Motif ID: HAND1,2.p2

Z-value: 2.634


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND2chr4_-_1746869180.146.2e-01Click!
HAND1chr5_-_153838013-0.097.5e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_10074332 6.229 NM_031917
ANGPTL6
angiopoietin-like 6
chr11_+_66927976 5.595 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr6_+_6533932 4.346 NM_004271
LY86
lymphocyte antigen 86
chr19_+_55614006 4.328 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr5_-_149772563 4.162 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr16_-_45339605 4.002 NM_182493
MYLK3
myosin light chain kinase 3
chr1_-_92724181 3.678 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr5_-_149772528 3.525


chr22_+_23333610 3.504 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr22_+_43451600 3.258 PRR5
proline rich 5 (renal)
chr7_+_99654806 3.202 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr16_-_28515868 3.051 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr19_-_56564068 2.967 NM_152353
CLDND2
claudin domain containing 2
chr1_-_158948176 2.865 NM_001778
CD48
CD48 molecule
chr16_+_28413421 2.824 NM_018690
APOBR
apolipoprotein B receptor
chr6_+_167445284 2.751 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr20_-_1113116 2.731 NM_018354
C20orf46
chromosome 20 open reading frame 46
chr15_+_42815851 2.695 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr3_+_99733432 2.666 NM_005290
GPR15
G protein-coupled receptor 15
chrX_-_48213508 2.664 SLC38A5
solute carrier family 38, member 5
chr22_+_23329113 2.639 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr19_+_10404110 2.578 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr5_-_149772469 2.568 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chrX_+_128741578 2.482 SASH3
SAM and SH3 domain containing 3
chr4_-_40326603 2.432 NM_001098634
RBM47
RNA binding motif protein 47
chr1_-_158815895 2.404 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chrX_+_49718954 2.374 NM_000084
CLCN5
chloride channel 5
chr10_-_104201234 2.355 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr14_+_75058591 2.355 BATF
basic leucine zipper transcription factor, ATF-like
chr14_+_75058518 2.350 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chrX_+_128741562 2.341 NM_018990
SASH3
SAM and SH3 domain containing 3
chr2_-_25328452 2.323 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_+_159899528 2.296 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr11_+_118463906 2.293 NM_001024382
HMBS
hydroxymethylbilane synthase
chrX_-_48213545 2.227 NM_033518
SLC38A5
solute carrier family 38, member 5
chr17_-_8711701 2.185 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr22_+_43451351 2.148 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr1_-_158815850 2.135 CD84
CD84 molecule
chr4_+_22608252 2.099


chr12_+_111900650 2.087 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr19_+_44886785 2.022 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr1_+_205328834 2.012 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr1_+_159817752 1.999 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr12_+_56114724 1.974 NM_005538
INHBC
inhibin, beta C
chr11_+_22646229 1.965 NM_177553
GAS2
growth arrest-specific 2
chr16_+_29582065 1.959 SPN
sialophorin
chr1_-_26517342 1.918 NM_145345
UBXN11
UBX domain protein 11
chr19_+_40465249 1.911 NM_021175
HAMP
hepcidin antimicrobial peptide
chr6_+_37081387 1.858 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr19_+_60850765 1.858 NM_013301
CCDC106
coiled-coil domain containing 106
chr18_+_53863865 1.842 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_133161318 1.830 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr1_+_26517045 1.752 CD52
CD52 molecule
chr21_+_41616590 1.752 FAM3B
family with sequence similarity 3, member B
chr9_-_99740243 1.711 NM_197978
HEMGN
hemogen
chr19_+_41085221 1.671 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr17_+_16259812 1.664 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr19_-_56585603 1.649 NM_001193623
LOC147646
hypothetical protein LOC147646
chr14_-_106240998 1.613 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_-_34886727 1.586 NM_145640
APOL3
apolipoprotein L, 3
chr16_+_56286212 1.550 NM_032269
CCDC135
coiled-coil domain containing 135
chr20_+_34937928 1.531 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr6_+_33151703 1.509 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr1_+_26516967 1.491 NM_001803
CD52
CD52 molecule
chr17_-_37590910 1.468 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr1_+_159943385 1.467 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr19_+_40224480 1.458 HPN
hepsin
chr19_-_10311262 1.444 NM_002162
ICAM3
intercellular adhesion molecule 3
chr11_-_63087430 1.437 NM_017878
HRASLS2
HRAS-like suppressor 2
chr5_-_176763789 1.435 F12
coagulation factor XII (Hageman factor)
chr17_-_36346240 1.429 KRT23
keratin 23 (histone deacetylase inducible)
chr14_-_23846993 1.429 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_106241445 1.402 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr8_-_82769761 1.400 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr6_-_25940247 1.398 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr2_+_228386800 1.386 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr1_+_28134090 1.350 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr2_-_85490984 1.339 CAPG
capping protein (actin filament), gelsolin-like
chr14_-_23846904 1.321 CIDEB
cell death-inducing DFFA-like effector b
chr20_+_764710 1.305 NM_207121
FAM110A
family with sequence similarity 110, member A
chr12_+_53177806 1.280 NCKAP1L
NCK-associated protein 1-like
chr8_+_11388918 1.279 NM_001715
BLK
B lymphoid tyrosine kinase
chr16_-_20495126 1.272 NM_001105069
NM_182617
ACSM2B

acyl-CoA synthetase medium-chain family member 2B

chr1_-_146543016 1.267


chr12_-_51887318 1.258 ITGB7
integrin, beta 7
chr17_+_16259636 1.249 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr19_+_40511909 1.241 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr12_+_53177789 1.235 NCKAP1L
NCK-associated protein 1-like
chr13_-_40491491 1.234 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr14_-_64479198 1.230 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_+_179269761 1.229 MR1
major histocompatibility complex, class I-related
chr11_+_359723 1.223 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr1_-_166149867 1.221 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr1_-_146543102 1.217


chr13_-_40491405 1.208 ELF1
E74-like factor 1 (ets domain transcription factor)
chr9_-_129707392 1.188 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr16_+_20370359 1.182 NM_001010845
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr12_-_120725210 1.173 LOC338799
hypothetical LOC338799
chr17_-_40380553 1.171 NM_001080443
KIF18B
kinesin family member 18B
chr17_+_16259573 1.160 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr4_+_76700281 1.158 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr6_-_41781655 1.153 TFEB
transcription factor EB
chr2_-_85490997 1.145 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr11_+_64737886 1.143 NM_001004326
SLC22A20
solute carrier family 22, member 20
chr7_-_100630912 1.142 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr4_-_40327396 1.134 RBM47
RNA binding motif protein 47
chr16_+_29581783 1.117 NM_001030288
SPN
sialophorin
chr13_+_112860968 1.110 NM_003891
PROZ
protein Z, vitamin K-dependent plasma glycoprotein
chr19_-_17819773 1.108 JAK3
Janus kinase 3
chr11_+_66927955 1.107 TBC1D10C
TBC1 domain family, member 10C
chr5_-_121842680 1.098


chr1_+_179269766 1.086 MR1
major histocompatibility complex, class I-related
chr11_+_22652894 1.085 NM_005256
GAS2
growth arrest-specific 2
chr11_+_2279932 1.085 TSPAN32
tetraspanin 32
chr9_-_70780574 1.082


chr12_-_51887266 1.061 NM_000889
ITGB7
integrin, beta 7
chr17_-_39630951 1.057 NM_001098833
NM_020218
ATXN7L3

ataxin 7-like 3

chr6_+_64289585 1.057 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_205329206 1.052 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr12_-_7153068 1.046 NM_016546
C1RL
complement component 1, r subcomponent-like
chr11_+_22652957 1.045 GAS2
growth arrest-specific 2
chr19_+_60851207 1.044 CCDC106
coiled-coil domain containing 106
chr10_+_4995453 1.042 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr22_+_21393107 1.036 IGLJ3
immunoglobulin lambda joining 3
chr1_-_154988647 1.034 NM_001126051
NM_001126050
HDGF

hepatoma-derived growth factor

chr1_+_26744929 1.029 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr11_-_64520964 1.028 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr19_+_11510578 1.027 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr1_-_114215768 1.018 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr1_+_154389945 1.015 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr5_-_138753443 1.015 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr2_+_68815416 1.014 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr1_+_26728846 1.011 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_179269689 1.009 MR1
major histocompatibility complex, class I-related
chr2_+_169367345 1.008 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr12_+_48003237 1.007 NM_001100620
NM_005480
TROAP

trophinin associated protein (tastin)

chr11_-_2279642 1.004 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr11_+_2279812 0.995 NM_139022
TSPAN32
tetraspanin 32
chr17_-_76897590 0.970 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr6_+_70633168 0.964 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr11_-_60880799 0.952 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr17_+_72958330 0.937 SEPT9
septin 9
chr6_-_39180390 0.937 C6orf64
chromosome 6 open reading frame 64
chr13_+_23742846 0.932 SPATA13
spermatogenesis associated 13
chr16_+_21152516 0.925 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr22_+_37823174 0.912 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr6_-_86407875 0.911 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr7_+_142270634 0.906 EPHB6
EPH receptor B6
chr21_-_45165204 0.906 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_+_3659358 0.903 TJP3
tight junction protein 3 (zona occludens 3)
chr16_-_66590856 0.903 NM_022355
DPEP2
dipeptidase 2
chr1_+_26744893 0.901 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_+_82287637 0.900 NM_207372
SH2D4B
SH2 domain containing 4B
chr12_-_9804682 0.899 NM_001781
CD69
CD69 molecule
chr13_-_45640679 0.896 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr11_-_117305277 0.892 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr22_-_49317408 0.882 ODF3B
outer dense fiber of sperm tails 3B
chr21_+_34112456 0.868 ITSN1
intersectin 1 (SH3 domain protein)
chr10_-_73149505 0.866 NM_001164375
C10orf105
chromosome 10 open reading frame 105
chr1_+_202033273 0.865 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr10_-_5035967 0.863 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr19_-_12807221 0.863 NM_031429
RTBDN
retbindin
chr16_-_31054321 0.855 PRSS8
protease, serine, 8
chr14_-_93512818 0.847 ASB2
ankyrin repeat and SOCS box containing 2
chr4_+_74500748 0.843 ALB
albumin
chr1_+_111215343 0.839 NM_001040033
CD53
CD53 molecule
chr3_+_153499883 0.829 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr12_+_53177758 0.829 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr7_+_110518297 0.825 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr7_-_84589182 0.825 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr19_-_56567602 0.823 NM_005601
NKG7
natural killer cell group 7 sequence
chr19_-_56582997 0.811 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr2_+_74913289 0.795 NM_000189
HK2
hexokinase 2
chr16_-_31054563 0.794 NM_002773
PRSS8
protease, serine, 8
chr9_-_106705780 0.792 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr17_+_14145051 0.790 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr6_-_41823056 0.789 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr22_-_35875890 0.786 NM_000878
IL2RB
interleukin 2 receptor, beta
chr16_+_2450081 0.783 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr14_-_23847000 0.780 CIDEB
cell death-inducing DFFA-like effector b
chr3_-_13032130 0.775


chr21_-_45165249 0.760 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr16_-_29817841 0.759 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr10_-_70846573 0.755 NM_001057
TACR2
tachykinin receptor 2
chr19_+_60879802 0.750 NM_001130071
EPN1
epsin 1
chr16_-_3089253 0.745 ZSCAN10
zinc finger and SCAN domain containing 10
chr16_+_10878539 0.740 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr2_-_138762909 0.733


chr1_+_116455898 0.728 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr14_-_105392671 0.728


chr3_+_49032911 0.728 NM_199074
NDUFAF3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr17_+_69974361 0.726 CD300A
CD300a molecule
chr14_+_23527866 0.725 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr12_+_117067214 0.725 PEBP1
phosphatidylethanolamine binding protein 1
chrX_-_32083506 0.723 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr11_-_62753574 0.722 NM_199352
SLC22A25
solute carrier family 22, member 25
chr2_+_201806410 0.718 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr10_-_121286034 0.716 NM_002925
RGS10
regulator of G-protein signaling 10
chr11_-_10630408 0.712 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chrX_-_63532057 0.711 NM_017677
MTMR8
myotubularin related protein 8

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.36 2.05e-02 GO:0006959 humoral immune response
2.30 2.20e-02 GO:0008202 steroid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 1.86e-05 GO:0071944 cell periphery
1.29 4.21e-05 GO:0005886 plasma membrane
1.41 5.76e-04 GO:0005576 extracellular region
1.66 2.17e-03 GO:0005615 extracellular space
4.52 1.44e-02 GO:0032994 protein-lipid complex
4.52 1.44e-02 GO:0034358 plasma lipoprotein particle
1.14 1.82e-02 GO:0016020 membrane
1.32 2.25e-02 GO:0044459 plasma membrane part
1.49 2.59e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.05 5.65e-05 GO:0004252 serine-type endopeptidase activity
2.64 1.28e-03 GO:0008236 serine-type peptidase activity
2.59 1.82e-03 GO:0017171 serine hydrolase activity
1.40 1.55e-02 GO:0004872 receptor activity
1.87 3.88e-02 GO:0004175 endopeptidase activity
7.30 4.02e-02 GO:0048019 receptor antagonist activity
12.65 4.10e-02 GO:0032052 bile acid binding