Motif ID: EP300.p2

Z-value: 2.932


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EP300chr22_+_398185530.421.0e-01Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_160964574 5.874 SCHIP1
schwannomin interacting protein 1
chr10_-_126839546 5.012 NM_001083914
CTBP2
C-terminal binding protein 2
chr5_+_96024434 4.587 CAST
calpastatin
chr13_+_113546841 4.543 NM_000820
GAS6
growth arrest-specific 6
chr1_+_156229934 4.129 KIRREL
kin of IRRE like (Drosophila)
chr12_+_6179736 4.125 NM_001769
CD9
CD9 molecule
chr13_+_113546897 3.951 GAS6
growth arrest-specific 6
chr3_+_113061296 3.844 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr12_-_26169074 3.811 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr3_+_113061218 3.799 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_+_113061330 3.784 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_+_156280539 3.556 MME
membrane metallo-endopeptidase
chr3_+_156280497 3.542 MME
membrane metallo-endopeptidase
chr4_-_177950658 3.435 NM_005429
VEGFC
vascular endothelial growth factor C
chr13_-_43259032 3.376 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr13_+_113546912 3.156 GAS6
growth arrest-specific 6
chr4_+_183302105 3.088 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr8_-_122722674 3.058 NM_005328
HAS2
hyaluronan synthase 2
chr13_+_113546943 3.034 GAS6
growth arrest-specific 6
chr8_+_106400322 2.999 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr9_-_116920232 2.863 NM_002160
TNC
tenascin C
chr1_-_94779727 2.720 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr8_-_145085616 2.677 NM_201384
PLEC
plectin
chr5_+_174084137 2.662 NM_002449
MSX2
msh homeobox 2
chr9_+_35782405 2.653 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr11_+_35117226 2.565 CD44
CD44 molecule (Indian blood group)
chr3_-_38046034 2.497 NM_006225
PLCD1
phospholipase C, delta 1
chr1_+_179148935 2.422 NM_020950
KIAA1614
KIAA1614
chr11_+_35116961 2.373 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
CD44




CD44 molecule (Indian blood group)




chr15_-_81743198 2.337 BNC1
basonuclin 1
chr11_+_131286513 2.333 NTM
neurotrimin
chr3_+_156280129 2.224 NM_000902
MME
membrane metallo-endopeptidase
chr6_-_72187168 2.185 C6orf155
chromosome 6 open reading frame 155
chr18_-_20231783 2.174 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr10_+_102782156 2.164 SFXN3
sideroflexin 3
chr3_+_156280604 2.158 NM_007288
MME
membrane metallo-endopeptidase
chr4_-_5761194 2.155 NM_147127
EVC2
Ellis van Creveld syndrome 2
chr1_+_156229686 2.146 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr17_+_76988134 2.138 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr3_+_156280338 2.120 NM_007287
MME
membrane metallo-endopeptidase
chr3_-_180652024 2.113 NM_021629
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr10_-_49483002 2.096 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr2_+_109112428 2.058 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr2_-_109728958 2.039 NM_144710
NM_178584
SEPT10

septin 10

chr17_-_76985538 2.013


chr18_-_20231709 2.004 OSBPL1A
oxysterol binding protein-like 1A
chr4_-_187884721 1.936


chr17_-_24068759 1.934 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr19_-_40938046 1.922 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr3_+_113060826 1.917 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr11_-_127897271 1.904 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr9_+_108665168 1.903 NM_021224
ZNF462
zinc finger protein 462
chr3_+_157875408 1.896 NM_001184717
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr8_-_23077392 1.872 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr3_+_113060716 1.858 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr7_-_45927263 1.851 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr17_+_58058783 1.842 MRC2
mannose receptor, C type 2
chr11_+_12355600 1.832 NM_018222
PARVA
parvin, alpha
chr1_+_154351200 1.830 LMNA
lamin A/C
chr2_+_109729176 1.811 NM_023016
ANKRD57
ankyrin repeat domain 57
chr11_-_122571198 1.797 NM_024769
CLMP
CXADR-like membrane protein
chr4_-_142273881 1.785 NM_020724
RNF150
ring finger protein 150
chr1_+_182622850 1.781 C1orf21
chromosome 1 open reading frame 21
chr13_-_39075304 1.780 LHFP
lipoma HMGIC fusion partner
chr2_-_40532651 1.776 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_-_189752575 1.753 NM_000393
COL5A2
collagen, type V, alpha 2
chr15_+_66658626 1.745 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr10_-_99151003 1.737 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr16_-_85099941 1.735 LOC400550
hypothetical LOC400550
chr9_-_25668230 1.734 TUSC1
tumor suppressor candidate 1
chr3_-_180651874 1.728 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr11_+_124539814 1.717 PKNOX2
PBX/knotted 1 homeobox 2
chr10_-_99150977 1.709 RRP12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr19_-_40938251 1.688 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr3_-_79151232 1.681 NM_001145845
NM_133631
ROBO1

roundabout, axon guidance receptor, homolog 1 (Drosophila)

chr9_-_128924706 1.680 ANGPTL2
angiopoietin-like 2
chr19_+_46417117 1.667 AXL
AXL receptor tyrosine kinase
chr13_-_32822759 1.659 STARD13
StAR-related lipid transfer (START) domain containing 13
chr4_-_122905731 1.656 NM_152399
TMEM155
transmembrane protein 155
chr4_-_122063118 1.638 NM_018699
PRDM5
PR domain containing 5
chrX_+_37093448 1.636 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr22_-_43040063 1.635 NM_001099294
KIAA1644
KIAA1644
chr9_-_128924782 1.635 ANGPTL2
angiopoietin-like 2
chr17_+_52026058 1.626 NM_005450
NOG
noggin
chr2_+_191818124 1.626 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr10_+_88720477 1.615 NM_133447
AGAP11
ankyrin repeat and GTPase domain Arf GTPase activating protein 11
chr1_+_182622751 1.603 NM_030806
C1orf21
chromosome 1 open reading frame 21
chr14_+_92049396 1.598 NM_024832
RIN3
Ras and Rab interactor 3
chr16_+_85158357 1.595 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr22_+_40800213 1.582 FAM109B
family with sequence similarity 109, member B
chr1_+_182622809 1.580 C1orf21
chromosome 1 open reading frame 21
chr11_-_127897098 1.577 ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr12_-_47468985 1.570 NM_020983
ADCY6
adenylate cyclase 6
chr15_-_66511488 1.557 NM_001004439
ITGA11
integrin, alpha 11
chr9_+_119506428 1.553 TLR4
toll-like receptor 4
chr1_-_151852128 1.552 NM_080388
S100A16
S100 calcium binding protein A16
chr1_+_199519202 1.546 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr15_-_80125514 1.538 MEX3B
mex-3 homolog B (C. elegans)
chr11_+_113672407 1.536 NNMT
nicotinamide N-methyltransferase
chr22_+_40800193 1.532 NM_001002034
FAM109B
family with sequence similarity 109, member B
chr11_-_27677755 1.525 NM_170734
BDNF
brain-derived neurotrophic factor
chr11_+_124539768 1.511 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr2_-_109728693 1.495 SEPT10
septin 10
chr2_-_229844198 1.488 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr15_-_80125403 1.474 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr5_-_92982927 1.471


chr8_+_22513043 1.468 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr5_-_33927724 1.467 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr1_-_93919789 1.464 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr1_-_29322993 1.447 NM_001003682
TMEM200B
transmembrane protein 200B
chr2_+_71149193 1.446 NAGK
N-acetylglucosamine kinase
chr6_-_33822659 1.440 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr5_+_158622843 1.437 UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr1_+_182622987 1.420 C1orf21
chromosome 1 open reading frame 21
chr7_+_115952279 1.417 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr13_-_37341859 1.410 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr1_+_213323182 1.407 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chrX_-_133984157 1.401 NM_001078173
FAM127C
family with sequence similarity 127, member C
chr2_+_149895274 1.391 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr9_+_90339835 1.385 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr3_+_157875063 1.384 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr1_-_68470585 1.380 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr12_-_104153920 1.373 NM_018171
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr9_-_4290028 1.368 NM_001042413
GLIS3
GLIS family zinc finger 3
chr10_+_52421120 1.364 PRKG1
protein kinase, cGMP-dependent, type I
chr10_+_52504239 1.361 NM_006258
PRKG1
protein kinase, cGMP-dependent, type I
chr15_+_68971835 1.357 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chrX_-_140098941 1.353 LDOC1
leucine zipper, down-regulated in cancer 1
chr7_+_128257698 1.340 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr10_+_20145350 1.330 NM_032812
PLXDC2
plexin domain containing 2
chr10_+_81882477 1.330 PLAC9
placenta-specific 9
chr19_-_63301402 1.328 ZSCAN18
zinc finger and SCAN domain containing 18
chr9_+_115396020 1.323 NM_144489
RGS3
regulator of G-protein signaling 3
chr7_+_115952074 1.317 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr12_+_26003218 1.317 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr11_+_35117242 1.314 CD44
CD44 molecule (Indian blood group)
chr11_+_101485946 1.311 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr9_-_4289915 1.310 GLIS3
GLIS family zinc finger 3
chr14_+_55654900 1.306 PELI2
pellino homolog 2 (Drosophila)
chr1_+_221955876 1.301 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr7_+_115952325 1.297 CAV1
caveolin 1, caveolae protein, 22kDa
chr1_-_154913712 1.287 NM_006617
NES
nestin
chr4_-_169638146 1.284 DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr3_-_31998241 1.280 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chrX_-_54538591 1.276 FGD1
FYVE, RhoGEF and PH domain containing 1
chr4_-_114901672 1.268 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr10_+_52420936 1.268 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr7_-_117300763 1.265 NM_033427
CTTNBP2
cortactin binding protein 2
chr15_+_90738108 1.263 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr4_-_122213018 1.262 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr9_+_119506446 1.262 TLR4
toll-like receptor 4
chr3_+_48482625 1.259 TREX1
three prime repair exonuclease 1
chr4_-_186693574 1.258 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr10_+_81882409 1.257 PLAC9
placenta-specific 9
chr19_-_60573552 1.256 NM_000641
IL11
interleukin 11
chr1_-_32940943 1.255 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr5_+_82803248 1.253 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican



chr1_-_108544486 1.253 NM_013386
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr4_-_157094443 1.253 NM_001334
CTSO
cathepsin O
chr7_-_32076985 1.252 NM_001191056
NM_001191057
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr4_+_86615275 1.242 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr16_-_30992574 1.240 ZNF668
zinc finger protein 668
chr16_+_79132354 1.240 NM_130897
DYNLRB2
dynein, light chain, roadblock-type 2
chr18_-_55515623 1.240 NM_133459
CCBE1
collagen and calcium binding EGF domains 1
chr11_+_35117391 1.232 CD44
CD44 molecule (Indian blood group)
chr14_+_104523660 1.230 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr19_-_1125201 1.220


chr7_+_55054152 1.217 NM_005228
NM_201282
NM_201283
NM_201284
EGFR



epidermal growth factor receptor



chr19_+_16157198 1.215 NM_014077
FAM32A
family with sequence similarity 32, member A
chrX_-_140098959 1.212 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr6_+_43151922 1.210 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr9_-_131555111 1.206 NM_004878
PTGES
prostaglandin E synthase
chr15_-_80123935 1.199 MEX3B
mex-3 homolog B (C. elegans)
chr11_+_113672378 1.198 NNMT
nicotinamide N-methyltransferase
chr6_-_86409701 1.189 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chrX_-_140099014 1.182 LDOC1
leucine zipper, down-regulated in cancer 1
chr16_-_30993004 1.176 NM_024706
ZNF668
zinc finger protein 668
chr18_-_63334902 1.175 NM_032160
DSEL
dermatan sulfate epimerase-like
chr19_-_63301386 1.162 ZSCAN18
zinc finger and SCAN domain containing 18
chr1_+_116320698 1.161 SLC22A15
solute carrier family 22, member 15
chr12_+_52806103 1.159 LOC400043
hypothetical LOC400043
chr8_-_134378630 1.154 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr14_+_78815406 1.153 NM_001105250
NM_138970
NRXN3

neurexin 3

chr11_+_35117408 1.150 CD44
CD44 molecule (Indian blood group)
chr2_-_175337386 1.146 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr1_-_225572419 1.132 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr6_-_110607496 1.124 WASF1
WAS protein family, member 1
chr5_-_92942680 1.112 FLJ42709
hypothetical LOC441094
chr1_-_32940850 1.109 SYNC
syncoilin, intermediate filament protein
chr4_+_108965167 1.106 NM_001136258
SGMS2
sphingomyelin synthase 2
chr21_+_46226072 1.105 NM_001848
COL6A1
collagen, type VI, alpha 1
chr3_+_157874898 1.104 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chrX_+_46977306 1.102 USP11
ubiquitin specific peptidase 11
chr1_-_108544416 1.101 SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr18_-_55515552 1.101 CCBE1
collagen and calcium binding EGF domains 1
chrX_-_140098871 1.101 LDOC1
leucine zipper, down-regulated in cancer 1
chr9_+_88953378 1.100 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr9_+_111442888 1.095 NM_001037293
PALM2
paralemmin 2
chr4_-_114902010 1.093 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr5_+_119827797 1.091 PRR16
proline rich 16

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.14 8.34e-07 GO:0050794 regulation of cellular process
1.13 9.67e-07 GO:0065007 biological regulation
1.13 8.51e-06 GO:0050789 regulation of biological process
1.25 8.28e-05 GO:0048522 positive regulation of cellular process
1.17 2.02e-04 GO:0044260 cellular macromolecule metabolic process
1.23 3.10e-04 GO:0048518 positive regulation of biological process
1.07 1.07e-03 GO:0009987 cellular process
1.25 1.55e-03 GO:0048523 negative regulation of cellular process
1.16 1.67e-02 GO:0031323 regulation of cellular metabolic process
1.16 1.72e-02 GO:0023052 signaling
1.21 1.78e-02 GO:0048519 negative regulation of biological process
1.26 1.82e-02 GO:0023051 regulation of signaling
1.23 2.00e-02 GO:0030154 cell differentiation
1.22 2.49e-02 GO:0048869 cellular developmental process
1.13 3.23e-02 GO:0043170 macromolecule metabolic process
1.43 3.37e-02 GO:0010629 negative regulation of gene expression
1.67 3.45e-02 GO:0030036 actin cytoskeleton organization
1.16 4.19e-02 GO:0080090 regulation of primary metabolic process
1.27 4.23e-02 GO:0009966 regulation of signal transduction
1.52 4.24e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 2.54e-08 GO:0005622 intracellular
2.15 1.28e-07 GO:0031252 cell leading edge
1.08 1.64e-07 GO:0044424 intracellular part
1.16 1.41e-06 GO:0005634 nucleus
1.09 2.03e-05 GO:0043229 intracellular organelle
1.09 2.39e-05 GO:0043226 organelle
1.52 3.23e-05 GO:0030054 cell junction
1.10 3.67e-05 GO:0005737 cytoplasm
1.98 8.03e-05 GO:0070161 anchoring junction
2.04 8.09e-05 GO:0005912 adherens junction
2.22 1.27e-04 GO:0030055 cell-substrate junction
2.29 3.59e-04 GO:0001726 ruffle
1.76 5.41e-04 GO:0016323 basolateral plasma membrane
1.09 5.67e-04 GO:0043227 membrane-bounded organelle
1.09 6.21e-04 GO:0043231 intracellular membrane-bounded organelle
2.13 1.05e-03 GO:0005924 cell-substrate adherens junction
2.12 2.20e-03 GO:0005925 focal adhesion
1.34 7.06e-03 GO:0042995 cell projection
1.24 8.85e-03 GO:0005856 cytoskeleton
1.57 1.36e-02 GO:0015629 actin cytoskeleton
2.08 2.04e-02 GO:0030027 lamellipodium
2.19 4.95e-02 GO:0030426 growth cone

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 8.55e-09 GO:0005515 protein binding
1.08 1.61e-08 GO:0005488 binding
1.61 1.34e-06 GO:0008092 cytoskeletal protein binding
1.61 2.73e-03 GO:0003779 actin binding