Motif ID: EN1,2.p2

Z-value: 3.041


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_154943466-0.572.1e-02Click!
EN1chr2_-_119322228-0.175.4e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_50318801 7.421 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr4_-_40211324 5.834 RBM47
RNA binding motif protein 47
chr2_+_96355661 4.682 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr10_-_98021144 4.668 NM_001114094
NM_013314
BLNK

B-cell linker

chr12_-_7172641 4.473 NM_031491
RBP5
retinol binding protein 5, cellular
chr3_+_188197029 4.045


chr1_+_173111306 3.980 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr4_+_39874921 3.535 NM_004310
RHOH
ras homolog gene family, member H
chr22_+_38627031 3.441 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr20_-_45410033 3.414 ZMYND8
zinc finger, MYND-type containing 8
chr4_-_80466177 3.379 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr2_-_158008763 3.292 NM_004288
CYTIP
cytohesin 1 interacting protein
chrX_-_48212683 3.283 SLC38A5
solute carrier family 38, member 5
chr2_+_102401580 2.907 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr11_-_47356650 2.805 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr17_+_43165608 2.798 NM_013351
TBX21
T-box 21
chr11_-_47356562 2.706 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr15_-_32416336 2.646 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr22_+_38627129 2.626 GRAP2
GRB2-related adaptor protein 2
chr11_-_47356642 2.625 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_+_59979857 2.577 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr11_-_47356672 2.550 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr17_-_40843530 2.549 ARHGAP27
Rho GTPase activating protein 27
chr11_+_123600553 2.541 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr6_-_43703024 2.477 GTPBP2
GTP binding protein 2
chr3_+_99733432 2.362 NM_005290
GPR15
G protein-coupled receptor 15
chr6_-_43703057 2.356 GTPBP2
GTP binding protein 2
chr2_+_68855436 2.348 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr12_+_6424293 2.326 NM_001242
CD27
CD27 molecule
chr4_-_38710376 2.307 NM_024943
TMEM156
transmembrane protein 156
chrX_+_65152004 2.301


chr10_-_104169458 2.249 PSD
pleckstrin and Sec7 domain containing
chrX_-_7855400 2.223 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr10_+_104169560 2.124 NM_024326
FBXL15
F-box and leucine-rich repeat protein 15
chr1_+_111217244 2.095 NM_000560
CD53
CD53 molecule
chr12_-_101396459 2.079 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_+_32515596 2.074 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr6_-_33085290 2.044 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr12_-_101115677 2.032 NM_002674
PMCH
pro-melanin-concentrating hormone
chr12_+_91620749 2.023 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr16_+_56567839 1.997 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr15_-_78050515 1.958 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr6_-_32121784 1.955 NM_032470
TNXB
tenascin XB
chr19_+_45973139 1.924 NM_006533
MIA
melanoma inhibitory activity
chr6_-_30188845 1.919 NM_007028
TRIM31
tripartite motif containing 31
chr17_-_53764867 1.917


chr11_-_47356479 1.883 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr19_+_47073029 1.867 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr6_-_33085329 1.789 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr3_-_150422474 1.789 NM_000096
CP
ceruloplasmin (ferroxidase)
chr6_-_123999640 1.786 NM_006073
TRDN
triadin
chrX_+_9391314 1.766 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr16_-_1761504 1.756 NME3
non-metastatic cells 3, protein expressed in
chr1_-_159306037 1.752 ARHGAP30
Rho GTPase activating protein 30
chr12_+_55018925 1.740 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr5_+_68703036 1.713 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr1_-_164402575 1.680 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr11_-_116605761 1.650 PCSK7
proprotein convertase subtilisin/kexin type 7
chr12_-_51585004 1.646 NM_002273
KRT8
keratin 8
chr14_+_87541220 1.634 NM_003608
GPR65
G protein-coupled receptor 65
chr1_-_180822686 1.627 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr3_-_113334657 1.622 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chrX_+_128741578 1.614 SASH3
SAM and SH3 domain containing 3
chr19_-_44518465 1.609 GMFG
glia maturation factor, gamma
chr3_-_185578621 1.609 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr11_-_64403712 1.607 EHD1
EH-domain containing 1
chr5_+_132021763 1.596 NM_002188
IL13
interleukin 13
chr11_+_22652957 1.594 GAS2
growth arrest-specific 2
chr18_+_27210737 1.592 NM_001134453
NM_177986
DSG4

desmoglein 4

chr20_+_54420574 1.590 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr22_+_49333327 1.589 NM_138433
KLHDC7B
kelch domain containing 7B
chr6_-_25834733 1.584 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr17_-_36594652 1.561 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr11_+_123639909 1.539 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr17_-_31441390 1.534 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr6_+_14032655 1.504 NM_001165034
RNF182
ring finger protein 182
chr1_+_57093030 1.494 NM_000562
C8A
complement component 8, alpha polypeptide
chr1_+_159032551 1.494 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr20_+_61838479 1.488 LIME1
Lck interacting transmembrane adaptor 1
chr7_-_25234582 1.476 NM_022150
NPVF
neuropeptide VF precursor
chr6_-_76022565 1.472 TMEM30A
transmembrane protein 30A
chr7_+_106897737 1.457 NM_005295
GPR22
G protein-coupled receptor 22
chrX_+_128741562 1.436 NM_018990
SASH3
SAM and SH3 domain containing 3
chr2_+_68445936 1.433 PLEK
pleckstrin
chr11_+_22652894 1.424 NM_005256
GAS2
growth arrest-specific 2
chr9_+_95886558 1.420 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr16_-_28425632 1.409 NM_145659
IL27
interleukin 27
chr6_+_42231121 1.409 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr22_+_29696662 1.407


chr6_+_6533932 1.406 NM_004271
LY86
lymphocyte antigen 86
chr20_-_34807882 1.377 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr1_-_240679380 1.376 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr10_-_91393610 1.375 NM_138316
NM_148978
PANK1

pantothenate kinase 1

chr14_+_22845851 1.374 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr2_-_88208650 1.361 NM_001443
FABP1
fatty acid binding protein 1, liver
chr12_-_101036407 1.343 NM_024057
NUP37
nucleoporin 37kDa
chrX_-_47374647 1.337 NM_002621
CFP
complement factor properdin
chr1_+_152206969 1.331 NM_130898
CREB3L4
cAMP responsive element binding protein 3-like 4
chr15_-_74091817 1.324 NM_138573
NRG4
neuregulin 4
chr14_+_99601498 1.324 NM_016337
EVL
Enah/Vasp-like
chr1_+_111544469 1.315


chr16_-_20271530 1.307 NM_001008389
NM_003361
UMOD

uromodulin

chr6_+_28601767 1.303 NM_001509
NM_003996
GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr7_-_38355949 1.289


chr6_+_160247962 1.281 NM_002377
MAS1
MAS1 oncogene
chr16_+_28850760 1.264 NM_001178098
NM_001770
CD19

CD19 molecule

chr16_-_79811475 1.261 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr14_-_20340377 1.255 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chrX_-_130792297 1.254 LOC286467
hypothetical LOC286467
chr19_-_44518516 1.251 NM_004877
GMFG
glia maturation factor, gamma
chr10_+_70152216 1.247 CCAR1
cell division cycle and apoptosis regulator 1
chr18_+_53863865 1.245 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_-_123918759 1.241 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr17_-_36209672 1.236 NM_181535
KRT28
keratin 28
chr14_+_77939845 1.235 NM_004796
NRXN3
neurexin 3
chr1_-_148854503 1.231


chr17_-_38081967 1.230 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr19_-_19487237 1.217 NM_032037
TSSK6
testis-specific serine kinase 6
chr1_-_114215768 1.217 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr4_-_54152480 1.215 NM_001126328
LNX1
ligand of numb-protein X 1
chr2_-_65013070 1.213 LOC400958
hypothetical LOC400958
chr11_-_56761250 1.213 NM_005161
APLNR
apelin receptor
chr10_-_116241572 1.206


chr14_+_59782222 1.204 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr1_+_160618143 1.203 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chrX_+_134803450 1.202 NM_018666
SAGE1
sarcoma antigen 1
chr6_+_35373632 1.198 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr11_+_123625632 1.185 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr19_-_40925151 1.176 NM_024660
TMEM149
transmembrane protein 149
chr3_-_184756101 1.175 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr15_+_42815851 1.174 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr20_+_61838389 1.172 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr12_+_49922592 1.161 DAZAP2
DAZ associated protein 2
chr8_-_107023 1.160 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr19_-_59309719 1.156 TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr1_+_25471470 1.150 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr12_-_54517241 1.149 MMP19
matrix metallopeptidase 19
chr1_+_154390939 1.148 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_+_110968594 1.147 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr1_-_218329684 1.139 BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr16_-_88358946 1.134 FANCA
Fanconi anemia, complementation group A
chr20_+_34019942 1.128 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr12_-_69434330 1.125 PTPRR
protein tyrosine phosphatase, receptor type, R
chr9_+_124072947 1.122 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr22_-_48865797 1.110 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr6_+_32713160 1.109 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr10_-_104168890 1.108 NM_002779
PSD
pleckstrin and Sec7 domain containing
chr6_+_31782618 1.100 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr5_-_86739683 1.099 CCNH
cyclin H
chr6_+_30212488 1.098 NM_138700
TRIM40
tripartite motif containing 40
chr14_-_20340830 1.095 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr6_-_41811916 1.093 NM_001167827
TFEB
transcription factor EB
chr14_-_22658078 1.081 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr1_+_144124547 1.079 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr7_-_26202626 1.079 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chrX_+_65300803 1.074 NM_001130860
NM_014799
HEPH

hephaestin

chr1_-_229627412 1.072 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr4_-_647974 1.069 PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr7_+_106293112 1.063 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr18_-_13905534 1.044 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr17_-_26648375 1.040 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr3_-_122862391 1.029 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr16_-_49272741 1.020 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr16_-_49272617 1.016 SNX20
sorting nexin 20
chr12_+_6925997 1.015 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr17_-_53946899 1.010 MTMR4
myotubularin related protein 4
chr18_-_22699650 1.010 NM_001650
AQP4
aquaporin 4
chrX_+_38545636 1.007 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr7_+_28418668 0.998 NM_182898
CREB5
cAMP responsive element binding protein 5
chr1_-_42574116 0.994 NM_001198850
FOXJ3
forkhead box J3
chr1_+_159943385 0.993 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr14_+_75907442 0.988 NM_004452
ESRRB
estrogen-related receptor beta
chr6_+_106653429 0.988 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr1_+_246635918 0.986 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr1_-_218329773 0.986 NM_006085
BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr12_+_6926014 0.982 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_+_43063817 0.979 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr1_-_47468029 0.977 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr15_+_89248423 0.975 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr11_+_5367182 0.970 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr1_+_224083047 0.968 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr6_+_161043214 0.964 NM_000301
NM_001168338
PLG

plasminogen

chr7_-_131843377 0.955 PLXNA4
plexin A4
chr1_+_15675182 0.950 NM_015849
CELA2B
chymotrypsin-like elastase family, member 2B
chr8_-_66863841 0.950 NM_002603
PDE7A
phosphodiesterase 7A
chr16_+_557011 0.948 NM_176677
NHLRC4
PIGQ
NHL repeat containing 4
phosphatidylinositol glycan anchor biosynthesis, class Q
chr2_+_171316462 0.947 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr20_-_57015698 0.942 NM_001336
CTSZ
cathepsin Z
chr6_-_159386007 0.940 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr1_+_210275735 0.935 DTL
denticleless homolog (Drosophila)
chr14_+_99601517 0.929 EVL
Enah/Vasp-like
chr4_+_186587537 0.928 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr6_+_14225836 0.925 NM_001040280
NM_004233
CD83

CD83 molecule

chr13_-_45654296 0.921 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_-_23107106 0.921 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr1_+_210275752 0.896 DTL
denticleless homolog (Drosophila)
chr12_-_48246488 0.893 NM_001012300
MCRS1
microspherule protein 1
chr1_+_157526127 0.893 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr12_-_94469357 0.890 NM_032147
USP44
ubiquitin specific peptidase 44
chr4_+_74500748 0.890 ALB
albumin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.40 6.01e-25 GO:0007608 sensory perception of smell
3.17 2.46e-23 GO:0007606 sensory perception of chemical stimulus
2.32 5.97e-17 GO:0007600 sensory perception
1.29 3.94e-10 GO:0050896 response to stimulus
1.65 2.37e-09 GO:0003008 system process
1.71 1.44e-08 GO:0050877 neurological system process
1.87 3.13e-06 GO:0006955 immune response
1.24 4.76e-05 GO:0032501 multicellular organismal process
3.36 2.73e-03 GO:0006959 humoral immune response
1.98 4.91e-03 GO:0045087 innate immune response
1.63 6.38e-03 GO:0006952 defense response
1.49 7.34e-03 GO:0002376 immune system process
2.54 1.49e-02 GO:0002252 immune effector process
4.16 1.66e-02 GO:0006956 complement activation
3.26 2.63e-02 GO:0002449 lymphocyte mediated immunity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 3.90e-11 GO:0071944 cell periphery
1.37 1.22e-10 GO:0005886 plasma membrane
1.22 1.95e-05 GO:0031224 intrinsic to membrane
1.22 3.03e-05 GO:0016021 integral to membrane
1.19 1.48e-04 GO:0044425 membrane part
1.13 5.25e-03 GO:0016020 membrane
1.32 8.22e-03 GO:0005576 extracellular region
1.52 2.49e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.57 2.36e-27 GO:0004984 olfactory receptor activity
2.36 2.73e-19 GO:0004930 G-protein coupled receptor activity
1.98 8.91e-17 GO:0004888 transmembrane receptor activity
1.68 2.28e-14 GO:0004871 signal transducer activity
1.68 2.28e-14 GO:0060089 molecular transducer activity
1.76 3.06e-14 GO:0004872 receptor activity