Motif ID: NFATC1..3.p2

Z-value: 2.556


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFATC3chr16_+_66676851-0.774.3e-04Click!
NFATC2chr20_-_49592444-0.692.8e-03Click!
NFATC1chr18_+_75354312-0.439.3e-02Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_13240983 11.425 EMP1
epithelial membrane protein 1
chr12_+_13240987 11.059 EMP1
epithelial membrane protein 1
chr12_+_13240868 9.665 NM_001423
EMP1
epithelial membrane protein 1
chr10_-_116434364 6.652 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr18_-_51219880 6.419 TCF4
transcription factor 4
chr10_-_116434102 5.272 ABLIM1
actin binding LIM protein 1
chr22_-_34566210 4.876 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr8_-_13416554 4.691 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr1_+_157246305 4.440 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr4_-_115120251 4.147 NM_024590
ARSJ
arylsulfatase family, member J
chr22_-_34566276 3.894 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_160868822 3.892 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr1_+_160868932 3.882 DDR2
discoidin domain receptor tyrosine kinase 2
chr21_-_27261276 3.862 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr22_-_34566367 3.722 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr21_-_26867138 3.441 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr9_+_74956494 3.362 NM_000700
ANXA1
annexin A1
chrX_+_100692071 3.333 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr13_-_32822759 3.258 STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_68470585 3.198 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr6_-_128883125 3.193 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr4_-_152366970 3.191 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr2_+_189547377 3.172 COL3A1
collagen, type III, alpha 1
chr4_-_153493133 3.001 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr12_+_118100977 2.854 NM_014365
HSPB8
heat shock 22kDa protein 8
chr13_-_79810972 2.848 SPRY2
sprouty homolog 2 (Drosophila)
chr7_+_115952074 2.827 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr4_-_141293572 2.818 MAML3
mastermind-like 3 (Drosophila)
chr14_+_62740878 2.814 NM_020663
RHOJ
ras homolog gene family, member J
chr2_+_189547323 2.814 NM_000090
COL3A1
collagen, type III, alpha 1
chr3_-_150533948 2.786 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr13_-_22905822 2.760 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr19_+_46417117 2.715 AXL
AXL receptor tyrosine kinase
chr1_+_161305558 2.693 NM_001113381
RGS4
regulator of G-protein signaling 4
chr12_+_32578513 2.641 FGD4
FYVE, RhoGEF and PH domain containing 4
chr9_-_36266930 2.640 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr2_+_189547358 2.640 COL3A1
collagen, type III, alpha 1
chr16_-_63713382 2.635 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_-_188021117 2.603 NM_005795
CALCRL
calcitonin receptor-like
chr6_+_116939500 2.578 NM_153711
FAM26E
family with sequence similarity 26, member E
chr15_-_40537002 2.569 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr11_+_113672407 2.541 NNMT
nicotinamide N-methyltransferase
chr9_+_35528890 2.434 RUSC2
RUN and SH3 domain containing 2
chr11_+_65027721 2.432


chr7_+_93388951 2.425 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr16_-_63713485 2.416 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr16_-_63713466 2.412 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr1_+_100957883 2.404 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr4_+_169654742 2.394 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr7_-_41709191 2.392 NM_002192
INHBA
inhibin, beta A
chr4_-_159312973 2.375 FAM198B
family with sequence similarity 198, member B
chr6_-_152744022 2.366 SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_-_94475504 2.355 ARHGAP29
Rho GTPase activating protein 29
chrX_+_56772391 2.348 LOC550643
hypothetical LOC550643
chr5_-_146813343 2.326 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr9_+_88953378 2.303 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr13_+_100902942 2.300 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr1_+_98899734 2.291 NM_015976
NM_152238
SNX7

sorting nexin 7

chr9_+_12764988 2.272 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr1_-_79244948 2.239 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr18_+_3443771 2.239 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr2_+_66519949 2.235 MEIS1
Meis homeobox 1
chr6_+_152053323 2.213 NM_001122742
ESR1
estrogen receptor 1
chr2_-_189752575 2.203 NM_000393
COL5A2
collagen, type V, alpha 2
chr9_+_35528628 2.202 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr12_-_50871953 2.196 NM_001081492
NM_182507
KRT80

keratin 80

chr3_-_113842553 2.196 CCDC80
coiled-coil domain containing 80
chr9_+_676640 2.184


chr3_+_158637273 2.180 NM_002852
PTX3
pentraxin 3, long
chr5_-_59100091 2.153 PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_54317102 2.151 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr5_+_38481392 2.148 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr17_-_15104768 2.147 NM_153322
PMP22
peripheral myelin protein 22
chr2_-_227952249 2.140 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr5_-_59100194 2.103 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_113841448 2.094 CCDC80
coiled-coil domain containing 80
chr1_-_94475840 2.070 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr3_-_113842652 2.065 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr14_+_64240996 2.061 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_+_66772393 2.058 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr7_+_22733626 2.054 IL6
interleukin 6 (interferon, beta 2)
chr6_+_39868770 2.030 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr1_+_85819004 2.018 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr9_-_35679902 2.014 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr2_-_192420168 1.995 NM_004657
SDPR
serum deprivation response
chr5_-_58607673 1.977 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_194118321 1.949 MB21D2
Mab-21 domain containing 2
chr11_+_101290930 1.946 NM_020802
KIAA1377
KIAA1377
chr2_-_202271598 1.941 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr4_-_152368492 1.923 SH3D19
SH3 domain containing 19
chr12_-_48902692 1.899 NM_001113547
LIMA1
LIM domain and actin binding 1
chr6_+_116798791 1.870 NM_013352
DSE
dermatan sulfate epimerase
chr11_-_85115105 1.865 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr8_-_49996353 1.855 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr15_+_37330176 1.848 NM_207445
C15orf54
chromosome 15 open reading frame 54
chrX_-_10504852 1.841 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr4_-_177427252 1.819 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr14_+_85066265 1.794 FLRT2
fibronectin leucine rich transmembrane protein 2
chr9_-_35679799 1.787 TPM2
tropomyosin 2 (beta)
chr12_-_90097384 1.784 NM_133503
DCN
decorin
chrX_-_19598912 1.766 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr2_-_192419896 1.766 SDPR
serum deprivation response
chr4_-_153820535 1.749 NM_152680
TMEM154
transmembrane protein 154
chr14_-_60818263 1.749 NM_001017970
TMEM30B
transmembrane protein 30B
chr3_+_161040439 1.702 SCHIP1
schwannomin interacting protein 1
chr6_-_134537637 1.697 SGK1
serum/glucocorticoid regulated kinase 1
chr11_-_35503720 1.697 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr16_+_81218074 1.688 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr2_+_110013297 1.685 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr8_+_70567634 1.679 SULF1
sulfatase 1
chr6_-_134537699 1.675 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_110665188 1.673 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr12_-_14929991 1.661 NM_000900
NM_001190839
MGP

matrix Gla protein

chr8_+_70567581 1.660 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr6_-_2580296 1.655 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr9_-_128924819 1.649 NM_012098
ANGPTL2
angiopoietin-like 2
chr6_-_134680888 1.646 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr5_-_124108672 1.638 NM_020747
ZNF608
zinc finger protein 608
chr6_-_112682401 1.632 LAMA4
laminin, alpha 4
chr5_+_155686750 1.608 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr9_-_13269562 1.599 MPDZ
multiple PDZ domain protein
chr3_+_11242666 1.598 NM_001098211
HRH1
histamine receptor H1
chr11_-_66898223 1.594 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr2_-_237987545 1.586 COL6A3
collagen, type VI, alpha 3
chr6_-_112682459 1.584 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr7_+_28692122 1.579 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr7_+_120416680 1.576 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr18_+_64616296 1.567 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr9_-_83493415 1.563 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr2_-_237987509 1.554 COL6A3
collagen, type VI, alpha 3
chr2_+_108637698 1.554 NM_001193485
LIMS1
LIM and senescent cell antigen-like domains 1
chr20_+_42644633 1.553 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr9_+_22437353 1.546 DMRTA1
DMRT-like family A1
chr1_+_201862845 1.539 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr12_+_26239535 1.536 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr9_-_72673753 1.523 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr1_-_224993498 1.522 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr17_-_30783631 1.521 NM_018042
SLFN12
schlafen family member 12
chr12_+_26239755 1.519 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr9_+_5500544 1.499 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr9_+_74956601 1.494 ANXA1
annexin A1
chr11_+_65023556 1.488


chr19_+_46417099 1.487 AXL
AXL receptor tyrosine kinase
chr2_-_237987553 1.482 COL6A3
collagen, type VI, alpha 3
chr3_+_25445071 1.482 RARB
retinoic acid receptor, beta
chr11_-_8849485 1.478 ST5
suppression of tumorigenicity 5
chr3_+_25444753 1.477 NM_016152
RARB
retinoic acid receptor, beta
chr8_-_116750427 1.470 TRPS1
trichorhinophalangeal syndrome I
chr19_+_42689881 1.456 ZNF793
zinc finger protein 793
chr6_-_112682573 1.438 LAMA4
laminin, alpha 4
chr2_-_204108151 1.433 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr17_+_29606408 1.429 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr8_-_93144039 1.426


chr20_+_12937616 1.404 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr5_+_145296313 1.402 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr9_+_74956614 1.397 ANXA1
annexin A1
chr21_-_38792173 1.396 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr22_+_29808845 1.394 SMTN
smoothelin
chr3_+_158743852 1.390 NM_001099777
NM_001130001
NM_001130002
C3orf55


chromosome 3 open reading frame 55


chr11_-_110917632 1.384


chr8_+_42671718 1.377 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr20_+_19863716 1.375 RIN2
Ras and Rab interactor 2
chr20_-_14266200 1.373 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr7_+_18502342 1.368 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr2_-_237987554 1.364 COL6A3
collagen, type VI, alpha 3
chr14_-_60817946 1.361


chr8_-_6407882 1.360 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr11_+_101488380 1.349 NM_001195045
YAP1
Yes-associated protein 1
chr13_+_96672541 1.347 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr2_-_198248828 1.338 NM_144629
RFTN2
raftlin family member 2
chr8_-_124622434 1.337 NM_058229
FBXO32
F-box protein 32
chr1_-_158161877 1.335 TAGLN2
transgelin 2
chr2_+_108637916 1.330 LIMS1
LIMS3
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 3
chr5_+_38882017 1.320 OSMR
oncostatin M receptor
chr13_-_66702433 1.316 NM_020403
NM_203487
PCDH9

protocadherin 9

chr4_+_71806538 1.309 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr8_-_95343696 1.306 GEM
GTP binding protein overexpressed in skeletal muscle
chr9_+_71848316 1.303 NM_153267
MAMDC2
MAM domain containing 2
chr1_-_158161902 1.302 NM_003564
TAGLN2
transgelin 2
chr3_+_190147633 1.300 TPRG1
tumor protein p63 regulated 1
chr5_+_61910318 1.297 NM_181506
LRRC70
leucine rich repeat containing 70
chr12_+_12829807 1.294 NM_030817
APOLD1
apolipoprotein L domain containing 1
chrX_+_2680092 1.294 NM_001141919
NM_001141920
NM_175569
XGPY2
XG


Xg pseudogene, Y-linked 2
Xg blood group


chr18_+_7936885 1.281 PTPRM
protein tyrosine phosphatase, receptor type, M
chr19_+_46416971 1.281 AXL
AXL receptor tyrosine kinase
chr21_+_32706615 1.279 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr2_-_237987579 1.278 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr21_-_35174742 1.270 RUNX1
runt-related transcription factor 1
chr18_+_3441589 1.263 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr9_+_111582317 1.255 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr12_-_47868563 1.246 TUBA1A
tubulin, alpha 1a
chr1_-_151804929 1.242 NM_005978
S100A2
S100 calcium binding protein A2
chr1_-_158161898 1.234 TAGLN2
transgelin 2
chr19_+_46416938 1.232 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr18_+_3437607 1.228 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr9_+_71848555 1.225 MAMDC2
MAM domain containing 2
chr9_-_116920232 1.223 NM_002160
TNC
tenascin C
chr14_+_99309688 1.221 EML1
echinoderm microtubule associated protein like 1
chrX_-_102829621 1.217 NM_001142419
NM_001142420
NM_001142421
NM_001142422
NM_001142427
NM_001142428
NM_001142431
NM_001142432
MORF4L2







mortality factor 4 like 2







chr10_-_62373828 1.215 NM_014836
RHOBTB1
Rho-related BTB domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.56 1.12e-04 GO:0007155 cell adhesion
1.56 1.12e-04 GO:0022610 biological adhesion
3.14 1.24e-02 GO:0051781 positive regulation of cell division
2.12 1.73e-02 GO:0007156 homophilic cell adhesion
2.02 3.49e-02 GO:0043062 extracellular structure organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 1.98e-05 GO:0044421 extracellular region part
1.30 3.31e-05 GO:0005576 extracellular region
1.17 2.17e-03 GO:0005886 plasma membrane
1.43 2.80e-03 GO:0005615 extracellular space
1.16 3.40e-03 GO:0071944 cell periphery
1.67 5.43e-03 GO:0005578 proteinaceous extracellular matrix
1.54 4.53e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.71 2.26e-03 GO:0003779 actin binding