Motif ID: MTF1.p2

Z-value: 3.563


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_380978110.107.1e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_160964574 10.063 SCHIP1
schwannomin interacting protein 1
chr10_+_124211353 7.295 HTRA1
HtrA serine peptidase 1
chr9_+_90339835 6.338 NM_001161625
NM_145283
 NXNL2

nucleoredoxin-like 2

chr14_+_105012106 6.296 NM_001312
 CRIP2
cysteine-rich protein 2
chr16_+_55217180 5.902 MT1E
metallothionein 1E
chr4_+_108965167 5.296 NM_001136258
 SGMS2
sphingomyelin synthase 2
chr16_+_55217085 5.282 NM_175617
 MT1E
metallothionein 1E
chr13_-_105985313 5.009 NM_004093
 EFNB2
ephrin-B2
chr13_-_109757442 4.876 NM_001845
 COL4A1
collagen, type IV, alpha 1
chr3_+_191714533 4.861 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
 IL1RAP





interleukin 1 receptor accessory protein





chr15_-_68933481 4.850 NM_018357
NM_197958
 LARP6

La ribonucleoprotein domain family, member 6

chr6_+_142664490 4.520 NM_001032394
NM_001032395
NM_020455
NM_198569
 GPR126



G protein-coupled receptor 126



chr3_+_61522219 4.428 NM_002841
 PTPRG
protein tyrosine phosphatase, receptor type, G
chr3_+_61522310 4.328 PTPRG
protein tyrosine phosphatase, receptor type, G
chr6_-_143307976 4.227 NM_006734
 HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr8_-_121893468 4.163 NM_021021
 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr10_-_725522 4.080 NM_014974
 DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr9_-_109291130 3.977 KLF4
Kruppel-like factor 4 (gut)
chr3_-_135575925 3.958 NM_016201
 AMOTL2
angiomotin like 2
chr2_-_40532651 3.957 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 170 entries
enrichment   p-value GO term description
3.42 4.13e-02 GO:0002040 sprouting angiogenesis
2.77 4.82e-02 GO:0010717 regulation of epithelial to mesenchymal transition
2.49 1.11e-02 GO:0045767 regulation of anti-apoptosis
2.37 1.42e-02 GO:0001933 negative regulation of protein phosphorylation
2.35 6.07e-04 GO:0042326 negative regulation of phosphorylation
2.28 1.04e-03 GO:0010563 negative regulation of phosphorus metabolic process
2.28 1.04e-03 GO:0045936 negative regulation of phosphate metabolic process
2.06 3.81e-02 GO:0007173 epidermal growth factor receptor signaling pathway
2.00 2.07e-04 GO:0022604 regulation of cell morphogenesis
1.98 4.20e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.98 9.31e-04 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.94 1.26e-02 GO:0010720 positive regulation of cell development
1.92 1.49e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.81 6.54e-03 GO:0034330 cell junction organization
1.80 4.07e-12 GO:0048812 neuron projection morphogenesis
1.80 1.79e-11 GO:0007409 axonogenesis
1.79 8.91e-12 GO:0048667 cell morphogenesis involved in neuron differentiation
1.75 3.94e-12 GO:0000904 cell morphogenesis involved in differentiation
1.75 6.08e-12 GO:0031175 neuron projection development
1.74 3.76e-07 GO:0007411 axon guidance

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
2.07 1.17e-02 GO:0030427 site of polarized growth
2.07 1.73e-02 GO:0030426 growth cone
1.97 8.80e-04 GO:0019898 extrinsic to membrane
1.84 2.23e-04 GO:0005912 adherens junction
1.78 9.64e-05 GO:0031252 cell leading edge
1.74 1.03e-03 GO:0070161 anchoring junction
1.55 4.15e-02 GO:0005911 cell-cell junction
1.51 3.58e-02 GO:0016323 basolateral plasma membrane
1.47 2.48e-02 GO:0015629 actin cytoskeleton
1.40 2.28e-02 GO:0043005 neuron projection
1.38 1.31e-03 GO:0030054 cell junction
1.27 2.49e-02 GO:0042995 cell projection
1.22 3.66e-05 GO:0044459 plasma membrane part
1.21 8.80e-03 GO:0005856 cytoskeleton
1.20 4.66e-04 GO:0005829 cytosol
1.11 5.97e-10 GO:0005737 cytoplasm
1.09 5.46e-12 GO:0044424 intracellular part
1.09 1.29e-02 GO:0005634 nucleus
1.09 2.51e-02 GO:0044444 cytoplasmic part
1.08 2.75e-11 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
3.73 4.89e-02 GO:0070411 I-SMAD binding
2.73 4.65e-05 GO:0046332 SMAD binding
2.33 1.97e-02 GO:0008013 beta-catenin binding
2.03 6.39e-03 GO:0019199 transmembrane receptor protein kinase activity
1.79 4.64e-02 GO:0019838 growth factor binding
1.56 4.22e-02 GO:0003924 GTPase activity
1.43 4.42e-04 GO:0008092 cytoskeletal protein binding
1.43 2.32e-02 GO:0019001 guanyl nucleotide binding
1.43 2.32e-02 GO:0032561 guanyl ribonucleotide binding
1.42 6.55e-03 GO:0019904 protein domain specific binding
1.42 4.07e-02 GO:0005525 GTP binding
1.35 9.65e-04 GO:0019899 enzyme binding
1.33 2.26e-02 GO:0004672 protein kinase activity
1.32 7.58e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.30 1.69e-02 GO:0016301 kinase activity
1.28 1.32e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.27 1.17e-02 GO:0030234 enzyme regulator activity
1.18 3.70e-02 GO:0032553 ribonucleotide binding
1.18 3.70e-02 GO:0032555 purine ribonucleotide binding
1.18 3.83e-02 GO:0035639 purine ribonucleoside triphosphate binding