrome b-245, beta polypeptide
chrX_-_10761729 0.397 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr7_+_37689903 0.393


chr4_+_166350620 0.393 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr16_-_3567354 0.393 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr3_+_63928459 0.392 NM_001128149
ATXN7
ataxin 7
chr7_+_90176647 0.392 NM_012395
CDK14
cyclin-dependent kinase 14
chr21_-_42219849 0.387 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr1_+_196874759 0.384 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr13_-_45323757 0.369 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr18_-_13905534 0.368 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chrX_+_55951280 0.367


chr2_+_161701711 0.365 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr19_-_60458915 0.365 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr6_-_76022565 0.361 TMEM30A
transmembrane protein 30A
chr3_+_188222337 0.358 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr13_-_40491405 0.356 ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_-_16652202 0.353 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_-_56824371 0.348 DST
dystonin
chrX_-_24600661 0.348 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr13_-_98708549 0.346 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr3_+_120799411 0.345 NM_015900
PLA1A
phospholipase A1 member A
chr7_+_28418668 0.342 NM_182898
CREB5
cAMP responsive element binding protein 5
chr20_+_5935897 0.342 NM_001127458
CRLS1
cardiolipin synthase 1
chr2_+_68815416 0.339 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr3_+_123779122 0.334 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr6_-_33016561 0.328 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_+_246682699 0.326 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr10_+_35466715 0.321 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr6_+_155579788 0.320 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr12_-_25041639 0.318 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr12_+_9871343 0.316 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr3_+_179759181 0.311 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr3_+_123385219 0.311 NM_000388
CASR
calcium-sensing receptor
chr17_-_9635325 0.309 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr13_+_47948586 0.308 RB1
retinoblastoma 1
chr10_+_18729518 0.308 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr20_-_18425811 0.307 NM_006606
RBBP9
retinoblastoma binding protein 9
chr4_+_123311207 0.305 NM_015312
KIAA1109
KIAA1109
chr1_-_149681265 0.305 NM_207171
POGZ
pogo transposable element with ZNF domain
chrX_+_107174855 0.302 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chrX_+_70682204 0.297 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr7_-_132371208 0.296 EEF1G
eukaryotic translation elongation factor 1 gamma
chr22_-_38619739 0.294 NM_152512
ENTHD1
ENTH domain containing 1
chr5_+_166644420 0.287 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr14_-_105610144 0.285 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr1_-_230717850 0.282 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr12_+_52696908 0.279 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr5_+_6799100 0.279 NM_001171806
PAPD7
PAP associated domain containing 7
chr10_+_63478974 0.277 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr5_-_1935764 0.277 NM_016358
IRX4
iroquois homeobox 4
chrX_+_99726445 0.276 NM_022144
TNMD
tenomodulin
chr6_+_31691745 0.275 NM_032955
AIF1
allograft inflammatory factor 1
chr6_-_138231006 0.273


chrX_+_85404626 0.273 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr9_+_92603832 0.268 NM_001135052
NM_003177
SYK

spleen tyrosine kinase

chr8_-_102872372 0.268 NCALD
neurocalcin delta
chr1_+_242283129 0.266 NM_006352
ZNF238
zinc finger protein 238
chrX_+_115215985 0.266 NM_000686
AGTR2
angiotensin II receptor, type 2
chr4_+_88790477 0.264 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr4_+_38740246 0.263 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr14_-_46882144 0.259 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr14_-_106249999 0.252 IGHA1
immunoglobulin heavy constant alpha 1
chr1_+_157067729 0.251 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr16_+_2593351 0.248 LOC652276
hypothetical LOC652276
chr5_+_140772691 0.247 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr1_+_173111306 0.244 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr2_-_32344192 0.244 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr1_+_111215343 0.240 NM_001040033
CD53
CD53 molecule
chr20_+_9146036 0.238 NM_182797
PLCB4
phospholipase C, beta 4
chr3_+_39399770 0.236 NM_017875
SLC25A38
solute carrier family 25, member 38
chrX_+_78087484 0.236 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr14_-_94306104 0.236 NM_173849
GSC
goosecoid homeobox
chr2_+_28892366 0.236 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr18_+_70352779 0.231 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr8_+_22266256 0.230 PIWIL2
piwi-like 2 (Drosophila)
chr12_+_25096755 0.229 LRMP
lymphoid-restricted membrane protein
chr16_-_66075216 0.229 NM_001138
AGRP
agouti related protein homolog (mouse)
chr4_+_88748704 0.228 NM_014208
DSPP
dentin sialophosphoprotein
chr6_-_29635680 0.227 NM_006398
UBD
ubiquitin D
chr18_+_31488530 0.226 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr1_+_242281199 0.225 ZNF238
zinc finger protein 238
chr4_-_83566246 0.224 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr11_+_6854431 0.224 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr11_-_117628211 0.223 NM_198275
MPZL3
myelin protein zero-like 3
chr14_+_19598043 0.223 NM_001004717
OR4L1
olfactory receptor, family 4, subfamily L, member 1
chr17_-_36528113 0.220 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr6_+_29963328 0.220 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr3_+_179736917 0.219 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chrX_-_72351392 0.219 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr4_-_83566045 0.218


chr6_+_50789215 0.218 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr1_-_89437098 0.217 NM_052941
GBP4
guanylate binding protein 4
chr6_+_152053323 0.214 NM_001122742
ESR1
estrogen receptor 1
chr1_+_78888064 0.214 NM_006417
IFI44
interferon-induced protein 44
chr12_-_101036407 0.212 NM_024057
NUP37
nucleoporin 37kDa
chr13_-_102517196 0.212 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr10_+_18589589 0.212 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr11_-_20138445 0.211 NM_001029865
DBX1
developing brain homeobox 1
chr18_+_70352649 0.211 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr18_-_72857665 0.210 MBP
myelin basic protein
chr6_+_167445284 0.209 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr13_+_77007809 0.209 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr3_-_54937001 0.208 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chrX_-_102418329 0.208 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr17_-_9863929 0.207 GAS7
growth arrest-specific 7
chr18_+_27210737 0.206 NM_001134453
NM_177986
DSG4

desmoglein 4

chr17_-_3129017 0.206 NM_002551
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr3_+_103029523 0.206 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr6_-_56824672 0.204 DST
dystonin
chr15_-_70350609 0.204 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr8_-_102872354 0.204 NCALD
neurocalcin delta
chr8_+_55691179 0.201 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr13_-_83354474 0.199 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr7_-_122627235 0.198 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr5_-_160211623 0.197 NM_025153
ATP10B
ATPase, class V, type 10B
chr12_+_14429499 0.197 ATF7IP
activating transcription factor 7 interacting protein
chr6_+_31661934 0.195 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr4_-_116254381 0.195 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr19_+_60962318 0.194 NM_001145014
RFPL4A
ret finger protein-like 4A
chr6_+_55147029 0.194 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr9_+_124173049 0.193 NM_000962
NM_080591
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr15_+_46271158 0.191 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr6_-_22405708 0.191 NM_000948
PRL
prolactin
chr12_-_56422120 0.191 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chrX_-_13745108 0.190 GPM6B
glycoprotein M6B
chr13_+_112349358 0.190 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr8_-_7207899 0.190 NM_001164457
ZNF705G
zinc finger protein 705G
chrX_-_76824726 0.188 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr11_-_118405288 0.188 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr17_-_36376663 0.187 NM_213656
KRT39
keratin 39
chrX_-_13745134 0.187 GPM6B
glycoprotein M6B
chr2_-_99238001 0.186 NM_175735
LYG2
lysozyme G-like 2
chr12_+_52708460 0.185 NM_004503
HOXC6
homeobox C6
chr18_-_3835295 0.184 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr2_-_80385227 0.184 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr8_+_32905027 0.184


chr8_+_67505091 0.183 RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chrX_-_110542040 0.182 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr13_-_40491491 0.181 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chrX_+_7147471 0.181 NM_000351
STS
steroid sulfatase (microsomal), isozyme S

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.48 7.31e-06 GO:0007608 sensory perception of smell
2.22 2.60e-04 GO:0007606 sensory perception of chemical stimulus
1.24 7.33e-04 GO:0050896 response to stimulus
1.55 1.16e-03 GO:0003008 system process
1.25 7.61e-03 GO:0032501 multicellular organismal process
1.55 1.68e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.34 1.58e-05 GO:0071944 cell periphery
1.33 2.30e-05 GO:0005886 plasma membrane
1.21 8.08e-03 GO:0016021 integral to membrane
1.20 2.18e-02 GO:0031224 intrinsic to membrane
1.17 4.37e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.16 3.62e-09 GO:0004930 G-protein coupled receptor activity
1.70 1.41e-07 GO:0004872 receptor activity
2.60 3.57e-07 GO:0004984 olfactory receptor activity
1.79 6.27e-07 GO:0004888 transmembrane receptor activity
1.55 5.99e-06 GO:0004871 signal transducer activity
1.55 5.99e-06 GO:0060089 molecular transducer activity
6.34 9.46e-03 GO:0001608 nucleotide receptor activity, G-protein coupled
6.34 9.46e-03 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled