Motif ID: FOXN1.p2

Z-value: 1.530


Transcription factors associated with FOXN1.p2:

Gene SymbolEntrez IDGene Name
FOXN1 8456 forkhead box N1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXN1chr17_+_23875085-0.656.6e-03Click!


Activity profile for motif FOXN1.p2.

activity profile for motif FOXN1.p2


Sorted Z-values histogram for motif FOXN1.p2

Sorted Z-values for motif FOXN1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXN1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_109290107 3.688 KLF4
Kruppel-like factor 4 (gut)
chr10_+_124211353 2.652 HTRA1
HtrA serine peptidase 1
chrX_-_106846253 2.267 NM_001015881
TSC22D3
TSC22 domain family, member 3
chrX_-_106846684 2.202 TSC22D3
TSC22 domain family, member 3
chr3_-_191321367 2.111 LEPREL1
leprecan-like 1
chr7_-_27120015 1.989 HOXA3
homeobox A3
chr3_+_33293915 1.948 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr15_+_68971835 1.883 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr14_+_75521806 1.864 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chrX_+_67965517 1.704 NM_004429
EFNB1
ephrin-B1
chr12_+_56406296 1.521 LOC100130776
hypothetical LOC100130776
chr3_-_87122936 1.433 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr3_-_87122958 1.412 VGLL3
vestigial like 3 (Drosophila)
chr15_-_68971665 1.400 NM_020147
THAP10
THAP domain containing 10
chr19_-_58449752 1.378 ZNF677
zinc finger protein 677
chr8_-_11096257 1.361 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr2_-_27966715 1.354 NM_022128
RBKS
ribokinase
chr12_+_3470685 1.352 NM_019854
PRMT8
protein arginine methyltransferase 8
chr4_+_57066131 1.285 NM_206919
ARL9
ADP-ribosylation factor-like 9
chr6_+_148705646 1.269 SASH1
SAM and SH3 domain containing 1
chr1_+_32992131 1.235


chr11_+_12088639 1.230 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr3_-_191321601 1.222 NM_018192
LEPREL1
leprecan-like 1
chr6_+_116798791 1.210 NM_013352
DSE
dermatan sulfate epimerase
chr3_+_159771646 1.186 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr13_+_35903966 1.159 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr8_-_38245694 1.141 NM_001102559
NM_001102560
NM_032483
PPAPDC1B


phosphatidic acid phosphatase type 2 domain containing 1B


chrX_-_83329562 1.137 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr2_+_27966985 1.135 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr8_+_32525269 1.097 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr4_+_148621567 1.091 EDNRA
endothelin receptor type A
chr2_+_27967116 1.088 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_+_27967102 1.083 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr9_+_127550298 1.080 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr15_-_57452361 1.054 NM_004998
MYO1E
myosin IE
chr10_+_103103797 1.042 NM_003939
NM_033637
BTRC

beta-transducin repeat containing

chr15_-_57452345 1.034 MYO1E
myosin IE
chr11_+_101423378 1.030 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr15_-_57452357 1.028 MYO1E
myosin IE
chr6_-_75972286 1.019 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr15_-_37999717 1.018 GPR176
G protein-coupled receptor 176
chr1_+_82038669 1.016 NM_012302
LPHN2
latrophilin 2
chr13_+_20770248 1.007 LOC650794
hypothetical LOC650794
chr15_+_43209422 0.999 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr4_-_156517394 0.977 MAP9
microtubule-associated protein 9
chr17_+_7883076 0.976 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr9_+_81377289 0.934 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr14_-_91372365 0.923 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chr21_-_26867138 0.921 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chrX_+_15666312 0.919 NM_007220
CA5B
carbonic anhydrase VB, mitochondrial
chr7_-_84654106 0.911 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr1_-_219982081 0.909 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr4_-_86106567 0.906 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr21_+_41461962 0.902 BACE2
beta-site APP-cleaving enzyme 2
chrX_+_105856531 0.891 NM_194463
RNF128
ring finger protein 128
chr17_-_40866062 0.877 NM_174919
SH3D20
SH3 domain containing 20
chr17_-_2250967 0.868 NM_020310
MNT
MAX binding protein
chr15_-_43209348 0.863 NM_144565
DUOXA1
dual oxidase maturation factor 1
chr4_-_156517423 0.859 MAP9
microtubule-associated protein 9
chr17_-_40865987 0.846 SH3D20
SH3 domain containing 20
chr5_-_140978664 0.836 DIAPH1
diaphanous homolog 1 (Drosophila)
chr17_-_60208083 0.836 LOC146880
hypothetical LOC146880
chr2_-_73193581 0.826 NM_015470
RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr1_-_219982049 0.825 DUSP10
dual specificity phosphatase 10
chr9_+_81377419 0.821 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chrX_+_101267315 0.820 NM_080390
TCEAL2
transcription elongation factor A (SII)-like 2
chr1_-_158091760 0.820 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr17_-_37196463 0.816 NM_002230
NM_021991
JUP

junction plakoglobin

chr12_+_70952729 0.808 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr2_-_73193419 0.807 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr1_-_219982016 0.803 DUSP10
dual specificity phosphatase 10
chr17_+_7279485 0.793 NM_178518
TMEM102
transmembrane protein 102
chr15_-_37999519 0.782


chr1_+_101134276 0.757 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr2_-_73193566 0.756 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr2_+_71534260 0.755 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr5_+_156819782 0.754 NIPAL4
NIPA-like domain containing 4
chr19_+_43447262 0.752 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr5_+_60663842 0.746 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr1_+_101134259 0.743 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr9_+_81376666 0.743 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr15_-_38000379 0.742 NM_007223
GPR176
G protein-coupled receptor 176
chr2_+_27967159 0.739 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr1_+_176329895 0.736 RASAL2
RAS protein activator like 2
chr17_-_28644118 0.732 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr14_+_69148066 0.725 KIAA0247
KIAA0247
chr1_+_101134237 0.724 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr1_+_101134177 0.721 NM_001144884
NM_133496
SLC30A7

solute carrier family 30 (zinc transporter), member 7

chr12_+_52653176 0.720 NM_014212
HOXC11
homeobox C11
chr1_+_176329925 0.719 RASAL2
RAS protein activator like 2
chr3_+_121944247 0.716 NM_005513
GTF2E1
general transcription factor IIE, polypeptide 1, alpha 56kDa
chr12_+_87060176 0.708 NM_181783
TMTC3
transmembrane and tetratricopeptide repeat containing 3
chr12_-_49950236 0.704 NM_001033873
NM_001031628
SMAGP

small cell adhesion glycoprotein

chr16_-_17472238 0.701 NM_022166
XYLT1
xylosyltransferase I
chr12_-_70952572 0.701 LOC283392
hypothetical LOC283392
chr14_+_64086366 0.701 NM_172365
C14orf50
chromosome 14 open reading frame 50
chr1_+_176329860 0.685 RASAL2
RAS protein activator like 2
chr13_-_23361430 0.683 NM_005932
MIPEP
mitochondrial intermediate peptidase
chr7_+_100302885 0.683 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr2_-_165406098 0.680 COBLL1
COBL-like 1
chr4_-_122521562 0.677 NM_198179
QRFPR
pyroglutamylated RFamide peptide receptor
chr10_+_127575097 0.674 NM_145235
FANK1
fibronectin type III and ankyrin repeat domains 1
chr19_-_45888259 0.674 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr1_-_6473216 0.673 NM_001042664
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr15_-_81667773 0.671 HDGFRP3
hepatoma-derived growth factor, related protein 3
chr3_-_197106828 0.670 NM_001010938
TNK2
tyrosine kinase, non-receptor, 2
chr5_-_140978747 0.665 DIAPH1
diaphanous homolog 1 (Drosophila)
chr10_+_90740364 0.662 FAS
Fas (TNF receptor superfamily, member 6)
chr14_-_88087575 0.656 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr3_+_157876051 0.652 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr3_-_121944052 0.649 NM_173825
RABL3
RAB, member of RAS oncogene family-like 3
chr22_+_40107878 0.649 NM_003216
TEF
thyrotrophic embryonic factor
chr2_-_235070431 0.643 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr12_+_103133631 0.636 NM_001093771
TXNRD1
thioredoxin reductase 1
chr14_-_52487022 0.632 FERMT2
fermitin family member 2
chr4_-_156517544 0.630 NM_001039580
MAP9
microtubule-associated protein 9
chrX_-_99778340 0.628 NM_003270
TSPAN6
tetraspanin 6
chr3_+_151013691 0.627 RNF13
ring finger protein 13
chr3_+_151013672 0.625 RNF13
ring finger protein 13
chr4_-_170770111 0.625 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr2_-_20114761 0.624 LAPTM4A
lysosomal protein transmembrane 4 alpha
chr6_+_25387630 0.620 NM_001173977
NM_017640
LRRC16A

leucine rich repeat containing 16A

chr5_+_149320480 0.614 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr8_+_38363150 0.606 NM_144652
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr2_-_20114881 0.603 LAPTM4A
lysosomal protein transmembrane 4 alpha
chr9_+_134743532 0.603 C9orf9
chromosome 9 open reading frame 9
chr6_+_25387273 0.600 LRRC16A
leucine rich repeat containing 16A
chr3_-_109423858 0.600 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr9_+_6747919 0.596 KDM4C
lysine (K)-specific demethylase 4C
chr6_+_30002084 0.595


chr2_-_202216451 0.594 NM_001044385
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr18_-_50004770 0.590 MBD2
methyl-CpG binding domain protein 2
chr22_+_27798887 0.589 NM_001039570
NM_032045
KREMEN1

kringle containing transmembrane protein 1

chr14_+_69148062 0.588 NM_014734
KIAA0247
KIAA0247
chr9_-_34448477 0.586 NM_001184940
NM_001184941
NM_001184942
NM_001184943
NM_001184944
NM_001184945
NM_147202
C9orf25






chromosome 9 open reading frame 25






chr2_-_20115269 0.584 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr11_+_7997366 0.579 TUB
tubby homolog (mouse)
chr7_-_82629735 0.575 PCLO
piccolo (presynaptic cytomatrix protein)
chrX_-_15263596 0.574 NM_002641
NM_020473
PIGA

phosphatidylinositol glycan anchor biosynthesis, class A

chr11_+_65311104 0.569 NM_004561
OVOL1
ovo-like 1(Drosophila)
chrX_-_106846924 0.564 NM_004089
TSC22D3
TSC22 domain family, member 3
chr5_-_140978751 0.560 NM_001079812
NM_005219
DIAPH1

diaphanous homolog 1 (Drosophila)

chrX_-_15263555 0.560 PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr10_-_30065760 0.552 SVIL
supervillin
chr5_+_174084137 0.551 NM_002449
MSX2
msh homeobox 2
chr12_+_32151351 0.551 NM_001003398
NM_001714
BICD1

bicaudal D homolog 1 (Drosophila)

chrX_-_15263586 0.548 PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr3_-_121944040 0.548


chr12_-_87059877 0.543 NM_025114
CEP290
centrosomal protein 290kDa
chr1_-_158091296 0.541 C1orf204
chromosome 1 open reading frame 204
chr6_+_43151922 0.539 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chrX_-_13307425 0.539


chrX_+_17665483 0.534 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr5_-_140978744 0.534 DIAPH1
diaphanous homolog 1 (Drosophila)
chr2_-_36384 0.533 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr11_-_107969554 0.533 NM_015065
EXPH5
exophilin 5
chr10_+_124210980 0.530 NM_002775
HTRA1
HtrA serine peptidase 1
chrX_-_134013644 0.530 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr11_+_65357972 0.529 NM_152760
SNX32
sorting nexin 32
chr13_+_44461657 0.528 NM_018559
KIAA1704
KIAA1704
chr2_-_227371698 0.521 NM_005544
IRS1
insulin receptor substrate 1
chr13_-_44461554 0.507 NM_012345
NUFIP1
nuclear fragile X mental retardation protein interacting protein 1
chr19_-_54188376 0.504 GYS1
glycogen synthase 1 (muscle)
chr12_+_8741746 0.503 NM_020734
RIMKLB
ribosomal modification protein rimK-like family member B
chr9_-_21984414 0.503 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr18_-_63334902 0.495 NM_032160
DSEL
dermatan sulfate epimerase-like
chr5_+_149320630 0.491 SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chrX_+_16714452 0.491 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr20_-_49073023 0.491 NM_002237
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr17_-_40263124 0.489 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr10_-_127574957 0.487 DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr2_-_156897286 0.486 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_218768423 0.483 MARK1
MAP/microtubule affinity-regulating kinase 1
chrX_-_51256166 0.483 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr2_+_36436316 0.482 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr19_-_54188332 0.482 GYS1
glycogen synthase 1 (muscle)
chr11_+_122031549 0.479 NM_032873
UBASH3B
ubiquitin associated and SH3 domain containing B
chr16_+_49333513 0.479 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr15_+_47235243 0.478 NM_001001556
GALK2
galactokinase 2
chr3_-_135575925 0.478 NM_016201
AMOTL2
angiomotin like 2
chr15_+_71763830 0.477 CD276
CD276 molecule
chr19_-_58449919 0.475 NM_182609
ZNF677
zinc finger protein 677
chr11_-_65094319 0.475 LOC254100
hypothetical protein LOC254100
chr5_+_99899133 0.472 FAM174A
family with sequence similarity 174, member A
chr5_+_122875691 0.472 NM_001031812
NM_001044722
NM_001044723
NM_004384
CSNK1G3



casein kinase 1, gamma 3



chr17_-_10042579 0.472 NM_201433
GAS7
growth arrest-specific 7
chr13_-_77390907 0.468 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr2_-_68547893 0.468 NM_001024680
FBXO48
F-box protein 48
chr19_-_54188378 0.466 NM_001161587
NM_002103
GYS1

glycogen synthase 1 (muscle)

chr3_-_49370682 0.462 GPX1
glutathione peroxidase 1
chr4_+_148621694 0.460 EDNRA
endothelin receptor type A
chr17_+_45488330 0.460 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr19_+_61711008 0.455 NM_020813
ZNF471
zinc finger protein 471
chr12_-_70952410 0.455 LOC283392
hypothetical LOC283392
chr6_+_7486836 0.454 DSP
desmoplakin
chr11_+_66580861 0.454 NM_014578
RHOD
ras homolog gene family, member D
chr11_+_65311142 0.453 OVOL1
ovo-like 1(Drosophila)
chr5_+_149320539 0.451 SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr1_-_203557379 0.449 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr6_-_18230829 0.448 NM_198586
NHLRC1
NHL repeat containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.33 3.75e-07 GO:0044260 cellular macromolecule metabolic process
1.44 5.56e-06 GO:0044267 cellular protein metabolic process
1.53 6.24e-06 GO:0006464 protein modification process
1.12 3.33e-05 GO:0009987 cellular process
1.48 4.40e-05 GO:0043412 macromolecule modification
1.22 4.80e-05 GO:0044237 cellular metabolic process
1.26 5.89e-05 GO:0043170 macromolecule metabolic process
1.20 1.04e-03 GO:0044238 primary metabolic process
1.33 1.25e-03 GO:0019538 protein metabolic process
1.62 8.00e-03 GO:0015031 protein transport
1.61 9.44e-03 GO:0045184 establishment of protein localization
1.47 1.00e-02 GO:0009966 regulation of signal transduction
1.16 1.26e-02 GO:0008152 metabolic process
2.60 1.54e-02 GO:0006184 GTP catabolic process
1.42 1.85e-02 GO:0023051 regulation of signaling
1.30 2.74e-02 GO:0071841 cellular component organization or biogenesis at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 5.33e-14 GO:0005622 intracellular
1.17 1.15e-13 GO:0044424 intracellular part
1.22 1.09e-10 GO:0005737 cytoplasm
1.17 9.93e-07 GO:0043231 intracellular membrane-bounded organelle
1.17 1.25e-06 GO:0043227 membrane-bounded organelle
1.25 2.30e-06 GO:0005634 nucleus
1.14 4.82e-06 GO:0043229 intracellular organelle
1.14 7.15e-06 GO:0043226 organelle
1.18 2.40e-03 GO:0044444 cytoplasmic part
1.67 2.44e-03 GO:0015630 microtubule cytoskeleton
1.05 2.55e-03 GO:0044464 cell part
1.05 2.62e-03 GO:0005623 cell
1.36 7.36e-03 GO:0031981 nuclear lumen
1.30 2.66e-02 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.23 1.10e-08 GO:0005515 protein binding
1.09 4.72e-03 GO:0005488 binding
1.82 4.77e-03 GO:0016874 ligase activity
2.00 2.08e-02 GO:0016881 acid-amino acid ligase activity
2.04 3.58e-02 GO:0019787 small conjugating protein ligase activity
1.90 4.47e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.70 4.75e-02 GO:0060589 nucleoside-triphosphatase regulator activity