Motif ID: MTF1.p2

Z-value: 3.563


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_380978110.107.1e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_160964574 10.063 SCHIP1
schwannomin interacting protein 1
chr10_+_124211353 7.295 HTRA1
HtrA serine peptidase 1
chr9_+_90339835 6.338 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr14_+_105012106 6.296 NM_001312
CRIP2
cysteine-rich protein 2
chr16_+_55217180 5.902 MT1E
metallothionein 1E
chr4_+_108965167 5.296 NM_001136258
SGMS2
sphingomyelin synthase 2
chr16_+_55217085 5.282 NM_175617
MT1E
metallothionein 1E
chr13_-_105985313 5.009 NM_004093
EFNB2
ephrin-B2
chr13_-_109757442 4.876 NM_001845
COL4A1
collagen, type IV, alpha 1
chr3_+_191714533 4.861 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr15_-_68933481 4.850 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr6_+_142664490 4.520 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr3_+_61522219 4.428 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr3_+_61522310 4.328 PTPRG
protein tyrosine phosphatase, receptor type, G
chr6_-_143307976 4.227 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr8_-_121893468 4.163 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr10_-_725522 4.080 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr9_-_109291130 3.977 KLF4
Kruppel-like factor 4 (gut)
chr3_-_135575925 3.958 NM_016201
AMOTL2
angiomotin like 2
chr2_-_40532651 3.957 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr15_-_23659329 3.891 NM_024490
ATP10A
ATPase, class V, type 10A
chr2_-_204108151 3.834 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr7_-_27136876 3.794 NM_002141
HOXA4
homeobox A4
chr10_+_124210980 3.608 NM_002775
HTRA1
HtrA serine peptidase 1
chr16_+_55199978 3.481 NM_005953
MT2A
metallothionein 2A
chr11_+_35596310 3.469 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr4_-_22126437 3.467 NM_145290
GPR125
G protein-coupled receptor 125
chr12_+_6179736 3.418 NM_001769
CD9
CD9 molecule
chr2_+_54537842 3.407 SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_+_208472817 3.391 NM_019605
SERTAD4
SERTA domain containing 4
chr9_-_83493415 3.350 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr9_-_83494198 3.327 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr8_+_121892719 3.310


chr20_-_10602139 3.293 JAG1
jagged 1
chr8_-_121893449 3.290 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr7_-_42243142 3.230 NM_000168
GLI3
GLI family zinc finger 3
chr7_+_288195 3.224 FAM20C
family with sequence similarity 20, member C
chr2_+_28469864 3.218 FOSL2
FOS-like antigen 2
chr14_+_73073570 3.216 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr4_+_148872902 3.211 NM_024605
ARHGAP10
Rho GTPase activating protein 10
chr2_+_235525355 3.185 NM_014521
SH3BP4
SH3-domain binding protein 4
chr10_+_128583984 3.175 NM_001380
DOCK1
dedicator of cytokinesis 1
chr8_-_121892877 3.168 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr19_-_36531958 3.125 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr12_-_105056577 3.106 NUAK1
NUAK family, SNF1-like kinase, 1
chr1_-_223907283 3.092 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr17_-_40263124 3.067 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr13_+_109757593 3.067 NM_001846
COL4A2
collagen, type IV, alpha 2
chr6_+_142665057 2.995 GPR126
G protein-coupled receptor 126
chr14_+_85069217 2.933


chr7_+_288051 2.901 NM_020223
FAM20C
family with sequence similarity 20, member C
chr10_-_35143900 2.855 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr9_-_109291575 2.805 KLF4
Kruppel-like factor 4 (gut)
chr16_+_27232745 2.794 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr2_-_238861830 2.792 NM_022817
PER2
period homolog 2 (Drosophila)
chr16_+_85169615 2.780 NM_005250
FOXL1
forkhead box L1
chr2_+_238060602 2.757 NM_001042467
NM_024101
MLPH

melanophilin

chr16_+_27232770 2.757 IL4R
interleukin 4 receptor
chr8_-_120033240 2.668 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr14_-_24588916 2.625 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr18_-_44731078 2.613 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr12_+_56406296 2.603 LOC100130776
hypothetical LOC100130776
chr8_-_121893196 2.595


chr20_+_6696744 2.591 NM_001200
BMP2
bone morphogenetic protein 2
chr7_-_81910956 2.586 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr2_+_20510312 2.571 NM_004040
RHOB
ras homolog gene family, member B
chr13_-_43259032 2.570 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr11_-_11986704 2.565 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr2_+_85834111 2.559 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr5_+_148631636 2.554 AFAP1L1
actin filament associated protein 1-like 1
chr14_+_95575319 2.554 C14orf132
chromosome 14 open reading frame 132
chr21_+_41461924 2.545 BACE2
beta-site APP-cleaving enzyme 2
chr14_+_99181232 2.542 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr5_+_148631588 2.539 NM_001146337
NM_152406
AFAP1L1

actin filament associated protein 1-like 1

chr12_-_41269679 2.537 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr16_+_55224034 2.531 NM_176870
MT1M
metallothionein 1M
chr5_-_146869811 2.514 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr3_+_61522922 2.495 PTPRG
protein tyrosine phosphatase, receptor type, G
chr1_-_68071635 2.486 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr5_-_146869613 2.462 DPYSL3
dihydropyrimidinase-like 3
chr8_+_1699276 2.457 NM_018941
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr2_-_207739815 2.428 KLF7
Kruppel-like factor 7 (ubiquitous)
chr9_+_90796169 2.369 NM_005226
S1PR3
sphingosine-1-phosphate receptor 3
chr9_-_112840064 2.358 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr8_-_134653194 2.357 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr7_+_27102508 2.354


chr15_+_97010219 2.347 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr9_+_115958051 2.332 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr16_-_63713466 2.330 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr9_-_93225780 2.322 NFIL3
nuclear factor, interleukin 3 regulated
chr2_-_160972606 2.306 RBMS1
RNA binding motif, single stranded interacting protein 1
chr16_-_63713485 2.304 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr19_+_61742111 2.290 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr8_+_32525269 2.288 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr16_-_63713382 2.287 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr8_+_1699418 2.250 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr1_-_115682374 2.237 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr12_+_95112131 2.232 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr2_-_101134146 2.231 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr1_+_181259317 2.231


chr5_+_14196287 2.199 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr6_-_170442090 2.175


chr6_+_17501589 2.169 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr2_+_28469199 2.167 FOSL2
FOS-like antigen 2
chr11_-_44928803 2.161 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chrX_+_149282097 2.148 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr3_-_48607596 2.140 NM_000094
COL7A1
collagen, type VII, alpha 1
chr2_-_56004366 2.131 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr7_+_116099648 2.124 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr21_+_32706615 2.110 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr2_+_36436316 2.109 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr19_+_58733144 2.106 NM_001079906
ZNF331
zinc finger protein 331
chr9_-_94936319 2.102 NM_004148
NINJ1
ninjurin 1
chr10_-_33663984 2.096 NRP1
neuropilin 1
chr3_-_64648370 2.096 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr10_-_63698463 2.093 NM_145307
RTKN2
rhotekin 2
chr2_+_152900076 2.084 FMNL2
formin-like 2
chr3_-_185025989 2.075 NM_024871
MAP6D1
MAP6 domain containing 1
chr12_+_26003218 2.049 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr7_-_42243318 2.044 GLI3
GLI family zinc finger 3
chr7_-_81910740 2.038 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr6_-_153494076 2.038 NM_012419
RGS17
regulator of G-protein signaling 17
chr17_+_32924049 2.031 NM_007026
DUSP14
dual specificity phosphatase 14
chr3_+_32408346 2.013 CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr2_+_28469850 2.011 FOSL2
FOS-like antigen 2
chr5_+_34692239 2.006 RAI14
retinoic acid induced 14
chr13_-_25523164 2.001 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr7_+_32963486 1.991 NM_007270
FKBP9
FK506 binding protein 9, 63 kDa
chr13_+_97593411 1.985 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr15_-_58671929 1.985 NM_134262
RORA
RAR-related orphan receptor A
chr2_+_28469172 1.972 FOSL2
FOS-like antigen 2
chr13_+_97593469 1.965 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr9_-_34448477 1.957 NM_001184940
NM_001184941
NM_001184942
NM_001184943
NM_001184944
NM_001184945
NM_147202
C9orf25






chromosome 9 open reading frame 25






chr21_+_36429079 1.953 NM_001236
CBR3
carbonyl reductase 3
chr14_+_73105618 1.951 ACOT2
acyl-CoA thioesterase 2
chr9_+_70161634 1.932 NM_021965
PGM5
phosphoglucomutase 5
chr15_+_29406335 1.930 NM_015995
KLF13
Kruppel-like factor 13
chr4_+_151218862 1.926 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr10_-_128884411 1.903 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr12_+_13045702 1.885 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chr11_+_101485946 1.883 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr10_-_116517945 1.876 ABLIM1
actin binding LIM protein 1
chr13_+_26029799 1.846 NM_006646
WASF3
WAS protein family, member 3
chr4_+_30330963 1.842 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr15_-_53667800 1.832 PYGO1
pygopus homolog 1 (Drosophila)
chr2_+_173000590 1.814 ITGA6
integrin, alpha 6
chr14_+_22375753 1.811 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr10_+_71232281 1.811 COL13A1
collagen, type XIII, alpha 1
chr4_-_125853166 1.792 NM_001167882
NM_020337
ANKRD50

ankyrin repeat domain 50

chr5_+_72452131 1.784 NM_001161342
NM_173490
TMEM171

transmembrane protein 171

chr7_+_2638156 1.782 TTYH3
tweety homolog 3 (Drosophila)
chr9_-_109291866 1.780 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr17_+_75625025 1.778 NM_017950
CCDC40
coiled-coil domain containing 40
chr1_+_19843261 1.769 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr8_-_75396016 1.765 NM_020647
JPH1
junctophilin 1
chr7_-_76883642 1.763 NM_017439
PION
pigeon homolog (Drosophila)
chr6_+_3697328 1.760


chr10_+_99463468 1.757 MARVELD1
MARVEL domain containing 1
chr19_+_39664706 1.756 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr3_+_32408155 1.743 NM_138410
NM_181472
CMTM7

CKLF-like MARVEL transmembrane domain containing 7

chr10_+_11100111 1.734 CELF2
CUGBP, Elav-like family member 2
chr21_+_41461597 1.720 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr1_+_156229934 1.718 KIRREL
kin of IRRE like (Drosophila)
chr6_-_170441493 1.702 NM_005618
DLL1
delta-like 1 (Drosophila)
chr2_-_165406564 1.700 COBLL1
COBL-like 1
chr6_-_3697244 1.696 NM_183373
C6orf145
chromosome 6 open reading frame 145
chr1_+_85819004 1.688 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_+_58058783 1.682 MRC2
mannose receptor, C type 2
chr2_+_28469275 1.670 NM_005253
FOSL2
FOS-like antigen 2
chr7_+_89678935 1.668 NM_152999
NM_001040665
STEAP2

six transmembrane epithelial antigen of the prostate 2

chr1_-_3437834 1.667 MEGF6
multiple EGF-like-domains 6
chr6_+_17389752 1.652 NM_001143942
RBM24
RNA binding motif protein 24
chr8_-_125809559 1.651 MTSS1
metastasis suppressor 1
chr17_-_75624048 1.648 NM_019020
TBC1D16
TBC1 domain family, member 16
chr22_-_23318829 1.646 NM_207644
C22orf36
chromosome 22 open reading frame 36
chr3_+_112273464 1.643 NM_015480
PVRL3
poliovirus receptor-related 3
chr18_-_20105814 1.639 OSBPL1A
oxysterol binding protein-like 1A
chr17_-_61618276 1.624 NM_145036
CCDC46
coiled-coil domain containing 46
chr5_-_171643247 1.623 UBTD2
ubiquitin domain containing 2
chr2_-_210744158 1.612 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr13_-_20533629 1.609 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr10_+_133850325 1.605 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr5_-_171643399 1.605 NM_152277
UBTD2
ubiquitin domain containing 2
chr14_-_89155078 1.603 NM_001085471
FOXN3
forkhead box N3
chr1_+_9275518 1.601 NM_025106
SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr22_-_19122047 1.590 SCARF2
scavenger receptor class F, member 2
chr10_+_89409332 1.586 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr5_+_72148173 1.580 NM_002270
TNPO1
transportin 1
chr16_-_79395379 1.576 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr20_+_34206070 1.569 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr13_-_39075200 1.567 LHFP
lipoma HMGIC fusion partner
chr7_-_27102049 1.565 NM_005522
NM_153620
HOXA1

homeobox A1

chr4_+_30331289 1.564 PCDH7
protocadherin 7
chr17_-_21395483 1.563 NM_001113434
C17orf51
chromosome 17 open reading frame 51
chr12_-_105165805 1.562 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr2_+_206255597 1.560 NRP2
neuropilin 2
chr6_-_16869579 1.559 NM_000332
NM_001128164
ATXN1

ataxin 1

chr4_+_148872661 1.547 ARHGAP10
Rho GTPase activating protein 10
chr6_+_170441715 1.532 FAM120B
family with sequence similarity 120B
chr2_-_179837490 1.526 NM_178123
SESTD1
SEC14 and spectrin domains 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.52 1.21e-19 GO:0007399 nervous system development
1.66 1.63e-18 GO:0022008 neurogenesis
1.48 1.65e-18 GO:0023051 regulation of signaling
1.67 1.19e-17 GO:0048699 generation of neurons
1.50 1.32e-17 GO:0009966 regulation of signal transduction
1.15 2.29e-15 GO:0065007 biological regulation
1.28 2.45e-15 GO:0007275 multicellular organismal development
1.26 2.54e-15 GO:0032502 developmental process
1.16 4.66e-15 GO:0050789 regulation of biological process
1.31 6.61e-15 GO:0048731 system development
1.17 2.42e-14 GO:0050794 regulation of cellular process
1.29 2.96e-14 GO:0048856 anatomical structure development
1.26 3.17e-14 GO:0023052 signaling
1.37 4.33e-14 GO:0030154 cell differentiation
1.44 9.07e-14 GO:0009653 anatomical structure morphogenesis
1.35 1.01e-13 GO:0048523 negative regulation of cellular process
1.66 1.34e-13 GO:0030182 neuron differentiation
1.33 1.70e-13 GO:0048519 negative regulation of biological process
1.09 4.45e-13 GO:0009987 cellular process
1.35 4.94e-13 GO:0048869 cellular developmental process
1.51 5.47e-13 GO:0010646 regulation of cell communication
1.37 7.54e-13 GO:0048583 regulation of response to stimulus
1.26 2.17e-12 GO:0007165 signal transduction
1.75 3.94e-12 GO:0000904 cell morphogenesis involved in differentiation
1.80 4.07e-12 GO:0048812 neuron projection morphogenesis
1.75 6.08e-12 GO:0031175 neuron projection development
1.79 8.91e-12 GO:0048667 cell morphogenesis involved in neuron differentiation
1.80 1.79e-11 GO:0007409 axonogenesis
1.62 6.05e-11 GO:0007167 enzyme linked receptor protein signaling pathway
1.66 1.01e-10 GO:0048666 neuron development
1.21 1.36e-10 GO:0051716 cellular response to stimulus
1.62 1.70e-10 GO:0030030 cell projection organization
1.48 2.10e-09 GO:0048468 cell development
1.67 2.42e-09 GO:0048858 cell projection morphogenesis
1.66 2.70e-09 GO:0032990 cell part morphogenesis
1.60 3.48e-09 GO:0000902 cell morphogenesis
1.27 6.25e-09 GO:0048522 positive regulation of cellular process
1.25 1.02e-08 GO:0048518 positive regulation of biological process
1.57 1.68e-08 GO:0032989 cellular component morphogenesis
1.64 6.99e-08 GO:0072358 cardiovascular system development
1.64 6.99e-08 GO:0072359 circulatory system development
1.52 2.02e-07 GO:0042325 regulation of phosphorylation
1.51 2.13e-07 GO:0045595 regulation of cell differentiation
1.21 2.86e-07 GO:0016043 cellular component organization
1.67 3.06e-07 GO:0009968 negative regulation of signal transduction
1.59 3.09e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.50 3.40e-07 GO:0019220 regulation of phosphate metabolic process
1.50 3.40e-07 GO:0051174 regulation of phosphorus metabolic process
1.74 3.76e-07 GO:0007411 axon guidance
1.30 5.33e-07 GO:0007166 cell surface receptor linked signaling pathway
1.52 5.57e-07 GO:0001932 regulation of protein phosphorylation
1.36 5.81e-07 GO:0051239 regulation of multicellular organismal process
1.34 6.44e-07 GO:0035556 intracellular signal transduction
1.47 1.34e-06 GO:2000026 regulation of multicellular organismal development
1.61 1.53e-06 GO:0023057 negative regulation of signaling
1.61 1.86e-06 GO:0010648 negative regulation of cell communication
1.28 2.82e-06 GO:0006464 protein modification process
1.48 2.92e-06 GO:0009790 embryo development
1.59 3.13e-06 GO:0048646 anatomical structure formation involved in morphogenesis
1.41 3.61e-06 GO:0050793 regulation of developmental process
1.43 3.76e-06 GO:0051128 regulation of cellular component organization
1.71 4.78e-06 GO:0060284 regulation of cell development
1.19 8.64e-06 GO:0071840 cellular component organization or biogenesis
1.72 1.46e-05 GO:0001944 vasculature development
1.54 1.75e-05 GO:0048585 negative regulation of response to stimulus
1.21 2.19e-05 GO:0071842 cellular component organization at cellular level
1.18 3.97e-05 GO:0060255 regulation of macromolecule metabolic process
1.17 5.17e-05 GO:0080090 regulation of primary metabolic process
1.50 6.09e-05 GO:0023056 positive regulation of signaling
1.25 6.16e-05 GO:0043412 macromolecule modification
1.35 8.04e-05 GO:0006793 phosphorus metabolic process
1.35 8.04e-05 GO:0006796 phosphate metabolic process
1.69 9.29e-05 GO:0035295 tube development
1.46 9.74e-05 GO:0009887 organ morphogenesis
1.49 1.22e-04 GO:0010647 positive regulation of cell communication
1.37 1.56e-04 GO:0040011 locomotion
1.17 1.58e-04 GO:0031323 regulation of cellular metabolic process
1.35 1.82e-04 GO:0032879 regulation of localization
1.67 1.98e-04 GO:0061061 muscle structure development
1.41 1.99e-04 GO:0006468 protein phosphorylation
2.00 2.07e-04 GO:0022604 regulation of cell morphogenesis
1.49 2.26e-04 GO:0009967 positive regulation of signal transduction
1.38 3.20e-04 GO:0031399 regulation of protein modification process
1.52 3.47e-04 GO:0051094 positive regulation of developmental process
1.21 3.59e-04 GO:0042221 response to chemical stimulus
1.15 3.98e-04 GO:0019222 regulation of metabolic process
1.98 4.20e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.62 5.47e-04 GO:0022603 regulation of anatomical structure morphogenesis
2.35 6.07e-04 GO:0042326 negative regulation of phosphorylation
1.59 6.16e-04 GO:0032535 regulation of cellular component size
1.19 6.29e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.32 6.31e-04 GO:0008104 protein localization
1.68 6.81e-04 GO:0050767 regulation of neurogenesis
1.52 7.13e-04 GO:0040008 regulation of growth
1.58 7.43e-04 GO:0045597 positive regulation of cell differentiation
1.57 8.62e-04 GO:0007389 pattern specification process
1.98 9.31e-04 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
2.28 1.04e-03 GO:0010563 negative regulation of phosphorus metabolic process
2.28 1.04e-03 GO:0045936 negative regulation of phosphate metabolic process
1.61 1.11e-03 GO:0048729 tissue morphogenesis
1.54 1.16e-03 GO:0090066 regulation of anatomical structure size
1.92 1.49e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.62 1.74e-03 GO:0051960 regulation of nervous system development
1.52 1.92e-03 GO:0007264 small GTPase mediated signal transduction
1.29 2.00e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.30 2.05e-03 GO:0051246 regulation of protein metabolic process
1.15 2.09e-03 GO:0051179 localization
1.31 2.48e-03 GO:0032268 regulation of cellular protein metabolic process
1.27 3.22e-03 GO:0033036 macromolecule localization
1.28 3.71e-03 GO:0031325 positive regulation of cellular metabolic process
1.61 3.95e-03 GO:0001568 blood vessel development
1.66 4.10e-03 GO:0002009 morphogenesis of an epithelium
1.20 4.27e-03 GO:0065008 regulation of biological quality
1.48 4.30e-03 GO:0008285 negative regulation of cell proliferation
1.33 4.56e-03 GO:0015031 protein transport
1.51 5.15e-03 GO:0043009 chordate embryonic development
1.51 5.42e-03 GO:0009792 embryo development ending in birth or egg hatching
1.32 5.68e-03 GO:0045184 establishment of protein localization
1.43 6.18e-03 GO:0051338 regulation of transferase activity
1.64 6.21e-03 GO:0007507 heart development
1.26 6.36e-03 GO:0009893 positive regulation of metabolic process
1.81 6.54e-03 GO:0034330 cell junction organization
1.41 7.09e-03 GO:0006928 cellular component movement
1.60 7.20e-03 GO:0045596 negative regulation of cell differentiation
1.63 7.60e-03 GO:0001558 regulation of cell growth
1.21 8.01e-03 GO:0048513 organ development
1.37 8.56e-03 GO:0009719 response to endogenous stimulus
1.43 9.25e-03 GO:0043549 regulation of kinase activity
1.56 9.47e-03 GO:0040012 regulation of locomotion
1.30 9.53e-03 GO:0009605 response to external stimulus
1.42 1.03e-02 GO:0007417 central nervous system development
1.62 1.03e-02 GO:0003002 regionalization
1.44 1.05e-02 GO:0045859 regulation of protein kinase activity
2.49 1.11e-02 GO:0045767 regulation of anti-apoptosis
1.32 1.12e-02 GO:0016310 phosphorylation
1.35 1.20e-02 GO:0051049 regulation of transport
1.10 1.22e-02 GO:0050896 response to stimulus
1.35 1.26e-02 GO:0009890 negative regulation of biosynthetic process
1.94 1.26e-02 GO:0010720 positive regulation of cell development
1.59 1.31e-02 GO:0008361 regulation of cell size
1.26 1.35e-02 GO:0010033 response to organic substance
1.31 1.39e-02 GO:0009888 tissue development
1.46 1.40e-02 GO:0016477 cell migration
1.38 1.41e-02 GO:0009725 response to hormone stimulus
2.37 1.42e-02 GO:0001933 negative regulation of protein phosphorylation
1.12 1.48e-02 GO:0044260 cellular macromolecule metabolic process
1.58 1.57e-02 GO:0030334 regulation of cell migration
1.29 1.69e-02 GO:0042127 regulation of cell proliferation
1.59 1.81e-02 GO:0000165 MAPKKK cascade
1.66 1.97e-02 GO:0045664 regulation of neuron differentiation
1.54 2.14e-02 GO:0051270 regulation of cellular component movement
1.45 2.15e-02 GO:0007243 intracellular protein kinase cascade
1.45 2.15e-02 GO:0023014 signal transduction via phosphorylation event
1.46 2.24e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.68 2.66e-02 GO:0035239 tube morphogenesis
1.56 2.72e-02 GO:2000145 regulation of cell motility
1.42 2.79e-02 GO:0048870 cell motility
1.42 2.79e-02 GO:0051674 localization of cell
1.28 2.90e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.11 3.22e-02 GO:0032501 multicellular organismal process
1.52 3.36e-02 GO:0051130 positive regulation of cellular component organization
1.28 3.46e-02 GO:0009892 negative regulation of metabolic process
1.39 3.62e-02 GO:0006935 chemotaxis
1.39 3.62e-02 GO:0042330 taxis
2.06 3.81e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.46 3.88e-02 GO:0051056 regulation of small GTPase mediated signal transduction
3.42 4.13e-02 GO:0002040 sprouting angiogenesis
1.73 4.56e-02 GO:0045165 cell fate commitment
2.77 4.82e-02 GO:0010717 regulation of epithelial to mesenchymal transition
1.16 4.89e-02 GO:0044267 cellular protein metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 5.46e-12 GO:0044424 intracellular part
1.08 2.75e-11 GO:0005622 intracellular
1.11 5.97e-10 GO:0005737 cytoplasm
1.22 3.66e-05 GO:0044459 plasma membrane part
1.78 9.64e-05 GO:0031252 cell leading edge
1.84 2.23e-04 GO:0005912 adherens junction
1.03 2.45e-04 GO:0044464 cell part
1.03 2.59e-04 GO:0005623 cell
1.20 4.66e-04 GO:0005829 cytosol
1.07 7.70e-04 GO:0043226 organelle
1.97 8.80e-04 GO:0019898 extrinsic to membrane
1.06 1.01e-03 GO:0043229 intracellular organelle
1.74 1.03e-03 GO:0070161 anchoring junction
1.38 1.31e-03 GO:0030054 cell junction
1.21 8.80e-03 GO:0005856 cytoskeleton
2.07 1.17e-02 GO:0030427 site of polarized growth
1.09 1.29e-02 GO:0005634 nucleus
2.07 1.73e-02 GO:0030426 growth cone
1.40 2.28e-02 GO:0043005 neuron projection
1.47 2.48e-02 GO:0015629 actin cytoskeleton
1.27 2.49e-02 GO:0042995 cell projection
1.09 2.51e-02 GO:0044444 cytoplasmic part
1.06 3.24e-02 GO:0043227 membrane-bounded organelle
1.51 3.58e-02 GO:0016323 basolateral plasma membrane
1.06 3.78e-02 GO:0043231 intracellular membrane-bounded organelle
1.55 4.15e-02 GO:0005911 cell-cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 3.41e-17 GO:0005515 protein binding
1.08 1.46e-11 GO:0005488 binding
2.73 4.65e-05 GO:0046332 SMAD binding
1.43 4.42e-04 GO:0008092 cytoskeletal protein binding
1.35 9.65e-04 GO:0019899 enzyme binding
2.03 6.39e-03 GO:0019199 transmembrane receptor protein kinase activity
1.42 6.55e-03 GO:0019904 protein domain specific binding
1.32 7.58e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.27 1.17e-02 GO:0030234 enzyme regulator activity
1.28 1.32e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.30 1.69e-02 GO:0016301 kinase activity
2.33 1.97e-02 GO:0008013 beta-catenin binding
1.33 2.26e-02 GO:0004672 protein kinase activity
1.43 2.32e-02 GO:0019001 guanyl nucleotide binding
1.43 2.32e-02 GO:0032561 guanyl ribonucleotide binding
1.18 3.70e-02 GO:0032553 ribonucleotide binding
1.18 3.70e-02 GO:0032555 purine ribonucleotide binding
1.18 3.83e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.42 4.07e-02 GO:0005525 GTP binding
1.56 4.22e-02 GO:0003924 GTPase activity
1.79 4.64e-02 GO:0019838 growth factor binding
3.73 4.89e-02 GO:0070411 I-SMAD binding