Motif ID: RXR{A,B,G}.p2

Z-value: 2.923


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRGchr1_-_163680941-0.401.2e-01Click!
RXRBchr6_-_332763470.273.0e-01Click!
RXRAchr9_+_1363581340.253.6e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_44429748 6.387 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr19_+_18391423 3.316


chr19_+_18391211 3.115 NM_001009998
NM_032627
SSBP4

single stranded DNA binding protein 4

chr21_-_45532176 3.003 NM_015227
NM_133635
POFUT2

protein O-fucosyltransferase 2

chr22_+_18081968 2.676 NM_002688
SEPT5
septin 5
chr6_-_2916786 2.413 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr18_+_75261231 2.400 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr15_-_53822468 2.394 NM_173814
PRTG
protogenin
chr17_+_35751796 2.258 NM_001024809
RARA
retinoic acid receptor, alpha
chr12_+_50686990 2.246 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr20_+_48032918 2.207 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr8_-_93184629 2.018 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr21_+_45649719 1.976


chr14_-_103058568 1.884 CKB
creatine kinase, brain
chr3_+_129690735 1.880


chr14_-_37795001 1.876 CLEC14A
C-type lectin domain family 14, member A
chr6_-_132314004 1.861 NM_001901
CTGF
connective tissue growth factor
chr11_+_14621972 1.824 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr6_-_2916280 1.802 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr14_-_37795290 1.758 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr10_-_135036805 1.755 NM_004092
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr17_+_6867090 1.741 NM_181844
BCL6B
B-cell CLL/lymphoma 6, member B
chr1_-_47468029 1.698 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr22_+_18085891 1.615 SEPT5
septin 5
chr17_+_6867138 1.612 BCL6B
B-cell CLL/lymphoma 6, member B
chr11_-_124137260 1.564 NM_138961
ESAM
endothelial cell adhesion molecule
chr10_-_17536181 1.559 NM_001004470
ST8SIA6
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr22_+_18085990 1.530 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr4_+_134292630 1.491 PCDH10
protocadherin 10
chr2_+_27155197 1.479 EMILIN1
elastin microfibril interfacer 1
chr2_+_113709553 1.451 LOC654433
hypothetical LOC654433
chr20_-_23014828 1.451 NM_012072
CD93
CD93 molecule
chr16_-_87244896 1.447 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr5_+_149845503 1.440 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr4_+_134293171 1.357 PCDH10
protocadherin 10
chr7_+_142788521 1.351 ZYX
zyxin
chr3_-_50335113 1.345 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr16_+_658158 1.344 RHOT2
ras homolog gene family, member T2
chr6_-_85529031 1.330 TBX18
T-box 18
chr11_-_86343737 1.315 FZD4
frizzled homolog 4 (Drosophila)
chr11_-_76059435 1.298 NM_001128922
LRRC32
leucine rich repeat containing 32
chr17_+_63799228 1.286 ARSG
arylsulfatase G
chr17_-_74433048 1.285 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr21_+_45649429 1.276 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr5_-_172687798 1.259 STC2
stanniocalcin 2
chr16_+_66129481 1.258 FAM65A
family with sequence similarity 65, member A
chr17_+_78286687 1.250 NM_022158
FN3K
fructosamine 3 kinase
chr17_-_63798851 1.249 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr16_-_69277355 1.240 NM_138383
MTSS1L
metastasis suppressor 1-like
chr1_+_12149662 1.238 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr16_+_658081 1.223 NM_138769
RHOT2
ras homolog gene family, member T2
chr1_-_152185764 1.209 NM_014856
DENND4B
DENN/MADD domain containing 4B
chr17_+_78630793 1.196 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr2_+_241586927 1.179 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr12_-_24946495 1.179 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr3_-_16529996 1.172 RFTN1
raftlin, lipid raft linker 1
chr7_+_142788480 1.169 NM_001010972
NM_003461
ZYX

zyxin

chr19_+_17691302 1.158 NM_018174
MAP1S
microtubule-associated protein 1S
chr18_+_2896956 1.143 EMILIN2
elastin microfibril interfacer 2
chr5_-_172688024 1.137 STC2
stanniocalcin 2
chr7_+_2638108 1.129 NM_025250
TTYH3
tweety homolog 3 (Drosophila)
chr17_+_76988134 1.128 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr9_+_35782405 1.120 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr19_+_10574055 1.117 NM_001145056
SLC44A2
solute carrier family 44, member 2
chr11_+_65162114 1.113 NM_006747
SIPA1
signal-induced proliferation-associated 1
chr19_-_18409788 1.108 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr7_-_107430566 1.107 NM_002291
LAMB1
laminin, beta 1
chr10_+_94439658 1.100 NM_002729
HHEX
hematopoietically expressed homeobox
chr12_+_130979729 1.096 NM_001002019
NM_025215
PUS1

pseudouridylate synthase 1

chr19_+_59064471 1.089 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr9_+_136673534 1.085 COL5A1
collagen, type V, alpha 1
chr10_-_30388439 1.084 NM_020848
KIAA1462
KIAA1462
chr19_+_18312365 1.080 NM_017712
FKBP8
PGPEP1
FK506 binding protein 8, 38kDa
pyroglutamyl-peptidase I
chr19_+_59064795 1.077 MYADM
myeloid-associated differentiation marker
chr12_+_130979696 1.067 NM_001002020
PUS1
pseudouridylate synthase 1
chr11_+_43920385 1.061 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr1_-_1840564 1.060 NM_178545
TMEM52
transmembrane protein 52
chr4_-_10068055 1.052 NM_053042
ZNF518B
zinc finger protein 518B
chr2_-_74583850 1.052 NM_001009812
LBX2
ladybird homeobox 2
chr11_+_113436438 1.043 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr17_-_53420473 1.037 VEZF1
vascular endothelial zinc finger 1
chr7_+_142788569 1.033 ZYX
zyxin
chr19_-_40146792 1.020 NM_175872
ZNF792
zinc finger protein 792
chr7_+_142788566 1.018 ZYX
zyxin
chr12_+_52105131 1.011 AMHR2
anti-Mullerian hormone receptor, type II
chr16_-_71650034 1.010 NM_001164766
ZFHX3
zinc finger homeobox 3
chr17_+_44643067 1.005 ABI3
ABI family, member 3
chr2_+_27154938 1.004 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr19_+_54723044 1.004 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr21_+_45532377 1.001 LOC642852
hypothetical LOC642852
chr4_+_184257337 0.996 NM_024949
WWC2
WW and C2 domain containing 2
chr11_-_86343859 0.993 NM_012193
FZD4
frizzled homolog 4 (Drosophila)
chr7_+_142788517 0.993 ZYX
zyxin
chr7_+_142788579 0.991 ZYX
zyxin
chr19_-_40146707 0.989 ZNF792
zinc finger protein 792
chr3_+_171558188 0.972 SKIL
SKI-like oncogene
chr17_-_74432800 0.968 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_+_50587468 0.957 NM_000020
ACVRL1
activin A receptor type II-like 1
chr19_-_40938251 0.955 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr5_-_131591380 0.953 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr2_+_74583762 0.940 LOC151534
hypothetical LOC151534
chr7_+_2638156 0.939 TTYH3
tweety homolog 3 (Drosophila)
chr17_-_39796649 0.937 NM_198475
FAM171A2
family with sequence similarity 171, member A2
chr20_+_52525538 0.934 NM_018431
DOK5
docking protein 5
chr3_+_171558215 0.932 SKIL
SKI-like oncogene
chr12_-_113328271 0.925 NM_181486
TBX5
T-box 5
chr3_+_171558143 0.924 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr17_+_1905104 0.913 NM_006497
HIC1
hypermethylated in cancer 1
chr15_+_39008822 0.909 NM_019074
DLL4
delta-like 4 (Drosophila)
chr1_+_26671488 0.908 NM_005517
HMGN2
high-mobility group nucleosomal binding domain 2
chr1_-_210939820 0.907 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr7_-_37454933 0.902 NM_014800
ELMO1
engulfment and cell motility 1
chr5_-_176857158 0.902 PDLIM7
PDZ and LIM domain 7 (enigma)
chr20_-_25514137 0.899 NM_025176
NINL
ninein-like
chr5_-_132141368 0.899 NM_001098813
SEPT8
septin 8
chr7_-_120285245 0.891 TSPAN12
tetraspanin 12
chrX_-_135677022 0.890 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr13_-_20533703 0.886 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chrX_+_153318662 0.876 GDI1
GDP dissociation inhibitor 1
chr6_+_69401660 0.875 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr2_-_127580975 0.875 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr7_-_124192265 0.871 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr9_-_16860719 0.871 NM_017637
BNC2
basonuclin 2
chr19_+_17691283 0.871 MAP1S
microtubule-associated protein 1S
chr11_+_67563093 0.861 TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr16_+_88315452 0.859 NM_001113525
ZNF276
zinc finger protein 276
chr7_-_150283794 0.839 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr19_-_55046718 0.839 LOC100506033
hypothetical LOC100506033
chr12_+_50104859 0.838 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr19_-_40938046 0.838 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr2_-_192767494 0.837 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr9_+_136673464 0.836 NM_000093
COL5A1
collagen, type V, alpha 1
chr11_-_63440891 0.834 NM_173587
RCOR2
REST corepressor 2
chr16_+_30815428 0.825 NM_001142544
NM_001330
CTF1

cardiotrophin 1

chr19_+_6323443 0.823 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr3_-_38666122 0.820 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr10_+_80569464 0.820 ZMIZ1
zinc finger, MIZ-type containing 1
chr19_+_16860807 0.814 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr17_-_53420595 0.813 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr5_-_176857207 0.811 NM_005451
NM_203352
NM_213636
PDLIM7


PDZ and LIM domain 7 (enigma)


chr1_-_210939929 0.809 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr10_+_97794139 0.807


chr17_-_74432671 0.805 TIMP2
TIMP metallopeptidase inhibitor 2
chr22_+_41279811 0.801 NM_014509
SERHL2
serine hydrolase-like 2
chr13_-_20533629 0.796 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr19_-_54350457 0.796 NM_002152
HRC
histidine rich calcium binding protein
chr21_+_46342440 0.795 NM_001849
NM_058174
NM_058175
COL6A2


collagen, type VI, alpha 2


chr7_+_128219307 0.793 NM_022742
CCDC136
coiled-coil domain containing 136
chr7_+_142788730 0.792 ZYX
zyxin
chr17_-_75808680 0.790 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr12_+_105873669 0.789 NM_152261
C12orf23
chromosome 12 open reading frame 23
chr20_-_43972949 0.788 PLTP
phospholipid transfer protein
chr12_+_50104936 0.787 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr12_+_130979994 0.786 PUS1
pseudouridylate synthase 1
chr8_+_69027166 0.786 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_+_71097147 0.780 MYO15B
myosin XVB pseudogene
chr7_+_78920846 0.780 LOC100505881
hypothetical LOC100505881
chr19_-_13074669 0.778 LYL1
lymphoblastic leukemia derived sequence 1
chr19_-_55046117 0.777 LOC100506033
hypothetical LOC100506033
chr17_-_6887965 0.777 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr12_+_12829807 0.766 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr11_+_117906965 0.763 NM_001144034
NM_001144035
NM_001144036
NM_001144037
NM_001144038
NM_032780
TMEM25





transmembrane protein 25





chr10_+_76256305 0.759 NM_012330
MYST4
MYST histone acetyltransferase (monocytic leukemia) 4
chr10_+_17310475 0.759 VIM
vimentin
chr8_+_16929116 0.757 NM_181723
EFHA2
EF-hand domain family, member A2
chr11_-_105398118 0.757 NM_032424
KIAA1826
KIAA1826
chr17_-_45562112 0.754 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr9_-_16860664 0.750 BNC2
basonuclin 2
chr19_-_7244876 0.748 NM_000208
NM_001079817
INSR

insulin receptor

chr17_+_56831951 0.741 NM_005994
TBX2
T-box 2
chr16_-_1369613 0.740 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr7_-_81910740 0.739 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr3_-_127558747 0.734 NM_014079
KLF15
Kruppel-like factor 15
chr19_-_13074973 0.732 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr8_+_69027277 0.731 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_+_16259573 0.731 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr11_+_117907083 0.729 TMEM25
transmembrane protein 25
chr19_+_55046229 0.729 PTOV1
prostate tumor overexpressed 1
chr9_-_130006309 0.727 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr19_+_55046088 0.724 NM_017432
PTOV1
prostate tumor overexpressed 1
chr7_-_81910956 0.719 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr19_-_12929008 0.716 GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr16_-_73857214 0.713 NM_001170720
NM_001170714
NM_001170718
BCAR1


breast cancer anti-estrogen resistance 1


chr17_-_1478293 0.713 SLC43A2
solute carrier family 43, member 2
chr20_+_32755778 0.712 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr17_-_33179118 0.707 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr7_-_126679540 0.705 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr6_-_2916980 0.704 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr5_-_132140786 0.704 NM_001098811
NM_001098812
NM_015146
SEPT8


septin 8


chr9_-_13269562 0.702 MPDZ
multiple PDZ domain protein
chr1_-_234295005 0.702 NID1
nidogen 1
chr10_-_17536351 0.701 ST8SIA6
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr6_-_37061902 0.700 MTCH1
mitochondrial carrier homolog 1 (C. elegans)
chr11_-_124175493 0.692 NM_024631
C11orf61
chromosome 11 open reading frame 61
chr19_-_12929033 0.691 NM_052850
GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr7_+_94374862 0.690 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr14_+_23937766 0.687 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr20_+_62158882 0.685 NM_198723
TCEA2
transcription elongation factor A (SII), 2
chr22_-_17891777 0.684 CLDN5
claudin 5
chr17_-_16197433 0.678 NM_181716
CENPV
centromere protein V

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 7.28e-05 GO:0065007 biological regulation
1.29 2.77e-04 GO:0048519 negative regulation of biological process
1.47 3.66e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.08 4.84e-04 GO:0009987 cellular process
1.29 6.11e-04 GO:0051252 regulation of RNA metabolic process
1.60 6.30e-04 GO:0010629 negative regulation of gene expression
1.13 7.03e-04 GO:0050789 regulation of biological process
1.13 7.82e-04 GO:0050794 regulation of cellular process
1.26 8.77e-04 GO:0010468 regulation of gene expression
1.27 1.64e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.20 2.72e-03 GO:0032502 developmental process
1.28 2.86e-03 GO:0048523 negative regulation of cellular process
1.60 3.00e-03 GO:0051253 negative regulation of RNA metabolic process
1.25 4.75e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.24 4.86e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.34 5.04e-03 GO:0009653 anatomical structure morphogenesis
1.54 6.05e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.21 6.10e-03 GO:0060255 regulation of macromolecule metabolic process
1.27 6.49e-03 GO:0006355 regulation of transcription, DNA-dependent
1.52 6.66e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.58 6.70e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.50 1.12e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.53 1.18e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.23 1.31e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.20 1.88e-02 GO:0048856 anatomical structure development
1.48 1.92e-02 GO:0009890 negative regulation of biosynthetic process
1.44 2.04e-02 GO:0051128 regulation of cellular component organization
1.22 2.12e-02 GO:0031326 regulation of cellular biosynthetic process
1.51 2.15e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.19 2.51e-02 GO:0007275 multicellular organismal development
1.19 2.58e-02 GO:0016043 cellular component organization
1.22 2.68e-02 GO:0009889 regulation of biosynthetic process
2.13 2.98e-02 GO:0001503 ossification
1.40 3.22e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.21 3.30e-02 GO:0048731 system development
2.96 3.69e-02 GO:0001649 osteoblast differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 1.16e-04 GO:0043229 intracellular organelle
1.10 1.18e-04 GO:0043226 organelle
1.08 1.80e-04 GO:0044424 intracellular part
1.07 2.40e-04 GO:0005622 intracellular
1.10 1.07e-03 GO:0043231 intracellular membrane-bounded organelle
1.10 1.11e-03 GO:0043227 membrane-bounded organelle
1.70 7.87e-03 GO:0015629 actin cytoskeleton
1.12 2.53e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.49 9.22e-06 GO:0030528 transcription regulator activity
1.47 4.61e-05 GO:0001071 nucleic acid binding transcription factor activity
1.47 4.61e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.28 1.29e-04 GO:0003677 DNA binding
1.54 2.89e-04 GO:0043565 sequence-specific DNA binding
1.12 1.06e-03 GO:0005515 protein binding
1.74 1.80e-03 GO:0016563 transcription activator activity
1.46 2.05e-02 GO:0005198 structural molecule activity