Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.123


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1725946910.381.4e-01Click!
NKX2-3chr10_+_1012826790.116.7e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_171280046 3.503 NM_001003845
SP5
Sp5 transcription factor
chr2_+_171280182 3.064


chr17_-_53849888 3.033 RNF43
ring finger protein 43
chr4_+_90252990 2.365 NM_145715
TIGD2
tigger transposable element derived 2
chr6_+_105511615 1.981 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr9_-_116305273 1.504 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr11_-_16380967 1.469 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr20_+_5935897 1.464 NM_001127458
CRLS1
cardiolipin synthase 1
chr3_-_121884091 1.434 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr12_-_120725210 1.367 LOC338799
hypothetical LOC338799
chr17_-_46479127 1.354 SPAG9
sperm associated antigen 9
chr3_-_121883647 1.286 HGD
homogentisate 1,2-dioxygenase
chr12_-_23995109 1.275 SOX5
SRY (sex determining region Y)-box 5
chr12_-_23995220 1.245 SOX5
SRY (sex determining region Y)-box 5
chrX_-_24600661 1.163 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr6_+_28237529 1.151 NM_001145129
ZNF389
zinc finger protein 389
chrX_-_48212683 1.139 SLC38A5
solute carrier family 38, member 5
chr16_+_20682812 1.139 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr10_+_7785360 1.133 ITIH2
inter-alpha (globulin) inhibitor H2
chr19_+_50100843 1.127 NM_000041
APOE
apolipoprotein E
chr6_-_49712483 1.126 NM_000324
RHAG
Rh-associated glycoprotein
chr7_+_139175420 1.114 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr13_+_23042722 1.087 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr12_+_54700955 1.053 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr5_+_59819761 1.047 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr5_+_71538456 1.047 MAP1B
microtubule-associated protein 1B
chr7_+_113842284 1.046 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr10_+_7785347 1.044 ITIH2
inter-alpha (globulin) inhibitor H2
chrX_+_68752635 1.041 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr14_-_37134050 1.027 FOXA1
forkhead box A1
chrX_+_115481774 1.019 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr7_+_113853790 1.012 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr14_+_31868229 1.002 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr4_-_83566045 0.992


chr4_-_176970895 0.988 GPM6A
glycoprotein M6A
chr10_+_7785290 0.958 ITIH2
inter-alpha (globulin) inhibitor H2
chr8_-_110724594 0.938 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chrX_+_105823723 0.934 NM_024539
RNF128
ring finger protein 128
chr2_+_157822355 0.923 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr10_+_7785331 0.923 ITIH2
inter-alpha (globulin) inhibitor H2
chr19_-_53081383 0.892 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr6_+_50789215 0.891 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr2_+_161981046 0.886 TBR1
T-box, brain, 1
chr17_-_36346240 0.878 KRT23
keratin 23 (histone deacetylase inducible)
chr19_-_53081326 0.873 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr4_+_69716298 0.864 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chrX_+_9391314 0.851 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr12_+_49605010 0.847 METTL7A
methyltransferase like 7A
chr12_+_49604782 0.837 NM_014033
METTL7A
methyltransferase like 7A
chr4_+_74493174 0.835 ALB
albumin
chr10_+_101532544 0.825 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr10_-_73953699 0.820 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr2_+_161981138 0.819 TBR1
T-box, brain, 1
chr9_-_14858974 0.818 FREM1
FRAS1 related extracellular matrix 1
chr14_-_37134191 0.813 NM_004496
FOXA1
forkhead box A1
chr2_+_37282516 0.808 LOC100505876
hypothetical LOC100505876
chr3_+_63859114 0.804 NM_001177387
ATXN7
ataxin 7
chr9_+_129066576 0.799 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr11_-_18214891 0.780 NM_006512
SAA4
serum amyloid A4, constitutive
chr5_-_59819642 0.780 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_32265489 0.778 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr5_-_148738980 0.770 NM_014443
IL17B
interleukin 17B
chr2_-_200033445 0.766 SATB2
SATB homeobox 2
chr14_-_37133927 0.761 FOXA1
forkhead box A1
chr17_+_7682355 0.748


chr4_-_176971175 0.747 NM_201591
GPM6A
glycoprotein M6A
chr2_+_161980865 0.730 NM_006593
TBR1
T-box, brain, 1
chrX_-_135783496 0.722


chr11_-_16454493 0.701 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chrX_+_70682204 0.700 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr1_-_180624380 0.687 GLUL
glutamate-ammonia ligase
chr17_-_36347197 0.665 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chrX_-_129347101 0.663 NM_178471
GPR119
G protein-coupled receptor 119
chr4_+_74493301 0.663 ALB
albumin
chr7_-_13992351 0.652 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr4_+_74520796 0.648 NM_001134
AFP
alpha-fetoprotein
chr17_-_61655915 0.645 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr17_+_24394281 0.641 PIPOX
pipecolic acid oxidase
chr4_-_23500706 0.639 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr10_-_52315390 0.635 A1CF
APOBEC1 complementation factor
chr7_+_116238309 0.635 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr10_+_101532450 0.634 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_+_165564904 0.629 NM_001198783
POU2F1
POU class 2 homeobox 1
chr1_+_165565006 0.627 POU2F1
POU class 2 homeobox 1
chr2_+_174907914 0.622 NM_001145250
SP9
Sp9 transcription factor homolog (mouse)
chr6_-_2696152 0.619 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chrX_+_115481848 0.618 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr3_-_188492163 0.617 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr6_+_31731647 0.615 NM_019101
APOM
apolipoprotein M
chr12_-_6354650 0.609 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr4_-_83566246 0.606 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr4_+_74493266 0.604 ALB
albumin
chrX_+_123062143 0.594 STAG2
stromal antigen 2
chr7_+_142053693 0.594 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chr5_+_140690387 0.594 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr10_+_7785235 0.590 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr20_+_31713750 0.589 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr21_-_32879617 0.582 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr1_-_214963279 0.574 NM_001438
ESRRG
estrogen-related receptor gamma
chr4_+_74493331 0.565 ALB
albumin
chr2_-_99238001 0.564 NM_175735
LYG2
lysozyme G-like 2
chr4_+_74493218 0.557 ALB
albumin
chr3_+_39484073 0.556 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr6_+_31731667 0.555 APOM
apolipoprotein M
chr15_+_38082041 0.553 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr18_+_71051713 0.552 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr12_-_6354818 0.552 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr7_-_92693716 0.548 NM_001039372
HEPACAM2
HEPACAM family member 2
chr14_+_38772870 0.545 NM_054024
MIA2
melanoma inhibitory activity 2
chr3_+_63928459 0.541 NM_001128149
ATXN7
ataxin 7
chr7_+_106897737 0.533 NM_005295
GPR22
G protein-coupled receptor 22
chr6_+_41128917 0.529 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr3_-_57209319 0.529 NM_003865
HESX1
HESX homeobox 1
chr4_-_69852090 0.520 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_-_186970366 0.514 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr6_-_76022565 0.514 TMEM30A
transmembrane protein 30A
chr9_-_14076901 0.514 NFIB
nuclear factor I/B
chr4_+_140806536 0.511 MGST2
microsomal glutathione S-transferase 2
chr12_-_101396459 0.506 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr13_-_35327798 0.502 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr15_+_97990705 0.500 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr12_+_40117751 0.498 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr8_-_82536312 0.494 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr7_-_96471544 0.491 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr22_-_21204597 0.486 NM_080740
ZNF280A
zinc finger protein 280A
chr10_-_52315436 0.486 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr16_+_68238460 0.476 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr17_-_1195096 0.476 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr22_-_36836620 0.475 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr15_+_56511466 0.474 NM_000236
LIPC
lipase, hepatic
chr7_+_128802719 0.468 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr2_+_143603439 0.468 ARHGAP15
Rho GTPase activating protein 15
chrX_-_130251068 0.465 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr2_+_101874809 0.465 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr17_-_36418869 0.464 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr14_+_99555471 0.458 EVL
Enah/Vasp-like
chr6_-_50039776 0.457 NM_001037499
DEFB114
defensin, beta 114
chr1_+_207944807 0.455 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr13_+_77213295 0.451 NM_144595
SLAIN1
SLAIN motif family, member 1
chr12_-_16652202 0.450 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_-_166149867 0.449 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr22_+_38903825 0.444 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr17_-_36209672 0.444 NM_181535
KRT28
keratin 28
chr10_-_123346148 0.443 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr14_+_19761708 0.438 NM_001004480
OR11H6
olfactory receptor, family 11, subfamily H, member 6
chr17_+_54188230 0.436 NM_014906
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr3_+_89239494 0.436 EPHA3
EPH receptor A3
chr17_-_36444626 0.435 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr1_+_50347188 0.433 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_-_44547382 0.425 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr12_+_50342814 0.425 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr6_+_155579788 0.424 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr3_+_161425946 0.423 NM_001168214
LOC401097
hypothetical protein LOC401097
chr16_-_45339605 0.421 NM_182493
MYLK3
myosin light chain kinase 3
chr19_-_5789740 0.419 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr10_+_24795465 0.417 KIAA1217
KIAA1217
chr1_-_220829704 0.413 NM_005681
NM_139352
TAF1A

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

chr7_+_94135384 0.410 PEG10
paternally expressed 10
chr4_+_74499651 0.410 ALB
albumin
chr1_-_180624494 0.409 GLUL
glutamate-ammonia ligase
chr17_+_54587882 0.408 PRR11
proline rich 11
chr10_+_24795446 0.406 KIAA1217
KIAA1217
chr15_-_32398220 0.406 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr17_-_9635325 0.406 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr2_-_215953818 0.402 FN1
fibronectin 1
chr4_+_71418886 0.402 NM_212557
AMTN
amelotin
chr2_+_143603368 0.395 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr20_-_33489383 0.393 NM_000557
GDF5
growth differentiation factor 5
chr11_+_86710076 0.390 TMEM135
transmembrane protein 135
chr14_+_30161285 0.387 SCFD1
sec1 family domain containing 1
chr22_-_36836478 0.383 BAIAP2L2
BAI1-associated protein 2-like 2
chr4_+_88939725 0.383 NM_004967
IBSP
integrin-binding sialoprotein
chr9_-_103185621 0.383 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr1_+_556968 0.383


chr11_-_102081654 0.378 NM_022122
MMP27
matrix metallopeptidase 27
chr12_+_28301399 0.373 NM_018318
CCDC91
coiled-coil domain containing 91
chr8_+_104900591 0.372 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr3_-_50583425 0.372 NM_001171741
C3orf18
chromosome 3 open reading frame 18
chr16_-_68317855 0.372 NQO1
NAD(P)H dehydrogenase, quinone 1
chrX_-_18600108 0.368 NM_000330
RS1
retinoschisin 1
chrX_+_44588192 0.364 NM_022076
DUSP21
dual specificity phosphatase 21
chr6_-_24491498 0.361 NM_001195610
DCDC2
doublecortin domain containing 2
chr16_-_68317868 0.359 NQO1
NAD(P)H dehydrogenase, quinone 1
chr6_+_88021644 0.358 ZNF292
zinc finger protein 292
chr7_-_36991189 0.358 NM_001039459
ELMO1
engulfment and cell motility 1
chr5_+_67622242 0.356 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_36721010 0.355 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr1_+_100089118 0.353 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chrX_+_21960841 0.352 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr1_+_117098579 0.352 NM_001767
CD2
CD2 molecule
chr17_-_71285992 0.352 H3F3B
H3 histone, family 3B (H3.3B)
chr12_-_51173238 0.352 NM_005554
KRT6A
keratin 6A
chr5_+_40945374 0.351 C7
complement component 7
chr7_+_129634935 0.351 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr7_-_25234582 0.349 NM_022150
NPVF
neuropeptide VF precursor
chr1_+_166516901 0.349 NM_005149
TBX19
T-box 19
chr16_-_66075216 0.349 NM_001138
AGRP
agouti related protein homolog (mouse)
chr19_-_47724365 0.348 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr13_-_45654292 0.348 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_101874765 0.346 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 1.04e-08 GO:0032501 multicellular organismal process
1.50 9.07e-04 GO:0003008 system process
2.03 1.03e-03 GO:0007606 sensory perception of chemical stimulus
1.74 1.36e-03 GO:0007600 sensory perception
1.53 3.81e-03 GO:0050877 neurological system process
1.98 1.11e-02 GO:0007608 sensory perception of smell
1.27 1.31e-02 GO:0032502 developmental process
1.18 2.43e-02 GO:0050896 response to stimulus
1.27 3.80e-02 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 3.98e-04 GO:0005576 extracellular region
1.24 3.51e-03 GO:0005886 plasma membrane
1.24 4.47e-03 GO:0071944 cell periphery
1.48 3.44e-02 GO:0044421 extracellular region part
1.56 3.49e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.99 3.76e-03 GO:0004984 olfactory receptor activity
1.40 1.34e-02 GO:0004872 receptor activity
1.60 1.49e-02 GO:0004930 G-protein coupled receptor activity
3.94 1.86e-02 GO:0005070 SH3/SH2 adaptor activity
1.45 3.51e-02 GO:0004888 transmembrane receptor activity
3.49 3.54e-02 GO:0035591 signaling adaptor activity
1.33 4.76e-02 GO:0004871 signal transducer activity
1.33 4.76e-02 GO:0060089 molecular transducer activity