Motif ID: EN1,2.p2

Z-value: 3.041


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_154943466-0.572.1e-02Click!
EN1chr2_-_119322228-0.175.4e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_50318801 7.421 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr4_-_40211324 5.834 RBM47
RNA binding motif protein 47
chr2_+_96355661 4.682 NM_178495
NM_001163524
 ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr10_-_98021144 4.668 NM_001114094
NM_013314
 BLNK

B-cell linker

chr12_-_7172641 4.473 NM_031491
 RBP5
retinol binding protein 5, cellular
chr3_+_188197029 4.045


chr1_+_173111306 3.980 NM_001035230
 RABGAP1L
RAB GTPase activating protein 1-like
chr4_+_39874921 3.535 NM_004310
 RHOH
ras homolog gene family, member H
chr22_+_38627031 3.441 NM_004810
 GRAP2
GRB2-related adaptor protein 2
chr20_-_45410033 3.414 ZMYND8
zinc finger, MYND-type containing 8
chr4_-_80466177 3.379 NM_032693
 NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr2_-_158008763 3.292 NM_004288
 CYTIP
cytohesin 1 interacting protein
chrX_-_48212683 3.283 SLC38A5
solute carrier family 38, member 5
chr2_+_102401580 2.907 NM_003853
 IL18RAP
interleukin 18 receptor accessory protein
chr11_-_47356650 2.805 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr17_+_43165608 2.798 NM_013351
 TBX21
T-box 21
chr11_-_47356562 2.706 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr15_-_32416336 2.646 NM_001042497
NM_133647
 SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr22_+_38627129 2.626 GRAP2
GRB2-related adaptor protein 2
chr11_-_47356642 2.625 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
4.16 1.66e-02 GO:0006956 complement activation
3.40 6.01e-25 GO:0007608 sensory perception of smell
3.36 2.73e-03 GO:0006959 humoral immune response
3.26 2.63e-02 GO:0002449 lymphocyte mediated immunity
3.17 2.46e-23 GO:0007606 sensory perception of chemical stimulus
2.54 1.49e-02 GO:0002252 immune effector process
2.32 5.97e-17 GO:0007600 sensory perception
1.98 4.91e-03 GO:0045087 innate immune response
1.87 3.13e-06 GO:0006955 immune response
1.71 1.44e-08 GO:0050877 neurological system process
1.65 2.37e-09 GO:0003008 system process
1.63 6.38e-03 GO:0006952 defense response
1.49 7.34e-03 GO:0002376 immune system process
1.29 3.94e-10 GO:0050896 response to stimulus
1.24 4.76e-05 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.52 2.49e-02 GO:0005615 extracellular space
1.38 3.90e-11 GO:0071944 cell periphery
1.37 1.22e-10 GO:0005886 plasma membrane
1.32 8.22e-03 GO:0005576 extracellular region
1.22 1.95e-05 GO:0031224 intrinsic to membrane
1.22 3.03e-05 GO:0016021 integral to membrane
1.19 1.48e-04 GO:0044425 membrane part
1.13 5.25e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
3.57 2.36e-27 GO:0004984 olfactory receptor activity
2.36 2.73e-19 GO:0004930 G-protein coupled receptor activity
1.98 8.91e-17 GO:0004888 transmembrane receptor activity
1.76 3.06e-14 GO:0004872 receptor activity
1.68 2.28e-14 GO:0004871 signal transducer activity
1.68 2.28e-14 GO:0060089 molecular transducer activity