Motif ID: ALX1.p2

Z-value: 0.877


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ALX1chr12_+_841980150.312.4e-01Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_224974954 1.905 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr2_-_188127430 1.238 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr11_-_5212168 1.050 NM_000519
HBD
hemoglobin, delta
chr1_+_194887630 1.031 NM_000186
NM_001014975
CFH

complement factor H

chr7_+_22733290 1.023 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr17_-_44006808 1.002 NM_002146
HOXB3
homeobox B3
chrX_-_21686079 0.921 NM_014332
SMPX
small muscle protein, X-linked
chr5_+_61910318 0.850 NM_181506
LRRC70
leucine rich repeat containing 70
chr2_-_188127294 0.806 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_+_143043871 0.799 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr4_+_43185 0.788 NM_182524
ZNF595
ZNF718
zinc finger protein 595
zinc finger protein 718
chr5_+_147775652 0.762 FBXO38
F-box protein 38
chr17_+_63766874 0.721 NM_014960
ARSG
arylsulfatase G
chr12_-_9913199 0.655 CLEC2B
C-type lectin domain family 2, member B
chr7_-_81237162 0.605 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr11_+_93940121 0.576 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr8_-_15140162 0.562 NM_139167
SGCZ
sarcoglycan, zeta
chr19_-_21438525 0.555


chr2_-_178681311 0.551 NM_001077197
PDE11A
phosphodiesterase 11A
chr1_+_166516901 0.550 NM_005149
TBX19
T-box 19
chr7_+_77307382 0.542 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr19_+_12064077 0.540 ZNF788
zinc finger family member 788
chr11_+_59580630 0.535 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr17_-_32730804 0.527 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr2_-_199922047 0.520 SATB2
SATB homeobox 2
chr8_+_17866373 0.518 PCM1
pericentriolar material 1
chr8_+_107807415 0.499 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_-_41399632 0.489 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr12_+_130004404 0.487 NM_198827
GPR133
G protein-coupled receptor 133
chr11_-_30910074 0.485 NM_020869
DCDC5
doublecortin domain containing 5
chr12_-_52939636 0.477 NM_001127321
CBX5
chromobox homolog 5
chr1_-_156923111 0.470 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr12_-_52939584 0.468 NM_001127322
CBX5
chromobox homolog 5
chr7_-_112545840 0.468 LOC401397
hypothetical LOC401397
chr19_-_11355882 0.463 NM_000121
EPOR
erythropoietin receptor
chr3_-_25658829 0.461 TOP2B
topoisomerase (DNA) II beta 180kDa
chr10_+_94584449 0.453 NM_001013848
EXOC6
exocyst complex component 6
chr7_-_112545847 0.446 LOC401397
hypothetical LOC401397
chr8_-_86477585 0.445 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr21_-_38792173 0.431 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr6_-_50045296 0.428 NM_001037729
DEFB113
defensin, beta 113
chr2_-_63518589 0.425 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr19_+_60962318 0.420 NM_001145014
RFPL4A
ret finger protein-like 4A
chr10_-_42183441 0.420 LOC283027
hypothetical protein LOC283027
chr6_+_27215039 0.417 NM_003495
HIST1H4I
histone cluster 1, H4i
chr17_+_31195760 0.412 TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr3_-_69120188 0.410 C3orf64
chromosome 3 open reading frame 64
chr1_+_559618 0.410


chr3_+_63238854 0.408 NM_001130003
SYNPR
synaptoporin
chr8_+_98772537 0.402 MTDH
metadherin
chr12_-_9913724 0.395 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr3_-_170864111 0.391 NM_004991
MECOM
MDS1 and EVI1 complex locus
chr15_-_40537002 0.383 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr5_+_162862808 0.375 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr5_+_81636921 0.373 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr10_+_69539255 0.358 NM_032578
MYPN
myopalladin
chr5_+_40877053 0.357 NM_032587
CARD6
caspase recruitment domain family, member 6
chr4_-_123761615 0.356 NM_021803
IL21
interleukin 21
chr3_+_108578877 0.350 NM_032600
CCDC54
coiled-coil domain containing 54
chr20_+_34019942 0.349 NM_080834
C20orf152
chromosome 20 open reading frame 152
chrX_-_11194015 0.346 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr7_-_115458010 0.344 NM_001018058
NM_012252
TFEC

transcription factor EC

chr7_-_115458047 0.341 TFEC
transcription factor EC
chr19_-_4510713 0.341 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr19_-_56564068 0.339 NM_152353
CLDND2
claudin domain containing 2
chr6_+_31791063 0.338 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr3_-_170347019 0.333 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr10_+_81882477 0.333 PLAC9
placenta-specific 9
chr1_+_154120170 0.332 SYT11
synaptotagmin XI
chr11_+_46255737 0.329 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr19_-_53444733 0.324 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr4_+_55956520 0.314


chr6_+_105511615 0.304 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr18_-_28247186 0.303


chr1_+_12149662 0.303 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr5_+_137701122 0.302 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr19_-_60528480 0.299 NM_001085488
TMEM150B
transmembrane protein 150B
chrX_+_47999740 0.294 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr7_-_25234582 0.292 NM_022150
NPVF
neuropeptide VF precursor
chr5_+_57823017 0.290 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr4_-_120462705 0.288 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr2_-_144991556 0.285 ZEB2
zinc finger E-box binding homeobox 2
chr11_-_59707074 0.283 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr19_+_21480229 0.280 NM_001001415
ZNF429
zinc finger protein 429
chr17_+_59875623 0.280 NM_001085423
C17orf60
chromosome 17 open reading frame 60
chr11_+_120478584 0.278 NM_005422
TECTA
tectorin alpha
chr3_+_123817151 0.278 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr12_-_9651748 0.278 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr2_+_165804157 0.276 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr11_+_123600553 0.275 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr19_+_21116666 0.274 NM_133473
ZNF431
zinc finger protein 431
chr12_+_9871343 0.273 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr12_-_69434598 0.272 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr14_-_34414603 0.272 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr1_+_559129 0.272


chr10_+_49279647 0.272 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr1_-_156635879 0.270 NM_001004475
OR10T2
olfactory receptor, family 10, subfamily T, member 2
chr1_+_78243181 0.269 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr22_-_20667131 0.266 NM_003935
TOP3B
topoisomerase (DNA) III beta
chr18_+_30589937 0.265 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr3_-_197726587 0.261 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr1_+_150005754 0.261 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr7_+_101810018 0.261


chr1_+_190394214 0.259 NM_130782
RGS18
regulator of G-protein signaling 18
chr10_+_81882409 0.257 PLAC9
placenta-specific 9
chr1_+_12149637 0.256 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr7_-_86433139 0.245 NM_152748
KIAA1324L
KIAA1324-like
chr20_+_31717964 0.244 NM_001024675
C20orf134
chromosome 20 open reading frame 134
chr16_+_54072969 0.239 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr12_+_9925354 0.239 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr19_-_4486202 0.237 NM_001013706
PLIN5
perilipin 5
chr12_-_21818881 0.235 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr7_-_107667728 0.234 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr2_+_108230082 0.234 NM_001008743
SULT1C3
sulfotransferase family, cytosolic, 1C, member 3
chr6_+_118976134 0.233 NM_002667
PLN
phospholamban
chr10_+_35524060 0.233 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr11_-_85103438 0.233 NM_032379
SYTL2
synaptotagmin-like 2
chr3_+_110338250 0.231 FLJ22763
hypothetical LOC401081
chr6_+_28425666 0.230 NM_024493
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr13_-_22905822 0.230 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr17_-_34377150 0.228 NM_001008777
FBXO47
F-box protein 47
chr12_-_90097384 0.225 NM_133503
DCN
decorin
chr16_+_15503623 0.224 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr8_+_133060353 0.222 EFR3A
EFR3 homolog A (S. cerevisiae)
chr7_+_91762227 0.221


chr10_-_27097782 0.220 ABI1
abl-interactor 1
chr6_-_2696152 0.215 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr4_+_70831387 0.214 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr12_+_53177806 0.212 NCKAP1L
NCK-associated protein 1-like
chr6_-_76259976 0.208 NM_015687
FILIP1
filamin A interacting protein 1
chr7_-_105009160 0.208 EFCAB10
EF-hand calcium binding domain 10
chr12_+_53177789 0.204 NCKAP1L
NCK-associated protein 1-like
chr2_-_127817143 0.202 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr4_-_91979113 0.201 NM_183049
TMSL3
thymosin-like 3
chr11_+_123625632 0.200 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr4_-_160175782 0.200 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr16_+_52037186 0.198 RBL2
retinoblastoma-like 2 (p130)
chr10_-_13382042 0.197 PHYH
phytanoyl-CoA 2-hydroxylase
chr11_+_28088406 0.195 METTL15
methyltransferase like 15
chr16_+_28993770 0.195 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr1_-_191341866 0.193 NM_016066
GLRX2
glutaredoxin 2
chr3_+_160473729 0.193 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chrX_+_77889861 0.193 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr7_-_92615593 0.191 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr19_+_53450743 0.189


chr1_-_172199799 0.187 RC3H1
ring finger and CCCH-type domains 1
chrX_-_2896285 0.187 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr10_-_93659164 0.187 NM_152429
FGFBP3
fibroblast growth factor binding protein 3
chr9_-_106407728 0.187 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr19_+_2770942 0.186 ZNF554
zinc finger protein 554
chr3_+_63613383 0.186 NM_001080537
SNTN
sentan, cilia apical structure protein
chr5_+_76470829 0.185


chr18_+_28023984 0.184 NM_005925
MEP1B
meprin A, beta
chr7_+_104539548 0.183 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr5_+_140709907 0.183 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr1_-_245237977 0.183 NM_020394
ZNF695
zinc finger protein 695
chrX_+_154764136 0.182 NM_001145149
NM_001185183
NM_005638
VAMP7


vesicle-associated membrane protein 7


chr19_+_59158101 0.182 NM_031895
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr17_-_16038607 0.182 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr10_+_90414125 0.181 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr19_+_20138991 0.181 NM_052852
ZNF486
zinc finger protein 486
chr12_+_53177758 0.180 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr9_+_89687560 0.180 NM_178828
C9orf79
chromosome 9 open reading frame 79
chr19_+_60053709 0.178 NM_006737
KIR3DL2
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
chr1_-_245237952 0.177 ZNF695
zinc finger protein 695
chr19_-_20011251 0.176 NM_033196
ZNF682
zinc finger protein 682
chr1_-_156954528 0.176 NM_001005327
OR6K3
olfactory receptor, family 6, subfamily K, member 3
chr11_+_59564323 0.175 NM_173801
PLAC1L
placenta-specific 1-like
chr5_+_140573692 0.170 NM_018933
PCDHB13
protocadherin beta 13
chr11_+_59920062 0.169 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr2_+_102320148 0.168 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr8_+_7340777 0.167 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr2_+_234624084 0.165 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr1_-_245237925 0.164 ZNF695
zinc finger protein 695
chr6_-_39180390 0.164 C6orf64
chromosome 6 open reading frame 64
chr6_+_132000134 0.163 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr4_+_156807311 0.161 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr15_+_36014748 0.159 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr4_+_53986759 0.159 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr5_-_39306465 0.159 FYB
FYN binding protein
chr3_+_160473784 0.158 SCHIP1
schwannomin interacting protein 1
chr4_-_75083160 0.158 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr17_+_58625086 0.156 TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr12_+_54172413 0.155 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr7_-_130069399 0.155 NM_138693
KLF14
Kruppel-like factor 14
chr2_+_108571177 0.154 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_+_221168388 0.154 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr1_-_42549347 0.154


chr13_-_40454360 0.152 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_+_169637255 0.152 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_180685878 0.151 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr19_+_1221925 0.151 CIRBP
cold inducible RNA binding protein
chr9_-_122852356 0.151 NM_001735
C5
complement component 5
chrX_-_23835868 0.151 NM_024122
APOO
apolipoprotein O
chr9_-_124949033 0.150 STRBP
spermatid perinuclear RNA binding protein
chr17_+_58440629 0.148 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr13_+_22653059 0.148 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr3_+_35658852 0.148 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_+_150319076 0.148 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr2_+_108571209 0.146 LIMS1
LIM and senescent cell antigen-like domains 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.17 1.57e-11 GO:0007606 sensory perception of chemical stimulus
3.17 4.28e-10 GO:0007608 sensory perception of smell
2.31 4.63e-08 GO:0007600 sensory perception
1.75 2.67e-04 GO:0050877 neurological system process
1.65 3.05e-04 GO:0003008 system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.34 3.60e-04 GO:0005886 plasma membrane
1.33 4.53e-04 GO:0071944 cell periphery
1.27 7.36e-04 GO:0016021 integral to membrane
1.27 8.26e-04 GO:0031224 intrinsic to membrane
1.21 6.64e-03 GO:0044425 membrane part
1.40 4.20e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.33 1.68e-11 GO:0004984 olfactory receptor activity
2.29 9.38e-09 GO:0004930 G-protein coupled receptor activity
1.96 5.55e-08 GO:0004888 transmembrane receptor activity
1.73 1.62e-06 GO:0004872 receptor activity
1.62 7.14e-06 GO:0004871 signal transducer activity
1.62 7.14e-06 GO:0060089 molecular transducer activity