Motif ID: EGR1..3.p2

Z-value: 1.260


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR1chr5_+_1378290650.514.3e-02Click!
EGR2chr10_-_642461290.381.5e-01Click!
EGR3chr8_-_226066530.322.2e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_44010543 1.789 NM_024015
 HOXB4
homeobox B4
chr7_+_128257698 1.378 NM_001127487
NM_001458
 FLNC

filamin C, gamma

chr2_+_109112428 1.213 NM_001099289
 SH3RF3
SH3 domain containing ring finger 3
chr22_+_18081968 1.167 NM_002688
 SEPT5
septin 5
chr1_-_31154023 1.165 NM_014654
 SDC3
syndecan 3
chr6_-_85530617 0.995 NM_001080508
 TBX18
T-box 18
chr2_-_144991386 0.971 ZEB2
zinc finger E-box binding homeobox 2
chr22_+_38075703 0.933 NM_004711
NM_145731
 SYNGR1

synaptogyrin 1

chr13_-_37341859 0.927 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
 TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr14_-_60022487 0.879 NM_174978
 C14orf39
chromosome 14 open reading frame 39
chr5_-_88215034 0.863 NM_001193350
NM_002397
 MEF2C

myocyte enhancer factor 2C

chr19_+_45799060 0.844 NM_001042545
 LTBP4
latent transforming growth factor beta binding protein 4
chr7_-_150283794 0.802 NM_172057
 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr14_-_64416307 0.782 SPTB
spectrin, beta, erythrocytic
chr19_-_1518875 0.773 NM_001174118
NM_203304
 MEX3D

mex-3 homolog D (C. elegans)

chr17_+_77582774 0.772 NM_005052
 RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr2_+_198377561 0.766 NM_006226
 PLCL1
phospholipase C-like 1
chr7_-_150576660 0.764 NM_001003801
 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr9_-_122679387 0.727 NM_001009936
NM_015651
 PHF19

PHD finger protein 19

chr1_-_32574185 0.722 NM_023009
 MARCKSL1
MARCKS-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 121 entries
enrichment   p-value GO term description
2.59 2.72e-02 GO:0031047 gene silencing by RNA
2.46 4.97e-04 GO:0016458 gene silencing
2.21 1.48e-04 GO:0040029 regulation of gene expression, epigenetic
2.00 3.04e-06 GO:0016569 covalent chromatin modification
2.00 1.87e-02 GO:0043414 macromolecule methylation
1.98 9.26e-06 GO:0016570 histone modification
1.87 1.69e-10 GO:0016568 chromatin modification
1.73 1.80e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.65 8.47e-03 GO:0050767 regulation of neurogenesis
1.64 1.89e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.63 5.07e-09 GO:0010629 negative regulation of gene expression
1.62 2.48e-06 GO:0006325 chromatin organization
1.59 5.62e-14 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.59 5.52e-09 GO:0010628 positive regulation of gene expression
1.58 2.43e-02 GO:0051960 regulation of nervous system development
1.57 2.74e-08 GO:0051254 positive regulation of RNA metabolic process
1.57 2.57e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.57 3.44e-06 GO:0051253 negative regulation of RNA metabolic process
1.56 8.53e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.55 4.41e-05 GO:0007417 central nervous system development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 42 entries
enrichment   p-value GO term description
3.11 3.72e-02 GO:0031519 PcG protein complex
3.05 2.46e-02 GO:0070603 SWI/SNF-type complex
2.60 1.04e-04 GO:0035770 RNA granule
2.54 4.30e-02 GO:0042641 actomyosin
2.46 2.19e-07 GO:0016585 chromatin remodeling complex
2.40 4.38e-02 GO:0000118 histone deacetylase complex
2.06 2.89e-03 GO:0008021 synaptic vesicle
1.84 4.33e-02 GO:0019717 synaptosome
1.62 3.18e-02 GO:0031252 cell leading edge
1.59 4.77e-02 GO:0030425 dendrite
1.57 1.05e-02 GO:0005667 transcription factor complex
1.55 7.43e-05 GO:0045202 synapse
1.49 2.40e-02 GO:0044456 synapse part
1.44 1.37e-02 GO:0043005 neuron projection
1.42 4.22e-04 GO:0030054 cell junction
1.36 1.24e-03 GO:0044451 nucleoplasm part
1.33 3.18e-09 GO:0031981 nuclear lumen
1.33 2.32e-03 GO:0031982 vesicle
1.31 1.32e-02 GO:0031410 cytoplasmic vesicle
1.31 1.95e-02 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
2.46 4.79e-02 GO:0018024 histone-lysine N-methyltransferase activity
2.02 4.60e-02 GO:0042393 histone binding
1.79 6.22e-03 GO:0003714 transcription corepressor activity
1.73 1.40e-03 GO:0010843 promoter binding
1.71 1.58e-03 GO:0000975 regulatory region DNA binding
1.71 1.58e-03 GO:0001067 regulatory region nucleic acid binding
1.71 1.58e-03 GO:0044212 transcription regulatory region DNA binding
1.68 2.17e-05 GO:0016564 transcription repressor activity
1.66 1.45e-02 GO:0003682 chromatin binding
1.65 9.74e-05 GO:0008134 transcription factor binding
1.62 8.52e-06 GO:0000988 protein binding transcription factor activity
1.62 8.52e-06 GO:0000989 transcription factor binding transcription factor activity
1.62 1.41e-05 GO:0003712 transcription cofactor activity
1.62 1.40e-04 GO:0016563 transcription activator activity
1.60 1.83e-16 GO:0030528 transcription regulator activity
1.60 1.59e-02 GO:0003713 transcription coactivator activity
1.54 1.54e-08 GO:0043565 sequence-specific DNA binding
1.53 1.08e-12 GO:0001071 nucleic acid binding transcription factor activity
1.53 1.08e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
1.44 7.77e-03 GO:0004674 protein serine/threonine kinase activity