Motif ID: PAX6.p2

Z-value: 0.417


Transcription factors associated with PAX6.p2:

Gene SymbolEntrez IDGene Name
PAX6 5080 paired box 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX6chr11_-_317891680.656.8e-03Click!


Activity profile for motif PAX6.p2.

activity profile for motif PAX6.p2


Sorted Z-values histogram for motif PAX6.p2

Sorted Z-values for motif PAX6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_165565006 0.796 POU2F1
POU class 2 homeobox 1
chr1_+_165564904 0.736 NM_001198783
POU2F1
POU class 2 homeobox 1
chr6_+_147568795 0.415 STXBP5
syntaxin binding protein 5 (tomosyn)
chr6_-_131333173 0.337 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr7_+_154943466 0.332 NM_001427
EN2
engrailed homeobox 2
chr15_+_49760841 0.300 NM_001165257
NM_013243
SCG3

secretogranin III

chr16_+_70654625 0.267 NM_020995
HPR
haptoglobin-related protein
chr22_+_24468168 0.258 MYO18B
myosin XVIIIB
chr22_+_38075703 0.230 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chr8_-_21827057 0.227 NM_003974
DOK2
docking protein 2, 56kDa
chr19_-_56825400 0.226 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr2_+_170074457 0.210 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chrX_-_106336199 0.200 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chr5_-_98290117 0.191 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr11_-_58099884 0.187 NM_004811
LPXN
leupaxin
chr10_-_82039158 0.186 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr4_-_174557191 0.180 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr9_+_102380156 0.158 NM_001018116
MURC
muscle-related coiled-coil protein
chr12_+_97513644 0.152 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chrX_-_13745134 0.137 GPM6B
glycoprotein M6B
chr1_-_31117948 0.136 SDC3
syndecan 3
chr11_+_111294868 0.136 C11orf52
chromosome 11 open reading frame 52
chr19_+_59941785 0.125 NM_015868
KIR2DS2
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr5_-_169657312 0.123 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_-_68379331 0.122 NM_032735
BEST3
bestrophin 3
chr4_+_130236731 0.117 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr1_+_87153025 0.116 HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr17_-_36294962 0.116 NM_019010
KRT20
keratin 20
chr6_-_42270671 0.113 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr1_+_93830106 0.112 LOC100129046
hypothetical LOC100129046
chr2_+_214984705 0.112 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chrX_+_52797004 0.112 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr8_+_21972804 0.111 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr1_-_87152372 0.110 SEP15
15 kDa selenoprotein
chr11_+_111294810 0.104 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr1_+_51855343 0.103 OSBPL9
oxysterol binding protein-like 9
chr1_-_87152396 0.102 SEP15
15 kDa selenoprotein
chr20_+_31713750 0.100 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr8_-_62764839 0.099 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chrX_-_130251068 0.099 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr6_+_152168500 0.096 NM_001122741
ESR1
estrogen receptor 1
chr1_+_202033273 0.093 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr1_-_6502655 0.084 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr17_-_1195096 0.083 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr3_+_16949585 0.083 NM_015184
PLCL2
phospholipase C-like 2
chr11_+_123600553 0.078 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr10_+_35934343 0.076 NM_153368
GJD4
gap junction protein, delta 4, 40.1kDa
chr16_-_46823682 0.076 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr1_-_108588186 0.075 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chr22_+_38652555 0.075 GRAP2
GRB2-related adaptor protein 2
chr8_+_124264054 0.074 FAM83A
family with sequence similarity 83, member A
chrX_-_135783496 0.074


chr11_+_4859624 0.073 NM_001004759
OR51T1
olfactory receptor, family 51, subfamily T, member 1
chr4_+_114190233 0.072 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr13_+_52500830 0.072 NM_006418
OLFM4
olfactomedin 4
chr16_-_11282595 0.072 NM_002761
PRM1
protamine 1
chr1_+_93830169 0.069 LOC100129046
hypothetical LOC100129046
chr5_+_42792676 0.069 NM_001134848
CCDC152
coiled-coil domain containing 152
chr3_-_120861959 0.068 NM_022135
POPDC2
popeye domain containing 2
chr2_+_108571177 0.068 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr20_-_32877029 0.067 NM_014071
NCOA6
nuclear receptor coactivator 6
chr11_-_57054756 0.066 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr2_+_38746742 0.066 GALM
galactose mutarotase (aldose 1-epimerase)
chrX_-_130250880 0.066 IGSF1
immunoglobulin superfamily, member 1
chr11_+_19328846 0.064 NM_001111018
NAV2
neuron navigator 2
chr2_-_171631728 0.062 NM_001136555
TLK1
tousled-like kinase 1
chr1_-_246804680 0.059 NM_001001821
OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr10_-_7699192 0.058 ITIH5
inter-alpha (globulin) inhibitor H5
chr2_-_157890400 0.058 NM_020711
ERMN
ermin, ERM-like protein
chr19_+_56990222 0.057 NM_002030
FPR3
formyl peptide receptor 3
chr5_+_40945315 0.057 NM_000587
C7
complement component 7
chr4_+_100714995 0.057 MTTP
microsomal triglyceride transfer protein
chr10_-_45350804 0.051 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr12_+_108035424 0.051


chr2_-_200033445 0.051 SATB2
SATB homeobox 2
chr1_-_87152596 0.051 NM_004261
NM_203341
SEP15

15 kDa selenoprotein

chr2_+_108571209 0.050 LIMS1
LIM and senescent cell antigen-like domains 1
chr5_-_141318810 0.049 NM_016580
PCDH12
protocadherin 12
chr2_+_62787534 0.048 NM_001142614
EHBP1
EH domain binding protein 1
chr17_+_22982344 0.048 LGALS9
lectin, galactoside-binding, soluble, 9
chr12_+_67366989 0.048 NM_020401
NUP107
nucleoporin 107kDa
chr4_-_10295412 0.048 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr16_-_49742008 0.048 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr5_-_135259403 0.047 NM_000590
IL9
interleukin 9
chr5_+_40945244 0.046 C7
complement component 7
chr2_+_39000007 0.046 NM_001145451
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chrX_+_49718954 0.046 NM_000084
CLCN5
chloride channel 5
chr7_+_45033757 0.044 NM_001029835
CCM2
cerebral cavernous malformation 2
chr16_+_70646008 0.044 NM_001126102
NM_005143
HP

haptoglobin

chr1_+_61697209 0.043 NFIA
nuclear factor I/A
chr20_-_45360903 0.043 ZMYND8
zinc finger, MYND-type containing 8
chr3_-_15538164 0.042 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr3_-_196792059 0.042 APOD
apolipoprotein D
chr6_+_155579788 0.042 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr16_-_18845223 0.042 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chrX_-_138742050 0.041 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr7_-_26198673 0.040 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr11_+_28086373 0.040 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr1_-_54861656 0.039 NM_176782
FAM151A
family with sequence similarity 151, member A
chr14_-_30927931 0.039 NM_015473
HEATR5A
HEAT repeat containing 5A
chr11_-_95715976 0.039 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr6_-_28591542 0.038 NM_182701
GPX6
glutathione peroxidase 6 (olfactory)
chr5_-_142795269 0.036 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr15_-_23204887 0.036 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr5_-_79982584 0.036 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chr8_-_102029997 0.034 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_+_51855133 0.034 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chr1_-_85946676 0.033 NM_001170670
NM_017953
ZNHIT6

zinc finger, HIT-type containing 6

chrX_-_13745234 0.032 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chrX_-_13745108 0.032 GPM6B
glycoprotein M6B
chr12_-_43556220 0.032 NELL2
NEL-like 2 (chicken)
chr3_-_147805715 0.032 PLSCR5
phospholipid scramblase family, member 5
chr7_-_107930170 0.031 PNPLA8
patatin-like phospholipase domain containing 8
chrX_+_36163971 0.029 NM_001098843
CXorf30
chromosome X open reading frame 30
chr22_+_29696662 0.029


chrX_-_65176564 0.029 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr2_-_18634257 0.029 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr12_-_131725848 0.028 POLE
polymerase (DNA directed), epsilon
chr10_+_91082218 0.027 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr11_-_117253354 0.026 NM_001164831
FXYD6
FXYD domain containing ion transport regulator 6
chr3_+_153499883 0.025 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr1_-_89230844 0.025 RBMXL1
CCBL2
RNA binding motif protein, X-linked-like 1
cysteine conjugate-beta lyase 2
chr6_+_167624792 0.024 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chrX_-_13744933 0.022 GPM6B
glycoprotein M6B
chr17_-_31616071 0.022 NM_001001418
NM_032258
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr1_+_84539876 0.022 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr1_-_12830728 0.021 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr11_-_5178505 0.021 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr17_+_22982372 0.021 LGALS9
lectin, galactoside-binding, soluble, 9
chr20_-_43577677 0.020 NM_006652
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr6_-_50097606 0.020 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr12_+_119224506 0.020 NM_012240
SIRT4
sirtuin 4
chrX_-_52700674 0.019 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr6_+_101953389 0.019 GRIK2
glutamate receptor, ionotropic, kainate 2
chr1_+_145841569 0.019 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr16_+_52037186 0.019 RBL2
retinoblastoma-like 2 (p130)
chr7_+_90176647 0.018 NM_012395
CDK14
cyclin-dependent kinase 14
chr3_-_195670256 0.018 NM_024524
ATP13A3
ATPase type 13A3
chr14_-_20694023 0.018 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr6_-_155818728 0.017 NM_015718
NOX3
NADPH oxidase 3
chr9_-_94206648 0.017 NM_014057
NM_033014
OGN

osteoglycin

chr11_-_28086277 0.017 NM_031217
KIF18A
kinesin family member 18A
chr8_+_7340777 0.015 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr13_+_23742846 0.015 SPATA13
spermatogenesis associated 13
chrX_-_48156287 0.014 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr22_-_48865907 0.014 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr7_+_72913424 0.013 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr6_-_152681171 0.013 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_+_134978615 0.013 TF
transferrin
chr8_-_59575249 0.012 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr2_-_133256097 0.012 NCKAP5
NCK-associated protein 5
chr19_-_59019240 0.011 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr6_-_31954795 0.011 NM_001178044
NM_025257
SLC44A4

solute carrier family 44, member 4

chr17_-_8602601 0.011 NM_001128076
SPDYE4
speedy homolog E4 (Xenopus laevis)
chr2_-_138762909 0.011


chr1_-_161105174 0.011 NM_178550
C1orf110
chromosome 1 open reading frame 110
chr6_+_101953581 0.010 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr4_-_91979113 0.010 NM_183049
TMSL3
thymosin-like 3
chr11_+_76561471 0.010 MYO7A
myosin VIIA
chr8_+_18123456 0.009 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr12_-_43555607 0.008 NM_001145109
NELL2
NEL-like 2 (chicken)
chr20_+_18070867 0.008 NM_020536
CSRP2BP
CSRP2 binding protein
chr17_-_36276987 0.008 NM_000223
KRT12
keratin 12
chr12_+_9925354 0.008 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr19_-_62659665 0.008 NM_020633
VN1R1
vomeronasal 1 receptor 1
chr17_-_33552166 0.007 NM_001123391
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr1_-_13263334 0.007 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr4_+_187385618 0.007 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr5_+_180399830 0.006 NM_152547
BTNL9
butyrophilin-like 9
chr2_+_178893216 0.006 NM_145739
OSBPL6
oxysterol binding protein-like 6
chrX_+_48127911 0.006 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr1_+_97033103 0.006


chr20_+_31106797 0.004 NM_182658
C20orf185
chromosome 20 open reading frame 185
chr19_+_54299686 0.004 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr19_+_15713200 0.003 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr2_+_119416214 0.003 NM_006770
MARCO
macrophage receptor with collagenous structure
chr5_-_22248630 0.003 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr10_+_18280773 0.003 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr9_+_122923864 0.003 CEP110
centrosomal protein 110kDa
chr8_-_7710547 0.002 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr1_-_209732881 0.002 NM_001164688
NM_183059
RD3

retinal degeneration 3

chr5_+_180399871 0.002 BTNL9
butyrophilin-like 9
chr2_-_199922047 0.001 SATB2
SATB homeobox 2
chr14_+_28311740 0.001 C14orf23
chromosome 14 open reading frame 23
chr15_+_43331719 0.000 NM_004212
SLC28A2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
11.21 4.64e-02 GO:0032483 regulation of Rab protein signal transduction

Nothing significant found in compartment category.

Nothing significant found in function category.