Motif ID: KLF4.p3

Z-value: 3.507


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_1092901070.401.2e-01Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_6718417 8.399 NM_005490
 SH2D3A
SH2 domain containing 3A
chr1_+_32992131 8.225


chr19_-_45888259 4.346 NM_004756
 NUMBL
numb homolog (Drosophila)-like
chr19_-_51829778 4.233 NM_033258
 GNG8
guanine nucleotide binding protein (G protein), gamma 8
chrX_+_15666312 4.224 NM_007220
 CA5B
carbonic anhydrase VB, mitochondrial
chr6_-_6632197 4.070


chr8_-_145609737 3.963 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr1_-_208046011 3.884 NM_006147
 IRF6
interferon regulatory factor 6
chr8_-_144887876 3.660 NM_198488
 FAM83H
family with sequence similarity 83, member H
chr1_+_26728846 3.529 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_-_126839546 3.420 NM_001083914
 CTBP2
C-terminal binding protein 2
chr18_-_26935883 3.341 NM_004949
NM_024422
 DSC2

desmocollin 2

chr11_+_384238 3.337 PKP3
plakophilin 3
chr3_-_46710137 3.301 NM_001190707
NM_147129
 ALS2CL

ALS2 C-terminal like

chr5_-_16989371 3.299 NM_012334
 MYO10
myosin X
chr1_+_26728827 3.245 NM_002953
 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr11_+_384199 3.222 NM_007183
 PKP3
plakophilin 3
chr19_-_16868674 3.211 CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr17_-_37196463 3.184 NM_002230
NM_021991
 JUP

junction plakoglobin

chr8_-_127639647 3.184 FAM84B
family with sequence similarity 84, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 48 entries
enrichment   p-value GO term description
1.34 4.24e-02 GO:0000165 MAPKKK cascade
1.24 3.36e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.23 2.06e-02 GO:0009887 organ morphogenesis
1.22 3.93e-02 GO:0030030 cell projection organization
1.21 2.24e-02 GO:0009790 embryo development
1.18 1.64e-05 GO:0023051 regulation of signaling
1.17 6.59e-04 GO:0009966 regulation of signal transduction
1.16 8.88e-04 GO:0009653 anatomical structure morphogenesis
1.16 3.17e-03 GO:0035556 intracellular signal transduction
1.15 7.47e-03 GO:0007399 nervous system development
1.14 2.10e-03 GO:0006464 protein modification process
1.14 5.63e-03 GO:0006996 organelle organization
1.12 9.42e-04 GO:0048518 positive regulation of biological process
1.12 1.63e-03 GO:0071842 cellular component organization at cellular level
1.12 1.74e-02 GO:0030154 cell differentiation
1.12 2.76e-02 GO:0048523 negative regulation of cellular process
1.12 3.34e-02 GO:0048869 cellular developmental process
1.12 3.52e-02 GO:0043412 macromolecule modification
1.11 5.49e-05 GO:0016043 cellular component organization
1.11 1.78e-04 GO:0031323 regulation of cellular metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
1.35 4.10e-02 GO:0005819 spindle
1.31 6.41e-03 GO:0015629 actin cytoskeleton
1.30 2.45e-02 GO:0000323 lytic vacuole
1.30 2.45e-02 GO:0005764 lysosome
1.29 2.34e-02 GO:0044456 synapse part
1.27 4.65e-02 GO:0005773 vacuole
1.24 3.71e-02 GO:0045202 synapse
1.23 4.07e-04 GO:0015630 microtubule cytoskeleton
1.23 1.31e-02 GO:0000139 Golgi membrane
1.23 3.63e-02 GO:0005768 endosome
1.22 3.61e-03 GO:0030054 cell junction
1.19 2.37e-07 GO:0012505 endomembrane system
1.18 5.47e-10 GO:0005829 cytosol
1.18 8.51e-04 GO:0005794 Golgi apparatus
1.15 4.59e-06 GO:0044428 nuclear part
1.15 3.82e-03 GO:0005654 nucleoplasm
1.15 4.28e-02 GO:0044430 cytoskeletal part
1.14 4.72e-04 GO:0031981 nuclear lumen
1.14 1.13e-03 GO:0005856 cytoskeleton
1.13 7.90e-07 GO:0043234 protein complex

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.28 1.14e-03 GO:0019904 protein domain specific binding
1.14 4.44e-04 GO:0017076 purine nucleotide binding
1.14 5.16e-04 GO:0032553 ribonucleotide binding
1.14 5.16e-04 GO:0032555 purine ribonucleotide binding
1.14 2.44e-03 GO:0030554 adenyl nucleotide binding
1.14 3.59e-03 GO:0032559 adenyl ribonucleotide binding
1.14 8.37e-03 GO:0005524 ATP binding
1.13 3.56e-26 GO:0005515 protein binding
1.13 8.53e-05 GO:0000166 nucleotide binding
1.13 1.94e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.07 1.62e-20 GO:0005488 binding