Motif ID: HNF1A.p2

Z-value: 6.701


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1199009310.997.4e-13Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_24491498 36.117 NM_001195610
 DCDC2
doublecortin domain containing 2
chr7_-_44547382 24.267 NM_001101648
NM_013389
 NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr20_+_42417752 22.538 NM_001030003
NM_001030004
NM_175914
 HNF4A


hepatocyte nuclear factor 4, alpha


chr20_+_41621119 22.482 SGK2
serum/glucocorticoid regulated kinase 2
chr12_-_15757114 22.344 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_-_977163 22.191 NM_022042
NM_134425
NM_213613
 SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr20_+_41621079 21.997 NM_170693
 SGK2
serum/glucocorticoid regulated kinase 2
chr16_-_86527608 21.155 NM_001739
 CA5A
carbonic anhydrase VA, mitochondrial
chr14_-_93924663 20.631 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr7_+_45894480 20.494 NM_000596
 IGFBP1
insulin-like growth factor binding protein 1
chrX_-_105169370 20.291 NM_000354
 SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_+_175908948 20.193 NM_017675
 CDHR2
cadherin-related family member 2
chr14_-_93829113 20.123 NM_016186
 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_93829309 19.378 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr17_-_61655915 19.310 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_-_40995606 19.233 PRODH2
proline dehydrogenase (oxidase) 2
chr20_+_42463419 19.189 HNF4A
hepatocyte nuclear factor 4, alpha
chr1_+_48460943 19.176 NM_001011547
NM_001135181
 SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr20_+_42417502 19.000 HNF4A
hepatocyte nuclear factor 4, alpha
chr19_+_11211282 18.773 NM_018687
 LOC55908
hepatocellular carcinoma-associated gene TD26

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
43.00 2.51e-02 GO:0015712 hexose phosphate transport
43.00 2.51e-02 GO:0015760 glucose-6-phosphate transport
26.06 8.03e-04 GO:0046415 urate metabolic process
25.48 1.29e-02 GO:0051918 negative regulation of fibrinolysis
23.89 1.36e-03 GO:0051917 regulation of fibrinolysis
22.93 2.13e-02 GO:0019934 cGMP-mediated signaling
15.09 1.80e-02 GO:0034381 plasma lipoprotein particle clearance
12.29 8.86e-03 GO:0030195 negative regulation of blood coagulation
11.86 1.10e-02 GO:0050819 negative regulation of coagulation
10.03 6.32e-03 GO:0030301 cholesterol transport
9.83 3.44e-02 GO:0097006 regulation of plasma lipoprotein particle levels
9.79 7.51e-03 GO:0015918 sterol transport
7.72 3.79e-02 GO:0048771 tissue remodeling
6.85 2.53e-02 GO:0015711 organic anion transport
5.18 4.52e-03 GO:0006805 xenobiotic metabolic process
5.18 4.52e-03 GO:0071466 cellular response to xenobiotic stimulus
5.14 4.88e-03 GO:0009410 response to xenobiotic stimulus
4.25 3.38e-02 GO:0015849 organic acid transport
3.65 4.05e-02 GO:0008202 steroid metabolic process
3.50 1.43e-04 GO:0071702 organic substance transport

Gene overrepresentation in compartment category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
24.57 3.35e-02 GO:0005577 fibrinogen complex
7.72 6.01e-03 GO:0031983 vesicle lumen
7.32 3.03e-02 GO:0031093 platelet alpha granule lumen
7.17 3.41e-02 GO:0034774 secretory granule lumen
6.92 1.24e-02 GO:0031091 platelet alpha granule
6.88 4.29e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
5.80 1.20e-06 GO:0016324 apical plasma membrane
5.17 1.07e-06 GO:0045177 apical part of cell
2.67 2.47e-05 GO:0005615 extracellular space
2.24 5.58e-04 GO:0044421 extracellular region part
2.17 1.52e-02 GO:0005624 membrane fraction
2.10 2.66e-02 GO:0005626 insoluble fraction
1.99 1.28e-02 GO:0000267 cell fraction
1.64 3.13e-02 GO:0005576 extracellular region
1.60 4.02e-02 GO:0044459 plasma membrane part
1.40 3.98e-02 GO:0005886 plasma membrane
1.39 4.17e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
19.11 1.20e-02 GO:0034185 apolipoprotein binding
15.29 3.18e-02 GO:0008514 organic anion transmembrane transporter activity
7.82 3.24e-02 GO:0043498 cell surface binding
5.21 4.48e-02 GO:0004867 serine-type endopeptidase inhibitor activity