The Integrated System for Motif
Actitivity Response Analysis is
an online tool for automatically
inferring regulatory networks
from gene expression (RNA-seq/
micro-array) or chromatin state
(ChIP-seq) data.
ISMARA directly processes raw
data of a set of samples,
i.e. FASTQ, BED, BAM, SAM
(RNA-seq/ChIP-seq) or CEL
(micro-array) files.
Using the gene expression or
chromatin state data across the
samples, ISMARA identifies the
key transcription factors and
miRNAs driving the observed
expression/chromatin state
changes, and makes detailed
predictions regarding their
regulatory roles.
Results include, for each
regulatory motif, inferred
activities across the input
samples, predicted genome-wide
targets, enriched pathways and
functional classes of genes, and
direct interactions between
regulators.
All results are presented within
interactive and easily navigable
HTML pages. Full results are also
available for download.
See the video tutorials for
futher information on how to
submit data and ISMARA's results.
The developers of ISMARA give permission to you and your institution to
use the ISMARA webserver for internal, research purposes, on the following
conditions:
The ISMARA webserver will be used by you and/or your institution solely
for non-commercial purposes, except with express permission from the
authors.
You may provide us with feedback on the use of the ISMARA webserver in
your research, and we are permitted to use any information you provide in
making changes to ISMARA.
Any risk associated with using the ISMARA webserver is with you and
your institution.
Commercial users should contact us for licensing arrangements.
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