Motif ID: SP1.p2

Z-value: 2.445


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_52060689-0.361.7e-01Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_34114924 4.367 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr2_+_10101081 4.006 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr7_-_158073121 3.033 NM_002847
NM_130842
NM_130843
PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr1_+_3679168 3.002 NM_001163724
LOC388588
hypothetical protein LOC388588
chr19_-_7840806 3.000 FLJ22184
hypothetical protein FLJ22184
chr14_-_20562962 2.979 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr6_+_37245860 2.928 NM_002648
PIM1
pim-1 oncogene
chr19_-_55524445 2.773 NM_004977
KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr19_+_59064795 2.764 MYADM
myeloid-associated differentiation marker
chr20_-_62151216 2.725 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr6_-_35572694 2.606 NM_003214
TEAD3
TEA domain family member 3
chr8_-_146023228 2.590 LOC100130027
hypothetical LOC100130027
chr8_-_145661545 2.582 NM_032687
NM_001129888
CYHR1

cysteine/histidine-rich 1

chr22_-_18807805 2.550 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr16_+_88422354 2.498 NM_032451
SPIRE2
spire homolog 2 (Drosophila)
chr22_+_20101661 2.450 NM_015094
HIC2
hypermethylated in cancer 2
chr5_+_176446425 2.441 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr20_-_3102169 2.394 ProSAPiP1
ProSAPiP1 protein
chr14_-_37134050 2.385 FOXA1
forkhead box A1
chr16_-_88295595 2.348 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr14_-_37134191 2.325 NM_004496
FOXA1
forkhead box A1
chr16_+_87047159 2.319 ZFPM1
zinc finger protein, multitype 1
chr20_+_1154763 2.265 NM_001136566
RAD21L1
RAD21-like 1 (S. pombe)
chr21_+_46473494 2.213 MCM3AP-AS1
MCM3AP antisense RNA 1 (non-protein coding)
chr19_+_59064471 2.139 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr16_-_88613287 2.136 NM_001042610
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr17_-_17667580 2.095 SREBF1
sterol regulatory element binding transcription factor 1
chr1_-_1840564 2.034 NM_178545
TMEM52
transmembrane protein 52
chr1_+_945472 2.031 AGRN
agrin
chr20_+_61841662 2.031 SLC2A4RG
SLC2A4 regulator
chr22_-_17545872 2.020 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr17_+_71033339 1.996 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr19_+_34994701 1.947 NM_001238
CCNE1
cyclin E1
chr19_-_1441403 1.935 NM_017573
PCSK4
proprotein convertase subtilisin/kexin type 4
chr5_-_134397740 1.914 NM_002653
PITX1
paired-like homeodomain 1
chr13_-_113066202 1.898 GRTP1
growth hormone regulated TBC protein 1
chr14_-_37133927 1.895 FOXA1
forkhead box A1
chr19_+_7891193 1.882 NM_003083
SNAPC2
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr8_-_145187553 1.876 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr7_+_36159300 1.864 NM_030636
EEPD1
endonuclease/exonuclease/phosphatase family domain containing 1
chr19_+_8180179 1.854 NM_024552
LASS4
LAG1 homolog, ceramide synthase 4
chr16_+_4948318 1.845 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr21_-_43368963 1.837 NM_000071
CBS
cystathionine-beta-synthase
chr17_+_34115383 1.806 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chrX_+_9392980 1.805 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr6_+_34312979 1.785 HMGA1
high mobility group AT-hook 1
chr20_-_60963390 1.769 NM_006602
TCFL5
transcription factor-like 5 (basic helix-loop-helix)
chr20_+_60898249 1.752 NM_018270
C20orf20
chromosome 20 open reading frame 20
chr13_-_113066366 1.747 NM_024719
GRTP1
growth hormone regulated TBC protein 1
chr16_+_88314884 1.722 NM_152287
ZNF276
zinc finger protein 276
chr17_+_44429748 1.719 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr2_+_10101822 1.713 NM_001177718
KLF11
Kruppel-like factor 11
chr6_-_33393696 1.712 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr18_+_58341637 1.707 NM_017742
ZCCHC2
zinc finger, CCHC domain containing 2
chr6_+_34312906 1.700 HMGA1
high mobility group AT-hook 1
chr2_+_112372651 1.698 NM_006343
MERTK
c-mer proto-oncogene tyrosine kinase
chr20_-_60375695 1.688 NM_005560
LAMA5
laminin, alpha 5
chr2_+_112372671 1.666 MERTK
c-mer proto-oncogene tyrosine kinase
chr19_+_54314292 1.648 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr1_-_44269615 1.639 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr9_-_139068269 1.637 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr16_+_49139694 1.634 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr3_-_12983959 1.624 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr7_+_36159369 1.615 EEPD1
endonuclease/exonuclease/phosphatase family domain containing 1
chr20_-_62181588 1.608 NM_001039467
RGS19
regulator of G-protein signaling 19
chr20_+_61841553 1.605 NM_020062
SLC2A4RG
SLC2A4 regulator
chr16_+_87047418 1.603 NM_153813
ZFPM1
zinc finger protein, multitype 1
chr11_+_45900731 1.602 GYLTL1B
glycosyltransferase-like 1B
chr19_+_38979502 1.593 NM_001129994
NM_001129995
NM_024076
KCTD15


potassium channel tetramerisation domain containing 15


chr20_+_43468046 1.582 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr1_+_945331 1.577 NM_198576
AGRN
agrin
chr11_-_65082208 1.575 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr17_-_78602931 1.575 NM_001009905
B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr1_-_20685314 1.564 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_18409788 1.560 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr1_+_226404037 1.560 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr19_-_864138 1.556 C19orf22
chromosome 19 open reading frame 22
chr8_-_145725289 1.548 C8orf82
chromosome 8 open reading frame 82
chr10_+_94439658 1.548 NM_002729
HHEX
hematopoietically expressed homeobox
chr20_+_254205 1.547 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr16_-_51138306 1.532 NM_001080430
TOX3
TOX high mobility group box family member 3
chr14_-_20636337 1.525 ZNF219
zinc finger protein 219
chr1_+_160306093 1.523 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chrX_+_30581377 1.523 NM_000167
NM_001128127
NM_203391
GK


glycerol kinase


chr13_+_99431417 1.522


chr8_+_27404508 1.503 NM_001979
EPHX2
epoxide hydrolase 2, cytoplasmic
chr4_+_1764802 1.501 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chrX_+_30581458 1.501 GK
glycerol kinase
chr11_-_65070625 1.497 LTBP3
latent transforming growth factor beta binding protein 3
chr1_+_945399 1.493


chr12_+_56291484 1.490 NM_182947
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr19_+_1442000 1.475 NM_138393
REEP6
receptor accessory protein 6
chr19_-_1441340 1.451 PCSK4
proprotein convertase subtilisin/kexin type 4
chr17_-_76622967 1.451 FLJ90757
hypothetical LOC440465
chr20_-_30534848 1.450 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr22_-_17546234 1.449 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr17_-_73636386 1.435 NM_001127198
TMC6
transmembrane channel-like 6
chr6_+_34313007 1.431 HMGA1
high mobility group AT-hook 1
chr22_-_17546296 1.428 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_+_59061422 1.428 NM_001020820
MYADM
myeloid-associated differentiation marker
chr14_+_104337923 1.422 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr19_+_659766 1.420 NM_001040134
NM_002579
PALM

paralemmin

chr9_-_122679387 1.419 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr22_-_17546276 1.417 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr2_+_218972963 1.411 NM_182642
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr21_+_17807167 1.411 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr20_+_32928065 1.406 ACSS2
acyl-CoA synthetase short-chain family member 2
chr19_+_10261646 1.395 NM_003259
ICAM5
intercellular adhesion molecule 5, telencephalin
chr1_-_925332 1.394 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr6_+_169866714 1.387 LOC729088
hypothetical LOC729088
chr19_-_864224 1.386 NM_138774
C19orf22
chromosome 19 open reading frame 22
chr22_+_19649417 1.376 NM_001018060
NM_144704
AIFM3

apoptosis-inducing factor, mitochondrion-associated, 3

chr8_-_145725197 1.369 NM_001001795
C8orf82
chromosome 8 open reading frame 82
chr16_-_65287967 1.362 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chrX_+_30581523 1.359 GK
glycerol kinase
chr17_-_34015631 1.356 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr20_+_30813851 1.352 NM_006892
NM_175848
NM_175849
DNMT3B


DNA (cytosine-5-)-methyltransferase 3 beta


chr7_-_4889772 1.345 NM_018059
RADIL
Ras association and DIL domains
chr21_+_45649719 1.343


chr14_+_105063975 1.342 NM_025268
TMEM121
transmembrane protein 121
chr16_+_1979959 1.339 NM_004209
SYNGR3
synaptogyrin 3
chr17_+_77582774 1.335 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr20_-_30535045 1.333 C20orf112
chromosome 20 open reading frame 112
chr11_+_359723 1.325 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr19_-_864194 1.324 C19orf22
chromosome 19 open reading frame 22
chr6_+_167970334 1.321 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr2_-_25328452 1.318 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr20_+_48240772 1.309 NM_005194
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr1_-_40903897 1.308 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr19_-_864203 1.308 C19orf22
chromosome 19 open reading frame 22
chr19_-_864201 1.297 C19orf22
chromosome 19 open reading frame 22
chr6_+_2945025 1.288 NM_000904
NQO2
NAD(P)H dehydrogenase, quinone 2
chr21_-_43369492 1.288 NM_001178008
NM_001178009
CBS

cystathionine-beta-synthase

chr1_-_2115950 1.288 NM_182533
C1orf86
chromosome 1 open reading frame 86
chr19_-_46551670 1.285 NM_000660
TGFB1
transforming growth factor, beta 1
chr22_+_48951286 1.275 NM_001160300
NM_052839
PANX2

pannexin 2

chr11_+_63829616 1.270 NM_004451
ESRRA
estrogen-related receptor alpha
chr22_+_19649460 1.267 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr16_-_960982 1.265 NM_022773
LMF1
lipase maturation factor 1
chr19_+_54786723 1.262 NM_020719
PRR12
proline rich 12
chr9_+_138497767 1.256 NM_152571
C9orf163
chromosome 9 open reading frame 163
chr17_+_26839143 1.254 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr17_+_72789086 1.249 NM_001113491
SEPT9
septin 9
chr16_-_18845223 1.247 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr17_-_77462325 1.247 PCYT2
phosphate cytidylyltransferase 2, ethanolamine
chr20_-_34635091 1.245


chr2_+_119905812 1.244 NM_183240
TMEM37
transmembrane protein 37
chr7_-_100078270 1.241 TFR2
transferrin receptor 2
chr17_+_75366524 1.238 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr17_+_53515725 1.226 NM_080677
DYNLL2
dynein, light chain, LC8-type 2
chr17_-_53515563 1.226


chr16_+_88315452 1.225 NM_001113525
ZNF276
zinc finger protein 276
chr3_-_50315983 1.225 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chrX_+_153318662 1.222 GDI1
GDP dissociation inhibitor 1
chr3_+_12304332 1.220 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr16_-_79687367 1.218 NM_004483
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr20_+_48781457 1.216 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr1_-_40903700 1.215 RIMS3
regulating synaptic membrane exocytosis 3
chr11_-_67153959 1.210 NM_181843
NUDT8
nudix (nucleoside diphosphate linked moiety X)-type motif 8
chr19_-_50963942 1.209


chr1_+_153366559 1.205 EFNA1
ephrin-A1
chr9_+_137511448 1.201 NM_014811
KIAA0649
KIAA0649
chr14_+_23937766 1.201 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr22_+_21742727 1.200 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chrX_+_138060 1.199 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr2_-_98713862 1.193 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr8_+_144706699 1.187 NM_001166237
GSDMD
gasdermin D
chr14_-_20563698 1.186 NDRG2
NDRG family member 2
chr7_-_149101227 1.186 NM_207336
ZNF467
zinc finger protein 467
chr17_-_3743019 1.181 CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr1_+_3360880 1.180 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr22_+_21742364 1.178 NM_002073
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr7_+_73136042 1.174 LIMK1
LIM domain kinase 1
chr12_+_6290127 1.174 PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr17_-_3743085 1.171 NM_032294
NM_172207
CAMKK1

calcium/calmodulin-dependent protein kinase kinase 1, alpha

chr1_+_7766966 1.170 PER3
period homolog 3 (Drosophila)
chr10_-_62431203 1.169 RHOBTB1
Rho-related BTB domain containing 1
chr17_-_77462506 1.167 NM_001184917
NM_002861
PCYT2

phosphate cytidylyltransferase 2, ethanolamine

chr22_+_27609889 1.157 NM_032173
ZNRF3
zinc and ring finger 3
chr22_-_21231421 1.156 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr20_+_32927988 1.155 NM_001076552
NM_018677
ACSS2

acyl-CoA synthetase short-chain family member 2

chr21_-_45173061 1.154 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr18_+_53253775 1.149 NM_004852
ONECUT2
one cut homeobox 2
chr1_-_21868380 1.148 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr20_+_61839931 1.146 LIME1
Lck interacting transmembrane adaptor 1
chr20_+_30814048 1.146 DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr1_-_23393808 1.145 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr17_-_38978772 1.144 NM_001986
ETV4
ets variant 4
chr16_-_87244896 1.141 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr17_+_40681060 1.137 LOC100133991
similar to hCG1995169
chr16_+_670115 1.130 NM_005861
STUB1
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
chr9_+_138680064 1.130 EGFL7
EGF-like-domain, multiple 7
chr6_+_33495824 1.129 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr17_-_77422400 1.127


chr6_-_33393471 1.124 NM_005453
ZBTB22
zinc finger and BTB domain containing 22
chr20_-_62181231 1.113 NM_005873
RGS19
regulator of G-protein signaling 19
chr9_+_129962292 1.109 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr11_+_46359878 1.107 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr9_+_132961723 1.106 AIF1L
allograft inflammatory factor 1-like
chr17_+_7125702 1.103 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 6.40e-27 GO:0009987 cellular process
1.13 5.73e-23 GO:0044237 cellular metabolic process
1.16 1.19e-20 GO:0044260 cellular macromolecule metabolic process
1.11 6.94e-18 GO:0050794 regulation of cellular process
1.10 2.58e-17 GO:0065007 biological regulation
1.10 6.75e-16 GO:0050789 regulation of biological process
1.10 8.36e-16 GO:0008152 metabolic process
1.18 3.21e-15 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.11 6.14e-15 GO:0044238 primary metabolic process
1.18 3.43e-14 GO:0071842 cellular component organization at cellular level
1.12 3.04e-13 GO:0043170 macromolecule metabolic process
1.17 3.18e-13 GO:0071841 cellular component organization or biogenesis at cellular level
1.15 5.73e-13 GO:0080090 regulation of primary metabolic process
1.16 9.14e-13 GO:0034641 cellular nitrogen compound metabolic process
1.15 1.39e-12 GO:0006807 nitrogen compound metabolic process
1.19 1.78e-12 GO:0090304 nucleic acid metabolic process
1.14 2.34e-12 GO:0031323 regulation of cellular metabolic process
1.15 2.36e-12 GO:0060255 regulation of macromolecule metabolic process
1.14 2.71e-12 GO:0019222 regulation of metabolic process
1.19 2.77e-12 GO:0048523 negative regulation of cellular process
1.15 3.57e-12 GO:0016043 cellular component organization
1.14 3.86e-11 GO:0071840 cellular component organization or biogenesis
1.17 1.76e-10 GO:0048519 negative regulation of biological process
1.20 1.25e-09 GO:0006996 organelle organization
1.16 2.00e-09 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.42 2.24e-09 GO:0016568 chromatin modification
1.16 2.55e-09 GO:0010468 regulation of gene expression
1.25 2.84e-09 GO:0007049 cell cycle
1.27 3.30e-09 GO:0010605 negative regulation of macromolecule metabolic process
1.19 4.08e-09 GO:0016070 RNA metabolic process
1.16 5.47e-09 GO:0044249 cellular biosynthetic process
1.15 6.53e-09 GO:0051171 regulation of nitrogen compound metabolic process
1.19 9.02e-09 GO:0034645 cellular macromolecule biosynthetic process
1.15 1.02e-08 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 1.31e-08 GO:0009059 macromolecule biosynthetic process
1.32 1.84e-08 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.15 4.22e-08 GO:0010556 regulation of macromolecule biosynthetic process
1.15 5.87e-08 GO:0009058 biosynthetic process
1.24 8.18e-08 GO:0009892 negative regulation of metabolic process
1.16 8.30e-08 GO:0051252 regulation of RNA metabolic process
1.25 1.48e-07 GO:0006351 transcription, DNA-dependent
1.30 2.66e-07 GO:0010629 negative regulation of gene expression
1.29 2.81e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
1.24 3.92e-07 GO:0032774 RNA biosynthetic process
1.24 4.43e-07 GO:0031324 negative regulation of cellular metabolic process
1.14 5.05e-07 GO:0031326 regulation of cellular biosynthetic process
1.26 5.57e-07 GO:0022402 cell cycle process
1.13 6.91e-07 GO:0009889 regulation of biosynthetic process
1.31 7.74e-07 GO:0045892 negative regulation of transcription, DNA-dependent
1.23 1.24e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.15 1.32e-06 GO:0006355 regulation of transcription, DNA-dependent
1.51 2.56e-06 GO:0016569 covalent chromatin modification
1.16 2.87e-06 GO:0010467 gene expression
1.30 2.96e-06 GO:0051253 negative regulation of RNA metabolic process
1.51 3.34e-06 GO:0016570 histone modification
1.29 3.72e-06 GO:0000278 mitotic cell cycle
1.21 3.78e-06 GO:0051246 regulation of protein metabolic process
1.22 5.07e-06 GO:0032268 regulation of cellular protein metabolic process
1.16 7.55e-06 GO:0006464 protein modification process
1.13 7.93e-06 GO:0044267 cellular protein metabolic process
1.13 8.14e-06 GO:0048518 positive regulation of biological process
1.15 9.26e-06 GO:0043412 macromolecule modification
1.26 9.86e-06 GO:0009890 negative regulation of biosynthetic process
1.26 1.14e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.13 1.33e-05 GO:0048522 positive regulation of cellular process
1.27 1.80e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 1.88e-05 GO:0007399 nervous system development
1.16 2.00e-05 GO:0023051 regulation of signaling
1.25 2.05e-05 GO:0022403 cell cycle phase
1.27 2.50e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.32 5.14e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.10 1.55e-04 GO:0023052 signaling
1.25 2.40e-04 GO:0051276 chromosome organization
1.16 3.15e-04 GO:0065009 regulation of molecular function
1.16 4.06e-04 GO:0009966 regulation of signal transduction
1.28 5.91e-04 GO:0006325 chromatin organization
1.16 7.35e-04 GO:0035556 intracellular signal transduction
1.10 1.19e-03 GO:0007165 signal transduction
1.08 1.27e-03 GO:0051716 cellular response to stimulus
1.33 2.00e-03 GO:0051329 interphase of mitotic cell cycle
1.32 3.00e-03 GO:0051325 interphase
1.33 3.18e-03 GO:0006366 transcription from RNA polymerase II promoter
1.27 3.34e-03 GO:0032583 regulation of gene-specific transcription
1.35 3.66e-03 GO:0051248 negative regulation of protein metabolic process
1.16 3.84e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.22 4.61e-03 GO:0051726 regulation of cell cycle
1.15 4.86e-03 GO:0051641 cellular localization
1.37 4.93e-03 GO:0071375 cellular response to peptide hormone stimulus
1.35 5.54e-03 GO:0032269 negative regulation of cellular protein metabolic process
1.24 5.66e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.30 5.89e-03 GO:0043434 response to peptide hormone stimulus
1.09 7.37e-03 GO:0051179 localization
1.30 9.53e-03 GO:0032870 cellular response to hormone stimulus
1.22 1.04e-02 GO:0009057 macromolecule catabolic process
1.45 1.06e-02 GO:0008286 insulin receptor signaling pathway
1.19 1.06e-02 GO:0031399 regulation of protein modification process
1.24 1.34e-02 GO:0048858 cell projection morphogenesis
1.28 1.42e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.20 1.46e-02 GO:0009790 embryo development
1.09 1.51e-02 GO:0051234 establishment of localization
1.28 1.67e-02 GO:0051301 cell division
1.57 1.93e-02 GO:0008629 induction of apoptosis by intracellular signals
1.25 1.99e-02 GO:0048812 neuron projection morphogenesis
1.32 2.01e-02 GO:0016567 protein ubiquitination
1.31 2.32e-02 GO:0051101 regulation of DNA binding
1.23 2.52e-02 GO:0031175 neuron projection development
1.41 2.69e-02 GO:0032147 activation of protein kinase activity
1.23 2.77e-02 GO:0006974 response to DNA damage stimulus
1.29 2.89e-02 GO:0048285 organelle fission
1.28 2.93e-02 GO:0071495 cellular response to endogenous stimulus
1.23 3.33e-02 GO:0032990 cell part morphogenesis
1.29 3.38e-02 GO:0000280 nuclear division
1.29 3.38e-02 GO:0007067 mitosis
1.27 3.48e-02 GO:0010564 regulation of cell cycle process
1.28 3.61e-02 GO:0051098 regulation of binding
1.16 3.64e-02 GO:0043067 regulation of programmed cell death
1.24 3.99e-02 GO:0010648 negative regulation of cell communication
1.33 3.99e-02 GO:0032868 response to insulin stimulus
1.15 4.10e-02 GO:0010646 regulation of cell communication
1.20 4.42e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.30 4.46e-02 GO:0007017 microtubule-based process
1.30 4.87e-02 GO:0032446 protein modification by small protein conjugation
1.38 4.88e-02 GO:0006417 regulation of translation
1.22 4.97e-02 GO:0000904 cell morphogenesis involved in differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 1.83e-59 GO:0044424 intracellular part
1.10 1.55e-58 GO:0005622 intracellular
1.12 4.39e-46 GO:0043226 organelle
1.12 6.14e-46 GO:0043229 intracellular organelle
1.13 8.99e-44 GO:0043227 membrane-bounded organelle
1.12 4.96e-43 GO:0043231 intracellular membrane-bounded organelle
1.12 4.26e-34 GO:0005737 cytoplasm
1.15 6.84e-29 GO:0044422 organelle part
1.15 1.56e-28 GO:0044446 intracellular organelle part
1.15 1.00e-27 GO:0005634 nucleus
1.26 3.94e-27 GO:0044428 nuclear part
1.27 1.09e-23 GO:0031981 nuclear lumen
1.23 1.94e-21 GO:0070013 intracellular organelle lumen
1.22 1.84e-20 GO:0031974 membrane-enclosed lumen
1.22 2.21e-20 GO:0043233 organelle lumen
1.12 1.82e-18 GO:0044444 cytoplasmic part
1.27 8.54e-17 GO:0005654 nucleoplasm
1.03 1.89e-15 GO:0044464 cell part
1.03 2.23e-15 GO:0005623 cell
1.19 2.76e-13 GO:0005829 cytosol
1.15 1.29e-12 GO:0043234 protein complex
1.13 2.16e-11 GO:0032991 macromolecular complex
1.15 7.63e-11 GO:0043228 non-membrane-bounded organelle
1.15 7.63e-11 GO:0043232 intracellular non-membrane-bounded organelle
1.30 3.98e-10 GO:0044451 nucleoplasm part
1.28 2.81e-08 GO:0015630 microtubule cytoskeleton
1.37 7.96e-06 GO:0005874 microtubule
1.27 4.90e-05 GO:0005730 nucleolus
1.24 3.71e-04 GO:0005694 chromosome
1.22 5.52e-04 GO:0030054 cell junction
1.17 8.05e-04 GO:0005794 Golgi apparatus
1.27 9.22e-04 GO:0043005 neuron projection
1.36 1.00e-03 GO:0000228 nuclear chromosome
1.13 1.16e-03 GO:0012505 endomembrane system
1.39 1.19e-03 GO:0005819 spindle
1.11 1.77e-03 GO:0031090 organelle membrane
1.17 2.99e-03 GO:0042995 cell projection
1.13 3.34e-03 GO:0005856 cytoskeleton
1.37 5.13e-03 GO:0044454 nuclear chromosome part
1.40 1.14e-02 GO:0000151 ubiquitin ligase complex
1.30 1.28e-02 GO:0005667 transcription factor complex
1.14 1.84e-02 GO:0005783 endoplasmic reticulum
1.48 2.04e-02 GO:0016585 chromatin remodeling complex
1.23 2.08e-02 GO:0045202 synapse
1.45 2.20e-02 GO:0005925 focal adhesion
1.35 2.52e-02 GO:0070161 anchoring junction
1.14 2.59e-02 GO:0044430 cytoskeletal part
1.30 2.90e-02 GO:0016604 nuclear body
1.36 3.26e-02 GO:0005912 adherens junction
1.61 3.52e-02 GO:0005793 ER-Golgi intermediate compartment
1.31 3.53e-02 GO:0030135 coated vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 3.81e-36 GO:0005515 protein binding
1.07 2.52e-25 GO:0005488 binding
1.29 1.97e-09 GO:0019899 enzyme binding
1.14 7.18e-07 GO:0000166 nucleotide binding
1.13 2.04e-06 GO:0003677 DNA binding
1.10 2.08e-05 GO:0003676 nucleic acid binding
1.08 2.68e-05 GO:0003824 catalytic activity
1.20 7.74e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.15 8.90e-05 GO:0032559 adenyl ribonucleotide binding
1.13 1.06e-04 GO:0032553 ribonucleotide binding
1.13 1.06e-04 GO:0032555 purine ribonucleotide binding
1.15 1.17e-04 GO:0030554 adenyl nucleotide binding
1.13 1.34e-04 GO:0017076 purine nucleotide binding
1.42 1.36e-04 GO:0003682 chromatin binding
1.28 1.57e-04 GO:0019904 protein domain specific binding
1.18 2.36e-04 GO:0030528 transcription regulator activity
1.15 3.12e-04 GO:0005524 ATP binding
1.13 3.98e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.13 4.79e-04 GO:0016740 transferase activity
1.32 6.06e-04 GO:0016564 transcription repressor activity
1.32 6.69e-04 GO:0008134 transcription factor binding
1.17 2.63e-03 GO:0001071 nucleic acid binding transcription factor activity
1.17 2.63e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.18 6.44e-03 GO:0016301 kinase activity
1.19 6.53e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.19 7.77e-03 GO:0043565 sequence-specific DNA binding
1.22 7.78e-03 GO:0008092 cytoskeletal protein binding
1.45 1.11e-02 GO:0015631 tubulin binding
1.40 1.33e-02 GO:0008022 protein C-terminus binding
1.25 1.49e-02 GO:0000988 protein binding transcription factor activity
1.25 1.49e-02 GO:0000989 transcription factor binding transcription factor activity
1.57 1.52e-02 GO:0008017 microtubule binding
1.25 1.88e-02 GO:0003712 transcription cofactor activity
1.27 2.10e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.17 2.20e-02 GO:0042802 identical protein binding