Motif ID: ATF5_CREB3.p2

Z-value: 3.861


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
ATF5 22809 activating transcription factor 5
CREB3 10488 cAMP responsive element binding protein 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF5chr19_+_55123770-0.811.5e-04Click!
CREB3chr9_+_357224900.656.4e-03Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_187884721 8.829


chr3_+_189354167 7.171 NM_001167672
 LPP
LIM domain containing preferred translocation partner in lipoma
chr19_+_50663089 7.078 NM_001114171
NM_006732
 FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr20_+_19863716 6.812 RIN2
Ras and Rab interactor 2
chr1_-_16355013 6.578 NM_004431
 EPHA2
EPH receptor A2
chr20_+_32610161 6.401 NM_032514
 MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr16_-_78192111 6.386 NM_001031804
NM_005360
 MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr2_-_156897286 6.333 NM_006186
 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr2_-_216009015 6.000 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr14_+_74815233 5.908 NM_005252
 FOS
FBJ murine osteosarcoma viral oncogene homolog
chr10_+_102782151 5.709 SFXN3
sideroflexin 3
chr12_-_121946581 5.132 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr11_+_12652427 4.962 NM_021961
 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr14_+_100362236 4.926 MEG3
maternally expressed 3 (non-protein coding)
chr18_+_44319365 4.903 NM_001142397
NM_014772
 CTIF

CBP80/20-dependent translation initiation factor

chr14_+_100362204 4.894 MEG3
maternally expressed 3 (non-protein coding)
chr7_+_28415495 4.889 LOC401317
hypothetical LOC401317
chr9_+_101623957 4.730 NM_006981
NM_173199
 NR4A3

nuclear receptor subfamily 4, group A, member 3

chr20_+_19903778 4.516 RIN2
Ras and Rab interactor 2
chr5_-_57791544 4.428 NM_006622
 PLK2
polo-like kinase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 62 entries
enrichment   p-value GO term description
2.80 2.63e-02 GO:0034130 toll-like receptor 1 signaling pathway
2.80 2.63e-02 GO:0034134 toll-like receptor 2 signaling pathway
2.77 1.94e-02 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
1.91 7.27e-03 GO:0010608 posttranscriptional regulation of gene expression
1.67 7.08e-06 GO:0046907 intracellular transport
1.62 2.33e-02 GO:0034613 cellular protein localization
1.61 2.99e-02 GO:0070727 cellular macromolecule localization
1.59 9.60e-05 GO:0045184 establishment of protein localization
1.58 1.12e-04 GO:0006351 transcription, DNA-dependent
1.58 1.79e-04 GO:0015031 protein transport
1.55 1.23e-05 GO:0051649 establishment of localization in cell
1.54 1.43e-06 GO:0051641 cellular localization
1.54 4.28e-05 GO:0008104 protein localization
1.49 2.23e-03 GO:0032774 RNA biosynthetic process
1.46 1.86e-07 GO:0010467 gene expression
1.46 8.18e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.45 3.26e-06 GO:0009059 macromolecule biosynthetic process
1.45 1.93e-04 GO:0033036 macromolecule localization
1.44 7.26e-06 GO:0034645 cellular macromolecule biosynthetic process
1.42 1.81e-05 GO:0016070 RNA metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
2.11 4.97e-02 GO:0016607 nuclear speck
1.65 3.83e-02 GO:0005815 microtubule organizing center
1.56 6.35e-04 GO:0015630 microtubule cytoskeleton
1.50 2.62e-02 GO:0044431 Golgi apparatus part
1.49 5.20e-03 GO:0044451 nucleoplasm part
1.45 1.38e-03 GO:0005794 Golgi apparatus
1.43 4.22e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.40 6.32e-08 GO:0044428 nuclear part
1.40 2.07e-06 GO:0031981 nuclear lumen
1.39 6.55e-04 GO:0005654 nucleoplasm
1.32 8.45e-05 GO:0070013 intracellular organelle lumen
1.31 8.96e-05 GO:0043233 organelle lumen
1.30 1.43e-04 GO:0031974 membrane-enclosed lumen
1.26 1.14e-11 GO:0005634 nucleus
1.26 8.68e-03 GO:0031090 organelle membrane
1.25 4.54e-11 GO:0044422 organelle part
1.25 1.10e-10 GO:0044446 intracellular organelle part
1.25 2.38e-02 GO:0005829 cytosol
1.24 1.18e-03 GO:0043234 protein complex
1.21 2.55e-17 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
2.02 2.86e-02 GO:0004721 phosphoprotein phosphatase activity
1.94 1.57e-03 GO:0003702 RNA polymerase II transcription factor activity
1.63 6.25e-05 GO:0043565 sequence-specific DNA binding
1.61 2.37e-07 GO:0001071 nucleic acid binding transcription factor activity
1.61 2.37e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.52 6.96e-04 GO:0003723 RNA binding
1.47 3.60e-04 GO:0030528 transcription regulator activity
1.32 1.33e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.31 1.79e-03 GO:0017076 purine nucleotide binding
1.31 2.35e-03 GO:0032553 ribonucleotide binding
1.31 2.35e-03 GO:0032555 purine ribonucleotide binding
1.30 2.77e-04 GO:0000166 nucleotide binding
1.24 1.55e-15 GO:0005515 protein binding
1.24 2.75e-04 GO:0003676 nucleic acid binding
1.12 4.17e-12 GO:0005488 binding