Motif ID: HMGA1,2.p2

Z-value: 1.976


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMGA2chr12_+_64504835-0.674.3e-03Click!
HMGA1chr6_+_343145450.391.4e-01Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_16471817 2.583 NM_015464
SOSTDC1
sclerostin domain containing 1
chr10_+_89257569 2.191 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr1_-_143708467 2.060 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr4_+_75449720 1.999 NM_001432
EREG
epiregulin
chr1_+_196874867 1.905 PTPRC
protein tyrosine phosphatase, receptor type, C
chr7_+_77307382 1.881 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr1_-_158815850 1.873 CD84
CD84 molecule
chr1_-_158815895 1.816 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_+_194887630 1.790 NM_000186
NM_001014975
CFH

complement factor H

chr1_-_205272619 1.790 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr7_+_123036312 1.744 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr1_+_239762179 1.743 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr4_+_159350850 1.731 NM_018342
TMEM144
transmembrane protein 144
chr7_-_7724762 1.726 NM_002947
RPA3
replication protein A3, 14kDa
chr1_+_234624266 1.716 NM_145861
EDARADD
EDAR-associated death domain
chr4_+_170817787 1.714 CLCN3
chloride channel 3
chr1_+_196874759 1.684 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr7_-_112545840 1.671 LOC401397
hypothetical LOC401397
chr7_-_112545847 1.658 LOC401397
hypothetical LOC401397
chr1_+_196874839 1.652 PTPRC
protein tyrosine phosphatase, receptor type, C
chr2_+_157822355 1.564 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr7_+_143043871 1.467 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr9_+_74956601 1.465 ANXA1
annexin A1
chr6_+_147568795 1.458 STXBP5
syntaxin binding protein 5 (tomosyn)
chr3_-_120761092 1.450 NM_005191
CD80
CD80 molecule
chr3_-_17757402 1.414 NM_014744
TBC1D5
TBC1 domain family, member 5
chr7_+_104468614 1.372 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr4_-_40211324 1.359 RBM47
RNA binding motif protein 47
chr17_-_72151314 1.316 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr9_-_99740243 1.313 NM_197978
HEMGN
hemogen
chr7_+_116447499 1.311 ST7
suppression of tumorigenicity 7
chr6_-_43703057 1.301 GTPBP2
GTP binding protein 2
chr12_+_97513644 1.293 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr8_+_107807415 1.271 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr11_-_5110383 1.254 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chrX_-_70243362 1.252 NM_001025265
CXorf65
chromosome X open reading frame 65
chr13_-_48873735 1.243 NM_030925
CAB39L
calcium binding protein 39-like
chr6_-_68655708 1.241


chr6_-_43703024 1.233 GTPBP2
GTP binding protein 2
chr4_+_22608252 1.232


chr10_+_70517863 1.223 SRGN
serglycin
chr9_+_74956614 1.203 ANXA1
annexin A1
chr2_+_169637255 1.196 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr14_-_62638336 1.189 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr11_-_107969554 1.176 NM_015065
EXPH5
exophilin 5
chrX_+_65300803 1.170 NM_001130860
NM_014799
HEPH

hephaestin

chr10_+_70517823 1.164 NM_002727
SRGN
serglycin
chr16_-_32596378 1.162 NM_001099687
TP53TG3B
TP53 target 3B
chr12_+_52696908 1.154 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr11_-_5130174 1.153 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr19_+_45973139 1.152 NM_006533
MIA
melanoma inhibitory activity
chr10_-_5035967 1.141 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chrX_+_153644210 1.139 NM_001142463
NM_001363
DKC1

dyskeratosis congenita 1, dyskerin

chr7_-_20223467 1.135 NM_182762
MACC1
metastasis associated in colon cancer 1
chr7_+_116447527 1.133 ST7
suppression of tumorigenicity 7
chr11_+_113671744 1.131 NM_006169
NNMT
nicotinamide N-methyltransferase
chr15_-_74091817 1.128 NM_138573
NRG4
neuregulin 4
chr1_+_234625338 1.125 NM_080738
EDARADD
EDAR-associated death domain
chr16_+_33111656 1.122 NM_001099687
TP53TG3B
TP53 target 3B
chr4_-_139382672 1.119 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr20_-_45410033 1.105 ZMYND8
zinc finger, MYND-type containing 8
chr12_-_53153613 1.101 GTSF1
gametocyte specific factor 1
chrX_-_78509662 1.066 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr4_+_75393053 1.063 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr11_+_93940121 1.061 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr2_+_102401580 1.058 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr9_+_74956494 1.041 NM_000700
ANXA1
annexin A1
chr2_+_169367345 1.036 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr5_+_40877053 1.027 NM_032587
CARD6
caspase recruitment domain family, member 6
chr5_-_39238818 1.017 FYB
FYN binding protein
chr1_-_160648429 1.014 NM_053282
SH2D1B
SH2 domain containing 1B
chr19_+_60109319 1.014 NM_001145457
NM_001145458
NM_004829
NCR1


natural cytotoxicity triggering receptor 1


chr3_+_123526700 1.012 NM_005213
CSTA
cystatin A (stefin A)
chr3_-_152517204 1.008 NM_023915
GPR87
G protein-coupled receptor 87
chr16_+_33168191 0.999 NM_001099687
TP53TG3B
TP53 target 3B
chr5_+_96237399 0.985 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr22_-_41685827 0.985 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr14_-_19867372 0.985 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr2_-_65447267 0.982 SPRED2
sprouty-related, EVH1 domain containing 2
chr12_-_101396459 0.964 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr2_-_65447370 0.956 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr10_-_69267774 0.955 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr12_+_52697160 0.951 HOXC5
HOXC6
homeobox C5
homeobox C6
chr2_-_200033445 0.920 SATB2
SATB homeobox 2
chr19_+_61624 0.916 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr12_-_49708279 0.911 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr2_-_170138558 0.909 NM_024622
FASTKD1
FAST kinase domains 1
chr3_-_42818221 0.902


chr12_-_8110268 0.894 C3AR1
complement component 3a receptor 1
chr10_+_118177371 0.883 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chrX_-_55074125 0.879 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr17_-_64462976 0.876 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr12_-_8110196 0.870 NM_004054
C3AR1
complement component 3a receptor 1
chr16_+_20682812 0.868 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr7_+_128802719 0.867 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr1_-_158759606 0.865 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr10_+_74540215 0.864 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr12_+_63090008 0.858 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr7_-_13992351 0.851 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr12_+_14429499 0.850 ATF7IP
activating transcription factor 7 interacting protein
chr5_-_64813459 0.845 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chrX_+_80343958 0.844 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chrX_-_11194015 0.843 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr1_-_191422346 0.842 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr10_-_5436781 0.838 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr7_-_92693716 0.836 NM_001039372
HEPACAM2
HEPACAM family member 2
chr10_-_62002672 0.831 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr12_-_9804682 0.823 NM_001781
CD69
CD69 molecule
chr7_+_141054621 0.819 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr15_-_70350609 0.815 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr10_+_5976354 0.801 NM_032807
FBXO18
F-box protein, helicase, 18
chr7_-_104696678 0.801 NM_182691
SRPK2
SRSF protein kinase 2
chr12_+_18305740 0.800 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr8_+_26206648 0.796 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr19_-_14750347 0.794 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr1_+_50344550 0.783 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_-_100070808 0.781 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr9_+_129893948 0.779 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr7_-_135263737 0.777 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr13_-_35686665 0.777 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr5_-_147996769 0.773 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr6_-_119137923 0.763 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr11_-_5247948 0.762 NM_005330
HBE1
hemoglobin, epsilon 1
chr10_+_4995597 0.752 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_-_21310462 0.750 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr15_-_41195994 0.749 RPS3A
ribosomal protein S3A
chr12_-_642786 0.747 NM_016533
NINJ2
ninjurin 2
chr19_-_43608641 0.747 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chr7_+_91762227 0.746


chrX_-_141120722 0.746 NM_016249
MAGEC2
melanoma antigen family C, 2
chr4_-_74704964 0.746 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr11_+_123491313 0.746 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr10_-_921694 0.743 NM_015155
LARP4B
La ribonucleoprotein domain family, member 4B
chr12_-_69434650 0.738 PTPRR
protein tyrosine phosphatase, receptor type, R
chr20_+_57027703 0.737 NM_030773
TUBB1
tubulin, beta 1
chr3_-_158703821 0.733 NM_001167911
NM_001167912
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr1_+_557269 0.731


chr1_+_242283129 0.726 NM_006352
ZNF238
zinc finger protein 238
chr12_-_53153639 0.719 NM_144594
GTSF1
gametocyte specific factor 1
chr19_+_10258642 0.716 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr8_-_116749382 0.713 TRPS1
trichorhinophalangeal syndrome I
chr3_-_15814678 0.709 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr6_-_49820030 0.706 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr7_-_91632525 0.704 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr6_-_49712483 0.704 NM_000324
RHAG
Rh-associated glycoprotein
chr11_+_113280727 0.699 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr13_+_107753764 0.697


chr19_-_12858956 0.691 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr7_-_92615593 0.690 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr3_+_142175329 0.687 SLC25A36
solute carrier family 25, member 36
chr4_+_159351092 0.681 TMEM144
transmembrane protein 144
chr2_-_174475528 0.679


chr10_+_4995685 0.677 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr8_-_62764839 0.676 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr16_-_53520208 0.673 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr11_+_4859624 0.669 NM_001004759
OR51T1
olfactory receptor, family 51, subfamily T, member 1
chr10_-_50066386 0.666 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chrX_-_80344096 0.666 NM_030763
HMGN5
high-mobility group nucleosome binding domain 5
chr1_-_26058434 0.665 NM_024037
C1orf135
chromosome 1 open reading frame 135
chr6_-_50039776 0.661 NM_001037499
DEFB114
defensin, beta 114
chr21_-_38415273 0.658 NM_005867
DSCR4
Down syndrome critical region gene 4
chr3_-_95230143 0.657 NM_001001850
STX19
syntaxin 19
chr11_-_33139449 0.652 NM_001033505
NM_001033506
NM_001326
CSTF3


cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa


chr15_-_100280784 0.648 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr10_+_47875229 0.648 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr20_-_30703219 0.647 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr7_+_120416103 0.646 C7orf58
chromosome 7 open reading frame 58
chr2_+_27046952 0.645 NM_012326
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr4_-_74307637 0.645 ANKRD17
ankyrin repeat domain 17
chr7_-_112515035 0.645 GPR85
G protein-coupled receptor 85
chr10_-_11614279 0.644 NM_001080491
USP6NL
USP6 N-terminal like
chr20_+_56904042 0.642 GNAS
GNAS complex locus
chr19_+_52532210 0.640 NM_018485
GPR77
G protein-coupled receptor 77
chr22_-_39189369 0.632 MKL1
megakaryoblastic leukemia (translocation) 1
chr12_-_8271460 0.623 NM_018088
FAM90A1
family with sequence similarity 90, member A1
chr11_+_10433241 0.619 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr1_-_47468029 0.618 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr10_+_74323344 0.616 NM_152635
OIT3
oncoprotein induced transcript 3
chr6_+_31782618 0.616 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chrX_+_47999740 0.609 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr16_+_52037186 0.607 RBL2
retinoblastoma-like 2 (p130)
chr1_-_172199799 0.607 RC3H1
ring finger and CCCH-type domains 1
chr11_-_125278296 0.607 NM_031307
PUS3
pseudouridylate synthase 3
chr6_-_42293564 0.605 MRPS10
mitochondrial ribosomal protein S10
chr2_+_170074457 0.605 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr18_-_27594696 0.598 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chrX_-_153698930 0.597 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr5_+_86712376 0.597


chr17_-_30909219 0.597 NM_001129820
SLFN14
schlafen family member 14
chr10_+_4995453 0.596 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr13_-_45654292 0.596 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_50688310 0.595 NM_206901
RTN2
reticulon 2
chr1_-_21249974 0.594 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr8_-_38324809 0.594 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr6_+_14032655 0.593 NM_001165034
RNF182
ring finger protein 182
chr4_+_100957003 0.589 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr6_-_123999640 0.586 NM_006073
TRDN
triadin
chrX_-_119095544 0.585 NM_001099685
NM_032498
RHOXF2B
RHOXF2
Rhox homeobox family, member 2B
Rhox homeobox family, member 2
chr2_-_232034638 0.584 NCL
nucleolin
chr8_-_13018123 0.582 NM_001164271
DLC1
deleted in liver cancer 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.23 3.98e-17 GO:0007606 sensory perception of chemical stimulus
2.25 1.37e-15 GO:0007608 sensory perception of smell
1.69 1.04e-09 GO:0007600 sensory perception
1.38 1.64e-04 GO:0050877 neurological system process
1.29 6.12e-03 GO:0003008 system process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.30 1.40e-16 GO:0004984 olfactory receptor activity
1.63 7.20e-09 GO:0004930 G-protein coupled receptor activity
1.33 2.93e-03 GO:0004888 transmembrane receptor activity
3.49 3.15e-02 GO:0005544 calcium-dependent phospholipid binding
1.24 3.80e-02 GO:0004872 receptor activity