Motif ID: STAT2,4,6.p2

Z-value: 1.391


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT4chr2_-_191723996-0.233.9e-01Click!
STAT2chr12_-_550401830.136.4e-01Click!
STAT6chr12_-_557914430.097.4e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_51200347 3.065 NM_000424
KRT5
keratin 5
chr3_-_188945921 2.554 BCL6
B-cell CLL/lymphoma 6
chr18_+_59295123 2.268 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr19_-_49552638 2.040 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr3_-_188946168 1.929 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr9_-_116920232 1.824 NM_002160
TNC
tenascin C
chr10_+_75343352 1.376 PLAU
plasminogen activator, urokinase
chr5_+_38882017 1.370 OSMR
oncostatin M receptor
chr1_-_68071635 1.366 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr2_-_178645718 1.309 NM_016953
PDE11A
phosphodiesterase 11A
chr9_-_88751923 1.248 NM_002048
GAS1
growth arrest-specific 1
chr19_-_54258935 1.221 NM_006179
NTF4
neurotrophin 4
chr7_-_5429702 1.205 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr3_+_189353502 1.198 LPP
LIM domain containing preferred translocation partner in lipoma
chr12_-_92488767 1.151


chr12_+_92488932 1.136 SOCS2
suppressor of cytokine signaling 2
chrX_+_105932536 1.067 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr1_-_27565923 1.050 NM_004672
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr5_+_145296313 1.041 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr6_+_54819527 1.028 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr12_+_51730101 1.012 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr5_+_38881719 0.991 NM_003999
OSMR
oncostatin M receptor
chr20_+_54637714 0.981 NM_003222
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr1_+_203740391 0.959 CDK18
cyclin-dependent kinase 18
chr5_-_38881636 0.947


chr19_+_15079141 0.944 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr7_-_13992351 0.938 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_-_35572694 0.899 NM_003214
TEAD3
TEA domain family member 3
chr2_-_151052391 0.892 NM_005168
RND3
Rho family GTPase 3
chr2_-_160764819 0.887 NM_000888
ITGB6
integrin, beta 6
chr19_+_49248003 0.879 NM_013361
ZNF223
zinc finger protein 223
chr9_-_131555111 0.873 NM_004878
PTGES
prostaglandin E synthase
chr19_+_40299058 0.858 FXYD3
FXYD domain containing ion transport regulator 3
chr8_-_130868315 0.857 NM_031415
GSDMC
gasdermin C
chr20_+_19903778 0.856 RIN2
Ras and Rab interactor 2
chr10_+_88718167 0.849 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr3_-_48607596 0.843 NM_000094
COL7A1
collagen, type VII, alpha 1
chr11_-_11986704 0.839 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr11_-_119504726 0.814 TRIM29
tripartite motif containing 29
chr20_-_14266200 0.805 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr11_-_119513429 0.803 TRIM29
tripartite motif containing 29
chr11_-_8788765 0.802 NM_213618
ST5
suppression of tumorigenicity 5
chr8_-_127639892 0.801 NM_174911
FAM84B
family with sequence similarity 84, member B
chr9_-_109291130 0.796 KLF4
Kruppel-like factor 4 (gut)
chr10_-_95231933 0.795 NM_013451
NM_133337
MYOF

myoferlin

chr1_-_20682541 0.791


chr12_-_83830670 0.772 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr5_+_38881716 0.770 NM_001168355
OSMR
oncostatin M receptor
chr2_-_160765008 0.764 ITGB6
integrin, beta 6
chr2_+_17585287 0.756 NM_003385
VSNL1
visinin-like 1
chr12_-_83830710 0.747 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr12_-_83830700 0.746 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr18_-_26876622 0.733 NM_001941
NM_024423
DSC3

desmocollin 3

chr1_+_24518501 0.720 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr20_+_51023159 0.714 TSHZ2
teashirt zinc finger homeobox 2
chr3_+_114414064 0.711 NM_033254
BOC
Boc homolog (mouse)
chr7_-_41709191 0.695 NM_002192
INHBA
inhibin, beta A
chr12_+_51729239 0.683 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr8_-_10550026 0.682 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr19_-_56196611 0.681 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr20_+_2743613 0.680 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr17_+_72827227 0.671 SEPT9
septin 9
chr16_-_28457728 0.666 NUPR1
nuclear protein, transcriptional regulator, 1
chr1_-_27565412 0.665 MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr17_-_68100537 0.659 LOC100499467
hypothetical LOC100499467
chr1_+_68070573 0.655


chr5_-_16561936 0.650 NM_019000
FAM134B
family with sequence similarity 134, member B
chr5_+_131437383 0.649 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr19_+_40298571 0.642 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr11_+_113672378 0.637 NNMT
nicotinamide N-methyltransferase
chr14_+_95792299 0.637 NM_000710
BDKRB1
bradykinin receptor B1
chr5_+_67558217 0.633 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_+_73145098 0.632 RGNEF
190 kDa guanine nucleotide exchange factor
chr17_+_7199178 0.631 NM_198154
TMEM95
transmembrane protein 95
chr1_+_24518398 0.622 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr17_-_38979178 0.617 NM_001079675
ETV4
ets variant 4
chr9_+_676640 0.609


chr1_-_143706300 0.609 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr17_-_73867748 0.608 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr16_-_28457825 0.602 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr3_+_189354167 0.599 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr15_+_60838053 0.596 TLN2
talin 2
chr6_-_56615544 0.595 NM_001723
NM_015548
DST

dystonin

chr11_+_113672407 0.595 NNMT
nicotinamide N-methyltransferase
chr8_-_127639647 0.594 FAM84B
family with sequence similarity 84, member B
chr12_+_6363482 0.591 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr3_-_170346760 0.591 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr12_+_50913220 0.585 NM_005556
KRT7
keratin 7
chr11_+_10283171 0.579 NM_001124
ADM
adrenomedullin
chr6_+_31190505 0.579 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr20_+_51022352 0.570 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr17_+_72827185 0.569 NM_006640
SEPT9
septin 9
chr11_+_93394025 0.568 NM_001098672
HEPHL1
hephaestin-like 1
chr14_-_50204612 0.567 SAV1
salvador homolog 1 (Drosophila)
chr11_+_57122153 0.563 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr20_+_17622319 0.561 NM_001159495
BANF2
barrier to autointegration factor 2
chr14_+_74815233 0.553 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr5_+_140454382 0.546 NM_018936
PCDHB2
protocadherin beta 2
chr3_+_184453547 0.545 NM_032047
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr21_-_27139563 0.541 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr9_-_109291575 0.540 KLF4
Kruppel-like factor 4 (gut)
chr20_-_44746529 0.540 NM_001011554
NM_001193340
SLC13A3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr12_+_50913274 0.535 KRT7
keratin 7
chr4_-_122063118 0.535 NM_018699
PRDM5
PR domain containing 5
chr3_-_14141371 0.533 NM_001098502
NM_144636
CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr18_+_3437607 0.532 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr12_+_8866416 0.526 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr3_-_14141247 0.524 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr12_+_7038240 0.523 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr5_+_148186348 0.508 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr8_-_48813236 0.507 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr15_-_69194854 0.503 NM_001102658
CT62
cancer/testis antigen 62
chrX_+_73557809 0.498 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr4_-_89963177 0.497 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr7_+_134114957 0.495 CALD1
caldesmon 1
chr16_+_88515917 0.491 NM_001197181
TUBB3
tubulin, beta 3
chr4_+_128773529 0.489 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr19_+_702108 0.488 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr3_+_184453907 0.487 B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr2_-_189752575 0.486 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_-_143706265 0.483 PDE4DIP
phosphodiesterase 4D interacting protein
chr11_+_131286513 0.481 NTM
neurotrimin
chr8_-_48813256 0.481 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_-_225572419 0.481 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr19_+_49023283 0.479 NM_181845
ZNF283
zinc finger protein 283
chr3_+_114192489 0.477 NM_014170
NM_138485
GTPBP8

GTP-binding protein 8 (putative)

chr11_+_129823667 0.477 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr22_+_29848923 0.475 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr3_-_152517204 0.473 NM_023915
GPR87
G protein-coupled receptor 87
chr7_+_134114912 0.472 CALD1
caldesmon 1
chr5_-_138238877 0.471 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr3_-_14141229 0.469 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr6_-_42218692 0.468 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr18_-_7107757 0.467 NM_005559
LAMA1
laminin, alpha 1
chr3_+_11153778 0.466 NM_001098213
HRH1
histamine receptor H1
chr2_+_235525355 0.465 NM_014521
SH3BP4
SH3-domain binding protein 4
chr11_+_7574992 0.460 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr9_-_106730157 0.458 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr2_+_159533329 0.458 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr19_-_56214765 0.457 NM_145888
KLK10
kallikrein-related peptidase 10
chr16_+_68516401 0.455 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr12_-_6356783 0.447 NM_001159575
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr9_-_106730256 0.446 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr3_-_14141293 0.446 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr5_-_138238891 0.440 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr1_-_143706196 0.438 PDE4DIP
phosphodiesterase 4D interacting protein
chr14_-_50204771 0.438 NM_021818
SAV1
salvador homolog 1 (Drosophila)
chr10_+_74540215 0.437 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr17_-_77884899 0.432 SECTM1
secreted and transmembrane 1
chr19_-_49644470 0.431 NM_014518
ZNF229
zinc finger protein 229
chr2_+_165858586 0.430 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr12_+_8958397 0.429 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr16_+_4485859 0.428 NM_001127205
HMOX2
heme oxygenase (decycling) 2
chr21_-_27139143 0.428 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_+_114699953 0.427 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr3_-_170347019 0.424 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr12_-_3472245 0.423 LOC100129223
hypothetical LOC100129223
chr1_-_199635240 0.423 NM_005558
LAD1
ladinin 1
chr5_-_138238953 0.422 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr9_-_109291866 0.421 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr15_-_65334022 0.420 NM_024666
AAGAB
alpha- and gamma-adaptin binding protein
chr3_+_137224266 0.417 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr9_+_129900637 0.416 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr20_-_48741481 0.416


chr17_+_71893014 0.412 SPHK1
sphingosine kinase 1
chr3_+_114192467 0.408 GTPBP8
GTP-binding protein 8 (putative)
chr14_-_50204791 0.407 SAV1
salvador homolog 1 (Drosophila)
chr20_-_42249146 0.405 JPH2
junctophilin 2
chr5_+_148631636 0.405 AFAP1L1
actin filament associated protein 1-like 1
chr1_+_170077234 0.404 NM_001136127
NM_015569
DNM3

dynamin 3

chr5_+_148631588 0.403 NM_001146337
NM_152406
AFAP1L1

actin filament associated protein 1-like 1

chr5_-_102926349 0.402 NM_031438
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr16_-_73842884 0.400 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr19_+_45973139 0.400 NM_006533
MIA
melanoma inhibitory activity
chr17_+_71892271 0.398 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr1_+_167603817 0.397 NM_003666
BLZF1
basic leucine zipper nuclear factor 1
chr3_+_199171467 0.397 NM_001136049
NM_033029
LMLN

leishmanolysin-like (metallopeptidase M8 family)

chrX_-_134013644 0.397 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr3_-_139315011 0.396 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr6_-_29081015 0.396 NM_001010877
ZNF311
zinc finger protein 311
chr1_+_36409277 0.396 MAP7D1
MAP7 domain containing 1
chr15_+_65334169 0.395 NM_001031715
NM_022784
IQCH

IQ motif containing H

chr1_+_35020425 0.395 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr15_-_88256922 0.393 NM_001199058
NM_182616
C15orf38-AP3S2
C15orf38
C15orf38-AP3S2 readthrough
chromosome 15 open reading frame 38
chr7_+_89870647 0.392 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr9_-_129729518 0.390 NM_173492
PIP5KL1
phosphatidylinositol-4-phosphate 5-kinase-like 1
chr22_+_27609889 0.388 NM_032173
ZNRF3
zinc and ring finger 3
chr17_-_77884926 0.387 SECTM1
secreted and transmembrane 1
chr1_-_116184846 0.387 NM_001111061
NHLH2
nescient helix loop helix 2
chr4_+_77575276 0.385 NM_020859
SHROOM3
shroom family member 3
chr10_+_71482362 0.384 NM_018649
H2AFY2
H2A histone family, member Y2
chr1_-_151788341 0.383 NM_002960
S100A3
S100 calcium binding protein A3
chr11_-_11987115 0.382 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr17_+_71892781 0.381 NM_001142602
SPHK1
sphingosine kinase 1
chr15_+_68971835 0.380 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chrX_-_10761729 0.380 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr7_-_13997574 0.379 NM_001163148
ETV1
ets variant 1
chr3_-_11585264 0.378 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr20_+_43470042 0.377 NM_001048225
NM_001048226
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr1_+_167604056 0.377 BLZF1
basic leucine zipper nuclear factor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.52 4.33e-03 GO:0030030 cell projection organization
1.51 2.36e-02 GO:0048666 neuron development
1.55 2.49e-02 GO:0031175 neuron projection development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.74 1.25e-02 GO:0016323 basolateral plasma membrane
1.15 2.10e-02 GO:0005886 plasma membrane
1.14 3.18e-02 GO:0071944 cell periphery
1.21 4.22e-02 GO:0044459 plasma membrane part

Nothing significant found in function category.