Motif ID: TEAD1.p2

Z-value: 5.596


Transcription factors associated with TEAD1.p2:

Gene SymbolEntrez IDGene Name
TEAD1 7003 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEAD2 8463 TEA domain family member 2
TEAD3 7005 TEAD3 TEA domain family member 3
TEAD4 7004 TEAD4 TEA domain family member 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TEAD1chr11_+_126524270.783.5e-04Click!
TEAD4chr12_+_29387030.711.9e-03Click!
TEAD2chr19_-_545574500.639.4e-03Click!
TEAD3chr6_-_355726940.312.4e-01Click!


Activity profile for motif TEAD1.p2.

activity profile for motif TEAD1.p2


Sorted Z-values histogram for motif TEAD1.p2

Sorted Z-values for motif TEAD1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TEAD1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_212791597 32.134 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr1_-_212791467 32.042 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr6_-_132314004 27.669 NM_001901
CTGF
connective tissue growth factor
chr19_+_39664706 26.629 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr4_+_184257337 21.144 NM_024949
WWC2
WW and C2 domain containing 2
chr3_-_135575925 20.607 NM_016201
AMOTL2
angiomotin like 2
chr5_-_39460687 18.760 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr15_+_37660568 18.051 NM_003246
THBS1
thrombospondin 1
chr6_-_75972286 14.937 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr10_+_123862430 13.880 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_-_128883125 13.783 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr5_-_39460787 12.472 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_-_160972606 12.389 RBMS1
RNA binding motif, single stranded interacting protein 1
chr11_-_8788765 12.191 NM_213618
ST5
suppression of tumorigenicity 5
chr11_-_6298284 11.717 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr2_-_189752575 11.330 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_+_85819004 11.163 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr10_-_90702490 11.121 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_-_115825742 11.005 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_94708641 10.492 NM_021229
NTN4
netrin 4
chrX_-_10548458 10.437 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr15_+_61121806 10.320 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr15_+_61122139 10.271 TPM1
tropomyosin 1 (alpha)
chr10_-_125843092 10.151 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr11_-_8789457 10.118 NM_139157
ST5
suppression of tumorigenicity 5
chr8_-_38505331 10.057 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr7_+_134114912 9.729 CALD1
caldesmon 1
chr7_+_134114701 9.555 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr10_-_116382089 9.386 ABLIM1
actin binding LIM protein 1
chr12_-_78608873 9.210 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr17_-_15495534 8.806 TRIM16
tripartite motif containing 16
chr6_-_42218692 8.691 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr9_+_112470871 8.673 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr1_-_16355013 8.573 NM_004431
EPHA2
EPH receptor A2
chr11_+_113671744 8.352 NM_006169
NNMT
nicotinamide N-methyltransferase
chr17_-_37828643 8.280 NM_012232
PTRF
polymerase I and transcript release factor
chr8_+_70541412 8.216 NM_001128204
NM_015170
SULF1

sulfatase 1

chr9_+_90339835 8.127 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr7_+_134114957 8.015 CALD1
caldesmon 1
chr5_-_39461054 7.961 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr5_-_151046638 7.928 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr8_+_1759502 7.779 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr5_-_151046680 7.742 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr1_+_78126787 7.738 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr10_+_102782151 7.652 SFXN3
sideroflexin 3
chr15_+_73728402 7.561 NM_153271
SNX33
sorting nexin 33
chr5_-_148422799 7.486 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr16_-_30983909 7.471 NM_001172669
NM_001172670
ZNF668

zinc finger protein 668

chr3_-_113842350 7.431 CCDC80
coiled-coil domain containing 80
chr2_+_102125616 7.418 IL1R1
interleukin 1 receptor, type I
chr3_-_113842133 7.228 CCDC80
coiled-coil domain containing 80
chr14_-_88090641 7.165 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr11_-_85107569 7.123 NM_206929
SYTL2
synaptotagmin-like 2
chr3_-_113841941 6.878 CCDC80
coiled-coil domain containing 80
chr9_+_88953378 6.687 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr6_-_75972473 6.684 COL12A1
collagen, type XII, alpha 1
chr4_-_152368492 6.623 SH3D19
SH3 domain containing 19
chr3_-_113842255 6.578 CCDC80
coiled-coil domain containing 80
chr3_-_113841967 6.572 CCDC80
coiled-coil domain containing 80
chrX_-_83644054 6.552 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr9_+_136673534 6.550 COL5A1
collagen, type V, alpha 1
chr1_-_199704773 6.517 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr2_+_102169864 6.450 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chr9_+_117955890 6.411 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr8_-_42184194 6.374 PLAT
plasminogen activator, tissue
chr11_-_47427263 6.361 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr3_-_113842237 6.336 CCDC80
coiled-coil domain containing 80
chr11_-_85108030 6.136 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr16_-_62573 6.105 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr7_+_115952279 6.025 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chrX_-_114703273 5.917


chr2_-_192419896 5.902 SDPR
serum deprivation response
chr10_+_102782156 5.889 SFXN3
sideroflexin 3
chr3_-_113842553 5.837 CCDC80
coiled-coil domain containing 80
chr19_-_54063522 5.673 NM_001161354
NM_020904
PLEKHA4

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4

chr15_-_58477407 5.635 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr8_-_42184350 5.598 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr2_-_192420168 5.592 NM_004657
SDPR
serum deprivation response
chr1_+_238321794 5.498 NM_020066
FMN2
formin 2
chr10_-_17699309 5.423 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr6_-_143307976 5.350 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr5_+_38882017 5.347 OSMR
oncostatin M receptor
chr1_-_207892296 5.237 NM_001127641
LAMB3
laminin, beta 3
chr1_-_207892420 5.155 NM_000228
LAMB3
laminin, beta 3
chr8_-_108579270 5.118 NM_001146
ANGPT1
angiopoietin 1
chr3_-_113842652 5.089 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr12_+_13044604 5.042 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chr10_-_33287184 4.980 NM_002211
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr14_-_22516271 4.830 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr17_+_71229151 4.794 ITGB4
integrin, beta 4
chr2_-_158439868 4.790 NM_001105
ACVR1
activin A receptor, type I
chr1_+_181422016 4.789 LAMC2
laminin, gamma 2
chr17_+_71229191 4.746 ITGB4
integrin, beta 4
chr6_-_134538762 4.738 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr19_+_50041424 4.711 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr11_+_1812115 4.646 NM_138567
SYT8
synaptotagmin VIII
chr6_+_144040751 4.617 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr1_-_199613427 4.577 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr18_+_30427279 4.508 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr9_+_111927601 4.431 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr12_-_13044448 4.332 HEBP1
heme binding protein 1
chr1_-_199613406 4.312 TNNT2
troponin T type 2 (cardiac)
chr12_+_27568311 4.307 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr10_-_123346148 4.295 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr7_+_115952325 4.252 CAV1
caveolin 1, caveolae protein, 22kDa
chr11_+_93394025 4.243 NM_001098672
HEPHL1
hephaestin-like 1
chr12_-_13044467 4.237 NM_015987
HEBP1
heme binding protein 1
chr5_-_38881636 4.235


chr12_+_26239755 4.223 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr18_-_51219880 4.190 TCF4
transcription factor 4
chr10_-_99436889 4.181 NM_021732
AVPI1
arginine vasopressin-induced 1
chr4_+_15089931 4.155 CC2D2A
coiled-coil and C2 domain containing 2A
chr22_+_40286957 4.147 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr6_-_134538526 4.147 SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_45506001 4.133 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr6_+_41712907 4.124 MDFI
MyoD family inhibitor
chr11_-_2907169 4.102 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr3_+_148609841 4.097 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr12_-_13044314 4.010 HEBP1
heme binding protein 1
chr17_+_19999784 3.957 NM_001033554
NM_001033555
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr11_+_66580884 3.923 RHOD
ras homolog gene family, member D
chr1_-_24311212 3.909 NM_152372
MYOM3
myomesin family, member 3
chr20_+_34603290 3.906 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr20_+_34603311 3.893 MYL9
myosin, light chain 9, regulatory
chr1_-_151848039 3.831 S100A16
S100 calcium binding protein A16
chr14_+_75114692 3.791 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr5_+_38881719 3.774 NM_003999
OSMR
oncostatin M receptor
chr11_+_66580861 3.774 NM_014578
RHOD
ras homolog gene family, member D
chr18_+_50646616 3.689 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr15_-_93671314 3.624 LOC400456
hypothetical LOC400456
chr14_+_54102518 3.553 LOC644925
hypothetical LOC644925
chr1_+_181421984 3.529 LAMC2
laminin, gamma 2
chr3_-_150533948 3.500 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr19_+_41980248 3.483 LOC284408
hypothetical LOC284408
chr1_+_216585298 3.479 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr6_+_123152044 3.444 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr12_-_119172339 3.441 NM_025157
PXN
paxillin
chr9_-_16717887 3.440 BNC2
basonuclin 2
chr10_+_24538094 3.437 KIAA1217
KIAA1217
chr7_+_115952074 3.414 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chrX_+_114701665 3.376 PLS3
plastin 3
chr3_+_25444753 3.366 NM_016152
RARB
retinoic acid receptor, beta
chr1_+_114323552 3.348 NM_020190
OLFML3
olfactomedin-like 3
chr19_-_41514390 3.340


chr5_+_38881716 3.335 NM_001168355
OSMR
oncostatin M receptor
chr12_-_12310969 3.330 NM_002336
LRP6
low density lipoprotein receptor-related protein 6
chr14_-_22515725 3.330 JUB
jub, ajuba homolog (Xenopus laevis)
chr5_-_16989371 3.312 NM_012334
MYO10
myosin X
chr2_-_75641587 3.309 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr8_-_37847095 3.270 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr3_+_113061218 3.251 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr15_-_39973566 3.248 NM_016642
SPTBN5
spectrin, beta, non-erythrocytic 5
chr2_-_75641535 3.212 FAM176A
family with sequence similarity 176, member A
chr5_-_58607673 3.203 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_-_106129854 3.178 MORC4
MORC family CW-type zinc finger 4
chr17_+_71229110 3.143 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr3_+_25444837 3.122 NM_000965
RARB
retinoic acid receptor, beta
chr19_-_14467890 3.122 GIPC1
GIPC PDZ domain containing family, member 1
chr5_+_76150637 3.112 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr19_-_14467939 3.095 NM_005716
NM_202467
NM_202468
NM_202469
NM_202470
NM_202494
GIPC1





GIPC PDZ domain containing family, member 1





chr1_+_24522116 3.094 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr8_-_116750427 3.091 TRPS1
trichorhinophalangeal syndrome I
chr1_-_201411533 3.082 NM_004997
MYBPH
myosin binding protein H
chr11_-_2127368 3.070 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_-_15706340 3.046 EPS8
epidermal growth factor receptor pathway substrate 8
chr1_+_181421796 3.045 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr12_+_51728999 3.035 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr19_-_56204615 3.027 NM_012315
KLK9
kallikrein-related peptidase 9
chr15_-_40537002 3.017 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr2_+_95303947 3.014 PROM2
prominin 2
chr2_-_238164452 2.986 NM_022449
RAB17
RAB17, member RAS oncogene family
chr7_-_137337352 2.973 CREB3L2
cAMP responsive element binding protein 3-like 2
chr12_-_8706746 2.970 MFAP5
microfibrillar associated protein 5
chrX_-_53327473 2.964 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr19_-_56147971 2.954 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr12_-_8706637 2.951 NM_003480
MFAP5
microfibrillar associated protein 5
chr10_+_24537725 2.908 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr11_-_126375895 2.893 NM_001161707
NM_032531
KIRREL3

kin of IRRE like 3 (Drosophila)

chr1_-_27604656 2.881 WASF2
WAS protein family, member 2
chr10_+_23768203 2.855 NM_001145373
OTUD1
OTU domain containing 1
chr2_+_157000225 2.842 GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr9_-_72673753 2.835 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr14_+_31615922 2.783 ARHGAP5
Rho GTPase activating protein 5
chr2_+_157000197 2.763 NM_001083112
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr3_+_113061296 2.746 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr7_-_137337318 2.738 CREB3L2
cAMP responsive element binding protein 3-like 2
chr6_+_31190505 2.714 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr5_-_83052606 2.707 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr5_+_152850276 2.693 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr3_-_65999548 2.666 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr6_+_83130220 2.662 TPBG
trophoblast glycoprotein
chr12_-_368689 2.635 NM_001042603
KDM5A
lysine (K)-specific demethylase 5A
chr11_-_14336606 2.625 NM_001177315
NM_001102669
RRAS2

related RAS viral (r-ras) oncogene homolog 2

chr5_-_140875591 2.616 DIAPH1
diaphanous homolog 1 (Drosophila)
chr6_+_134251957 2.615 TCF21
transcription factor 21
chr7_+_39739690 2.602 NCRNA00265
non-protein coding RNA 265
chr10_-_88720908 2.598 LOC100133190
hypothetical LOC100133190
chr1_-_17179694 2.597 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr6_+_134251940 2.596 NM_198392
NM_003206
TCF21

transcription factor 21

chr8_-_38444398 2.576 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.44 3.32e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.77 3.64e-03 GO:0048468 cell development
1.85 5.02e-03 GO:0007155 cell adhesion
1.85 5.02e-03 GO:0022610 biological adhesion
1.54 2.95e-02 GO:0009966 regulation of signal transduction
1.81 4.22e-02 GO:0042325 regulation of phosphorylation
1.79 4.79e-02 GO:0019220 regulation of phosphate metabolic process
1.79 4.79e-02 GO:0051174 regulation of phosphorus metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 2.67e-05 GO:0005576 extracellular region
3.62 1.78e-04 GO:0044420 extracellular matrix part
2.21 1.08e-03 GO:0031012 extracellular matrix
1.68 1.32e-03 GO:0044421 extracellular region part
4.09 2.02e-03 GO:0005604 basement membrane
2.28 2.31e-03 GO:0005578 proteinaceous extracellular matrix
1.25 2.37e-02 GO:0071944 cell periphery
13.63 2.54e-02 GO:0001527 microfibril
1.24 4.54e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.63 4.65e-04 GO:0019838 growth factor binding
1.89 1.21e-03 GO:0005509 calcium ion binding
2.20 7.10e-03 GO:0003779 actin binding
6.54 7.69e-03 GO:0050840 extracellular matrix binding
9.43 8.05e-03 GO:0001968 fibronectin binding
3.58 1.44e-02 GO:0005201 extracellular matrix structural constituent
8.18 2.16e-02 GO:0043236 laminin binding
1.16 3.34e-02 GO:0005515 protein binding