Motif ID: HES1.p2

Z-value: 1.316


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_195336631-0.611.3e-02Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_77094426 1.695 ACTG1
actin, gamma 1
chr5_+_75734759 1.612 NM_006633
 IQGAP2
IQ motif containing GTPase activating protein 2
chr19_-_50963942 1.556


chr9_-_125070613 1.474 NM_018387
 STRBP
spermatid perinuclear RNA binding protein
chr20_-_62081434 1.421 NM_080621
 SAMD10
sterile alpha motif domain containing 10
chr19_+_34994701 1.394 NM_001238
 CCNE1
cyclin E1
chr21_-_45786709 1.394 NM_194255
 SLC19A1
solute carrier family 19 (folate transporter), member 1
chr22_-_27405708 1.352 NM_001145418
 TTC28
tetratricopeptide repeat domain 28
chr8_-_12657339 1.287 NM_152271
 LONRF1
LON peptidase N-terminal domain and ring finger 1
chr17_-_77094375 1.202 NM_001614
 ACTG1
actin, gamma 1
chr20_-_62151216 1.159 NM_018419
 SOX18
SRY (sex determining region Y)-box 18
chr15_+_39573363 1.067 NM_002220
 ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr1_-_45444812 1.060 NM_020883
 ZSWIM5
zinc finger, SWIM-type containing 5
chr17_+_37941476 1.059 NM_000263
 NAGLU
N-acetylglucosaminidase, alpha
chr18_+_2836979 1.040 NM_032048
 EMILIN2
elastin microfibril interfacer 2
chr17_-_3814334 1.039 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
 ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr16_-_87244896 0.997 NM_000101
 CYBA
cytochrome b-245, alpha polypeptide
chr9_-_125070675 0.984 NM_001171137
 STRBP
spermatid perinuclear RNA binding protein
chr3_+_129690735 0.970


chr19_+_2240996 0.905



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 65 entries
enrichment   p-value GO term description
2.05 1.23e-04 GO:0016569 covalent chromatin modification
2.05 1.65e-04 GO:0016570 histone modification
1.94 1.01e-08 GO:0016568 chromatin modification
1.82 1.63e-08 GO:0006325 chromatin organization
1.79 9.11e-03 GO:0032868 response to insulin stimulus
1.71 1.27e-08 GO:0051276 chromosome organization
1.64 1.01e-02 GO:0043434 response to peptide hormone stimulus
1.60 1.17e-04 GO:0051253 negative regulation of RNA metabolic process
1.60 3.62e-02 GO:0070647 protein modification by small protein conjugation or removal
1.59 2.80e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.58 3.59e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.58 3.97e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.56 1.34e-04 GO:0010629 negative regulation of gene expression
1.56 2.91e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.55 1.59e-02 GO:0032583 regulation of gene-specific transcription
1.53 3.34e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.50 9.30e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.49 1.82e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.48 1.67e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.47 2.17e-03 GO:0009890 negative regulation of biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
3.64 2.01e-02 GO:0031519 PcG protein complex
1.70 5.42e-03 GO:0000785 chromatin
1.52 4.29e-12 GO:0005654 nucleoplasm
1.49 2.49e-05 GO:0044451 nucleoplasm part
1.49 9.69e-04 GO:0005694 chromosome
1.45 2.34e-13 GO:0031981 nuclear lumen
1.45 2.84e-02 GO:0044427 chromosomal part
1.44 7.41e-16 GO:0044428 nuclear part
1.43 2.79e-02 GO:0030529 ribonucleoprotein complex
1.40 3.39e-13 GO:0070013 intracellular organelle lumen
1.39 3.67e-13 GO:0031974 membrane-enclosed lumen
1.38 1.24e-12 GO:0043233 organelle lumen
1.30 1.49e-03 GO:0005739 mitochondrion
1.28 9.50e-23 GO:0005634 nucleus
1.28 2.36e-05 GO:0005829 cytosol
1.22 1.54e-13 GO:0044446 intracellular organelle part
1.21 1.01e-29 GO:0043231 intracellular membrane-bounded organelle
1.21 1.25e-29 GO:0043227 membrane-bounded organelle
1.21 2.30e-12 GO:0044422 organelle part
1.19 4.69e-28 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
5.03 1.36e-02 GO:0046965 retinoid X receptor binding
4.72 8.99e-03 GO:0042974 retinoic acid receptor binding
2.50 8.55e-04 GO:0042393 histone binding
1.82 6.31e-06 GO:0016564 transcription repressor activity
1.82 5.16e-03 GO:0003682 chromatin binding
1.78 4.68e-02 GO:0000287 magnesium ion binding
1.74 2.24e-04 GO:0008134 transcription factor binding
1.71 2.45e-03 GO:0016881 acid-amino acid ligase activity
1.67 2.52e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.66 1.22e-03 GO:0016563 transcription activator activity
1.64 4.85e-02 GO:0019787 small conjugating protein ligase activity
1.57 5.10e-04 GO:0016874 ligase activity
1.52 6.54e-03 GO:0019904 protein domain specific binding
1.51 3.08e-02 GO:0003712 transcription cofactor activity
1.51 3.43e-02 GO:0000988 protein binding transcription factor activity
1.51 3.43e-02 GO:0000989 transcription factor binding transcription factor activity
1.47 4.09e-07 GO:0030528 transcription regulator activity
1.41 4.05e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.40 2.33e-03 GO:0016301 kinase activity
1.39 6.36e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups