Motif ID: EGR1..3.p2

Z-value: 1.260


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR1chr5_+_1378290650.514.3e-02Click!
EGR2chr10_-_642461290.381.5e-01Click!
EGR3chr8_-_226066530.322.2e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_44010543 1.789 NM_024015
HOXB4
homeobox B4
chr7_+_128257698 1.378 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr2_+_109112428 1.213 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr22_+_18081968 1.167 NM_002688
SEPT5
septin 5
chr1_-_31154023 1.165 NM_014654
SDC3
syndecan 3
chr6_-_85530617 0.995 NM_001080508
TBX18
T-box 18
chr2_-_144991386 0.971 ZEB2
zinc finger E-box binding homeobox 2
chr22_+_38075703 0.933 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chr13_-_37341859 0.927 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr14_-_60022487 0.879 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr5_-_88215034 0.863 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr19_+_45799060 0.844 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chr7_-_150283794 0.802 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr14_-_64416307 0.782 SPTB
spectrin, beta, erythrocytic
chr19_-_1518875 0.773 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr17_+_77582774 0.772 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr2_+_198377561 0.766 NM_006226
PLCL1
phospholipase C-like 1
chr7_-_150576660 0.764 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr9_-_122679387 0.727 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr1_-_32574185 0.722 NM_023009
MARCKSL1
MARCKS-like 1
chr17_+_78630793 0.670 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chrX_+_9392980 0.657 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr7_-_100331417 0.652 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr5_-_178704934 0.649 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr12_+_50271283 0.645 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr12_+_50586958 0.642 ACVRL1
activin A receptor type II-like 1
chr1_+_65763978 0.623 LEPR
leptin receptor
chr7_+_106472243 0.617 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr1_+_65763945 0.615 NM_001198687
NM_001198688
NM_001198689
LEPR


leptin receptor


chr2_+_181553333 0.610 NM_182678
NM_006357
UBE2E3

ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)

chr19_+_18391423 0.604


chr5_-_178705036 0.601 NM_014244
NM_021599
ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif, 2

chr17_-_71747867 0.598 NM_052916
RNF157
ring finger protein 157
chr12_+_46133 0.592 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr7_-_106088565 0.589 NM_175884
FLJ36031
hypothetical protein FLJ36031
chr1_-_38243747 0.588 NM_004468
FHL3
four and a half LIM domains 3
chr17_-_44058612 0.588 NM_024017
HOXB9
homeobox B9
chr9_+_138341752 0.587 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr19_+_7891884 0.585 SNAPC2
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr9_-_129701644 0.581 NM_013443
ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr15_-_81113676 0.580 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr1_+_41022066 0.575 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chrX_-_135161185 0.575 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr14_+_106009489 0.568 NCRNA00221
non-protein coding RNA 221
chr7_-_525556 0.568 PDGFA
platelet-derived growth factor alpha polypeptide
chr1_-_38243716 0.567 FHL3
four and a half LIM domains 3
chr2_+_10101081 0.564 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr19_+_14405216 0.562 PKN1
protein kinase N1
chr4_+_72271218 0.558 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr7_-_50828159 0.553 GRB10
growth factor receptor-bound protein 10
chr17_-_1029758 0.549 NM_021962
ABR
active BCR-related gene
chr7_-_130069399 0.544 NM_138693
KLF14
Kruppel-like factor 14
chr1_+_35507145 0.541 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr4_+_151218862 0.540 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr3_-_172660545 0.536 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr1_-_39877883 0.534 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr10_+_112394094 0.526 NM_001134363
RBM20
RNA binding motif protein 20
chr1_+_177261627 0.526 FAM20B
family with sequence similarity 20, member B
chr21_-_43368963 0.525 NM_000071
CBS
cystathionine-beta-synthase
chr22_+_18091065 0.525 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr6_+_135544138 0.524 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr1_+_199884072 0.524 NM_020443
NAV1
neuron navigator 1
chr1_-_39877928 0.522 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr15_-_76890626 0.520 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr15_-_27901628 0.518 TJP1
tight junction protein 1 (zona occludens 1)
chr4_+_129951877 0.518 PHF17
PHD finger protein 17
chr2_+_42128521 0.512 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr9_-_129701695 0.511 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr13_-_113916066 0.510 RASA3
RAS p21 protein activator 3
chr1_-_109742020 0.506 NM_002959
SORT1
sortilin 1
chr2_-_236740710 0.504


chr6_+_99389300 0.503 NM_005604
POU3F2
POU class 3 homeobox 2
chr9_-_122679283 0.501 PHF19
PHD finger protein 19
chr19_+_16296734 0.500 KLF2
Kruppel-like factor 2 (lung)
chr16_-_53520208 0.496 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr4_+_81406765 0.495 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr4_-_809879 0.494 NM_006651
CPLX1
complexin 1
chr4_-_109308893 0.494 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr6_-_46566969 0.492 RCAN2
regulator of calcineurin 2
chr19_+_60487345 0.491 NM_032430
BRSK1
BR serine/threonine kinase 1
chr4_-_25473528 0.491 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr8_+_15442100 0.490 NM_006765
NM_178234
TUSC3

tumor suppressor candidate 3

chr19_+_659766 0.490 NM_001040134
NM_002579
PALM

paralemmin

chr5_-_81082699 0.488 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr6_+_135544170 0.488 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr16_-_19803606 0.487 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr13_-_113916115 0.485 RASA3
RAS p21 protein activator 3
chr16_+_2016807 0.485 NM_001130012
NM_004785
SLC9A3R2

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

chr7_-_81910956 0.483 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr19_-_45888259 0.483 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr1_+_117950029 0.481 NM_017709
FAM46C
family with sequence similarity 46, member C
chr7_-_156125876 0.479 C7orf13
chromosome 7 open reading frame 13
chr6_+_133604181 0.479 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr19_-_15172773 0.477 NM_000435
NOTCH3
notch 3
chr15_-_80125403 0.475 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chrX_+_153339814 0.475 NM_017514
PLXNA3
plexin A3
chr18_-_51406359 0.475 TCF4
transcription factor 4
chr1_-_182273114 0.470 GLT25D2
glycosyltransferase 25 domain containing 2
chr22_-_18384251 0.469 NM_001670
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr6_+_99389318 0.467 POU3F2
POU class 3 homeobox 2
chr9_-_129701602 0.464 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr18_-_21186107 0.462 NM_015461
ZNF521
zinc finger protein 521
chr11_-_32413486 0.462 WT1
Wilms tumor 1
chr15_-_23659329 0.459 NM_024490
ATP10A
ATPase, class V, type 10A
chr19_-_3737382 0.459 NM_139354
NM_139355
MATK

megakaryocyte-associated tyrosine kinase

chr19_+_60487578 0.457 BRSK1
BR serine/threonine kinase 1
chr9_-_129701707 0.457 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr13_-_113916159 0.455 RASA3
RAS p21 protein activator 3
chr19_+_3536541 0.454 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr15_+_38520594 0.452 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr22_-_20551937 0.452 MAPK1
mitogen-activated protein kinase 1
chr1_-_15723363 0.452 NM_001229
NM_032996
CASP9

caspase 9, apoptosis-related cysteine peptidase

chr1_-_11663762 0.452 NM_006341
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr10_+_98582005 0.449 NM_001170765
NM_001170766
LCOR

ligand dependent nuclear receptor corepressor

chr2_+_102602579 0.448 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr18_+_12397894 0.448 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr22_-_20551722 0.447 MAPK1
mitogen-activated protein kinase 1
chr13_-_107317460 0.443 NM_001080396
FAM155A
family with sequence similarity 155, member A
chrX_-_152592450 0.443 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chrX_-_152591936 0.442 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr5_-_176857207 0.441 NM_005451
NM_203352
NM_213636
PDLIM7


PDZ and LIM domain 7 (enigma)


chr1_+_35507197 0.440 ZMYM4
zinc finger, MYM-type 4
chr8_+_16929116 0.439 NM_181723
EFHA2
EF-hand domain family, member A2
chr6_+_133604203 0.435 EYA4
eyes absent homolog 4 (Drosophila)
chr7_+_44754700 0.435 ZMIZ2
zinc finger, MIZ-type containing 2
chr1_+_246087230 0.434 TRIM58
tripartite motif containing 58
chr12_+_119562737 0.434 NM_001033677
CABP1
calcium binding protein 1
chr21_-_38210531 0.433 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr11_+_279113 0.432 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr13_-_113916186 0.430 NM_007368
RASA3
RAS p21 protein activator 3
chr11_+_46359878 0.428 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr19_+_34994701 0.426 NM_001238
CCNE1
cyclin E1
chr2_+_120820140 0.426 NM_002193
INHBB
inhibin, beta B
chr7_-_150576634 0.426 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr22_+_42751487 0.425 NM_013327
PARVB
parvin, beta
chr18_-_21185968 0.423 ZNF521
zinc finger protein 521
chr7_-_81910740 0.421 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr2_-_236741352 0.420 NM_001485
GBX2
gastrulation brain homeobox 2
chr3_-_38666122 0.419 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr6_+_19945578 0.419 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr10_-_17536181 0.418 NM_001004470
ST8SIA6
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr1_-_15723279 0.415 CASP9
caspase 9, apoptosis-related cysteine peptidase
chr7_+_156126157 0.411 NM_030936
NM_001184996
RNF32

ring finger protein 32

chr7_-_526005 0.411 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr1_+_78126787 0.411 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr9_-_13269562 0.410 MPDZ
multiple PDZ domain protein
chr17_+_56832492 0.408 TBX2
T-box 2
chr20_-_61600834 0.408 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr1_+_148788410 0.407 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr20_+_30814048 0.406 DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr9_+_115678365 0.405 NM_133374
ZNF618
zinc finger protein 618
chr1_+_21708502 0.401 ALPL
alkaline phosphatase, liver/bone/kidney
chr7_+_154720547 0.399 INSIG1
insulin induced gene 1
chr3_-_39170105 0.399 NM_033027
CSRNP1
cysteine-serine-rich nuclear protein 1
chr19_+_16296632 0.398 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr7_+_93861808 0.396 NM_000089
COL1A2
collagen, type I, alpha 2
chr11_+_46359821 0.396 MDK
midkine (neurite growth-promoting factor 2)
chr17_+_56832255 0.396 TBX2
T-box 2
chr5_-_176857158 0.392 PDLIM7
PDZ and LIM domain 7 (enigma)
chr1_-_54644566 0.392 NM_018070
NM_145716
SSBP3

single stranded DNA binding protein 3

chr5_+_172000793 0.389 NM_001142651
NEURL1B
neuralized homolog 1B (Drosophila)
chr11_-_61415429 0.388 NM_021727
FADS3
fatty acid desaturase 3
chr14_-_57688560 0.388 NM_001001872
C14orf37
chromosome 14 open reading frame 37
chr8_-_72919161 0.386 MSC
musculin
chr7_+_44754978 0.384 NM_031449
ZMIZ2
zinc finger, MIZ-type containing 2
chr10_+_11099860 0.383 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr22_+_20101661 0.381 NM_015094
HIC2
hypermethylated in cancer 2
chr7_-_150576957 0.381 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr20_-_4177519 0.380 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr19_+_10261646 0.380 NM_003259
ICAM5
intercellular adhesion molecule 5, telencephalin
chr3_-_159306214 0.380


chr5_-_81082614 0.379 SSBP2
single-stranded DNA binding protein 2
chr19_+_10574055 0.376 NM_001145056
SLC44A2
solute carrier family 44, member 2
chr1_-_51198328 0.376 FAF1
Fas (TNFRSF6) associated factor 1
chr19_-_7896974 0.375 NM_206833
CTXN1
cortexin 1
chr11_-_32413635 0.374 NM_000378
NM_024424
NM_024426
WT1


Wilms tumor 1


chr10_+_11100075 0.372 CELF2
CUGBP, Elav-like family member 2
chr19_+_1226510 0.371 NM_017914
C19orf24
chromosome 19 open reading frame 24
chr11_+_46359781 0.371 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr20_+_30813851 0.370 NM_006892
NM_175848
NM_175849
DNMT3B


DNA (cytosine-5-)-methyltransferase 3 beta


chr3_-_39170038 0.370 CSRNP1
cysteine-serine-rich nuclear protein 1
chr2_+_200031333 0.370


chr19_+_540849 0.369 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr5_+_176493488 0.369 NSD1
nuclear receptor binding SET domain protein 1
chr17_+_58058774 0.368 MRC2
mannose receptor, C type 2
chr21_-_37260488 0.367 HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr8_+_72918889 0.366


chr11_-_2863536 0.363 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr4_-_10068055 0.362 NM_053042
ZNF518B
zinc finger protein 518B
chr10_-_126839000 0.360 CTBP2
C-terminal binding protein 2
chr2_-_200028977 0.359 SATB2
SATB homeobox 2
chr8_-_72919241 0.358 NM_005098
MSC
musculin
chr5_-_10814179 0.358 DAP
death-associated protein
chr16_-_1862162 0.358 NM_001163560
C16orf73
chromosome 16 open reading frame 73
chr14_-_57688669 0.358 C14orf37
chromosome 14 open reading frame 37
chr3_-_159306532 0.357 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr5_-_10814344 0.356 NM_004394
DAP
death-associated protein
chr16_+_1143241 0.355 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr7_+_150387649 0.354 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr12_-_123023312 0.353 CCDC92
coiled-coil domain containing 92

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 2.56e-21 GO:0050794 regulation of cellular process
1.20 8.59e-21 GO:0050789 regulation of biological process
1.18 3.28e-18 GO:0065007 biological regulation
1.11 2.25e-15 GO:0009987 cellular process
1.35 2.65e-15 GO:0010468 regulation of gene expression
1.30 2.75e-15 GO:0060255 regulation of macromolecule metabolic process
1.28 1.11e-14 GO:0031323 regulation of cellular metabolic process
1.24 2.45e-14 GO:0044260 cellular macromolecule metabolic process
1.59 5.62e-14 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.35 7.46e-14 GO:0010556 regulation of macromolecule biosynthetic process
1.36 9.08e-14 GO:0051252 regulation of RNA metabolic process
1.35 9.61e-14 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.26 9.94e-14 GO:0019222 regulation of metabolic process
1.35 5.35e-13 GO:0048519 negative regulation of biological process
1.32 7.09e-13 GO:0009889 regulation of biosynthetic process
1.27 1.36e-12 GO:0080090 regulation of primary metabolic process
1.32 1.54e-12 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.32 1.54e-12 GO:0031326 regulation of cellular biosynthetic process
1.35 3.73e-12 GO:0048523 negative regulation of cellular process
1.35 4.12e-12 GO:0006355 regulation of transcription, DNA-dependent
1.44 4.81e-12 GO:0007399 nervous system development
1.21 6.40e-12 GO:0043170 macromolecule metabolic process
1.30 1.60e-11 GO:0051171 regulation of nitrogen compound metabolic process
1.17 8.64e-11 GO:0044237 cellular metabolic process
1.87 1.69e-10 GO:0016568 chromatin modification
1.31 2.44e-10 GO:0048522 positive regulation of cellular process
1.35 8.65e-10 GO:0006464 protein modification process
1.34 1.86e-09 GO:0043412 macromolecule modification
1.28 2.11e-09 GO:0048518 positive regulation of biological process
1.22 3.54e-09 GO:0032502 developmental process
1.63 5.07e-09 GO:0010629 negative regulation of gene expression
1.59 5.52e-09 GO:0010628 positive regulation of gene expression
1.23 1.09e-08 GO:0007275 multicellular organismal development
1.49 2.18e-08 GO:0022008 neurogenesis
1.15 2.25e-08 GO:0044238 primary metabolic process
1.57 2.74e-08 GO:0051254 positive regulation of RNA metabolic process
1.27 8.27e-08 GO:0044267 cellular protein metabolic process
1.42 9.13e-08 GO:0010604 positive regulation of macromolecule metabolic process
1.54 2.16e-07 GO:0031327 negative regulation of cellular biosynthetic process
1.13 2.19e-07 GO:0008152 metabolic process
1.57 2.57e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.53 2.58e-07 GO:0009890 negative regulation of biosynthetic process
1.33 2.90e-07 GO:0023051 regulation of signaling
1.47 4.34e-07 GO:0048699 generation of neurons
1.38 4.82e-07 GO:0009893 positive regulation of metabolic process
1.39 7.70e-07 GO:0031325 positive regulation of cellular metabolic process
1.24 9.59e-07 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.49 1.31e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.42 1.67e-06 GO:0009892 negative regulation of metabolic process
1.22 1.80e-06 GO:0048856 anatomical structure development
1.44 1.87e-06 GO:0050793 regulation of developmental process
1.45 2.07e-06 GO:0006351 transcription, DNA-dependent
1.62 2.48e-06 GO:0006325 chromatin organization
1.53 2.61e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.00 3.04e-06 GO:0016569 covalent chromatin modification
1.57 3.44e-06 GO:0051253 negative regulation of RNA metabolic process
1.52 3.61e-06 GO:0010558 negative regulation of macromolecule biosynthetic process
1.47 3.95e-06 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.47 4.35e-06 GO:0051173 positive regulation of nitrogen compound metabolic process
1.22 4.75e-06 GO:0019538 protein metabolic process
1.35 4.94e-06 GO:0051239 regulation of multicellular organismal process
1.42 6.69e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.56 8.53e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.98 9.26e-06 GO:0016570 histone modification
1.23 1.35e-05 GO:0071842 cellular component organization at cellular level
1.64 1.89e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.26 1.92e-05 GO:0030154 cell differentiation
1.22 2.48e-05 GO:0048731 system development
1.50 3.14e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.47 3.34e-05 GO:0030182 neuron differentiation
1.25 3.47e-05 GO:0048869 cellular developmental process
1.40 3.53e-05 GO:0048468 cell development
1.55 4.41e-05 GO:0007417 central nervous system development
1.41 4.61e-05 GO:0009891 positive regulation of biosynthetic process
1.49 4.79e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.22 5.04e-05 GO:0071841 cellular component organization or biogenesis at cellular level
1.36 6.30e-05 GO:0010646 regulation of cell communication
1.41 1.14e-04 GO:0031328 positive regulation of cellular biosynthetic process
2.21 1.48e-04 GO:0040029 regulation of gene expression, epigenetic
1.39 1.59e-04 GO:0031324 negative regulation of cellular metabolic process
1.54 1.88e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.44 2.19e-04 GO:0045595 regulation of cell differentiation
1.40 2.21e-04 GO:0051128 regulation of cellular component organization
1.46 2.82e-04 GO:0051276 chromosome organization
1.42 2.91e-04 GO:2000026 regulation of multicellular organismal development
1.19 2.94e-04 GO:0034641 cellular nitrogen compound metabolic process
1.23 3.37e-04 GO:0090304 nucleic acid metabolic process
1.17 3.44e-04 GO:0023052 signaling
1.26 4.49e-04 GO:0016070 RNA metabolic process
2.46 4.97e-04 GO:0016458 gene silencing
1.18 7.44e-04 GO:0006807 nitrogen compound metabolic process
1.26 1.76e-03 GO:0006996 organelle organization
1.73 1.80e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.34 1.84e-03 GO:0032774 RNA biosynthetic process
1.27 2.19e-03 GO:0009966 regulation of signal transduction
1.43 4.22e-03 GO:0048666 neuron development
1.39 4.43e-03 GO:0009790 embryo development
1.26 5.42e-03 GO:0009653 anatomical structure morphogenesis
1.46 5.73e-03 GO:0031175 neuron projection development
1.53 7.72e-03 GO:0007420 brain development
1.65 8.47e-03 GO:0050767 regulation of neurogenesis
1.39 8.50e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.54 8.84e-03 GO:0018193 peptidyl-amino acid modification
1.16 8.95e-03 GO:0016043 cellular component organization
1.36 1.72e-02 GO:0006468 protein phosphorylation
2.00 1.87e-02 GO:0043414 macromolecule methylation
1.15 1.99e-02 GO:0071840 cellular component organization or biogenesis
1.58 2.43e-02 GO:0051960 regulation of nervous system development
1.29 2.69e-02 GO:0006793 phosphorus metabolic process
1.29 2.69e-02 GO:0006796 phosphate metabolic process
1.46 2.70e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
2.59 2.72e-02 GO:0031047 gene silencing by RNA
1.42 3.01e-02 GO:0000904 cell morphogenesis involved in differentiation
1.46 3.61e-02 GO:0007409 axonogenesis
1.25 3.62e-02 GO:0035556 intracellular signal transduction
1.41 3.66e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.49 3.82e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.44 3.93e-02 GO:0048812 neuron projection morphogenesis
1.42 3.93e-02 GO:0019226 transmission of nerve impulse
1.42 3.93e-02 GO:0035637 multicellular organismal signaling
1.44 4.55e-02 GO:0032583 regulation of gene-specific transcription

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 1.38e-32 GO:0044424 intracellular part
1.13 1.49e-30 GO:0005622 intracellular
1.16 1.78e-21 GO:0043227 membrane-bounded organelle
1.24 3.42e-21 GO:0005634 nucleus
1.16 4.15e-21 GO:0043231 intracellular membrane-bounded organelle
1.14 7.54e-21 GO:0043226 organelle
1.14 3.29e-20 GO:0043229 intracellular organelle
1.14 1.40e-13 GO:0005737 cytoplasm
1.30 1.45e-09 GO:0044428 nuclear part
1.33 3.18e-09 GO:0031981 nuclear lumen
1.04 6.94e-08 GO:0044464 cell part
1.04 7.44e-08 GO:0005623 cell
2.46 2.19e-07 GO:0016585 chromatin remodeling complex
1.24 3.05e-06 GO:0070013 intracellular organelle lumen
1.13 4.31e-06 GO:0044444 cytoplasmic part
1.23 6.20e-06 GO:0031974 membrane-enclosed lumen
1.20 1.06e-05 GO:0043234 protein complex
1.23 1.24e-05 GO:0043233 organelle lumen
1.30 5.61e-05 GO:0005654 nucleoplasm
1.55 7.43e-05 GO:0045202 synapse
1.23 9.05e-05 GO:0005829 cytosol
2.60 1.04e-04 GO:0035770 RNA granule
1.12 1.71e-04 GO:0044446 intracellular organelle part
1.12 2.47e-04 GO:0044422 organelle part
1.42 4.22e-04 GO:0030054 cell junction
1.36 1.24e-03 GO:0044451 nucleoplasm part
1.33 2.32e-03 GO:0031982 vesicle
2.06 2.89e-03 GO:0008021 synaptic vesicle
1.14 3.34e-03 GO:0032991 macromolecular complex
1.57 1.05e-02 GO:0005667 transcription factor complex
1.31 1.32e-02 GO:0031410 cytoplasmic vesicle
1.44 1.37e-02 GO:0043005 neuron projection
1.31 1.95e-02 GO:0031988 membrane-bounded vesicle
1.49 2.40e-02 GO:0044456 synapse part
3.05 2.46e-02 GO:0070603 SWI/SNF-type complex
1.31 2.83e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.62 3.18e-02 GO:0031252 cell leading edge
3.11 3.72e-02 GO:0031519 PcG protein complex
2.54 4.30e-02 GO:0042641 actomyosin
1.84 4.33e-02 GO:0019717 synaptosome
2.40 4.38e-02 GO:0000118 histone deacetylase complex
1.59 4.77e-02 GO:0030425 dendrite

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.21 4.94e-25 GO:0005515 protein binding
1.11 1.09e-19 GO:0005488 binding
1.60 1.83e-16 GO:0030528 transcription regulator activity
1.53 1.08e-12 GO:0001071 nucleic acid binding transcription factor activity
1.53 1.08e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
1.30 1.40e-10 GO:0003677 DNA binding
1.24 1.70e-10 GO:0003676 nucleic acid binding
1.54 1.54e-08 GO:0043565 sequence-specific DNA binding
1.24 6.28e-06 GO:0000166 nucleotide binding
1.25 6.73e-06 GO:0008270 zinc ion binding
1.62 8.52e-06 GO:0000988 protein binding transcription factor activity
1.62 8.52e-06 GO:0000989 transcription factor binding transcription factor activity
1.62 1.41e-05 GO:0003712 transcription cofactor activity
1.68 2.17e-05 GO:0016564 transcription repressor activity
1.65 9.74e-05 GO:0008134 transcription factor binding
1.62 1.40e-04 GO:0016563 transcription activator activity
1.73 1.40e-03 GO:0010843 promoter binding
1.71 1.58e-03 GO:0000975 regulatory region DNA binding
1.71 1.58e-03 GO:0001067 regulatory region nucleic acid binding
1.71 1.58e-03 GO:0044212 transcription regulatory region DNA binding
1.21 2.53e-03 GO:0032553 ribonucleotide binding
1.21 2.53e-03 GO:0032555 purine ribonucleotide binding
1.19 2.83e-03 GO:0046914 transition metal ion binding
1.21 3.57e-03 GO:0017076 purine nucleotide binding
1.14 4.76e-03 GO:0046872 metal ion binding
1.79 6.22e-03 GO:0003714 transcription corepressor activity
1.44 7.77e-03 GO:0004674 protein serine/threonine kinase activity
1.20 9.06e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.13 1.01e-02 GO:0043167 ion binding
1.13 1.03e-02 GO:0043169 cation binding
1.66 1.45e-02 GO:0003682 chromatin binding
1.60 1.59e-02 GO:0003713 transcription coactivator activity
1.31 2.09e-02 GO:0016301 kinase activity
1.35 2.69e-02 GO:0004672 protein kinase activity
1.21 3.66e-02 GO:0032559 adenyl ribonucleotide binding
1.31 4.35e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.21 4.53e-02 GO:0030554 adenyl nucleotide binding
2.02 4.60e-02 GO:0042393 histone binding
2.46 4.79e-02 GO:0018024 histone-lysine N-methyltransferase activity