Motif ID: FOX{C1,C2}.p2

Z-value: 1.240


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXC1chr6_+_1556543-0.292.7e-01Click!
FOXC2chr16_+_85158357-0.097.3e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_115826481 2.987 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr2_+_189547377 2.650 COL3A1
collagen, type III, alpha 1
chr2_+_189547358 2.483 COL3A1
collagen, type III, alpha 1
chr2_+_189547323 2.437 NM_000090
COL3A1
collagen, type III, alpha 1
chr4_+_74491272 1.822 ALB
albumin
chr4_-_100359353 1.410 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr14_-_93988838 1.391 NM_001080451
SERPINA11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr4_+_120276386 1.366 NM_016599
MYOZ2
myozenin 2
chr5_+_140690387 1.362 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr14_+_94117511 1.324 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr5_+_38481392 1.242 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr14_+_94117483 1.130 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr5_+_140454382 1.122 NM_018936
PCDHB2
protocadherin beta 2
chr10_+_7785347 1.054 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_+_99309688 1.038 EML1
echinoderm microtubule associated protein like 1
chr17_-_61655915 1.032 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr6_-_152744022 1.023 SYNE1
spectrin repeat containing, nuclear envelope 1
chr10_+_7785360 1.015 ITIH2
inter-alpha (globulin) inhibitor H2
chr20_+_42417752 0.991 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr10_+_7785331 0.931 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785290 0.927 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_+_186529376 0.926 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr11_-_2113297 0.907 IGF2
insulin-like growth factor 2 (somatomedin A)
chr22_+_19239221 0.905 MED15
mediator complex subunit 15
chr12_+_99391870 0.893 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr2_-_216008689 0.848 FN1
fibronectin 1
chr4_+_74500748 0.847 ALB
albumin
chr12_+_99391681 0.829 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr10_+_7785235 0.784 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr13_-_25523164 0.778 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr2_-_88208650 0.763 NM_001443
FABP1
fatty acid binding protein 1, liver
chr10_-_91393610 0.763 NM_138316
NM_148978
PANK1

pantothenate kinase 1

chr1_+_111573855 0.762 NM_001025199
CHI3L2
chitinase 3-like 2
chr1_-_36721010 0.751 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr4_-_159312973 0.718 FAM198B
family with sequence similarity 198, member B
chr17_-_7023378 0.693 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr3_-_116272911 0.674 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr17_-_7023283 0.660 ASGR1
asialoglycoprotein receptor 1
chr17_+_70984173 0.656 KIAA0195
KIAA0195
chr21_-_35343065 0.653 RUNX1
runt-related transcription factor 1
chr10_-_60792225 0.637 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr10_+_24538094 0.637 KIAA1217
KIAA1217
chr1_+_158352143 0.632 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr1_+_179148935 0.626 NM_020950
KIAA1614
KIAA1614
chr7_+_134483305 0.624 NM_018295
TMEM140
transmembrane protein 140
chr4_-_159313167 0.595 NM_016613
FAM198B
family with sequence similarity 198, member B
chr11_-_85107569 0.586 NM_206929
SYTL2
synaptotagmin-like 2
chr11_+_111294868 0.573 C11orf52
chromosome 11 open reading frame 52
chr21_-_42608531 0.565 TFF3
trefoil factor 3 (intestinal)
chr11_+_111288686 0.565 HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr20_+_9146036 0.560 NM_182797
PLCB4
phospholipase C, beta 4
chr9_+_115958051 0.556 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr7_-_50600536 0.554 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr11_+_111294810 0.548 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr4_+_14985272 0.542 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr3_-_33675484 0.541 CLASP2
cytoplasmic linker associated protein 2
chr6_+_17390910 0.528 NM_153020
RBM24
RNA binding motif protein 24
chr2_-_188127294 0.513 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr14_+_94117545 0.513 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_-_16816113 0.509 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr17_-_3546047 0.505 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr3_-_150578023 0.491 TM4SF1
transmembrane 4 L six family member 1
chr17_-_45626364 0.490


chr1_-_53972464 0.486 NM_147193
GLIS1
GLIS family zinc finger 1
chrX_-_77801480 0.484 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr9_-_103237851 0.472 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr11_-_13474101 0.472 NM_000315
PTH
parathyroid hormone
chr6_+_142510075 0.469 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr1_+_242281199 0.466 ZNF238
zinc finger protein 238
chr2_+_158666627 0.464 NM_173355
UPP2
uridine phosphorylase 2
chr2_-_190635566 0.462 NM_005259
MSTN
myostatin
chr11_+_111288669 0.461 NM_001541
HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr22_+_16423147 0.454 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr19_-_47723183 0.450 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr5_-_35266305 0.441 PRLR
prolactin receptor
chr6_-_131333173 0.434 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr2_-_174968595 0.419 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr12_+_32546243 0.409 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr22_-_28992787 0.407 NM_020530
OSM
oncostatin M
chr3_-_150578103 0.397 TM4SF1
transmembrane 4 L six family member 1
chr18_-_63333487 0.395 DSEL
dermatan sulfate epimerase-like
chr10_+_111755715 0.387 NM_019903
ADD3
adducin 3 (gamma)
chr6_+_142510094 0.380 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr6_+_142510108 0.379 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr17_-_45620313 0.378


chr6_+_142510034 0.375 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr13_+_96592051 0.375 MBNL2
muscleblind-like 2 (Drosophila)
chr12_+_8216416 0.375 NM_001004328
ZNF705A
zinc finger protein 705A
chr2_+_87536174 0.368 NCRNA00152
non-protein coding RNA 152
chr10_+_60607232 0.366 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr10_+_90414125 0.365 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr11_-_8789457 0.362 NM_139157
ST5
suppression of tumorigenicity 5
chr1_-_56750235 0.359 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_+_238432925 0.346 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr4_-_45820686 0.341 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr9_+_111442888 0.340 NM_001037293
PALM2
paralemmin 2
chr4_-_84254912 0.340 PLAC8
placenta-specific 8
chr5_+_35892747 0.340 NM_002185
IL7R
interleukin 7 receptor
chr1_-_201321711 0.338 MYOG
myogenin (myogenic factor 4)
chr3_-_150578148 0.328 TM4SF1
transmembrane 4 L six family member 1
chr4_-_84254873 0.327 PLAC8
placenta-specific 8
chr7_-_7724762 0.327 NM_002947
RPA3
replication protein A3, 14kDa
chr7_+_94123672 0.325 PEG10
paternally expressed 10
chr4_+_146820805 0.324 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr1_-_110735158 0.321 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr8_+_70541412 0.321 NM_001128204
NM_015170
SULF1

sulfatase 1

chr15_+_60838053 0.317 TLN2
talin 2
chr2_+_87536106 0.316 NCRNA00152
non-protein coding RNA 152
chr19_-_6671585 0.311 NM_000064
C3
complement component 3
chr2_+_170074457 0.310 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr10_+_86174665 0.307 FAM190B
family with sequence similarity 190, member B
chr17_+_7563763 0.305 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr11_-_113935789 0.304 NM_152315
FAM55A
family with sequence similarity 55, member A
chr20_+_17628592 0.301 NM_001014977
NM_178477
BANF2

barrier to autointegration factor 2

chr7_-_98643024 0.301 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr6_+_12825818 0.299 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr3_-_102194938 0.296 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr20_-_32924219 0.296 NM_178026
GGT7
gamma-glutamyltransferase 7
chr7_+_143263191 0.294 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chrX_+_70438352 0.292 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chrX_+_135106578 0.292 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr2_+_190710730 0.291 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr6_-_169392771 0.290


chr1_+_151867483 0.288 NM_006271
S100A1
S100 calcium binding protein A1
chr11_+_48194937 0.284 NM_001005470
OR4B1
olfactory receptor, family 4, subfamily B, member 1
chr1_+_144149794 0.283 NM_006472
TXNIP
thioredoxin interacting protein
chr14_-_23623657 0.281 NM_006177
NRL
neural retina leucine zipper
chr11_-_61823078 0.280 NM_206998
SCGB1D4
secretoglobin, family 1D, member 4
chr6_-_159386007 0.280 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr22_+_49272078 0.279 NM_017584
MIOX
myo-inositol oxygenase
chr9_+_139265533 0.277 NM_001004353
C9orf173
chromosome 9 open reading frame 173
chrX_-_135690699 0.276 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chrX_+_68752635 0.273 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr20_+_56904042 0.273 GNAS
GNAS complex locus
chr4_-_84254932 0.272 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr5_+_173405343 0.272 HMP19
HMP19 protein
chr2_-_215998181 0.272 FN1
fibronectin 1
chr14_-_23846904 0.268 CIDEB
cell death-inducing DFFA-like effector b
chr11_-_116199145 0.268 NM_000482
APOA4
apolipoprotein A-IV
chr3_-_166397142 0.268 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr6_+_47732181 0.259 NM_153839
GPR111
G protein-coupled receptor 111
chrX_-_130250880 0.256 IGSF1
immunoglobulin superfamily, member 1
chr7_+_99263571 0.252 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr18_-_51219880 0.252 TCF4
transcription factor 4
chr17_-_33179118 0.250 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr5_+_173405298 0.250 NM_015980
HMP19
HMP19 protein
chr5_-_156525756 0.250 NM_130899
FAM71B
family with sequence similarity 71, member B
chr9_-_94338072 0.249 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr4_+_186368277 0.248 NM_031953
SNX25
sorting nexin 25
chr9_-_74735669 0.247 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_-_133076873 0.246 NM_004666
VNN1
vanin 1
chr14_-_93924663 0.244 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_-_82039158 0.240 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_+_242281175 0.230 NM_205768
ZNF238
zinc finger protein 238
chr16_-_52295214 0.226 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chr4_+_166519392 0.224 NM_001873
CPE
carboxypeptidase E
chr2_-_202271598 0.223 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr8_+_70567634 0.223 SULF1
sulfatase 1
chr3_+_99733432 0.218 NM_005290
GPR15
G protein-coupled receptor 15
chr5_-_156468571 0.218 HAVCR2
hepatitis A virus cellular receptor 2
chr14_+_23527866 0.218 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr2_+_149895274 0.216 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr17_-_36347197 0.216 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_200246370 0.212 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr2_-_188127430 0.210 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr18_-_53438854 0.210


chr4_+_71054492 0.209 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr10_-_98315090 0.208 TM9SF3
transmembrane 9 superfamily member 3
chr17_+_37967690 0.205 COASY
CoA synthase
chr21_-_42608774 0.205 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr11_+_113672407 0.203 NNMT
nicotinamide N-methyltransferase
chr8_-_95298706 0.202 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr8_-_23619866 0.201 NM_001136271
NKX2-6
NK2 transcription factor related, locus 6 (Drosophila)
chr3_-_195571748 0.201 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr3_+_153499883 0.200 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr5_+_357290 0.199 NM_020731
AHRR
aryl-hydrocarbon receptor repressor
chr17_+_37967617 0.198 NM_001042529
NM_001042530
NM_001042531
NM_001042532
NM_025233
COASY




CoA synthase




chr2_+_73864823 0.196 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chr20_+_56903595 0.192 GNAS
GNAS complex locus
chr19_-_59309719 0.192 TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr14_+_87541220 0.192 NM_003608
GPR65
G protein-coupled receptor 65
chr1_+_94656517 0.191 NM_001122674
NM_002858
ABCD3

ATP-binding cassette, sub-family D (ALD), member 3

chr21_-_35343500 0.190 RUNX1
runt-related transcription factor 1
chr5_-_58918031 0.190 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_45626967 0.190


chr14_-_93924873 0.188 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_158358067 0.188 NM_001178088
SYNJ2
synaptojanin 2
chr4_+_17125885 0.188 NM_001079827
CLRN2
clarin 2
chr2_+_121271336 0.185 NM_005270
GLI2
GLI family zinc finger 2
chr11_+_120478584 0.184 NM_005422
TECTA
tectorin alpha
chr17_+_19917420 0.184 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr13_-_98757634 0.182 NM_004951
GPR183
G protein-coupled receptor 183
chr12_-_110378240 0.181


chr2_+_27109341 0.179 TMEM214
transmembrane protein 214
chr11_+_124984559 0.178 STT3A
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
chr14_+_94160046 0.178


chr2_-_56266408 0.177 LOC100129434
hypothetical LOC100129434
chr7_+_91762227 0.176


chr8_+_55691179 0.173 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr8_+_11388918 0.172 NM_001715
BLK
B lymphoid tyrosine kinase

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.39 3.97e-03 GO:0071944 cell periphery
2.65 5.74e-03 GO:0031012 extracellular matrix
1.60 7.94e-03 GO:0005576 extracellular region
1.37 1.29e-02 GO:0005886 plasma membrane
1.79 4.71e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
18.50 1.21e-02 GO:0016175 superoxide-generating NADPH oxidase activity