Motif ID: SPI1.p2

Z-value: 3.747


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPI1chr11_-_473565620.674.6e-03Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_35586950 7.768 NM_000631
NM_013416
 NCF4

neutrophil cytosolic factor 4, 40kDa

chr16_-_87570716 5.892 NM_005187
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr5_-_88215034 5.289 NM_001193350
NM_002397
 MEF2C

myocyte enhancer factor 2C

chr11_+_63864263 5.116 NM_032251
 CCDC88B
coiled-coil domain containing 88B
chr6_-_32268267 5.096 GPSM3
G-protein signaling modulator 3
chr3_-_113334657 4.885 NM_001190259
NM_001190260
NM_152785
 GCET2


germinal center expressed transcript 2


chr10_+_49562866 4.823 WDFY4
WDFY family member 4
chr16_-_29664765 4.649 NM_175900
 C16orf54
chromosome 16 open reading frame 54
chr1_+_111544469 4.508


chr10_+_26767698 4.392 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr11_+_107304344 4.375 NM_017516
 RAB39
RAB39, member RAS oncogene family
chr11_+_65164767 4.344 SIPA1
signal-induced proliferation-associated 1
chr21_+_25856311 4.276 MIR155HG
MIR155 host gene (non-protein coding)
chr1_+_159899528 4.264 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
 FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr1_-_111544603 4.014


chr5_-_88214720 4.005 MEF2C
myocyte enhancer factor 2C
chr17_+_44643067 3.935 ABI3
ABI family, member 3
chr17_+_44642587 3.836 NM_001135186
NM_016428
 ABI3

ABI family, member 3

chr6_-_32268615 3.819 GPSM3
G-protein signaling modulator 3
chr1_-_31003260 3.818 NM_006762
 LAPTM5
lysosomal protein transmembrane 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 102 entries
enrichment   p-value GO term description
2.59 9.65e-03 GO:0001776 leukocyte homeostasis
2.55 2.51e-02 GO:0002260 lymphocyte homeostasis
1.92 3.99e-02 GO:0030217 T cell differentiation
1.86 1.08e-03 GO:0030098 lymphocyte differentiation
1.67 3.58e-02 GO:0042110 T cell activation
1.64 5.83e-06 GO:0045321 leukocyte activation
1.64 2.98e-04 GO:0046649 lymphocyte activation
1.59 5.65e-03 GO:0002757 immune response-activating signal transduction
1.58 4.60e-02 GO:0050900 leukocyte migration
1.56 1.74e-02 GO:0002764 immune response-regulating signaling pathway
1.54 3.32e-03 GO:0071156 regulation of cell cycle arrest
1.52 9.20e-09 GO:0001775 cell activation
1.52 1.40e-02 GO:0000075 cell cycle checkpoint
1.51 8.18e-03 GO:0030168 platelet activation
1.47 2.82e-02 GO:0030097 hemopoiesis
1.42 4.34e-02 GO:0002520 immune system development
1.41 1.48e-03 GO:0007243 intracellular protein kinase cascade
1.41 1.48e-03 GO:0023014 signal transduction via phosphorylation event
1.41 3.45e-03 GO:0007264 small GTPase mediated signal transduction
1.40 1.80e-04 GO:0007599 hemostasis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
1.88 3.21e-02 GO:0016605 PML body
1.49 3.55e-03 GO:0016604 nuclear body
1.35 4.23e-06 GO:0044451 nucleoplasm part
1.32 1.62e-10 GO:0005654 nucleoplasm
1.28 2.40e-02 GO:0005694 chromosome
1.23 8.12e-09 GO:0005829 cytosol
1.22 1.75e-06 GO:0031981 nuclear lumen
1.21 1.89e-07 GO:0044428 nuclear part
1.14 6.38e-03 GO:0043233 organelle lumen
1.14 9.70e-03 GO:0031974 membrane-enclosed lumen
1.13 2.03e-10 GO:0005634 nucleus
1.13 2.33e-02 GO:0070013 intracellular organelle lumen
1.12 9.99e-03 GO:0043234 protein complex
1.10 1.57e-02 GO:0032991 macromolecular complex
1.08 4.90e-06 GO:0005737 cytoplasm
1.08 3.51e-03 GO:0044446 intracellular organelle part
1.08 5.37e-03 GO:0044422 organelle part
1.07 5.99e-10 GO:0044424 intracellular part
1.07 6.56e-05 GO:0043227 membrane-bounded organelle
1.07 6.99e-05 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
1.82 2.02e-02 GO:0047485 protein N-terminus binding
1.72 1.12e-02 GO:0051427 hormone receptor binding
1.53 8.91e-06 GO:0016564 transcription repressor activity
1.49 1.31e-03 GO:0005096 GTPase activator activity
1.43 1.47e-05 GO:0030695 GTPase regulator activity
1.42 1.67e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.40 8.07e-04 GO:0008047 enzyme activator activity
1.40 1.25e-03 GO:0000988 protein binding transcription factor activity
1.40 1.25e-03 GO:0000989 transcription factor binding transcription factor activity
1.39 1.78e-03 GO:0003712 transcription cofactor activity
1.38 1.94e-02 GO:0016563 transcription activator activity
1.33 1.88e-05 GO:0019899 enzyme binding
1.27 8.39e-05 GO:0030528 transcription regulator activity
1.27 1.29e-02 GO:0043565 sequence-specific DNA binding
1.23 1.11e-02 GO:0030234 enzyme regulator activity
1.15 6.22e-21 GO:0005515 protein binding
1.05 6.17e-07 GO:0005488 binding