Motif ID: RXRG_dimer.p3

Z-value: 1.071


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR1H2chr19_+_55571493-0.601.3e-02Click!
PPARGchr3_+_123043320.552.8e-02Click!
RXRAchr9_+_1363581450.401.3e-01Click!
PPARAchr22_+_44925354-0.165.5e-01Click!
RXRGchr1_-_1636809410.136.4e-01Click!
RXRBchr6_-_332761310.078.0e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_116205830 2.076 NM_000040
APOC3
apolipoprotein C-III
chr12_-_6535481 2.076 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr5_+_92944680 2.042 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr2_+_138438277 1.462 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr11_-_116213511 1.442 NM_000039
APOA1
apolipoprotein A-I
chr5_+_80292313 1.432 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr6_+_30702586 1.376 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr6_+_144040751 1.236 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr16_-_86527608 1.192 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr12_+_54910767 1.171 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr7_-_100630912 1.071 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr16_+_4654710 1.006 MGRN1
mahogunin, ring finger 1
chr20_-_19981005 0.942 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr5_-_42847716 0.941 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr2_+_73294852 0.917 NM_006062
SMYD5
SMYD family member 5
chr2_-_27966715 0.894 NM_022128
RBKS
ribokinase
chr2_+_219354692 0.881 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr12_+_119900677 0.879 HNF1A
HNF1 homeobox A
chr20_+_41621079 0.864 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr20_+_19981157 0.861 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr1_+_78126787 0.851 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr18_-_44731078 0.841 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr2_+_218992053 0.834 NM_007127
VIL1
villin 1
chr16_+_79829794 0.827 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr18_-_44730706 0.793 SMAD7
SMAD family member 7
chr20_+_41621119 0.789 SGK2
serum/glucocorticoid regulated kinase 2
chr10_-_52315390 0.758 A1CF
APOBEC1 complementation factor
chr19_+_54708302 0.736 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_219141761 0.718 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_-_206732348 0.712 NM_005006
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr2_+_206732575 0.698 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr19_+_54708312 0.695 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_+_144439069 0.694 NM_002614
PDZK1
PDZ domain containing 1
chr12_+_119900931 0.674 NM_000545
HNF1A
HNF1 homeobox A
chr2_+_206732562 0.672 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr6_+_142510075 0.658 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr1_+_61320213 0.647 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr10_-_21854616 0.629 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr17_-_33178987 0.626 HNF1B
HNF1 homeobox B
chr2_+_27966985 0.626 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr11_+_117948301 0.615 NM_001142281
NM_001655
ARCN1

archain 1

chr20_+_55569542 0.611 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr3_-_49424322 0.603 RHOA
ras homolog gene family, member A
chr11_+_117948350 0.599 ARCN1
archain 1
chr2_+_27967116 0.590 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr3_-_114947681 0.588 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr6_+_142510094 0.586 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_+_27967102 0.582 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_+_161725172 0.571 TANK
TRAF family member-associated NFKB activator
chr1_-_172153087 0.568 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr17_-_33179118 0.563 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr3_-_49424413 0.561 RHOA
ras homolog gene family, member A
chr9_+_103335983 0.557 RNF20
ring finger protein 20
chr10_-_52315436 0.550 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr6_+_142510108 0.548 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_+_198073358 0.547 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr3_-_49424380 0.538 RHOA
ras homolog gene family, member A
chr3_-_49424397 0.537 RHOA
ras homolog gene family, member A
chr3_-_49424427 0.534 RHOA
ras homolog gene family, member A
chr3_-_49424361 0.491 RHOA
ras homolog gene family, member A
chr17_+_7474128 0.489 SHBG
sex hormone-binding globulin
chr11_-_123261549 0.486 NM_001013743
TMEM225
transmembrane protein 225
chr18_+_45594326 0.468


chr6_+_142510034 0.454 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_-_198072805 0.451 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr3_-_49424404 0.450 RHOA
ras homolog gene family, member A
chr22_+_22445035 0.449 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr10_+_102722275 0.445 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr2_+_159021653 0.445 PKP4
plakophilin 4
chr2_+_27967159 0.440 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr14_-_74713062 0.438 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr14_-_74713086 0.433 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_-_219141199 0.416 NM_020935
USP37
ubiquitin specific peptidase 37
chr2_-_198072767 0.410 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr14_-_94693359 0.410 DICER1
dicer 1, ribonuclease type III
chr20_+_36095263 0.401 NM_021215
RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr1_-_172153024 0.399 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr4_+_30330963 0.393 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr3_-_114947330 0.392 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr14_-_74713088 0.391 NM_006827
TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr9_+_103335964 0.390 RNF20
ring finger protein 20
chr2_+_219141546 0.388 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr4_-_102487356 0.386 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr13_+_99539269 0.385 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr19_+_16169664 0.382 NM_001130524
NM_032493
AP1M1

adaptor-related protein complex 1, mu 1 subunit

chr2_+_198072965 0.380 NM_002157
HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr6_-_2785682 0.379 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr2_+_198073257 0.366 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr14_-_74713039 0.360 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr19_+_41980248 0.358 LOC284408
hypothetical LOC284408
chr2_+_206732859 0.353 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr2_-_218843109 0.342 NM_001087
AAMP
angio-associated, migratory cell protein
chr1_-_15784048 0.342 NM_024758
AGMAT
agmatine ureohydrolase (agmatinase)
chr17_+_3324096 0.339 NM_001128085
ASPA
aspartoacylase
chr20_+_36095621 0.339


chr10_+_685887 0.330 C10orf108
chromosome 10 open reading frame 108
chr14_+_94693744 0.328 FLJ45244
hypothetical locus FLJ45244
chr17_+_7474177 0.320 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr3_-_49424506 0.309 RHOA
ras homolog gene family, member A
chr11_+_117735502 0.309 NM_004788
UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr11_+_117735529 0.307 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr8_-_81104938 0.304 NM_014018
MRPS28
mitochondrial ribosomal protein S28
chr14_-_20642214 0.304


chr8_+_22909305 0.297 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr3_-_49424529 0.295 NM_001664
RHOA
ras homolog gene family, member A
chr15_+_94674849 0.295 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr5_+_132237253 0.287 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr12_+_105692466 0.284 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr2_-_218843088 0.283 AAMP
angio-associated, migratory cell protein
chr12_+_65949327 0.282 NM_018448
CAND1
cullin-associated and neddylation-dissociated 1
chr18_-_45594206 0.275 NM_006111
ACAA2
acetyl-CoA acyltransferase 2
chr12_-_52407470 0.272 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr9_+_88086932 0.270


chr16_-_3433490 0.269 NM_152457
ZNF597
zinc finger protein 597
chr2_-_198073242 0.269 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr11_+_117735530 0.268 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr1_-_120112989 0.268 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr1_-_95311031 0.267 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr14_-_74713012 0.267 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr12_+_65949414 0.266 CAND1
cullin-associated and neddylation-dissociated 1
chr2_-_218843039 0.265 AAMP
angio-associated, migratory cell protein
chr3_-_49178773 0.263 NM_022903
CCDC71
coiled-coil domain containing 71
chr2_-_64099935 0.260 VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr2_-_198072868 0.260 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr19_+_54708389 0.259 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr17_+_1592893 0.257 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr20_+_30409649 0.255 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr11_+_64079665 0.253 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr3_-_49178762 0.251 CCDC71
coiled-coil domain containing 71
chr19_+_54708247 0.246 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr9_+_114182216 0.244 HSDL2
hydroxysteroid dehydrogenase like 2
chr16_+_30617962 0.243 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr9_+_103335941 0.241 NM_019592
RNF20
ring finger protein 20
chr8_-_82769761 0.240 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr11_+_117735558 0.238 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr20_-_32363268 0.235 NM_001161766
AHCY
adenosylhomocysteinase
chr3_-_49178738 0.230 CCDC71
coiled-coil domain containing 71
chr9_+_114182009 0.230 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr11_-_61415429 0.229 NM_021727
FADS3
fatty acid desaturase 3
chr1_+_45046740 0.222 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr4_+_30331289 0.222 PCDH7
protocadherin 7
chr20_+_36095552 0.219 RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr1_-_101263867 0.216 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr10_+_103995297 0.207 NM_004193
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr2_+_218843358 0.205 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr6_+_143813472 0.204 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr12_+_67489063 0.203 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr12_-_49708279 0.199 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr9_+_73954100 0.197 NM_004293
GDA
guanine deaminase
chr13_+_20612709 0.193 SAP18
Sin3A-associated protein, 18kDa
chr22_-_40194602 0.191 NM_032758
PHF5A
PHD finger protein 5A
chr2_-_19421852 0.187 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr20_+_42593849 0.185 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr1_-_153213454 0.184 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr20_+_54400979 0.180 NM_001324
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr1_-_201411533 0.180 NM_004997
MYBPH
myosin binding protein H
chr2_-_24160683 0.171 TP53I3
tumor protein p53 inducible protein 3
chr20_-_36095236 0.171 NM_014657
TTI1
Tel2 interacting protein 1 homolog (S. pombe)
chr17_+_1592879 0.167 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr12_-_117295095 0.166 NM_016281
TAOK3
TAO kinase 3
chr1_-_158579653 0.165 COPA
coatomer protein complex, subunit alpha
chr9_+_91123204 0.164 NM_024077
SECISBP2
SECIS binding protein 2
chr7_+_288195 0.164 FAM20C
family with sequence similarity 20, member C
chrX_+_105823723 0.161 NM_024539
RNF128
ring finger protein 128
chrX_+_38305634 0.159 NM_004615
TSPAN7
tetraspanin 7
chr1_-_158579680 0.159 COPA
coatomer protein complex, subunit alpha
chr19_-_40317829 0.149 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chr18_-_45593852 0.148 ACAA2
acetyl-CoA acyltransferase 2
chr10_+_103995248 0.148 GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr1_-_154147787 0.147 NM_006912
RIT1
Ras-like without CAAX 1
chr1_-_79244948 0.146 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr14_-_94693418 0.146 NM_177438
DICER1
dicer 1, ribonuclease type III
chr9_+_73954206 0.146 GDA
guanine deaminase
chr1_+_158579685 0.143 NM_015331
NCSTN
nicastrin
chr10_-_62431203 0.142 RHOBTB1
Rho-related BTB domain containing 1
chr22_+_48927610 0.138 NM_001164106
MOV10L1
Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
chr22_+_28493351 0.138 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr9_+_73954174 0.138 GDA
guanine deaminase
chr1_-_153213425 0.136 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr4_+_109761170 0.135 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr14_+_23937766 0.135 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr9_+_73954237 0.133 GDA
guanine deaminase
chr1_-_158579583 0.131


chr1_-_149404954 0.129 NM_212551
NM_001136543
LYSMD1

LysM, putative peptidoglycan-binding, domain containing 1

chr19_-_55708936 0.128 NM_001114598
ASPDH
aspartate dehydrogenase domain containing
chr12_+_65949631 0.128 CAND1
cullin-associated and neddylation-dissociated 1
chr14_-_20636337 0.126 ZNF219
zinc finger protein 219
chr20_+_43943254 0.125 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr9_+_73954214 0.123 GDA
guanine deaminase
chr4_-_84150885 0.120 LIN54
lin-54 homolog (C. elegans)
chr15_-_98091118 0.119 LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr2_+_108432008 0.118 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr17_+_38403935 0.118 NM_000988
RPL27
ribosomal protein L27
chr4_+_140806536 0.117 MGST2
microsomal glutathione S-transferase 2
chr3_-_52287297 0.116 WDR82
WD repeat domain 82
chr1_+_1351370 0.114 NM_001146685
TMEM88B
transmembrane protein 88B
chr8_+_67787444 0.114 NM_001033578
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr17_+_38403991 0.114 RPL27
ribosomal protein L27
chr11_+_86426518 0.112 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr6_+_31731647 0.108 NM_019101
APOM
apolipoprotein M

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
20.47 3.31e-03 GO:0048199 vesicle targeting, to, from or within Golgi

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
30.70 1.67e-02 GO:0034366 spherical high-density lipoprotein particle

Gene overrepresentation in function category:

enrichment   p-value GO term description
27.29 3.07e-02 GO:0003706 ligand-regulated transcription factor activity