Motif ID: RXR{A,B,G}.p2

Z-value: 2.923


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRGchr1_-_163680941-0.401.2e-01Click!
RXRBchr6_-_332763470.273.0e-01Click!
RXRAchr9_+_1363581340.253.6e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_44429748 6.387 NM_001160423
NM_006546
 IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr19_+_18391423 3.316


chr19_+_18391211 3.115 NM_001009998
NM_032627
 SSBP4

single stranded DNA binding protein 4

chr21_-_45532176 3.003 NM_015227
NM_133635
 POFUT2

protein O-fucosyltransferase 2

chr22_+_18081968 2.676 NM_002688
 SEPT5
septin 5
chr6_-_2916786 2.413 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr18_+_75261231 2.400 NM_172387
NM_172389
 NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr15_-_53822468 2.394 NM_173814
 PRTG
protogenin
chr17_+_35751796 2.258 NM_001024809
 RARA
retinoic acid receptor, alpha
chr12_+_50686990 2.246 NM_181711
 GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr20_+_48032918 2.207 NM_005985
 SNAI1
snail homolog 1 (Drosophila)
chr8_-_93184629 2.018 NM_001198633
NM_175634
 RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr21_+_45649719 1.976


chr14_-_103058568 1.884 CKB
creatine kinase, brain
chr3_+_129690735 1.880


chr14_-_37795001 1.876 CLEC14A
C-type lectin domain family 14, member A
chr6_-_132314004 1.861 NM_001901
 CTGF
connective tissue growth factor
chr11_+_14621972 1.824 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr6_-_2916280 1.802 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr14_-_37795290 1.758 NM_175060
 CLEC14A
C-type lectin domain family 14, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
2.96 3.69e-02 GO:0001649 osteoblast differentiation
2.13 2.98e-02 GO:0001503 ossification
1.60 6.30e-04 GO:0010629 negative regulation of gene expression
1.60 3.00e-03 GO:0051253 negative regulation of RNA metabolic process
1.58 6.70e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.54 6.05e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.53 1.18e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 6.66e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.51 2.15e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.50 1.12e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.48 1.92e-02 GO:0009890 negative regulation of biosynthetic process
1.47 3.66e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.44 2.04e-02 GO:0051128 regulation of cellular component organization
1.40 3.22e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.34 5.04e-03 GO:0009653 anatomical structure morphogenesis
1.29 2.77e-04 GO:0048519 negative regulation of biological process
1.29 6.11e-04 GO:0051252 regulation of RNA metabolic process
1.28 2.86e-03 GO:0048523 negative regulation of cellular process
1.27 1.64e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.27 6.49e-03 GO:0006355 regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.70 7.87e-03 GO:0015629 actin cytoskeleton
1.12 2.53e-02 GO:0005634 nucleus
1.10 1.16e-04 GO:0043229 intracellular organelle
1.10 1.18e-04 GO:0043226 organelle
1.10 1.07e-03 GO:0043231 intracellular membrane-bounded organelle
1.10 1.11e-03 GO:0043227 membrane-bounded organelle
1.08 1.80e-04 GO:0044424 intracellular part
1.07 2.40e-04 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.74 1.80e-03 GO:0016563 transcription activator activity
1.54 2.89e-04 GO:0043565 sequence-specific DNA binding
1.49 9.22e-06 GO:0030528 transcription regulator activity
1.47 4.61e-05 GO:0001071 nucleic acid binding transcription factor activity
1.47 4.61e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.46 2.05e-02 GO:0005198 structural molecule activity
1.28 1.29e-04 GO:0003677 DNA binding
1.12 1.06e-03 GO:0005515 protein binding