ISMARA results for ENCODE cell lines, H4K20me1 (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
NRF1.p2 5.389 NRF1 (EWG, ALPHA-PAL)
KLF12.p2 5.180 KLF12 (AP-2rep, HSPC122, AP2REP)
PRRX1,2.p2 5.043 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
RREB1.p2 4.720 RREB1 (HNT)
YY1.p2 4.714 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
PITX1..3.p2 4.385 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
TFDP1.p2 4.327 TFDP1 (Dp-1, DRTF1, DP1)
SMAD1..7,9.p2 4.325 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
EBF1.p2 3.978 EBF1 (OLF1)
ELK1,4_GABP{A,B1}.p3 3.905 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
MAZ.p2 3.859 MAZ (ZF87, Pur-1, Zif87, ZNF801)
HNF4A_NR2F1,2.p2 3.830 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
MYB.p2 3.783 MYB (c-myb)
HMGA1,2.p2 3.780 HMGA1
HMGA2 (BABL, LIPO)
TFCP2.p2 3.638 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
EHF.p2 3.463 EHF
ZNF143.p2 3.441 ZNF143 (SBF, pHZ-1, STAF)
ZNF423.p2 3.307 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
NFY{A,B,C}.p2 3.263 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
MAFB.p2 3.186 MAFB
TBP.p2 3.098 TBP (TFIID)
GTF2A1,2.p2 2.946 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
ZBTB16.p2 2.917 ZBTB16 (PLZF)
NR5A1,2.p2 2.908 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
MZF1.p2 2.866 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
ETS1,2.p2 2.859 ETS2
ETS1 (FLJ10768, ETS-1)
TLX1..3_NFIC{dimer}.p2 2.801 TLX1
TLX3 (RNX)
SP1.p2 2.777 SP1
TFAP2{A,C}.p2 2.733 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
AHR_ARNT_ARNT2.p2 2.677 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
REST.p3 2.613 REST (NRSF, XBR)
ATF5_CREB3.p2 2.562 ATF5
CREB3 (LZIP, Luman)
ESR1.p2 2.517 ESR1 (NR3A1, Era)
CDC5L.p2 2.514 CDC5L (PCDC5RP, hCDC5, CEF1)
TFAP4.p2 2.473 TFAP4 (AP-4)
FOXN1.p2 2.468 FOXN1 (FKHL20)
NFATC1..3.p2 2.451 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
MYOD1.p2 2.451 MYOD1 (PUM, MYOD, bHLHc1)
HIC1.p2 2.432 HIC1 (ZBTB29)
MTF1.p2 2.425 MTF1
EGR1..3.p2 2.423 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
ZNF148.p2 2.390 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
PAX5.p2 2.383 PAX5 (BSAP)
CDX1,2,4.p2 2.367 CDX1
CDX2
CDX4
GLI1..3.p2 2.357 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
IKZF2.p2 2.341 IKZF2 (Helios)
HBP1_HMGB_SSRP1_UBTF.p2 2.331 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
BPTF.p2 2.300 BPTF (FAC1, NURF301)
POU1F1.p2 2.290 POU1F1 (GHF-1)
TCF4_dimer.p2 2.271 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
ZNF384.p2 2.251 ZNF384 (CAGH1A, CIZ, NMP4, NP)
E2F1..5.p2 2.234 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
NKX2-2,8.p2 2.217 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
NR1H4.p2 2.165 NR1H4 (FXR, RIP14, HRR1, HRR-1)
NKX3-1.p2 2.138 NKX3-1 (NKX3.1, BAPX2)
RUNX1..3.p2 2.061 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
POU2F1..3.p2 2.046 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
NFE2L1.p2 2.042 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
HES1.p2 2.039 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
GATA6.p2 2.032 GATA6
SRY.p2 2.001 SRY (TDF)
NHLH1,2.p2 1.933 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
GATA1..3.p2 1.914 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
CTCF.p2 1.906 CTCF
CREB1.p2 1.883 CREB1
IRF1,2,7.p3 1.875 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
JUN.p2 1.848 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
SRF.p3 1.822 SRF (MCM1)
NFKB1_REL_RELA.p2 1.808 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
SNAI1..3.p2 1.807 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
HOX{A5,B5}.p2 1.787 HOXB5
HOXA5
HMX1.p2 1.770 HMX1 (H6, NKX5-3)
CRX.p2 1.735 CRX (CRD, LCA7, OTX3)
SOX5.p2 1.716 SOX5 (L-SOX5, MGC35153)
HAND1,2.p2 1.700 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
GFI1.p2 1.700 GFI1
MYFfamily.p2 1.700 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
STAT5{A,B}.p2 1.692 STAT5B
STAT5A (MGF)
FOX{I1,J2}.p2 1.691 FOXI1 (FREAC6)
FOXJ2 (FHX)
TFAP2B.p2 1.690 TFAP2B (AP2-B)
FOXO1,3,4.p2 1.678 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
EN1,2.p2 1.668 EN1
EN2
ELF1,2,4.p2 1.662 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
FOX{D1,D2}.p2 1.655 FOXD2 (FREAC9)
FOXD1 (FREAC4)
bHLH_family.p2 1.652 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
RXR{A,B,G}.p2 1.652 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
FOXA2.p3 1.627 FOXA2
NFIX.p2 1.626 NFIX (NF1A)
FOXL1.p2 1.619 FOXL1 (FREAC7, FKH6)
RFX1..5_RFXANK_RFXAP.p2 1.617 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
TFEB.p2 1.616 TFEB
RXRG_dimer.p3 1.613 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
NKX3-2.p2 1.608 NKX3-2 (NKX3B, NKX3.2)
KLF4.p3 1.595 KLF4 (EZF, GKLF)
ADNP_IRX_SIX_ZHX.p2 1.586 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
SOX{8,9,10}.p2 1.580 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
TLX2.p2 1.571 TLX2 (Enx, Tlx2, NCX)
POU5F1_SOX2{dimer}.p2 1.554 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
XBP1.p3 1.529 XBP1
GTF2I.p2 1.479 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
HOX{A6,A7,B6,B7}.p2 1.449 HOXB6
HOXA7
HOXB7
HOXA6
PPARG.p2 1.448 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
ALX1.p2 1.429 ALX1
BACH2.p2 1.428 BACH2
LEF1_TCF7_TCF7L1,2.p2 1.419 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
ONECUT1,2.p2 1.413 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
HNF1A.p2 1.405 HNF1A (HNF1, LFB1)
ZFP161.p2 1.403 ZFP161 (ZNF478, ZBTB14)
HSF1,2.p2 1.394 HSF1 (HSTF1)
HSF2
TBX4,5.p2 1.393 TBX5
TBX4
SPI1.p2 1.391 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
SPIB.p2 1.380 SPIB (SPI-B)
NFE2L2.p2 1.378 NFE2L2 (NRF2)
ESRRA.p2 1.368 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
SOX17.p2 1.351 SOX17
NANOG.p2 1.351 NANOG (FLJ12581, FLJ40451)
FOSL2.p2 1.348 FOSL2 (FRA2, FLJ23306)
PAX4.p2 1.322 PAX4
STAT2,4,6.p2 1.321 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
ZEB1.p2 1.309 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
DBP.p2 1.290 DBP (DABP)
PATZ1.p2 1.274 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
NKX6-1,2.p2 1.259 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 1.255 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
FOXQ1.p2 1.251 FOXQ1 (HFH1)
FOXP3.p2 1.238 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
TGIF1.p2 1.232 TGIF1
LMO2.p2 1.220 LMO2 (TTG2, RHOM2, RBTN2)
EVI1.p2 1.216 EVI1 (MDS1-EVI1, PRDM3)
ATF4.p2 1.213 ATF4 (TAXREB67, CREB-2)
PAX2.p2 1.204 PAX2
EP300.p2 1.188 EP300 (p300, KAT3B)
ZIC1..3.p2 1.174 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
HOX{A4,D4}.p2 1.167 HOXA4
HOXD4
FOXD3.p2 1.165 FOXD3 (Genesis, HFH2)
POU3F1..4.p2 1.158 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
PRDM1.p3 1.158 PRDM1 (PRDI-BF1)
FEV.p2 1.111 FEV (PET-1, HSRNAFEV)
FOS_FOS{B,L1}_JUN{B,D}.p2 1.106 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
NKX2-3_NKX2-5.p2 1.105 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
ARID5B.p2 1.097 ARID5B (FLJ21150, MRF2)
SREBF1,2.p2 1.088 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
ATF6.p2 1.087 ATF6 (ATF6A)
TEAD1.p2 1.077 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
MEF2{A,B,C,D}.p2 1.074 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
SPZ1.p2 1.045 SPZ1 (NYD-TSP1, FLJ25709)
NFE2.p2 1.033 NFE2 (NF-E2)
PBX1.p2 1.019 PBX1
HIF1A.p2 1.011 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
SOX2.p2 1.009 SOX2
RBPJ.p2 0.999 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
HLF.p2 0.999 HLF (MGC33822)
RXRA_VDR{dimer}.p2 0.969 VDR (NR1I1)
NFIL3.p2 0.962 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
DMAP1_NCOR{1,2}_SMARC.p2 0.958 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
NANOG{mouse}.p2 0.946 NANOG (FLJ12581, FLJ40451)
EOMES.p2 0.944 EOMES (TBR2)
GFI1B.p2 0.939 GFI1B
MYBL2.p2 0.922 MYBL2 (BMYB, B-MYB)
ATF2.p2 0.914 ATF2 (TREB7, CRE-BP1, HB16)
CEBPA,B_DDIT3.p2 0.897 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
EWSR1-FLI1.p2 0.896 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
NR3C1.p2 0.888 NR3C1 (GR)
POU6F1.p2 0.877 POU6F1 (BRN5, MPOU, TCFB1)
POU5F1.p2 0.850 POU5F1 (OCT3, Oct4, MGC22487)
NKX2-1,4.p2 0.847 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
IKZF1.p2 0.832 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
ZNF238.p2 0.827 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
LHX3,4.p2 0.827 LHX3
LHX4 (Gsh4)
T.p2 0.826 T
ZBTB6.p2 0.816 ZBTB6 (ZID)
FOX{C1,C2}.p2 0.753 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
FOX{F1,F2,J1}.p2 0.710 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
CUX2.p2 0.709 CUX2 (KIAA0293, CDP2)
HOXA9_MEIS1.p2 0.693 MEIS1
HOXA9
MSX1,2.p2 0.656 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
NR6A1.p2 0.655 NR6A1 (GCNF1, RTR)
AIRE.p2 0.587 AIRE (PGA1, APS1)
STAT1,3.p3 0.580 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
AR.p2 0.576 AR (AIS, NR3C4, SMAX1, HUMARA)
PAX6.p2 0.564 PAX6 (D11S812E, AN, WAGR)
RORA.p2 0.548 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
PDX1.p2 0.430 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
TAL1_TCF{3,4,12}.p2 0.423 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
GZF1.p2 0.376 GZF1 (dJ322G13.2, ZBTB23)
TP53.p2 0.345 TP53 (p53, LFS1)
VSX1,2.p2 0.343 VSX2 (RET1)
VSX1 (PPD)
PAX3,7.p2 0.217 PAX7 (Hup1)
PAX3 (HUP2)
PAX8.p2 0.110 PAX8

All samples sorted alphabetically


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Project name:

Sample name Condition Replicate/Batch
Rep1_GM12878
Rep1_HepG2
Rep1_HMEC
Rep1_HSMM
Rep1_Huvec
Rep1_K562
Rep1_NHEK
Rep1_NHLF
Rep2_GM12878
Rep2_HepG2
Rep2_HMEC
Rep2_HSMM
Rep2_Huvec
Rep2_K562
Rep2_NHEK
Rep2_NHLF