Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.123


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1725946910.381.4e-01Click!
NKX2-3chr10_+_1012826790.116.7e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_171280046 3.503 NM_001003845
 SP5
Sp5 transcription factor
chr2_+_171280182 3.064


chr17_-_53849888 3.033 RNF43
ring finger protein 43
chr4_+_90252990 2.365 NM_145715
 TIGD2
tigger transposable element derived 2
chr6_+_105511615 1.981 NM_001004317
 LIN28B
lin-28 homolog B (C. elegans)
chr9_-_116305273 1.504 NM_001083885
 DFNB31
deafness, autosomal recessive 31
chr11_-_16380967 1.469 NM_001145819
NM_017508
 SOX6

SRY (sex determining region Y)-box 6

chr20_+_5935897 1.464 NM_001127458
 CRLS1
cardiolipin synthase 1
chr3_-_121884091 1.434 NM_000187
 HGD
homogentisate 1,2-dioxygenase
chr12_-_120725210 1.367 LOC338799
hypothetical LOC338799
chr17_-_46479127 1.354 SPAG9
sperm associated antigen 9
chr3_-_121883647 1.286 HGD
homogentisate 1,2-dioxygenase
chr12_-_23995109 1.275 SOX5
SRY (sex determining region Y)-box 5
chr12_-_23995220 1.245 SOX5
SRY (sex determining region Y)-box 5
chrX_-_24600661 1.163 NM_001163264
 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr6_+_28237529 1.151 NM_001145129
 ZNF389
zinc finger protein 389
chrX_-_48212683 1.139 SLC38A5
solute carrier family 38, member 5
chr16_+_20682812 1.139 NM_005622
NM_202000
 ACSM3

acyl-CoA synthetase medium-chain family member 3

chr10_+_7785360 1.133 ITIH2
inter-alpha (globulin) inhibitor H2
chr19_+_50100843 1.127 NM_000041
 APOE
apolipoprotein E

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.03 1.03e-03 GO:0007606 sensory perception of chemical stimulus
1.98 1.11e-02 GO:0007608 sensory perception of smell
1.74 1.36e-03 GO:0007600 sensory perception
1.53 3.81e-03 GO:0050877 neurological system process
1.50 9.07e-04 GO:0003008 system process
1.34 1.04e-08 GO:0032501 multicellular organismal process
1.27 1.31e-02 GO:0032502 developmental process
1.27 3.80e-02 GO:0007275 multicellular organismal development
1.18 2.43e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.56 3.49e-02 GO:0005615 extracellular space
1.48 3.44e-02 GO:0044421 extracellular region part
1.42 3.98e-04 GO:0005576 extracellular region
1.24 3.51e-03 GO:0005886 plasma membrane
1.24 4.47e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
3.94 1.86e-02 GO:0005070 SH3/SH2 adaptor activity
3.49 3.54e-02 GO:0035591 signaling adaptor activity
1.99 3.76e-03 GO:0004984 olfactory receptor activity
1.60 1.49e-02 GO:0004930 G-protein coupled receptor activity
1.45 3.51e-02 GO:0004888 transmembrane receptor activity
1.40 1.34e-02 GO:0004872 receptor activity
1.33 4.76e-02 GO:0004871 signal transducer activity
1.33 4.76e-02 GO:0060089 molecular transducer activity