Motif ID: PITX1..3.p2

Z-value: 6.424


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PITX1chr5_-_1343977400.611.3e-02Click!
PITX2chr4_-_111777651-0.486.0e-02Click!
PITX3chr10_-_103991219-0.165.6e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_73654028 10.116 NM_001163075
C17orf99
chromosome 17 open reading frame 99
chr3_+_188222337 9.181 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr16_+_29597829 8.673 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr19_-_2036227 8.601 MOBKL2A
MOB1, Mps One Binder kinase activator-like 2A (yeast)
chr12_-_116021473 8.598 NM_001168325
NM_017899
TESC

tescalcin

chr4_-_38710376 8.392 NM_024943
TMEM156
transmembrane protein 156
chr16_+_11966464 7.964 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr16_-_30301634 7.820 NM_052838
SEPT1
septin 1
chr19_-_56585603 7.293 NM_001193623
LOC147646
hypothetical protein LOC147646
chr16_-_18705578 7.040


chrX_+_9391314 6.682 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr19_+_16115454 6.560 HSH2D
hematopoietic SH2 domain containing
chr19_-_56564068 6.434 NM_152353
CLDND2
claudin domain containing 2
chr19_+_16860807 6.387 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr1_-_100003936 6.361 NM_001013660
FRRS1
ferric-chelate reductase 1
chr22_-_20314274 6.336 NM_001017964
YDJC
YdjC homolog (bacterial)
chr12_-_120220493 6.276 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chr1_-_24112345 6.262 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr5_-_43029180 6.231 FLJ32255
hypothetical LOC643977
chr6_-_32268615 6.074 GPSM3
G-protein signaling modulator 3
chr7_+_73262283 6.067 LAT2
linker for activation of T cells family, member 2
chr7_+_73262264 6.022 LAT2
linker for activation of T cells family, member 2
chr2_+_218992053 5.985 NM_007127
VIL1
villin 1
chr19_-_60241424 5.867 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr19_+_17723285 5.726 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr19_+_40465249 5.722 NM_021175
HAMP
hepcidin antimicrobial peptide
chr9_+_263025 5.720 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr19_+_52532210 5.669 NM_018485
GPR77
G protein-coupled receptor 77
chr6_-_143874463 5.574 NM_032020
FUCA2
fucosidase, alpha-L- 2, plasma
chr7_+_73262188 5.544 LAT2
linker for activation of T cells family, member 2
chr2_+_38746555 5.383 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr20_+_309272 5.140 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr22_-_20314366 5.067 YDJC
YdjC homolog (bacterial)
chr16_-_29664765 5.058 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr17_-_78599695 5.044 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr7_-_99518294 4.991 ZNF3
zinc finger protein 3
chr2_+_105834635 4.910 NM_001004720
NCK2
NCK adaptor protein 2
chr1_-_92144146 4.877 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr19_+_17198012 4.827 NM_024578
OCEL1
occludin/ELL domain containing 1
chr19_+_12064077 4.749 ZNF788
zinc finger family member 788
chr1_+_16203317 4.747 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr16_+_88511787 4.646 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr15_+_89274413 4.596 NM_001039675
UNC45A
unc-45 homolog A (C. elegans)
chr16_+_30391609 4.480


chr16_+_30391550 4.392 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr18_+_2896178 4.350 EMILIN2
elastin microfibril interfacer 2
chr12_+_53178834 4.274 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr19_-_44518465 4.259 GMFG
glia maturation factor, gamma
chr16_-_4464600 4.244 NMRAL1
NmrA-like family domain containing 1
chr16_+_30391460 4.228 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr6_-_26297282 4.224 NM_003539
HIST1H4D
histone cluster 1, H4d
chr9_-_115178161 4.212 NM_031219
HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chrX_-_16640590 4.194 NM_175859
NM_019857
CTPS2

CTP synthase II

chr16_-_4464896 4.190 NM_020677
NMRAL1
NmrA-like family domain containing 1
chr17_-_76897590 4.179 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr5_-_10361167 4.161 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr16_+_65918220 4.135 NM_018296
LRRC36
leucine rich repeat containing 36
chr19_+_14554895 4.107 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr17_-_59818033 4.107 PECAM1
platelet/endothelial cell adhesion molecule
chr16_+_29597965 4.097 QPRT
quinolinate phosphoribosyltransferase
chr15_-_20638283 4.067 NM_001142275
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr13_+_49100435 4.028 NM_138450
ARL11
ADP-ribosylation factor-like 11
chr12_+_120132233 4.017 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr16_+_30118036 4.008 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr4_-_40212670 3.978 NM_019027
RBM47
RNA binding motif protein 47
chr1_+_40631603 3.973 NM_001198979
SMAP2
small ArfGAP2
chr16_+_170334 3.927 NM_005331
HBQ1
hemoglobin, theta 1
chr16_+_29378694 3.923 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr22_-_40666168 3.889 NM_001110215
CENPM
centromere protein M
chr3_+_171238427 3.884 NM_014373
GPR160
G protein-coupled receptor 160
chr20_+_35445350 3.836 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr16_+_43009 3.823 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr10_+_124885556 3.811 NM_001105574
HMX3
H6 family homeobox 3
chr19_+_522260 3.783 NM_198591
BSG
basigin (Ok blood group)
chr4_-_1185144 3.763 LOC100130872
hypothetical LOC100130872
chr12_-_120219941 3.712 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr19_-_13074513 3.709 LYL1
lymphoblastic leukemia derived sequence 1
chr3_-_50350654 3.700 NM_170712
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr1_-_27825178 3.625 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr1_+_11646735 3.610 NM_018438
FBXO6
F-box protein 6
chr2_+_201755865 3.590 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr19_-_6621598 3.586 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr11_-_66961709 3.562 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr11_-_117718532 3.518 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr19_+_50100843 3.505 NM_000041
APOE
apolipoprotein E
chr1_+_159032551 3.487 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr22_-_22714230 3.485 NM_000853
GSTT1
glutathione S-transferase theta 1
chr6_-_44341296 3.480 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr17_+_7180571 3.475 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr7_+_73262022 3.467 NM_014146
NM_032463
NM_032464
LAT2


linker for activation of T cells family, member 2


chr9_+_130504591 3.467 NM_013355
PKN3
protein kinase N3
chr19_-_5821546 3.462 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr19_+_16860871 3.460 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr16_-_30301357 3.421 SEPT1
septin 1
chr19_-_44518516 3.412 NM_004877
GMFG
glia maturation factor, gamma
chr16_+_29581783 3.374 NM_001030288
SPN
sialophorin
chr19_-_12858956 3.355 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr12_+_45896318 3.336 NM_138371
FAM113B
family with sequence similarity 113, member B
chr9_-_115178969 3.261 HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr7_-_72676750 3.245 NM_032951
NM_032952
NM_032953
NM_032954
MLXIPL



MLX interacting protein-like



chr1_+_28528099 3.224 NM_001127350
NM_017638
MED18

mediator complex subunit 18

chr22_+_37747063 3.217 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr11_+_66927955 3.216 TBC1D10C
TBC1 domain family, member 10C
chr11_+_61861349 3.211 NM_001083926
NM_025080
ASRGL1

asparaginase like 1

chr1_+_111573855 3.206 NM_001025199
CHI3L2
chitinase 3-like 2
chr19_-_55539769 3.204 NAPSB
napsin B aspartic peptidase pseudogene
chr6_-_31882704 3.182 NM_021177
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr11_-_73371452 3.164 UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr17_+_73694992 3.159 NM_001010982
NM_001145526
AFMID

arylformamidase

chr15_+_26876480 3.142


chr20_-_43972061 3.126 PLTP
phospholipid transfer protein
chr12_-_7793335 3.126 NM_130441
NM_203503
CLEC4C

C-type lectin domain family 4, member C

chr11_-_73371531 3.122 NM_003355
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr19_+_51059357 3.119 NM_004497
FOXA3
forkhead box A3
chr14_+_23633101 3.116 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr19_+_55123770 3.109 NM_012068
ATF5
activating transcription factor 5
chr19_+_3679373 3.107 NM_014428
TJP3
tight junction protein 3 (zona occludens 3)
chr1_+_6191506 3.103 RNF207
ring finger protein 207
chr6_-_27966548 3.099 NM_003535
HIST1H3J
histone cluster 1, H3j
chr3_+_128799961 3.093 MCM2
minichromosome maintenance complex component 2
chr11_+_66927976 3.070 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr19_+_10083196 3.060 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr16_-_27187559 3.058 NM_145080
NSMCE1
non-SMC element 1 homolog (S. cerevisiae)
chr11_+_61861458 3.046 ASRGL1
asparaginase like 1
chr6_-_144427340 3.021 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr17_+_38186141 3.002 NM_032387
WNK4
WNK lysine deficient protein kinase 4
chr11_-_65070625 2.998 LTBP3
latent transforming growth factor beta binding protein 3
chr12_-_6611075 2.989 NM_001142961
LPAR5
lysophosphatidic acid receptor 5
chr17_+_73721924 2.959 BIRC5
baculoviral IAP repeat containing 5
chr1_+_114298021 2.958 NM_181358
HIPK1
homeodomain interacting protein kinase 1
chr6_-_31668476 2.942 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr16_-_1862080 2.935 NM_152764
C16orf73
chromosome 16 open reading frame 73
chr12_-_55042793 2.934 NM_001638
APOF
apolipoprotein F
chr1_-_226357663 2.934 C1orf35
chromosome 1 open reading frame 35
chr16_+_28850760 2.934 NM_001178098
NM_001770
CD19

CD19 molecule

chr1_-_148854503 2.925


chr2_+_38746742 2.916 GALM
galactose mutarotase (aldose 1-epimerase)
chr11_-_66967838 2.914 NM_001018070
CORO1B
coronin, actin binding protein, 1B
chr14_-_62638336 2.910 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr21_-_38415273 2.903 NM_005867
DSCR4
Down syndrome critical region gene 4
chr12_+_6893751 2.894 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr6_+_34313347 2.885 HMGA1
high mobility group AT-hook 1
chrX_-_70755023 2.879 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr1_-_1701313 2.867 NM_001198994
NADK
NAD kinase
chr16_+_20682812 2.864 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chrX_+_138060 2.860 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr8_-_38127489 2.859 NM_000349
STAR
steroidogenic acute regulatory protein
chr16_-_27187549 2.854 NSMCE1
non-SMC element 1 homolog (S. cerevisiae)
chr1_+_244954000 2.851 NM_016002
SCCPDH
saccharopine dehydrogenase (putative)
chr19_+_49455872 2.839 NM_181756
ZNF233
zinc finger protein 233
chr19_-_54093749 2.838 NM_003323
TULP2
tubby like protein 2
chr3_+_128799902 2.832 NM_004526
MCM2
minichromosome maintenance complex component 2
chr3_-_180452096 2.830 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr3_-_197726587 2.827 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr16_+_65552600 2.816 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr3_+_128799964 2.807 MCM2
minichromosome maintenance complex component 2
chr19_+_811615 2.803 CFD
complement factor D (adipsin)
chr2_+_68815416 2.784 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr22_-_16080265 2.769 CECR1
cat eye syndrome chromosome region, candidate 1
chr22_-_28307063 2.748 NM_003634
NIPSNAP1
nipsnap homolog 1 (C. elegans)
chrX_-_30505804 2.727 NM_025159
CXorf21
chromosome X open reading frame 21
chr17_-_37599953 2.723 NM_001142622
NM_001142623
NM_032484
GHDC


GH3 domain containing


chr11_+_22652957 2.707 GAS2
growth arrest-specific 2
chr22_+_19458378 2.706 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr1_-_149611768 2.699 NM_003944
SELENBP1
selenium binding protein 1
chr9_+_129962292 2.694 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr22_+_20350272 2.682 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr2_-_112729072 2.671 NM_032494
ZC3H8
zinc finger CCCH-type containing 8
chr19_+_3536541 2.654 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr19_+_23737651 2.639 RPSAP58
ribosomal protein SA pseudogene 58
chr16_-_1862162 2.634 NM_001163560
C16orf73
chromosome 16 open reading frame 73
chr17_+_37694007 2.624 STAT5A
signal transducer and activator of transcription 5A
chr17_+_37957509 2.623 NM_000413
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chr12_+_120132319 2.612 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr1_-_28375722 2.593 NM_001164723
PTAFR
platelet-activating factor receptor
chr12_+_53177806 2.592 NCKAP1L
NCK-associated protein 1-like
chrX_-_70243362 2.588 NM_001025265
CXorf65
chromosome X open reading frame 65
chr12_+_53177789 2.587 NCKAP1L
NCK-associated protein 1-like
chr4_+_73123712 2.581 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr2_-_27210792 2.568 PREB
prolactin regulatory element binding
chr11_-_64520964 2.557 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr17_-_59451662 2.552 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr5_+_67622242 2.550 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr19_-_17236522 2.549 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chrX_+_153101278 2.548 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr11_-_107235123 2.546 NM_017515
SLC35F2
solute carrier family 35, member F2
chr11_-_118405288 2.542 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr3_-_184363157 2.542 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr19_+_50141068 2.537 NM_000483
APOC2
apolipoprotein C-II
chr4_+_74499651 2.535 ALB
albumin
chr12_-_52975777 2.532 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr6_-_30793436 2.530 NM_014641
MDC1
mediator of DNA-damage checkpoint 1
chr17_-_59437782 2.527 NM_000873
ICAM2
intercellular adhesion molecule 2
chr7_+_99562255 2.519 NM_203397
MBLAC1
metallo-beta-lactamase domain containing 1
chr12_+_122510338 2.517 NM_180699
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr1_+_984972 2.513 LOC100288175
hypothetical LOC100288175
chr17_-_36938111 2.506 NM_002276
KRT19
keratin 19
chr22_+_20715340 2.503


chr19_+_17495109 2.501 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr19_+_18069596 2.498 NM_015016
MAST3
microtubule associated serine/threonine kinase 3

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.