Motif ID: GATA6.p2

Z-value: 3.835


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GATA6chr18_+_18003401-0.342.0e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_70745615 20.025 NM_033496
HK1
hexokinase 1
chr7_-_100077072 18.168 NM_003227
TFR2
transferrin receptor 2
chr12_-_52975823 13.604 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_52975777 13.566 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr7_-_142369534 13.013 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr7_-_142369519 12.754 KEL
Kell blood group, metallo-endopeptidase
chr1_-_156923111 12.023 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr6_+_31782618 11.610 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr6_-_49712483 10.977 NM_000324
RHAG
Rh-associated glycoprotein
chr9_-_99740243 10.261 NM_197978
HEMGN
hemogen
chr1_-_27113018 9.474 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr16_-_87570716 9.425 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr11_+_118463906 9.210 NM_001024382
HMBS
hydroxymethylbilane synthase
chr12_+_52105131 8.159 AMHR2
anti-Mullerian hormone receptor, type II
chr1_+_43063817 7.967 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chrX_+_65152004 7.841


chr17_-_59437782 7.652 NM_000873
ICAM2
intercellular adhesion molecule 2
chr19_-_12858956 7.114 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr17_-_53764867 7.098


chr1_+_152560179 6.700 NM_080429
AQP10
aquaporin 10
chr16_+_142853 6.681 NM_005332
HBZ
hemoglobin, zeta
chr11_+_63730766 6.545 FERMT3
fermitin family member 3
chr8_-_38127489 6.529 NM_000349
STAR
steroidogenic acute regulatory protein
chr1_+_181028016 6.402 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr1_-_153537810 6.290 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr2_+_27573206 5.912 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chrX_+_44588192 5.738 NM_022076
DUSP21
dual specificity phosphatase 21
chrX_+_152684150 5.692 PLXNB3
plexin B3
chr19_-_60241424 5.632 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr16_+_557011 5.420 NM_176677
NHLRC4
PIGQ
NHL repeat containing 4
phosphatidylinositol glycan anchor biosynthesis, class Q
chr19_-_11355882 5.397 NM_000121
EPOR
erythropoietin receptor
chr21_+_42697058 5.263 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr8_+_124263932 5.213 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr19_+_10258642 5.135 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr9_+_263025 5.035 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr19_+_16860807 5.008 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr8_+_124264054 4.967 FAM83A
family with sequence similarity 83, member A
chr16_-_45339605 4.952 NM_182493
MYLK3
myosin light chain kinase 3
chr2_-_43919392 4.940 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_+_220145197 4.837 NM_002191
INHA
inhibin, alpha
chr19_+_40824486 4.780 NM_014209
ETV2
ets variant 2
chr19_+_16860871 4.775 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr19_-_13074513 4.731 LYL1
lymphoblastic leukemia derived sequence 1
chr17_-_3766708 4.571 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr9_-_113977285 4.469 NM_022486
SUSD1
sushi domain containing 1
chr1_-_153537362 4.426 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr2_+_43919606 4.414 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr17_-_39822366 4.378 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr10_-_48036698 4.330 NM_016204
GDF2
growth differentiation factor 2
chr2_+_108571336 4.214 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr19_-_13074669 4.134 LYL1
lymphoblastic leukemia derived sequence 1
chr11_+_63730720 4.119 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr17_-_3766441 3.997 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr12_+_25096472 3.881 NM_006152
LRMP
lymphoid-restricted membrane protein
chr16_+_31446703 3.856 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr7_+_106293112 3.843 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chrX_-_55074125 3.799 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr17_-_71352090 3.786 UNC13D
unc-13 homolog D (C. elegans)
chr5_-_176868483 3.775 DOK3
docking protein 3
chr2_-_68952006 3.770 NM_014482
BMP10
bone morphogenetic protein 10
chr2_+_138438277 3.750 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr17_-_45196465 3.673 FAM117A
family with sequence similarity 117, member A
chr22_+_33792125 3.669 NM_001008494
ISX
intestine-specific homeobox
chr19_+_13999959 3.665 NM_080864
RLN3
relaxin 3
chr19_-_60360768 3.651 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr17_-_45196516 3.595 NM_030802
FAM117A
family with sequence similarity 117, member A
chr6_-_49820030 3.471 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr1_+_25471470 3.432 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr1_-_25619863 3.359 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chrX_+_65299352 3.332 HEPH
hephaestin
chr17_+_53761293 3.306 LOC100506779
hypothetical LOC100506779
chr20_-_45410033 3.260 ZMYND8
zinc finger, MYND-type containing 8
chr7_+_150321771 3.205 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chrX_+_65299157 3.185 NM_138737
HEPH
hephaestin
chr17_-_71352017 3.090 UNC13D
unc-13 homolog D (C. elegans)
chr20_+_42463387 3.041 HNF4A
hepatocyte nuclear factor 4, alpha
chr19_-_53081326 3.005 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr1_+_157441133 2.890 NM_002036
DARC
Duffy blood group, chemokine receptor
chr2_+_220087135 2.864 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr22_-_25205376 2.861 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr4_-_40212670 2.849 NM_019027
RBM47
RNA binding motif protein 47
chr2_-_175207521 2.845 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr9_+_138677197 2.800 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr15_-_48626193 2.797 NM_203494
USP50
ubiquitin specific peptidase 50
chr1_-_26266571 2.749 NM_032588
TRIM63
tripartite motif containing 63
chr8_-_86477585 2.734 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr9_-_70780574 2.704


chr13_-_45654296 2.699 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_200698493 2.698 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr19_-_53081383 2.623 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr6_-_11887265 2.614 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr8_-_41774296 2.609 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr21_+_37714470 2.590 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr6_-_50025115 2.576 NM_001166478
DEFB133
defensin, beta 133
chr2_-_74424041 2.555 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr14_+_19681734 2.549 NM_001004724
OR4N5
olfactory receptor, family 4, subfamily N, member 5
chr13_-_45654327 2.511 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_145672525 2.478 NM_003923
FOXH1
forkhead box H1
chr10_-_99521701 2.409 NM_003015
SFRP5
secreted frizzled-related protein 5
chr15_-_41300316 2.393 EPB42
erythrocyte membrane protein band 4.2
chr3_-_10309600 2.389 NM_001134944
NM_001134945
NM_001134946
GHRL


ghrelin/obestatin prepropeptide


chr11_+_60858611 2.381 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr1_+_196874867 2.375 PTPRC
protein tyrosine phosphatase, receptor type, C
chr10_+_11246934 2.360 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr6_-_30236667 2.298 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr9_+_124177421 2.283 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr13_-_45654292 2.265 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_-_78509662 2.243 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr1_-_30969016 2.210 NM_002379
MATN1
matrilin 1, cartilage matrix protein
chr5_-_34020445 2.202 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr17_+_54188205 2.193 PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr20_+_42463279 2.156 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr11_-_116213511 2.149 NM_000039
APOA1
apolipoprotein A-I
chrX_-_76824726 2.146 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr7_-_112515068 2.128 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr17_-_53761119 2.121 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr9_+_33230165 2.096 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr12_+_25096755 2.093 LRMP
lymphoid-restricted membrane protein
chr11_-_59369501 2.064 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr22_+_21543671 2.032 IGLV4-3
immunoglobulin lambda variable 4-3
chr17_-_71352182 2.031 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr1_+_198263352 2.008 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr9_+_71009746 2.004 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr16_+_80086454 1.983 NM_030629
CMIP
c-Maf-inducing protein
chr1_-_100416358 1.982 NM_144620
LRRC39
leucine rich repeat containing 39
chr9_-_126309510 1.952 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr4_-_68678181 1.939 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr7_+_139175420 1.938 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_-_180636373 1.916 NM_172000
TEDDM1
transmembrane epididymal protein 1
chr16_+_24765052 1.915 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr13_-_48873735 1.913 NM_030925
CAB39L
calcium binding protein 39-like
chr11_+_93940121 1.912 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chrX_-_78509367 1.902 ITM2A
integral membrane protein 2A
chr10_+_70517863 1.894 SRGN
serglycin
chr3_-_57209319 1.887 NM_003865
HESX1
HESX homeobox 1
chr12_-_14887648 1.848 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr5_+_1254709 1.840 NM_001003841
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chr2_+_201756048 1.838 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr2_-_188127294 1.815 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr6_-_32251654 1.806 AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr7_-_112515035 1.802 GPR85
G protein-coupled receptor 85
chr22_+_24468168 1.774 MYO18B
myosin XVIIIB
chr22_+_24468110 1.756 NM_032608
MYO18B
myosin XVIIIB
chr1_+_196874839 1.750 PTPRC
protein tyrosine phosphatase, receptor type, C
chr2_+_108571209 1.733 LIMS1
LIM and senescent cell antigen-like domains 1
chr6_-_118103062 1.730


chr3_-_180467483 1.669 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr1_-_109651140 1.655 NM_001010985
MYBPHL
myosin binding protein H-like
chr7_-_112514990 1.643 GPR85
G protein-coupled receptor 85
chr10_+_70517823 1.616 NM_002727
SRGN
serglycin
chr4_+_39084936 1.614 KLB
klotho beta
chr4_-_123596921 1.613 NM_000586
IL2
interleukin 2
chr12_-_69434330 1.601 PTPRR
protein tyrosine phosphatase, receptor type, R
chr3_+_88270951 1.570 NM_018293
ZNF654
zinc finger protein 654
chr15_-_32398220 1.567 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr16_+_20682812 1.564 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr11_-_64520964 1.559 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr9_-_205892 1.543 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr15_-_41300488 1.542 EPB42
erythrocyte membrane protein band 4.2
chr20_-_54400628 1.536 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr1_-_166149867 1.514 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr6_+_31623370 1.507 NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr7_+_129634935 1.497 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr6_+_135558572 1.497


chr15_-_41300526 1.490 NM_000119
NM_001114134
EPB42

erythrocyte membrane protein band 4.2

chrX_-_24600661 1.469 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr3_-_3127057 1.467 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr1_+_26517032 1.462 CD52
CD52 molecule
chr12_+_70618892 1.450 NM_173353
TPH2
tryptophan hydroxylase 2
chr2_-_96924582 1.442 NM_001172667
FAM178B
family with sequence similarity 178, member B
chr6_-_123999640 1.437 NM_006073
TRDN
triadin
chr16_-_4778317 1.437 NM_001154458
NM_144605
SEPT12

septin 12

chr15_-_74091817 1.431 NM_138573
NRG4
neuregulin 4
chr11_-_16387001 1.430 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr20_+_55569542 1.414 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr6_+_135558744 1.393 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr2_-_43756964 1.390 NM_001101330
LOC728819
hCG1645220
chr6_+_167624792 1.389 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr4_-_54152385 1.385 LNX1
ligand of numb-protein X 1
chr19_-_45611110 1.353 NM_020956
NM_181882
PRX

periaxin

chr10_+_11247419 1.343 CELF2
CUGBP, Elav-like family member 2
chr2_+_169637255 1.342 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr2_+_241456834 1.327 NM_000030
AGXT
alanine-glyoxylate aminotransferase
chr21_-_14840506 1.319 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_+_26473376 1.317 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr20_+_42463350 1.317 HNF4A
hepatocyte nuclear factor 4, alpha
chr16_+_24709922 1.314 TNRC6A
trinucleotide repeat containing 6A
chr16_-_66535457 1.305 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr9_+_96561750 1.297 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr12_-_68291208 1.281 NM_201550
LRRC10
leucine rich repeat containing 10
chr3_+_186529376 1.278 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr2_-_121875610 1.278 CLASP1
cytoplasmic linker associated protein 1
chr2_+_158666627 1.274 NM_173355
UPP2
uridine phosphorylase 2
chr1_-_41399632 1.272 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr8_-_30121741 1.267 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr21_+_37377116 1.266 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr17_-_36594652 1.261 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr18_+_2836979 1.261 NM_032048
EMILIN2
elastin microfibril interfacer 2
chr7_+_127020924 1.255 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr17_+_72047709 1.249 NM_001077620
PRCD
progressive rod-cone degeneration

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 4.24e-09 GO:0032501 multicellular organismal process
1.63 2.47e-06 GO:0065008 regulation of biological quality
4.60 1.59e-05 GO:0007586 digestion
1.66 3.37e-05 GO:0003008 system process
3.74 7.96e-05 GO:0006805 xenobiotic metabolic process
3.74 7.96e-05 GO:0071466 cellular response to xenobiotic stimulus
3.71 9.20e-05 GO:0009410 response to xenobiotic stimulus
2.38 2.49e-04 GO:0007608 sensory perception of smell
1.25 8.35e-04 GO:0050896 response to stimulus
2.75 2.25e-03 GO:0008202 steroid metabolic process
2.74 2.47e-03 GO:0030168 platelet activation
2.13 5.05e-03 GO:0007606 sensory perception of chemical stimulus
1.97 5.64e-03 GO:0048878 chemical homeostasis
2.07 1.07e-02 GO:0007596 blood coagulation
2.07 1.07e-02 GO:0050817 coagulation
2.05 1.26e-02 GO:0007599 hemostasis
2.04 1.49e-02 GO:0001775 cell activation
1.92 3.27e-02 GO:0050878 regulation of body fluid levels
2.66 3.47e-02 GO:0003013 circulatory system process
2.66 3.47e-02 GO:0008015 blood circulation
7.56 3.71e-02 GO:0072378 blood coagulation, fibrin clot formation
1.71 4.45e-02 GO:0042592 homeostatic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 1.67e-07 GO:0071944 cell periphery
1.40 4.74e-07 GO:0005886 plasma membrane
1.49 4.25e-04 GO:0005576 extracellular region
1.21 3.40e-03 GO:0044425 membrane part
1.64 5.62e-03 GO:0044421 extracellular region part
1.23 6.32e-03 GO:0031224 intrinsic to membrane
1.21 2.45e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.43 4.76e-05 GO:0004984 olfactory receptor activity
1.53 1.72e-03 GO:0004872 receptor activity
1.73 7.67e-03 GO:0004930 G-protein coupled receptor activity
4.80 1.51e-02 GO:0019825 oxygen binding
1.54 2.06e-02 GO:0004888 transmembrane receptor activity
1.39 3.44e-02 GO:0004871 signal transducer activity
1.39 3.44e-02 GO:0060089 molecular transducer activity