Motif ID: EP300.p2

Z-value: 2.932


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EP300chr22_+_398185530.421.0e-01Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_160964574 5.874 SCHIP1
schwannomin interacting protein 1
chr10_-_126839546 5.012 NM_001083914
 CTBP2
C-terminal binding protein 2
chr5_+_96024434 4.587 CAST
calpastatin
chr13_+_113546841 4.543 NM_000820
 GAS6
growth arrest-specific 6
chr1_+_156229934 4.129 KIRREL
kin of IRRE like (Drosophila)
chr12_+_6179736 4.125 NM_001769
 CD9
CD9 molecule
chr13_+_113546897 3.951 GAS6
growth arrest-specific 6
chr3_+_113061296 3.844 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr12_-_26169074 3.811 NM_030762
 BHLHE41
basic helix-loop-helix family, member e41
chr3_+_113061218 3.799 NM_001134439
 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_+_113061330 3.784 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_+_156280539 3.556 MME
membrane metallo-endopeptidase
chr3_+_156280497 3.542 MME
membrane metallo-endopeptidase
chr4_-_177950658 3.435 NM_005429
 VEGFC
vascular endothelial growth factor C
chr13_-_43259032 3.376 NM_017993
 ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr13_+_113546912 3.156 GAS6
growth arrest-specific 6
chr4_+_183302105 3.088 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr8_-_122722674 3.058 NM_005328
 HAS2
hyaluronan synthase 2
chr13_+_113546943 3.034 GAS6
growth arrest-specific 6
chr8_+_106400322 2.999 NM_012082
 ZFPM2
zinc finger protein, multitype 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
1.67 3.45e-02 GO:0030036 actin cytoskeleton organization
1.52 4.24e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.43 3.37e-02 GO:0010629 negative regulation of gene expression
1.27 4.23e-02 GO:0009966 regulation of signal transduction
1.26 1.82e-02 GO:0023051 regulation of signaling
1.25 8.28e-05 GO:0048522 positive regulation of cellular process
1.25 1.55e-03 GO:0048523 negative regulation of cellular process
1.23 3.10e-04 GO:0048518 positive regulation of biological process
1.23 2.00e-02 GO:0030154 cell differentiation
1.22 2.49e-02 GO:0048869 cellular developmental process
1.21 1.78e-02 GO:0048519 negative regulation of biological process
1.17 2.02e-04 GO:0044260 cellular macromolecule metabolic process
1.16 1.67e-02 GO:0031323 regulation of cellular metabolic process
1.16 1.72e-02 GO:0023052 signaling
1.16 4.19e-02 GO:0080090 regulation of primary metabolic process
1.14 8.34e-07 GO:0050794 regulation of cellular process
1.13 9.67e-07 GO:0065007 biological regulation
1.13 8.51e-06 GO:0050789 regulation of biological process
1.13 3.23e-02 GO:0043170 macromolecule metabolic process
1.07 1.07e-03 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
2.29 3.59e-04 GO:0001726 ruffle
2.22 1.27e-04 GO:0030055 cell-substrate junction
2.19 4.95e-02 GO:0030426 growth cone
2.15 1.28e-07 GO:0031252 cell leading edge
2.13 1.05e-03 GO:0005924 cell-substrate adherens junction
2.12 2.20e-03 GO:0005925 focal adhesion
2.08 2.04e-02 GO:0030027 lamellipodium
2.04 8.09e-05 GO:0005912 adherens junction
1.98 8.03e-05 GO:0070161 anchoring junction
1.76 5.41e-04 GO:0016323 basolateral plasma membrane
1.57 1.36e-02 GO:0015629 actin cytoskeleton
1.52 3.23e-05 GO:0030054 cell junction
1.34 7.06e-03 GO:0042995 cell projection
1.24 8.85e-03 GO:0005856 cytoskeleton
1.16 1.41e-06 GO:0005634 nucleus
1.10 3.67e-05 GO:0005737 cytoplasm
1.09 2.03e-05 GO:0043229 intracellular organelle
1.09 2.39e-05 GO:0043226 organelle
1.09 5.67e-04 GO:0043227 membrane-bounded organelle
1.09 6.21e-04 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.61 1.34e-06 GO:0008092 cytoskeletal protein binding
1.61 2.73e-03 GO:0003779 actin binding
1.14 8.55e-09 GO:0005515 protein binding
1.08 1.61e-08 GO:0005488 binding